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The map label for this gene is tolC [H]

Identifier: 77456719

GI number: 77456719

Start: 568234

End: 569667

Strand: Reverse

Name: tolC [H]

Synonym: Pfl01_0491

Alternate gene names: 77456719

Gene position: 569667-568234 (Counterclockwise)

Preceding gene: 77456722

Following gene: 77456716

Centisome position: 8.85

GC content: 63.46

Gene sequence:

>1434_bases
ATGCTGCGCAAACTCTCACTGGCTGTTGCCGTGTCTTGTGCGTCCACCACAACGGTCTGGGCAGCAGAAGCGCCTTTATC
GACCAAGACTGATCTGGTCAGCGTCTATCAGGAAGCGGTCGACAACAACGCCGACCTGGCCGCCGCCCGCGCCCAGTACG
GTGCGCAGAAAGAAGTCGTGCCCCAGGCCCGCGCCGGGTTGCTGCCGAACCTGTCCGGCGGCGCTGAAGTCGCCAACGTA
CGCACGTCGATCGACCAGCCCTCGGCCATCGCCAACCGCAGCGCGCACTCCTATCAGGCGACCCTGGCGCAGCCGCTGTT
CCGCGCCGACCGCTGGTTCCAGTACCAGGCCGCCAAGGACGTCAACGAGCAGGCCGCGCTGCAACTCTCGGCCACCGAGC
AGAACCTGATCCTGCAAACCGCCGAAAGCTATTTCAACGTGCTGCGCAGCCAGGACAACCTGGCCTCGACCAAAGCCGAG
GAAGCCGCGTTCAAGCGCCAGCTCGATCAGTCCAACGAGCGCTTCGATGTGGGCCTGTCGGACAAGACCGACGTGCTGCA
ATCGCAAGCCAGTTACGACACCGCACGCGCCAACCGGATCGTCGCCCAGCGTCAGGTCGATGATGCGTTCGAAGCGCTGA
TCACCCTGACCAACCGCCAGTACAACTCGATCCAGGGCATCGTCCACACCCTGCCGATCCTGCCGCCGGCACCGAACGAC
GCCAAGGCCTGGGTCGATACCGCCGCGAAACAGAACCTCAATCTGCTGGCCAGCAACTATGCGGTCAGCTCCGCCGAACA
GACCCTGAAACAGCGCAAGGCCGGCCACCTGCCGACCCTCGACGCCGTGGCCAAATACGAAAAGGGCGACAACGACGCCC
TGGGTTTCTCCAACCCGAATGCGTTCGGTACGCCGTACAGTGGCAATGTCGAGCAGAGCACCGTGGGCCTGCAACTGAAC
ATTCCGATCTACAGTGGCGGATTGACCAGCTCCCAGGTGCGCGAGTCCTACTCACGGCTGGACCAGACCGAACAGCAGCG
TGAAGGCCTGCGTCGGCAAGTGGTCGAGAACACCCGCAACCTGCACCGCGCGGTGAACACCGACGTCGAGCAGGTGCAGG
CGCGCCGCCAGTCGATCATCTCCAACCAGAGTGCGGTGGAAGCCACGGAAATCGGTTATCAGGTGGGGACGCGCAACATC
GTCGACGTGCTCGACGCCCAGCGTCAGCTGTACACCTCGGTGCGCAACTACAACAACACCCGCTACGACTACATCCTCGA
CAATCTGCGCTTGAAGCAGGCGGCGGGGACGTTGAACCCGGGCGACTTGCAGGATCTGACCCGCTACCTGAAGGCCGACT
ACAACCCGGACAAGGATTTCCTGCCGCCGGATCTGGCCAAGGCTGCCGAAGCCCAGCTCAAGGCCCGGCCTTAA

Upstream 100 bases:

>100_bases
CTACACTCGCTACGCCATGCTGCGCCTTGACGCTGCATGGGCCGCGCCTTACCTTTGGCGCCCGGATTATTTCCATAATA
TTCATGCTAGGGATCGCCTC

Downstream 100 bases:

>100_bases
ACAAGAAACGCAGCCCTGAGGCTGCGTTTTTTTATGGGCGGTCGATCAACCTTCCCAGTCCATCGAGCAAGCGCTGCAAC
GCGCCCTGATTGCGGCGCAT

Product: Type I secretion outer membrane protein, TolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MLRKLSLAVAVSCASTTTVWAAEAPLSTKTDLVSVYQEAVDNNADLAAARAQYGAQKEVVPQARAGLLPNLSGGAEVANV
RTSIDQPSAIANRSAHSYQATLAQPLFRADRWFQYQAAKDVNEQAALQLSATEQNLILQTAESYFNVLRSQDNLASTKAE
EAAFKRQLDQSNERFDVGLSDKTDVLQSQASYDTARANRIVAQRQVDDAFEALITLTNRQYNSIQGIVHTLPILPPAPND
AKAWVDTAAKQNLNLLASNYAVSSAEQTLKQRKAGHLPTLDAVAKYEKGDNDALGFSNPNAFGTPYSGNVEQSTVGLQLN
IPIYSGGLTSSQVRESYSRLDQTEQQREGLRRQVVENTRNLHRAVNTDVEQVQARRQSIISNQSAVEATEIGYQVGTRNI
VDVLDAQRQLYTSVRNYNNTRYDYILDNLRLKQAAGTLNPGDLQDLTRYLKADYNPDKDFLPPDLAKAAEAQLKARP

