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The map label for this gene is parC [H]

Identifier: 77456731

GI number: 77456731

Start: 581842

End: 584106

Strand: Direct

Name: parC [H]

Synonym: Pfl01_0503

Alternate gene names: 77456731

Gene position: 581842-584106 (Clockwise)

Preceding gene: 77456730

Following gene: 77456732

Centisome position: 9.04

GC content: 61.28

Gene sequence:

>2265_bases
ATGAGCGACAACCTTGCAGACAGCTTAGATGGCGTAGAACGCCGGTCGCTGGCTGACTTCACCGAAAATGCCTACCTCAA
CTACTCCATGTACGTGATCATGGACCGTGCCCTGCCGCATATCGGCGACGGTCTGAAACCGGTACAGCGGCGTATCGTCT
ACGCCATGAGCGAGCTGGGGCTGGACGCCGATTCCAAGCACAAGAAGTCGGCGCGTACCGTCGGCGACGTGCTCGGCAAG
TTCCACCCGCACGGCGATTCGGCGTGCTACGAAGCGATGGTGTTGATGGCCCAGCCGTTCAGCTATCGCTACACGCTGGT
GGACGGTCAGGGTAACTGGGGTGCGCCGGACGATCCGAAGTCCTTCGCCGCCATGCGTTACACCGAAGCGCGGCTGTCGC
GTTATTCCGAAGTACTGCTCAGCGAACTGGGCCAGGGCACCGCAGACTGGGGCCCGAACTTCGACGGCACCCTGCAGGAG
CCGTTGGTGTTGCCGGCACGTTTGCCGAACATCCTGCTCAACGGCACCACCGGCATCGCCGTGGGTATGGCCACCGACGT
ACCGCCGCACAACCTGCGCGAAGTCGCCACCGCGTGCGTGCGCCTGCTCGATGAGCCGAAAGCTACGGTTGAACAGCTCT
GCGAGCACATTCAGGGCCCGGACTATCCGACCGAAGCGGAAATCATCACGCCGCGCGCAGACCTGCTGAAAATGTACGAA
ACCGGCAAGGGCTCGGTGCGCATGCGCGCCGTGTACCACGTCGAGGACGGCGACATCATCGTTACCGCGCTGCCGCACCA
GGTCTCCGGGGCCAAGGTACTGGAACAGATCGCCGCGCTGATGCAGGCCAAACCGTCGAAAGCGCCGCAGATCGCCGATC
TTCGCGACGAATCCGACCACGAAAACCCGTGCCGCATCGTGATCATCCCGGTCAACAGCCGTGTCGATCACGAAGCACTG
ATGCAGCACCTGTTCGCCAGCACCGAGCTGGAGTCGACCTACCGGGTCAACGTCAACATCATCGGTCTGGACGGCAAGCC
GCAGCTGAAAAACCTCCGTGCGTTGCTGGTGGAGTGGCTGGAATTCCGCGTGCTGACCGTGCGTCGCCGTCTGCAATTCC
GACTCGACAAGGTCGAGCGTCGCCTGCACCTGTTGGACGGTTTGCTGATCGCCTACCTCAATCTGGATGAAGTGATTCAT
ATCATCCGCACCGAGGAGCATCCGAAAGCCAAGCTGATCGAGCGTTTTGCCCTCAGCGAAATCCAGGCCGACTACATCCT
CGACACCCGTCTGCGTCAGTTGGCGCGACTGGAAGAGATGAAGCTGCGCGACGAGCAGGACGAACTGCTCAAGGAACAAG
CCAAGCTGCAAGCCCTGCTGAGCAGCGAAGCCAAGCTGAAGAAGCTGGTTCGCAGCGAACTGCTGAAAGACGCCGAAACC
TACGGCGATGACCGTCGGTCGCCAATCGTTGAACGTGCCGAAGCCAAGGCGTTGACCGAACACGATCTGCTGCCGAACGA
GAAGGTTACCGTCGTACTGTCGGAAAAAGGCTGGATCCGTTCGGCCAAGGGCCACGAGATCGACGCCACTGGCCTGTCGT
ACAAGGCCGGAGACGGCTTCAAGACTTCGGCGGCGGGGCGTTCGAACCAGTCAGCCGTGGTCATCGACTCCACGGGCCGC
AGTTACTCGCTGGCCACCCACACCCTGCCATCGGCACGGGGTCAGGGCGAGCCGTTGACCGGCCGTCTGACGCCACCGCC
GGGCGCAACGTTCGAGTGTGTGCTGATGCCTGAGGAGGACTCGCTGTACGTGATCGCCTCCGACGCCGGTTACGGTTTTG
TGGTGAAAGGTGAAGACCTGCAGGCCAAGAACAAGGCCGGCAAGGCCCTGTTGAGCCTGCCCAACAACGCCAAGGTGATC
GCGCCGCGTCCGGTGGCCGATCGCGAGCACAACTGGCTGGCCTCGGTGACGACCGAGGGTCGCCTGCTGATCTTCAAGAT
CAGCGATCTGCCACAATTAGGAAAGGGCAAAGGCAACAAGATCATCGGTATTTCCGGTGAGCGTGTGGCCAGTCGCGAAG
AATATGTCACGGACATCGCCGTTCTTCCGGAAGGCGCCACCTTGGTGCTGCAGGCCGGAAAACGCACCTTGTCGCTGAAA
GCCGACGACCTCGAACACTACAAAGGTGAACGTGGTCGCCGTGGTAACAAACTGCCACGTGGCTTCCAGCGGGTGGATGC
GCTGCTCGTCGAAAACCTCAATTAA

Upstream 100 bases:

>100_bases
GATCAGGTGCTGCTCGGCATGAGCGCCCTGAACAAACTTGAATTTACTCAGCGCGGCGGCACCATGCTGCTGCGCCAGAC
AACGAACCGATGAGGCCCGC

Downstream 100 bases:

>100_bases
GCGGCCAGGAAGCGTTCGTACTGTTTTCTCCTTCGGGGAAAATGACTGAGAACGCCTCTCTAGAGCGTCCGATCTACGAT
TTAACCCGTAGATCGGCGCT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 754; Mature: 753

Protein sequence:

>754_residues
MSDNLADSLDGVERRSLADFTENAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLDADSKHKKSARTVGDVLGK
FHPHGDSACYEAMVLMAQPFSYRYTLVDGQGNWGAPDDPKSFAAMRYTEARLSRYSEVLLSELGQGTADWGPNFDGTLQE
PLVLPARLPNILLNGTTGIAVGMATDVPPHNLREVATACVRLLDEPKATVEQLCEHIQGPDYPTEAEIITPRADLLKMYE
TGKGSVRMRAVYHVEDGDIIVTALPHQVSGAKVLEQIAALMQAKPSKAPQIADLRDESDHENPCRIVIIPVNSRVDHEAL
MQHLFASTELESTYRVNVNIIGLDGKPQLKNLRALLVEWLEFRVLTVRRRLQFRLDKVERRLHLLDGLLIAYLNLDEVIH
IIRTEEHPKAKLIERFALSEIQADYILDTRLRQLARLEEMKLRDEQDELLKEQAKLQALLSSEAKLKKLVRSELLKDAET
YGDDRRSPIVERAEAKALTEHDLLPNEKVTVVLSEKGWIRSAKGHEIDATGLSYKAGDGFKTSAAGRSNQSAVVIDSTGR
SYSLATHTLPSARGQGEPLTGRLTPPPGATFECVLMPEEDSLYVIASDAGYGFVVKGEDLQAKNKAGKALLSLPNNAKVI
APRPVADREHNWLASVTTEGRLLIFKISDLPQLGKGKGNKIIGISGERVASREEYVTDIAVLPEGATLVLQAGKRTLSLK
ADDLEHYKGERGRRGNKLPRGFQRVDALLVENLN

