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The map label for this gene is pdhR [H]

Identifier: 77456981

GI number: 77456981

Start: 887597

End: 888364

Strand: Direct

Name: pdhR [H]

Synonym: Pfl01_0754

Alternate gene names: 77456981

Gene position: 887597-888364 (Clockwise)

Preceding gene: 77456973

Following gene: 77456983

Centisome position: 13.79

GC content: 59.51

Gene sequence:

>768_bases
ATGGGGTTTGATCAGATACGTCAGCGCCGTTTGTCTGATGACATTGTCGAGCGACTGGAAGGGATGATTCTCGAGGGCAC
GCTGAAGTCCGGCGAGCGTCTGCCGGCCGAGCGGGCACTGGCGGAGCAGTTCGGCGTTTCCCGGCCTTCGTTGCGCGAGG
CGATTCAGAAACTGGCGGCCAAGGGCTTGCTGGTCAGCAAGCAGGGCGGCGGCAACTATGTTGTGGAAAGCCTCGGTTCG
ACGTTCAGCGATCCGCTGCTGCAATTGCTGGAAAGCAATCCCGAGGCACAGCGCGATCTGCTGGAATTTCGTCACACACT
GGAGGCATCGTGCGCCTATTACGCAGCGTTGCGCGCCACAGACGTGGATCGTGAACGGCTGACGGCGGCGTTTGAAGAGT
TACAGGATTGCTATTCGCGTCACGATGAAGTGAGCCGGGCGGAAGAGGGTGCGGCGGATGCGAAATTCCACCTGGCGATT
GCCGAAGCCAGTCACAACGCAGTGTTGCTGCACACCATTCGCGGCTTGTTCGATCTGCTCAAGCGTAACGTGGTGACCAA
CATCGGTGGCATGTACAAGCAGCGCACGGAAACCCGCGACATGCTGATCACCCAGCATCGGGAATTGTATCTGGCGATTA
TCGAGGGGCGCGCGGAGCAGGCGCGTGAGGTCTCCAGCCGACACATTCTGTATGTGCAGGAAGTGCTGGAAGAAGTGCGA
CAGGAAGTGCAGCGCATGGCTCGCGCCGAGCGACGCAAAGGGATGTAA

Upstream 100 bases:

>100_bases
TGATCCGGTCCGGGGCGTTTCATCTGGCAGGTGTCGGCAAGGCGCCGATAGGCCAGAATAGAGAGCCCGGCGAGCGGTCG
GGATGGTGGAGAATTGAGTG

Downstream 100 bases:

>100_bases
AAAAGACCGCTCCCGTGCCAGGCGCGGGAACGGTCATTCAGGCAGAGGAATCAGTCTTCCTTGCCCTTGTTGCGCACCGC
ACGCTGCAACTCGCGACCGG

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MGFDQIRQRRLSDDIVERLEGMILEGTLKSGERLPAERALAEQFGVSRPSLREAIQKLAAKGLLVSKQGGGNYVVESLGS
TFSDPLLQLLESNPEAQRDLLEFRHTLEASCAYYAALRATDVDRERLTAAFEELQDCYSRHDEVSRAEEGAADAKFHLAI
AEASHNAVLLHTIRGLFDLLKRNVVTNIGGMYKQRTETRDMLITQHRELYLAIIEGRAEQAREVSSRHILYVQEVLEEVR
QEVQRMARAERRKGM

Sequences:

>Translated_255_residues
MGFDQIRQRRLSDDIVERLEGMILEGTLKSGERLPAERALAEQFGVSRPSLREAIQKLAAKGLLVSKQGGGNYVVESLGS
TFSDPLLQLLESNPEAQRDLLEFRHTLEASCAYYAALRATDVDRERLTAAFEELQDCYSRHDEVSRAEEGAADAKFHLAI
AEASHNAVLLHTIRGLFDLLKRNVVTNIGGMYKQRTETRDMLITQHRELYLAIIEGRAEQAREVSSRHILYVQEVLEEVR
QEVQRMARAERRKGM
>Mature_254_residues
GFDQIRQRRLSDDIVERLEGMILEGTLKSGERLPAERALAEQFGVSRPSLREAIQKLAAKGLLVSKQGGGNYVVESLGST
FSDPLLQLLESNPEAQRDLLEFRHTLEASCAYYAALRATDVDRERLTAAFEELQDCYSRHDEVSRAEEGAADAKFHLAIA
EASHNAVLLHTIRGLFDLLKRNVVTNIGGMYKQRTETRDMLITQHRELYLAIIEGRAEQAREVSSRHILYVQEVLEEVRQ
EVQRMARAERRKGM

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=237, Percent_Identity=48.1012658227848, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1790032, Length=251, Percent_Identity=39.8406374501992, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1789353, Length=242, Percent_Identity=30.5785123966942, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1790780, Length=223, Percent_Identity=30.9417040358744, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI48994955, Length=162, Percent_Identity=32.0987654320988, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87082208, Length=171, Percent_Identity=29.2397660818713, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789621, Length=190, Percent_Identity=30, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28923; Mature: 28792

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFDQIRQRRLSDDIVERLEGMILEGTLKSGERLPAERALAEQFGVSRPSLREAIQKLAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
KGLLVSKQGGGNYVVESLGSTFSDPLLQLLESNPEAQRDLLEFRHTLEASCAYYAALRAT
CCCEEECCCCCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DVDRERLTAAFEELQDCYSRHDEVSRAEEGAADAKFHLAIAEASHNAVLLHTIRGLFDLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
KRNVVTNIGGMYKQRTETRDMLITQHRELYLAIIEGRAEQAREVSSRHILYVQEVLEEVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
QEVQRMARAERRKGM
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
GFDQIRQRRLSDDIVERLEGMILEGTLKSGERLPAERALAEQFGVSRPSLREAIQKLAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
KGLLVSKQGGGNYVVESLGSTFSDPLLQLLESNPEAQRDLLEFRHTLEASCAYYAALRAT
CCCEEECCCCCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DVDRERLTAAFEELQDCYSRHDEVSRAEEGAADAKFHLAIAEASHNAVLLHTIRGLFDLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
KRNVVTNIGGMYKQRTETRDMLITQHRELYLAIIEGRAEQAREVSSRHILYVQEVLEEVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
QEVQRMARAERRKGM
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]