Sequences:

>Translated_477_residues
MLRKLSLAVAVSCASTTTVWAAEAPLSTKTDLVSVYQEAVDNNADLAAARAQYGAQKEVVPQARAGLLPNLSGGAEVANV
RTSIDQPSAIANRSAHSYQATLAQPLFRADRWFQYQAAKDVNEQAALQLSATEQNLILQTAESYFNVLRSQDNLASTKAE
EAAFKRQLDQSNERFDVGLSDKTDVLQSQASYDTARANRIVAQRQVDDAFEALITLTNRQYNSIQGIVHTLPILPPAPND
AKAWVDTAAKQNLNLLASNYAVSSAEQTLKQRKAGHLPTLDAVAKYEKGDNDALGFSNPNAFGTPYSGNVEQSTVGLQLN
IPIYSGGLTSSQVRESYSRLDQTEQQREGLRRQVVENTRNLHRAVNTDVEQVQARRQSIISNQSAVEATEIGYQVGTRNI
VDVLDAQRQLYTSVRNYNNTRYDYILDNLRLKQAAGTLNPGDLQDLTRYLKADYNPDKDFLPPDLAKAAEAQLKARP
>Mature_477_residues
MLRKLSLAVAVSCASTTTVWAAEAPLSTKTDLVSVYQEAVDNNADLAAARAQYGAQKEVVPQARAGLLPNLSGGAEVANV
RTSIDQPSAIANRSAHSYQATLAQPLFRADRWFQYQAAKDVNEQAALQLSATEQNLILQTAESYFNVLRSQDNLASTKAE
EAAFKRQLDQSNERFDVGLSDKTDVLQSQASYDTARANRIVAQRQVDDAFEALITLTNRQYNSIQGIVHTLPILPPAPND
AKAWVDTAAKQNLNLLASNYAVSSAEQTLKQRKAGHLPTLDAVAKYEKGDNDALGFSNPNAFGTPYSGNVEQSTVGLQLN
IPIYSGGLTSSQVRESYSRLDQTEQQREGLRRQVVENTRNLHRAVNTDVEQVQARRQSIISNQSAVEATEIGYQVGTRNI
VDVLDAQRQLYTSVRNYNNTRYDYILDNLRLKQAAGTLNPGDLQDLTRYLKADYNPDKDFLPPDLAKAAEAQLKARP

Specific function: May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=441, Percent_Identity=35.827664399093, Blast_Score=231, Evalue=9e-62,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 52449; Mature: 52449

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKLSLAVAVSCASTTTVWAAEAPLSTKTDLVSVYQEAVDNNADLAAARAQYGAQKEVV
CCCHHEEHHHEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHC
PQARAGLLPNLSGGAEVANVRTSIDQPSAIANRSAHSYQATLAQPLFRADRWFQYQAAKD
HHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
VNEQAALQLSATEQNLILQTAESYFNVLRSQDNLASTKAEEAAFKRQLDQSNERFDVGLS
CCHHHEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEECCCC
DKTDVLQSQASYDTARANRIVAQRQVDDAFEALITLTNRQYNSIQGIVHTLPILPPAPND
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
AKAWVDTAAKQNLNLLASNYAVSSAEQTLKQRKAGHLPTLDAVAKYEKGDNDALGFSNPN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCC
AFGTPYSGNVEQSTVGLQLNIPIYSGGLTSSQVRESYSRLDQTEQQREGLRRQVVENTRN
CCCCCCCCCCCCEEEEEEEECEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHRAVNTDVEQVQARRQSIISNQSAVEATEIGYQVGTRNIVDVLDAQRQLYTSVRNYNNT
HHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC
RYDYILDNLRLKQAAGTLNPGDLQDLTRYLKADYNPDKDFLPPDLAKAAEAQLKARP
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLRKLSLAVAVSCASTTTVWAAEAPLSTKTDLVSVYQEAVDNNADLAAARAQYGAQKEVV
CCCHHEEHHHEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHC
PQARAGLLPNLSGGAEVANVRTSIDQPSAIANRSAHSYQATLAQPLFRADRWFQYQAAKD
HHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
VNEQAALQLSATEQNLILQTAESYFNVLRSQDNLASTKAEEAAFKRQLDQSNERFDVGLS
CCHHHEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEECCCC
DKTDVLQSQASYDTARANRIVAQRQVDDAFEALITLTNRQYNSIQGIVHTLPILPPAPND
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
AKAWVDTAAKQNLNLLASNYAVSSAEQTLKQRKAGHLPTLDAVAKYEKGDNDALGFSNPN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCC
AFGTPYSGNVEQSTVGLQLNIPIYSGGLTSSQVRESYSRLDQTEQQREGLRRQVVENTRN
CCCCCCCCCCCCEEEEEEEECEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHRAVNTDVEQVQARRQSIISNQSAVEATEIGYQVGTRNIVDVLDAQRQLYTSVRNYNNT
HHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC
RYDYILDNLRLKQAAGTLNPGDLQDLTRYLKADYNPDKDFLPPDLAKAAEAQLKARP
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]