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The map label for this gene is fabR [H]

Identifier: 77456792

GI number: 77456792

Start: 657333

End: 657965

Strand: Reverse

Name: fabR [H]

Synonym: Pfl01_0564

Alternate gene names: 77456792

Gene position: 657965-657333 (Counterclockwise)

Preceding gene: 77456793

Following gene: 77456791

Centisome position: 10.22

GC content: 61.93

Gene sequence:

>633_bases
ATGCTGCCCCGCGCCGAACAGAAACAACAGACCCGCAACGCCCTGATGGACGCTGCCCGCCACTTGATGGAAAGCGGCCG
AGGATTCGGCAGCCTGAGCCTGCGTGAAGTGACAAAAACCGCCGGCATCGTGCCCACCGGTTTCTACCGGCATTTCGCCG
ACATGGACGAACTCGGCCTGGTACTGGTCAGCGAAGTCGGCCAGACCTTCCGCGAAACCATCCGCCTGGTGCGCCACAAC
GAATTCGTCATGGGCGGGATCATCGATGCGTCGGTGCGGATCTTCCTCGACGTGGTCAGCGCCAACCGTTCGCAATTTCT
GTTTCTGGCCCGCGAGCAGTACGGCGGATCGTTGCCGGTGCGTCAGGCCATTGGCCGCTTGCGTGAGGACATCAGCTCCG
ACCTGGCGGCGGACTTGGCCCTGATGCCCAAACTTCAGCACCTCAATCGCGAGGGTCTGAGCGTGATGGCCGACCTGATC
GTCAAATCGGTGTTCGCCACCCTGCCGGACATCATCGATCCGCCCGCCGAAGCCCTGCCGGAGCATCTGACGCCACAGGC
GAAGATCACCCAGCAGCTGCGCTTCATCTTTATCGGGTTGAAGCACTGGCAAGGACTCGGCAGTACCGAGTAA

Upstream 100 bases:

>100_bases
TCGCGATTTCCCTGCTCCATCTCCCCCGCTGCCGTTCGACGCCGACAAAGCCGATTTGCTAGAGTGCGGCGCTTGTCTTG
CCTAAGAACACACCCTTGCG

Downstream 100 bases:

>100_bases
GTAAGCAAAAATCGCAGCCTGAAGCTGCGATTTTTTTTGCGCCGCAAATTGGTGCATGTAAAAAACTTCATGCACCAAAA
CACCCCACAATCCTGCAACA

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MLPRAEQKQQTRNALMDAARHLMESGRGFGSLSLREVTKTAGIVPTGFYRHFADMDELGLVLVSEVGQTFRETIRLVRHN
EFVMGGIIDASVRIFLDVVSANRSQFLFLAREQYGGSLPVRQAIGRLREDISSDLAADLALMPKLQHLNREGLSVMADLI
VKSVFATLPDIIDPPAEALPEHLTPQAKITQQLRFIFIGLKHWQGLGSTE

Sequences:

>Translated_210_residues
MLPRAEQKQQTRNALMDAARHLMESGRGFGSLSLREVTKTAGIVPTGFYRHFADMDELGLVLVSEVGQTFRETIRLVRHN
EFVMGGIIDASVRIFLDVVSANRSQFLFLAREQYGGSLPVRQAIGRLREDISSDLAADLALMPKLQHLNREGLSVMADLI
VKSVFATLPDIIDPPAEALPEHLTPQAKITQQLRFIFIGLKHWQGLGSTE
>Mature_210_residues
MLPRAEQKQQTRNALMDAARHLMESGRGFGSLSLREVTKTAGIVPTGFYRHFADMDELGLVLVSEVGQTFRETIRLVRHN
EFVMGGIIDASVRIFLDVVSANRSQFLFLAREQYGGSLPVRQAIGRLREDISSDLAADLALMPKLQHLNREGLSVMADLI
VKSVFATLPDIIDPPAEALPEHLTPQAKITQQLRFIFIGLKHWQGLGSTE

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=200, Percent_Identity=36.5, Blast_Score=118, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23377; Mature: 23377

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPRAEQKQQTRNALMDAARHLMESGRGFGSLSLREVTKTAGIVPTGFYRHFADMDELGL
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCHHHHHH
VLVSEVGQTFRETIRLVRHNEFVMGGIIDASVRIFLDVVSANRSQFLFLAREQYGGSLPV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEEHHHCCCCCCH
RQAIGRLREDISSDLAADLALMPKLQHLNREGLSVMADLIVKSVFATLPDIIDPPAEALP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EHLTPQAKITQQLRFIFIGLKHWQGLGSTE
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLPRAEQKQQTRNALMDAARHLMESGRGFGSLSLREVTKTAGIVPTGFYRHFADMDELGL
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCHHHHHH
VLVSEVGQTFRETIRLVRHNEFVMGGIIDASVRIFLDVVSANRSQFLFLAREQYGGSLPV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEEHHHCCCCCCH
RQAIGRLREDISSDLAADLALMPKLQHLNREGLSVMADLIVKSVFATLPDIIDPPAEALP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EHLTPQAKITQQLRFIFIGLKHWQGLGSTE
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA