BacMap

Definition	Pseudomonas fluorescens Pf0-1 chromosome, complete genome.
Accession	NC_007492
Length	6,438,405

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The map label for this gene is sdh [H]

Identifier: 77456785

GI number: 77456785

Start: 651648

End: 652412

Strand: Direct

Name: sdh [H]

Synonym: Pfl01_0557

Alternate gene names: 77456785

Gene position: 651648-652412 (Clockwise)

Preceding gene: 77456784

Following gene: 77456786

Centisome position: 10.12

GC content: 63.53

Gene sequence:

>765_bases
ATGTCCAACACCCTGTTTATCACCGGCGCGACCTCCGGTTTTGGTGAAGCCTGTGCCCGTCGTTTTGCCGAGGCCGGCTG
GAAACTGGTGCTGACCGGTCGTCGTGAAGAACGCCTCAACGCGCTGTGCGCCGAGCTGTCGAAGCAGACCGAAGTGCATG
GTCTGGTGCTGGACGTGCGTGATCGCAAGGCGATGGAGGAGGCGATTGCCAACCTGCCGCCATCGTTCGCCAAGCTGCGC
GGCCTGATCAACAACGCCGGCCTGGCGCTGGGCGTGGACCCTGCACCGAAGTGCGACCTCGATGATTGGGACACCATGGT
CGACACCAACGTCAAAGGCCTGATGTACAGCACTCGCCTGTTGCTGCCGCGCCTGATCGCCCACGGTCGCGGCGCCGGTA
TCATCAACCTCGGTTCCATCGCCGGTAATTACCCGTACCCGGGCAGCCACGTTTATGGCGCGACCAAGGCGTTCGTCAAA
CAGTTCTCGCTGAACCTGCGCTGCGACCTGCAGGGCACTGGCGTGCGCGTGAGCAACATCGAGCCGGGCCTGTGCGAGAG
CGAGTTCTCGCTGGTGCGTTTCGCCGGCGATCAGGCGCGTTACGACGCCACCTACGCCGGTGCCGAGCCGATCCAGCCGC
AGGACATCGCCGAGACGATCTTCTGGGTGCTGAACGCGCCGGCGCACATCAACATCAACAGCCTGGAACTGATGCCGGTG
AGCCAGACCTGGGCCGGTTTTGCCATCGAGCGCAACAAGGCTTGA

Upstream 100 bases:

>100_bases
AGCAGGATTCGGTGGTTGCCGGTTAAAGCAGGGCCGGGCATGCTGCCCGCTGATTTTCTATTCCAATGGCTGCCCCGGCG
GCCGAAGCAAGGAGAACACG

Downstream 100 bases:

>100_bases
TACGGTTTTGCCCTCTTTGTCAGTGGGCTGGCAAAGAGGGCAAATCGGCCAAAATCTGGCAGTAAGGTAGACTCACTCCT
CAACAACCCGCCGCACCCAG

Product: Short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSNTLFITGATSGFGEACARRFAEAGWKLVLTGRREERLNALCAELSKQTEVHGLVLDVRDRKAMEEAIANLPPSFAKLR
GLINNAGLALGVDPAPKCDLDDWDTMVDTNVKGLMYSTRLLLPRLIAHGRGAGIINLGSIAGNYPYPGSHVYGATKAFVK
QFSLNLRCDLQGTGVRVSNIEPGLCESEFSLVRFAGDQARYDATYAGAEPIQPQDIAETIFWVLNAPAHININSLELMPV
SQTWAGFAIERNKA

Sequences:

>Translated_254_residues
MSNTLFITGATSGFGEACARRFAEAGWKLVLTGRREERLNALCAELSKQTEVHGLVLDVRDRKAMEEAIANLPPSFAKLR
GLINNAGLALGVDPAPKCDLDDWDTMVDTNVKGLMYSTRLLLPRLIAHGRGAGIINLGSIAGNYPYPGSHVYGATKAFVK
QFSLNLRCDLQGTGVRVSNIEPGLCESEFSLVRFAGDQARYDATYAGAEPIQPQDIAETIFWVLNAPAHININSLELMPV
SQTWAGFAIERNKA
>Mature_253_residues
SNTLFITGATSGFGEACARRFAEAGWKLVLTGRREERLNALCAELSKQTEVHGLVLDVRDRKAMEEAIANLPPSFAKLRG
LINNAGLALGVDPAPKCDLDDWDTMVDTNVKGLMYSTRLLLPRLIAHGRGAGIINLGSIAGNYPYPGSHVYGATKAFVKQ
FSLNLRCDLQGTGVRVSNIEPGLCESEFSLVRFAGDQARYDATYAGAEPIQPQDIAETIFWVLNAPAHININSLELMPVS
QTWAGFAIERNKA

Specific function: Catalyzes the oxidation of the hydroxyl group of serine to form 2-aminomalonate semialdehyde which is spontaneously converted into 2-aminoacetaldehyde and CO(2). Also acts on D- serine, L-glycerate, D-glycerate and 2-methyl-DL-serine. Does not act on O-me

COG id: COG4221

COG function: function code R; Short-chain alcohol dehydrogenase of unknown specificity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI109715829, Length=249, Percent_Identity=31.3253012048193, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI20149619, Length=225, Percent_Identity=32.4444444444444, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI7705855, Length=193, Percent_Identity=29.0155440414508, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI40548397, Length=188, Percent_Identity=32.9787234042553, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI214010158, Length=188, Percent_Identity=32.9787234042553, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI214010156, Length=188, Percent_Identity=32.9787234042553, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI22758144, Length=188, Percent_Identity=32.9787234042553, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI7706318, Length=205, Percent_Identity=31.219512195122, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI157739938, Length=192, Percent_Identity=29.6875, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI150247226, Length=181, Percent_Identity=32.5966850828729, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI32483357, Length=186, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI5031737, Length=216, Percent_Identity=28.2407407407407, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI19923817, Length=233, Percent_Identity=21.0300429184549, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=28.4210526315789, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI50726952, Length=186, Percent_Identity=31.1827956989247, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI119392083, Length=191, Percent_Identity=29.3193717277487, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI19743808, Length=181, Percent_Identity=30.3867403314917, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI22507405, Length=181, Percent_Identity=29.8342541436464, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787820, Length=248, Percent_Identity=52.4193548387097, Blast_Score=271, Evalue=4e-74,
Organism=Escherichia coli, GI87082100, Length=192, Percent_Identity=32.2916666666667, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786812, Length=242, Percent_Identity=26.8595041322314, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787335, Length=187, Percent_Identity=26.7379679144385, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI2367175, Length=234, Percent_Identity=23.9316239316239, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786701, Length=195, Percent_Identity=28.2051282051282, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=237, Percent_Identity=31.6455696202532, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=230, Percent_Identity=30, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17562904, Length=241, Percent_Identity=28.6307053941909, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=231, Percent_Identity=29.8701298701299, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=230, Percent_Identity=26.9565217391304, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17562910, Length=236, Percent_Identity=29.6610169491525, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17562908, Length=197, Percent_Identity=30.9644670050761, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=238, Percent_Identity=28.9915966386555, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=193, Percent_Identity=31.0880829015544, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=240, Percent_Identity=30.4166666666667, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=236, Percent_Identity=30.0847457627119, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=244, Percent_Identity=29.0983606557377, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=200, Percent_Identity=31.5, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=197, Percent_Identity=28.9340101522843, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=194, Percent_Identity=29.8969072164948, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=193, Percent_Identity=30.0518134715026, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=242, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=193, Percent_Identity=28.4974093264249, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=195, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=201, Percent_Identity=27.363184079602, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534660, Length=182, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=240, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=245, Percent_Identity=36.3265306122449, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322227, Length=195, Percent_Identity=27.1794871794872, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319635, Length=204, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640442, Length=209, Percent_Identity=33.0143540669856, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24643142, Length=187, Percent_Identity=32.0855614973262, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI116007236, Length=249, Percent_Identity=27.710843373494, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI23397609, Length=186, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24644339, Length=182, Percent_Identity=31.8681318681319, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358495, Length=225, Percent_Identity=27.5555555555556, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21355319, Length=198, Percent_Identity=31.3131313131313, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357041, Length=234, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24584748, Length=184, Percent_Identity=32.0652173913043, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571526, Length=231, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI161076933, Length=182, Percent_Identity=32.4175824175824, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24641388, Length=257, Percent_Identity=26.8482490272374, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281364494, Length=251, Percent_Identity=23.5059760956175, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28571387, Length=252, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24663911, Length=244, Percent_Identity=22.9508196721311, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24584752, Length=193, Percent_Identity=26.4248704663212, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI116007234, Length=250, Percent_Identity=26.4, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24584744, Length=195, Percent_Identity=29.2307692307692, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28574402, Length=195, Percent_Identity=29.2307692307692, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648944, Length=237, Percent_Identity=24.4725738396624, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24641232, Length=251, Percent_Identity=23.9043824701195, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45553409, Length=228, Percent_Identity=26.7543859649123, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647948, Length=228, Percent_Identity=26.7543859649123, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647946, Length=199, Percent_Identity=27.6381909547739, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: 1300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.276 [H]

Molecular weight: Translated: 27596; Mature: 27465

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTLFITGATSGFGEACARRFAEAGWKLVLTGRREERLNALCAELSKQTEVHGLVLDVR
CCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECH
DRKAMEEAIANLPPSFAKLRGLINNAGLALGVDPAPKCDLDDWDTMVDTNVKGLMYSTRL
HHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHH
LLPRLIAHGRGAGIINLGSIAGNYPYPGSHVYGATKAFVKQFSLNLRCDLQGTGVRVSNI
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEECCC
EPGLCESEFSLVRFAGDQARYDATYAGAEPIQPQDIAETIFWVLNAPAHININSLELMPV
CCCCCCCHHHEEEECCCCHHCCEEECCCCCCCHHHHHHHHHHHHCCCCEEECCCEEEEEC
SQTWAGFAIERNKA
CCCCCCEEEECCCC
>Mature Secondary Structure 
SNTLFITGATSGFGEACARRFAEAGWKLVLTGRREERLNALCAELSKQTEVHGLVLDVR
CCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECH
DRKAMEEAIANLPPSFAKLRGLINNAGLALGVDPAPKCDLDDWDTMVDTNVKGLMYSTRL
HHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHH
LLPRLIAHGRGAGIINLGSIAGNYPYPGSHVYGATKAFVKQFSLNLRCDLQGTGVRVSNI
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEECCC
EPGLCESEFSLVRFAGDQARYDATYAGAEPIQPQDIAETIFWVLNAPAHININSLELMPV
CCCCCCCHHHEEEECCCCHHCCEEECCCCCCCHHHHHHHHHHHHCCCCEEECCCEEEEEC
SQTWAGFAIERNKA
CCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]