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The map label for this gene is fruA [H]

Identifier: 77457022

GI number: 77457022

Start: 934615

End: 936348

Strand: Direct

Name: fruA [H]

Synonym: Pfl01_0795

Alternate gene names: 77457022

Gene position: 934615-936348 (Clockwise)

Preceding gene: 77457021

Following gene: 77457023

Centisome position: 14.52

GC content: 64.71

Gene sequence:

>1734_bases
ATGAAGTTAGCCATTGTCACGTCCTGCCCGAACGGCATGGTCACCAGTGTGCTGTGCGCCCGGTTGCTGGATGCTGCGGC
CCAGCGTCAGGGCTGGAGCACCAGCGTCGAAGTGGTGGACGCCGCGCACCCTGAACGTGAATTGTCGGCGGCCACCATCG
AGGCTGCCGAGTGGGTGTTGCTGGTGGCCACGGGACCGGTGGACATGACCCGGTTCATCGGCAAGAAAGTCTTTCGGATC
GCACCGGCGCAAGCCCTGCAGGATGTCGAAGACGTGCTGCGGCGTGGCGCTGTCGAGGCCGAGGTGTACGTCGCTGTCGA
AACGCCGCCCGTGGCTGCCAGCGCTCAGGCGCCGCGTCTGGTCGCGGTCACCGCCTGCCCGACCGGCGTCGCCCACACCT
TCATGGCCGCCGAAGCCTTGCAGCAAGCCGCCAAGCGTCTGGGCTACGACCTGCAAGTCGAAACCCAGGGCTCGGTCGGC
GCGCGCAATCCGCTGAGCGCGGCAGCCATCGCCGAGGCTGACGTGGTGCTGCTGGCGGCTGACATCGAAGTCGCCACCGA
GCGTTTCGCCGGCAAGAAAATCTACCGCTGTGGCACCGGAATCGCTTTGAAGCAATCCGAAGCCACACTGAAAAAAGCCC
TGGCCGAAGGTGTCGTGGAAAGCGCTGCCGGCGACGGCAAGGCCCCGGCCAAACAAGAGAAAAGCGGCGTCTACAAACAC
CTGCTGACCGGTGTGTCGTTCATGCTGCCGATGGTGGTGGCGGGCGGTCTGATGATCGCCTTGTCGTTCGTGTTCGGCAT
CACCGCGTTCAAGGAAGAGGGTACGCTGGCGGCGGCGCTGATGCAGATCGGTGGCGAGACCGCGTTCAAATTGATGGTGC
CGTTGCTGGCCGGTTACATCGCCTGGTCGATTGCCGACCGTCCCGGACTCGCGCCGGGCATGATCGGCGGTTTGCTGGCG
AGCACCCTGGGCGCCGGTTTCATCGGCGGGATCGTCGCCGGATTTATCGCAGGCTACGCGGCCAAGGCGATCAGTCGTTA
TGTGGCGCTGCCGCAAAGCCTGGAAGCGCTGAAACCGATTCTGATCATCCCGTTGTTCGCCAGTCTGTTCACCGGGCTGG
TGATGATTTACGTGGTCGGCAAACCGGTGGCCGGGATGCTCGCGGCGCTGACGCATTTTCTCGACAGCATGGGCACCACT
AACGCAATTCTGCTCGGTGTGCTGCTGGGCGGCATGATGTGCGTCGACCTCGGCGGGCCGATCAACAAGGCCGCGTATGC
GTTCTCGGTGGGGCTGCTGGCCTCTCAGAGTTATGCACCGATGGCCGCGACCATGGCCGCCGGCATGGTGCCGCCGATCG
GTCTGGGCATCGCCACGTTCATCGCCCGGCGCAAGTTCGCCCAGACCGAACGCGAAGCCGGTAAAGCGGCGCTGGTGCTC
GGGTTGTGCTTCATCTCTGAAGGGGCGATTCCGTTTGCCGCGAAAGATCCGTTGCGGGTGATCCCGGCAAGCATTGCCGG
CGGTGCGCTGACCGGTGCGTTGTCGATGTATTTCGGCTGCAAGCTGATGGCGCCCCACGGTGGCCTGTTCGTGCTGGCGA
TCCCGAACGCGATCAACCATGCGCTGCTGTATCTGCTGGCAATCGTCGCGGGCAGCCTGCTGACGGCGGTGGTGTATGCG
CTGGTCAAGCGGCCGGAGGCCGTGGAACTGGCGCTGGAGCCCGCGAAGGCGTGA

