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The map label for this gene is folP [H]

Identifier: 77457000

GI number: 77457000

Start: 907890

End: 908741

Strand: Direct

Name: folP [H]

Synonym: Pfl01_0773

Alternate gene names: 77457000

Gene position: 907890-908741 (Clockwise)

Preceding gene: 77456999

Following gene: 77457001

Centisome position: 14.1

GC content: 60.33

Gene sequence:

>852_bases
ATGACTTCTGTACAGTCCCTGACCCGGTTGCCTTGCGGCAACCGGGTTCTTGATTTGGCCCGGACGCACGTCATGGGCAT
TCTCAACGTAACTCCCGATTCCTTTTCCGACGGTGGCCGATACAGCCAGCACGATGCTGCCTTGCGTCATGCAGAAGCCA
TGGTTGCAGCGGGTGCGACGCTGATCGATGTGGGCGGGGAGTCGACCCGTCCGGGCGCGCGGGCGGTTTCTCCGTTGGAG
GAGCTGGAACGTGTCGCTCCCGTCGTCGAGCTGATCAATCGCGAACTGGATGTGGTCATATCGGTCGATACGTCCACTCC
GGCGGTCATGCGCGAAACAGCGCGTTTGGGTGCTGGCTTGATCAACGACGTTCGTTCGCTACGGCGGGATGGCGCGCTTG
ATGCGGCAGCGGCCACGGGATTGCCCGTGTGCCTGATGCACATGCTCGGCGAGCCTGGCGACATGCAGGATGATCCGCGT
TACCAGGATGTCACCCGGGAAGTGGGTGAGTTTCTTGCTGAACGCATGGCTCGGTGTGAGGTGGCAGGCATTCCGGCCGA
GCGGATCGTTCTCGATCCGGGCTTCGGCTTCGCCAAAACCCTGCAGCACAATCTAAGCTTGTTCAAGCATATGGAAGCCC
TGCATGCGCTGGGGCGGCCACTGTTAGTGGGCGTTTCGCGCAAAAGCATGATCGGTCATGCGTTGAATCGCTCTGTAGGT
GAGCGTCTTTACGGTGGTCTGGCATTGGCTGCCCTGGCATCGGTGAAAGGTGCGCGTATATTGCGCGTCCATGATGTGGC
GGAAACGGTGGACGTGGTGCGAATGCTCGCAGCCGTGGAATCAGCCGAATAA

Upstream 100 bases:

>100_bases
ACTGGTCGGGTGGTACCGGTACTGGCACGCCGCCTGTCATTCAGGGCGAGCGTCCGGAAACACCGATTGGCGGCCCGGCT
GCCGACGTTTAAGGTTTGAA

Downstream 100 bases:

>100_bases
GAATGATGGAGCACTTATGAGCAAGAAATACTTTGGTACTGACGGCATTCGTGGTCGTGTCGGGGAATACCCGATCACGC
CGGACTTCATGCTCAAGCTC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTSVQSLTRLPCGNRVLDLARTHVMGILNVTPDSFSDGGRYSQHDAALRHAEAMVAAGATLIDVGGESTRPGARAVSPLE
ELERVAPVVELINRELDVVISVDTSTPAVMRETARLGAGLINDVRSLRRDGALDAAAATGLPVCLMHMLGEPGDMQDDPR
YQDVTREVGEFLAERMARCEVAGIPAERIVLDPGFGFAKTLQHNLSLFKHMEALHALGRPLLVGVSRKSMIGHALNRSVG
ERLYGGLALAALASVKGARILRVHDVAETVDVVRMLAAVESAE

Sequences:

>Translated_283_residues
MTSVQSLTRLPCGNRVLDLARTHVMGILNVTPDSFSDGGRYSQHDAALRHAEAMVAAGATLIDVGGESTRPGARAVSPLE
ELERVAPVVELINRELDVVISVDTSTPAVMRETARLGAGLINDVRSLRRDGALDAAAATGLPVCLMHMLGEPGDMQDDPR
YQDVTREVGEFLAERMARCEVAGIPAERIVLDPGFGFAKTLQHNLSLFKHMEALHALGRPLLVGVSRKSMIGHALNRSVG
ERLYGGLALAALASVKGARILRVHDVAETVDVVRMLAAVESAE
>Mature_282_residues
TSVQSLTRLPCGNRVLDLARTHVMGILNVTPDSFSDGGRYSQHDAALRHAEAMVAAGATLIDVGGESTRPGARAVSPLEE
LERVAPVVELINRELDVVISVDTSTPAVMRETARLGAGLINDVRSLRRDGALDAAAATGLPVCLMHMLGEPGDMQDDPRY
QDVTREVGEFLAERMARCEVAGIPAERIVLDPGFGFAKTLQHNLSLFKHMEALHALGRPLLVGVSRKSMIGHALNRSVGE
RLYGGLALAALASVKGARILRVHDVAETVDVVRMLAAVESAE

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=267, Percent_Identity=59.1760299625468, Blast_Score=317, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6324073, Length=324, Percent_Identity=27.7777777777778, Blast_Score=118, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30237; Mature: 30106

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVQSLTRLPCGNRVLDLARTHVMGILNVTPDSFSDGGRYSQHDAALRHAEAMVAAGAT
CCCHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCE
LIDVGGESTRPGARAVSPLEELERVAPVVELINRELDVVISVDTSTPAVMRETARLGAGL
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHH
INDVRSLRRDGALDAAAATGLPVCLMHMLGEPGDMQDDPRYQDVTREVGEFLAERMARCE
HHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VAGIPAERIVLDPGFGFAKTLQHNLSLFKHMEALHALGRPLLVGVSRKSMIGHALNRSVG
HCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHH
ERLYGGLALAALASVKGARILRVHDVAETVDVVRMLAAVESAE
HHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSVQSLTRLPCGNRVLDLARTHVMGILNVTPDSFSDGGRYSQHDAALRHAEAMVAAGAT
CCHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCE
LIDVGGESTRPGARAVSPLEELERVAPVVELINRELDVVISVDTSTPAVMRETARLGAGL
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHH
INDVRSLRRDGALDAAAATGLPVCLMHMLGEPGDMQDDPRYQDVTREVGEFLAERMARCE
HHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VAGIPAERIVLDPGFGFAKTLQHNLSLFKHMEALHALGRPLLVGVSRKSMIGHALNRSVG
HCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHH
ERLYGGLALAALASVKGARILRVHDVAETVDVVRMLAAVESAE
HHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]