Sequences:

>Translated_754_residues
MSDNLADSLDGVERRSLADFTENAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLDADSKHKKSARTVGDVLGK
FHPHGDSACYEAMVLMAQPFSYRYTLVDGQGNWGAPDDPKSFAAMRYTEARLSRYSEVLLSELGQGTADWGPNFDGTLQE
PLVLPARLPNILLNGTTGIAVGMATDVPPHNLREVATACVRLLDEPKATVEQLCEHIQGPDYPTEAEIITPRADLLKMYE
TGKGSVRMRAVYHVEDGDIIVTALPHQVSGAKVLEQIAALMQAKPSKAPQIADLRDESDHENPCRIVIIPVNSRVDHEAL
MQHLFASTELESTYRVNVNIIGLDGKPQLKNLRALLVEWLEFRVLTVRRRLQFRLDKVERRLHLLDGLLIAYLNLDEVIH
IIRTEEHPKAKLIERFALSEIQADYILDTRLRQLARLEEMKLRDEQDELLKEQAKLQALLSSEAKLKKLVRSELLKDAET
YGDDRRSPIVERAEAKALTEHDLLPNEKVTVVLSEKGWIRSAKGHEIDATGLSYKAGDGFKTSAAGRSNQSAVVIDSTGR
SYSLATHTLPSARGQGEPLTGRLTPPPGATFECVLMPEEDSLYVIASDAGYGFVVKGEDLQAKNKAGKALLSLPNNAKVI
APRPVADREHNWLASVTTEGRLLIFKISDLPQLGKGKGNKIIGISGERVASREEYVTDIAVLPEGATLVLQAGKRTLSLK
ADDLEHYKGERGRRGNKLPRGFQRVDALLVENLN
>Mature_753_residues
SDNLADSLDGVERRSLADFTENAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLDADSKHKKSARTVGDVLGKF
HPHGDSACYEAMVLMAQPFSYRYTLVDGQGNWGAPDDPKSFAAMRYTEARLSRYSEVLLSELGQGTADWGPNFDGTLQEP
LVLPARLPNILLNGTTGIAVGMATDVPPHNLREVATACVRLLDEPKATVEQLCEHIQGPDYPTEAEIITPRADLLKMYET
GKGSVRMRAVYHVEDGDIIVTALPHQVSGAKVLEQIAALMQAKPSKAPQIADLRDESDHENPCRIVIIPVNSRVDHEALM
QHLFASTELESTYRVNVNIIGLDGKPQLKNLRALLVEWLEFRVLTVRRRLQFRLDKVERRLHLLDGLLIAYLNLDEVIHI
IRTEEHPKAKLIERFALSEIQADYILDTRLRQLARLEEMKLRDEQDELLKEQAKLQALLSSEAKLKKLVRSELLKDAETY
GDDRRSPIVERAEAKALTEHDLLPNEKVTVVLSEKGWIRSAKGHEIDATGLSYKAGDGFKTSAAGRSNQSAVVIDSTGRS
YSLATHTLPSARGQGEPLTGRLTPPPGATFECVLMPEEDSLYVIASDAGYGFVVKGEDLQAKNKAGKALLSLPNNAKVIA
PRPVADREHNWLASVTTEGRLLIFKISDLPQLGKGKGNKIIGISGERVASREEYVTDIAVLPEGATLVLQAGKRTLSLKA
DDLEHYKGERGRRGNKLPRGFQRVDALLVENLN

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=743, Percent_Identity=65.6796769851952, Blast_Score=1016, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=757, Percent_Identity=36.1955085865258, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI212645845, Length=513, Percent_Identity=22.6120857699805, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=279, Percent_Identity=24.0143369175627, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83544; Mature: 83412

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNLADSLDGVERRSLADFTENAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELG
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LDADSKHKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYTLVDGQGNWGAPDDPK
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCH
SFAAMRYTEARLSRYSEVLLSELGQGTADWGPNFDGTLQEPLVLPARLPNILLNGTTGIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCEEEECCCCEE
VGMATDVPPHNLREVATACVRLLDEPKATVEQLCEHIQGPDYPTEAEIITPRADLLKMYE
EEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHH
TGKGSVRMRAVYHVEDGDIIVTALPHQVSGAKVLEQIAALMQAKPSKAPQIADLRDESDH
CCCCCEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ENPCRIVIIPVNSRVDHEALMQHLFASTELESTYRVNVNIIGLDGKPQLKNLRALLVEWL
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHH
EFRVLTVRRRLQFRLDKVERRLHLLDGLLIAYLNLDEVIHIIRTEEHPKAKLIERFALSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHH
IQADYILDTRLRQLARLEEMKLRDEQDELLKEQAKLQALLSSEAKLKKLVRSELLKDAET
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGDDRRSPIVERAEAKALTEHDLLPNEKVTVVLSEKGWIRSAKGHEIDATGLSYKAGDGF
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCCCEEECCCCCEECCCCC
KTSAAGRSNQSAVVIDSTGRSYSLATHTLPSARGQGEPLTGRLTPPPGATFECVLMPEED
CCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
SLYVIASDAGYGFVVKGEDLQAKNKAGKALLSLPNNAKVIAPRPVADREHNWLASVTTEG
CEEEEEECCCCEEEEECCCCCCHHHHCCEEEECCCCCEEEECCCCCCCCCCEEEEEECCC
RLLIFKISDLPQLGKGKGNKIIGISGERVASREEYVTDIAVLPEGATLVLQAGKRTLSLK
EEEEEEECCCCCCCCCCCCEEEEECCCHHHCHHHHHHEEEECCCCCEEEEECCCCEEEEE
ADDLEHYKGERGRRGNKLPRGFQRVDALLVENLN
CHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDNLADSLDGVERRSLADFTENAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELG
CCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LDADSKHKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYTLVDGQGNWGAPDDPK
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCH
SFAAMRYTEARLSRYSEVLLSELGQGTADWGPNFDGTLQEPLVLPARLPNILLNGTTGIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCEEEECCCCEE
VGMATDVPPHNLREVATACVRLLDEPKATVEQLCEHIQGPDYPTEAEIITPRADLLKMYE
EEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHH
TGKGSVRMRAVYHVEDGDIIVTALPHQVSGAKVLEQIAALMQAKPSKAPQIADLRDESDH
CCCCCEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ENPCRIVIIPVNSRVDHEALMQHLFASTELESTYRVNVNIIGLDGKPQLKNLRALLVEWL
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHH
EFRVLTVRRRLQFRLDKVERRLHLLDGLLIAYLNLDEVIHIIRTEEHPKAKLIERFALSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHH
IQADYILDTRLRQLARLEEMKLRDEQDELLKEQAKLQALLSSEAKLKKLVRSELLKDAET
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGDDRRSPIVERAEAKALTEHDLLPNEKVTVVLSEKGWIRSAKGHEIDATGLSYKAGDGF
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCCCEEECCCCCEECCCCC
KTSAAGRSNQSAVVIDSTGRSYSLATHTLPSARGQGEPLTGRLTPPPGATFECVLMPEED
CCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
SLYVIASDAGYGFVVKGEDLQAKNKAGKALLSLPNNAKVIAPRPVADREHNWLASVTTEG
CEEEEEECCCCEEEEECCCCCCHHHHCCEEEECCCCCEEEECCCCCCCCCCEEEEEECCC
RLLIFKISDLPQLGKGKGNKIIGISGERVASREEYVTDIAVLPEGATLVLQAGKRTLSLK
EEEEEEECCCCCCCCCCCCEEEEECCCHHHCHHHHHHEEEECCCCCEEEEECCCCEEEEE
ADDLEHYKGERGRRGNKLPRGFQRVDALLVENLN
CHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]