Upstream 100 bases:

>100_bases
TAACCCAGATCGGTTTCGGTATTCACGATGCTGCGCAACTGGTGCAGCTCGAACAGGGCGTGCGCGTGCGCCCCCTGACA
GAACAATAAGAGGGTTTGTC

Downstream 100 bases:

>100_bases
GGTGTCACACCCCTTTCATCTAGTGGTGCTTAAGTTTTCCTTTTTTCAGGGAGAACACCATGAGCGATTTCAATCCCGGT
CGCCGGCGCGTGATGCAAGC

Product: PTS fructose IIC component

Products: NA

Alternate protein names: EIIBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MKLAIVTSCPNGMVTSVLCARLLDAAAQRQGWSTSVEVVDAAHPERELSAATIEAAEWVLLVATGPVDMTRFIGKKVFRI
APAQALQDVEDVLRRGAVEAEVYVAVETPPVAASAQAPRLVAVTACPTGVAHTFMAAEALQQAAKRLGYDLQVETQGSVG
ARNPLSAAAIAEADVVLLAADIEVATERFAGKKIYRCGTGIALKQSEATLKKALAEGVVESAAGDGKAPAKQEKSGVYKH
LLTGVSFMLPMVVAGGLMIALSFVFGITAFKEEGTLAAALMQIGGETAFKLMVPLLAGYIAWSIADRPGLAPGMIGGLLA
STLGAGFIGGIVAGFIAGYAAKAISRYVALPQSLEALKPILIIPLFASLFTGLVMIYVVGKPVAGMLAALTHFLDSMGTT
NAILLGVLLGGMMCVDLGGPINKAAYAFSVGLLASQSYAPMAATMAAGMVPPIGLGIATFIARRKFAQTEREAGKAALVL
GLCFISEGAIPFAAKDPLRVIPASIAGGALTGALSMYFGCKLMAPHGGLFVLAIPNAINHALLYLLAIVAGSLLTAVVYA
LVKRPEAVELALEPAKA

Sequences:

>Translated_577_residues
MKLAIVTSCPNGMVTSVLCARLLDAAAQRQGWSTSVEVVDAAHPERELSAATIEAAEWVLLVATGPVDMTRFIGKKVFRI
APAQALQDVEDVLRRGAVEAEVYVAVETPPVAASAQAPRLVAVTACPTGVAHTFMAAEALQQAAKRLGYDLQVETQGSVG
ARNPLSAAAIAEADVVLLAADIEVATERFAGKKIYRCGTGIALKQSEATLKKALAEGVVESAAGDGKAPAKQEKSGVYKH
LLTGVSFMLPMVVAGGLMIALSFVFGITAFKEEGTLAAALMQIGGETAFKLMVPLLAGYIAWSIADRPGLAPGMIGGLLA
STLGAGFIGGIVAGFIAGYAAKAISRYVALPQSLEALKPILIIPLFASLFTGLVMIYVVGKPVAGMLAALTHFLDSMGTT
NAILLGVLLGGMMCVDLGGPINKAAYAFSVGLLASQSYAPMAATMAAGMVPPIGLGIATFIARRKFAQTEREAGKAALVL
GLCFISEGAIPFAAKDPLRVIPASIAGGALTGALSMYFGCKLMAPHGGLFVLAIPNAINHALLYLLAIVAGSLLTAVVYA
LVKRPEAVELALEPAKA
>Mature_577_residues
MKLAIVTSCPNGMVTSVLCARLLDAAAQRQGWSTSVEVVDAAHPERELSAATIEAAEWVLLVATGPVDMTRFIGKKVFRI
APAQALQDVEDVLRRGAVEAEVYVAVETPPVAASAQAPRLVAVTACPTGVAHTFMAAEALQQAAKRLGYDLQVETQGSVG
ARNPLSAAAIAEADVVLLAADIEVATERFAGKKIYRCGTGIALKQSEATLKKALAEGVVESAAGDGKAPAKQEKSGVYKH
LLTGVSFMLPMVVAGGLMIALSFVFGITAFKEEGTLAAALMQIGGETAFKLMVPLLAGYIAWSIADRPGLAPGMIGGLLA
STLGAGFIGGIVAGFIAGYAAKAISRYVALPQSLEALKPILIIPLFASLFTGLVMIYVVGKPVAGMLAALTHFLDSMGTT
NAILLGVLLGGMMCVDLGGPINKAAYAFSVGLLASQSYAPMAATMAAGMVPPIGLGIATFIARRKFAQTEREAGKAALVL
GLCFISEGAIPFAAKDPLRVIPASIAGGALTGALSMYFGCKLMAPHGGLFVLAIPNAINHALLYLLAIVAGSLLTAVVYA
LVKRPEAVELALEPAKA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=570, Percent_Identity=57.0175438596491, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1786951, Length=434, Percent_Identity=38.7096774193548, Blast_Score=283, Evalue=3e-77,
Organism=Escherichia coli, GI87082348, Length=432, Percent_Identity=37.962962962963, Blast_Score=252, Evalue=5e-68,
Organism=Escherichia coli, GI1790386, Length=303, Percent_Identity=41.5841584158416, Blast_Score=208, Evalue=8e-55,
Organism=Escherichia coli, GI1788729, Length=372, Percent_Identity=28.2258064516129, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790387, Length=96, Percent_Identity=52.0833333333333, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788730, Length=97, Percent_Identity=39.1752577319588, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790390, Length=87, Percent_Identity=44.8275862068966, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 59328; Mature: 59328

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAIVTSCPNGMVTSVLCARLLDAAAQRQGWSTSVEVVDAAHPERELSAATIEAAEWVL
CEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCHHHHHHHEECCCEEE
LVATGPVDMTRFIGKKVFRIAPAQALQDVEDVLRRGAVEAEVYVAVETPPVAASAQAPRL
EEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCE
VAVTACPTGVAHTFMAAEALQQAAKRLGYDLQVETQGSVGARNPLSAAAIAEADVVLLAA
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHCCEEEEEE
DIEVATERFAGKKIYRCGTGIALKQSEATLKKALAEGVVESAAGDGKAPAKQEKSGVYKH
CHHHHHHHHCCCHHEECCCCCEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LLTGVSFMLPMVVAGGLMIALSFVFGITAFKEEGTLAAALMQIGGETAFKLMVPLLAGYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
AWSIADRPGLAPGMIGGLLASTLGAGFIGGIVAGFIAGYAAKAISRYVALPQSLEALKPI
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LIIPLFASLFTGLVMIYVVGKPVAGMLAALTHFLDSMGTTNAILLGVLLGGMMCVDLGGP
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCC
INKAAYAFSVGLLASQSYAPMAATMAAGMVPPIGLGIATFIARRKFAQTEREAGKAALVL
CHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
GLCFISEGAIPFAAKDPLRVIPASIAGGALTGALSMYFGCKLMAPHGGLFVLAIPNAINH
HHHHHHCCCCCCCCCCCHHCCCHHHCCHHHHHHHHHHHCCEEECCCCCEEEEECCHHHHH
ALLYLLAIVAGSLLTAVVYALVKRPEAVELALEPAKA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
>Mature Secondary Structure
MKLAIVTSCPNGMVTSVLCARLLDAAAQRQGWSTSVEVVDAAHPERELSAATIEAAEWVL
CEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCHHHHHHHEECCCEEE
LVATGPVDMTRFIGKKVFRIAPAQALQDVEDVLRRGAVEAEVYVAVETPPVAASAQAPRL
EEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCE
VAVTACPTGVAHTFMAAEALQQAAKRLGYDLQVETQGSVGARNPLSAAAIAEADVVLLAA
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHCCEEEEEE
DIEVATERFAGKKIYRCGTGIALKQSEATLKKALAEGVVESAAGDGKAPAKQEKSGVYKH
CHHHHHHHHCCCHHEECCCCCEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LLTGVSFMLPMVVAGGLMIALSFVFGITAFKEEGTLAAALMQIGGETAFKLMVPLLAGYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
AWSIADRPGLAPGMIGGLLASTLGAGFIGGIVAGFIAGYAAKAISRYVALPQSLEALKPI
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LIIPLFASLFTGLVMIYVVGKPVAGMLAALTHFLDSMGTTNAILLGVLLGGMMCVDLGGP
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCC
INKAAYAFSVGLLASQSYAPMAATMAAGMVPPIGLGIATFIARRKFAQTEREAGKAALVL
CHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
GLCFISEGAIPFAAKDPLRVIPASIAGGALTGALSMYFGCKLMAPHGGLFVLAIPNAINH
HHHHHHCCCCCCCCCCCHHCCCHHHCCHHHHHHHHHHHCCEEECCCCCEEEEECCHHHHH
ALLYLLAIVAGSLLTAVVYALVKRPEAVELALEPAKA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3076173; 9278503; 9097040; 1981619 [H]