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The map label for this gene is tpiA [H]

Identifier: 77457002

GI number: 77457002

Start: 910161

End: 910916

Strand: Direct

Name: tpiA [H]

Synonym: Pfl01_0775

Alternate gene names: 77457002

Gene position: 910161-910916 (Clockwise)

Preceding gene: 77457001

Following gene: 77457003

Centisome position: 14.14

GC content: 58.07

Gene sequence:

>756_bases
ATGCGTCGCCCTATGGTAGCTGGTAACTGGAAGATGCACGGTACCCGCGCCAGCGTCGCTGAGCTGATCAACGGCCTTCG
TCATCTGGCCTTGCCAAGCGGTGTTGATGTCGCGGTATTCCCGCCTTGCTTGTATATCAATCAAGTGATTGATGGCTTGA
AAGGTAAATCGATTTCGGTTGGTGCGCAGAATTCTGCGGTGGAATCCATGCAAGGTGCCTTGACGGGCGAGATTGCGCCG
AGTCAGTTGGTGGATGCAGGTTGTTCCCTGGTGCTTGTCGGGCACTCCGAGCGTCGCCAGATCATGGGCGAGCGAGACGG
AATGCTGAATCGCAAGTTTGCAGCGGCGCAGGCATGTGGCTTGATTCCGGTGTTGTGTGTAGGGGAGACCCTGGAGCAGC
GCGAAGCCGGAAAGACTCTTGAGGTTGTCGGGCGTCAGCTGGGCAGTATCATCGAGGAGCTGGGTGTCGGTGCTTTTGCC
AATGCGGTGATTGCTTATGAGCCGGTCTGGGCGATTGGTACCGGGCTGACTGCAACGCCGCAGCAGGCTCAGGATGTGCA
TAAGGCCATTCGTGAGCAGTTGGCGGCAGAGAATTCTGAAGTGGCACGAGGTGTGCGACTTCTATACGGCGGCAGCGTGA
AGGCGGCCAATGCGGTCGAACTGTTCGGCATGCCGGATATCGATGGGGGGCTCATTGGTGGGGCTTCCCTGAATGCAGAT
GAGTTCGGTGCGATTTGTCGCGCCGCGGGAAACTGA

Upstream 100 bases:

>100_bases
AACTGGCAAAACTGGTAACTGAAGTTTCTGCCTGATTCGGCTTGCCAGCCATGATTGTGTTGGGTAACATCTGCGCCCAC
TTTGACCGACGAGGTACAGC

Downstream 100 bases:

>100_bases
AAAAATGCTGGAAACAGTCGTAGTCGTTTTTCATCTGCTGGGTGCATTGGGCGTAGTTGCTCTGGTTTTGCTGCAGCAGG
GTAAAGGTGCGGACGCTGGC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MRRPMVAGNWKMHGTRASVAELINGLRHLALPSGVDVAVFPPCLYINQVIDGLKGKSISVGAQNSAVESMQGALTGEIAP
SQLVDAGCSLVLVGHSERRQIMGERDGMLNRKFAAAQACGLIPVLCVGETLEQREAGKTLEVVGRQLGSIIEELGVGAFA
NAVIAYEPVWAIGTGLTATPQQAQDVHKAIREQLAAENSEVARGVRLLYGGSVKAANAVELFGMPDIDGGLIGGASLNAD
EFGAICRAAGN

Sequences:

>Translated_251_residues
MRRPMVAGNWKMHGTRASVAELINGLRHLALPSGVDVAVFPPCLYINQVIDGLKGKSISVGAQNSAVESMQGALTGEIAP
SQLVDAGCSLVLVGHSERRQIMGERDGMLNRKFAAAQACGLIPVLCVGETLEQREAGKTLEVVGRQLGSIIEELGVGAFA
NAVIAYEPVWAIGTGLTATPQQAQDVHKAIREQLAAENSEVARGVRLLYGGSVKAANAVELFGMPDIDGGLIGGASLNAD
EFGAICRAAGN
>Mature_251_residues
MRRPMVAGNWKMHGTRASVAELINGLRHLALPSGVDVAVFPPCLYINQVIDGLKGKSISVGAQNSAVESMQGALTGEIAP
SQLVDAGCSLVLVGHSERRQIMGERDGMLNRKFAAAQACGLIPVLCVGETLEQREAGKTLEVVGRQLGSIIEELGVGAFA
NAVIAYEPVWAIGTGLTATPQQAQDVHKAIREQLAAENSEVARGVRLLYGGSVKAANAVELFGMPDIDGGLIGGASLNAD
EFGAICRAAGN

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=248, Percent_Identity=46.3709677419355, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI4507645, Length=248, Percent_Identity=46.3709677419355, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI1790353, Length=250, Percent_Identity=50.4, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17536593, Length=240, Percent_Identity=48.75, Blast_Score=200, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6320255, Length=239, Percent_Identity=45.1882845188285, Blast_Score=209, Evalue=3e-55,
Organism=Drosophila melanogaster, GI28572008, Length=248, Percent_Identity=47.1774193548387, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28572006, Length=248, Percent_Identity=47.1774193548387, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28572004, Length=248, Percent_Identity=47.1774193548387, Blast_Score=201, Evalue=3e-52,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26126; Mature: 26126

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPMVAGNWKMHGTRASVAELINGLRHLALPSGVDVAVFPPCLYINQVIDGLKGKSISV
CCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCEEEC
GAQNSAVESMQGALTGEIAPSQLVDAGCSLVLVGHSERRQIMGERDGMLNRKFAAAQACG
CCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHC
LIPVLCVGETLEQREAGKTLEVVGRQLGSIIEELGVGAFANAVIAYEPVWAIGTGLTATP
CHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEECCHHHHCCCCCCCH
QQAQDVHKAIREQLAAENSEVARGVRLLYGGSVKAANAVELFGMPDIDGGLIGGASLNAD
HHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCEEEECCCCCCCCCEECCCCCCHH
EFGAICRAAGN
HHHHHHHCCCC
>Mature Secondary Structure
MRRPMVAGNWKMHGTRASVAELINGLRHLALPSGVDVAVFPPCLYINQVIDGLKGKSISV
CCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCEEEC
GAQNSAVESMQGALTGEIAPSQLVDAGCSLVLVGHSERRQIMGERDGMLNRKFAAAQACG
CCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHC
LIPVLCVGETLEQREAGKTLEVVGRQLGSIIEELGVGAFANAVIAYEPVWAIGTGLTATP
CHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEECCHHHHCCCCCCCH
QQAQDVHKAIREQLAAENSEVARGVRLLYGGSVKAANAVELFGMPDIDGGLIGGASLNAD
HHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCEEEECCCCCCCCCEECCCCCCHH
EFGAICRAAGN
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA