Click here to switch to the map view.

The map label for this gene is trxC [H]

Identifier: 77456671

GI number: 77456671

Start: 500615

End: 501049

Strand: Reverse

Name: trxC [H]

Synonym: Pfl01_0443

Alternate gene names: 77456671

Gene position: 501049-500615 (Counterclockwise)

Preceding gene: 77456672

Following gene: 77456669

Centisome position: 7.78

GC content: 64.14

Gene sequence:

>435_bases
ATGACCGACCCACTCCTCATCCCCTGCCCCTCCTGCAACGGCCTCAACCGCATCCCCGCCGAGCGCCTCAACGACCACCC
GAAGTGCGGGCGCTGCAAGTCCGAGGTGCTGTTGAACAAGCCGTTCGAACTCAAGCAAGGCGATTACGCCAGTCAGATCA
AGGGCGATCTGCCGTTACTGGTGGACGTATGGGCGGACTGGTGTGGGCCGTGCAAGTCGTTTGCGCCGGTGTTCGAGCAG
GCGGCTGCGCAGTTGGCAGGCAAGTGCCGGCTGGCCAAGCTGGACAGCGAGGCCAATCAGCAGTTGTCGGCGCAGTTGGG
GATTCGTTCGATTCCGAGCCTGATTCTGTTGCGCAACGGCCGGGAAGTGGCCCGTCAGAGCGGGGCCTTCCCGTTGCCGC
AGTTGATGGCCTGGCTGCGCAGCCAGGGCATCTGA

Upstream 100 bases:

>100_bases
GATCAGTTGTTCGTCGTAAGCGGGAACGACTGAACCTTGATAATCGATCCGTACGGCTCCAGATCAGTCGTACGATCCCG
TTTTATTCACCGAGCCGATC

Downstream 100 bases:

>100_bases
CGAGGCCTCAGGCGTCTTCGAGCAGGTTGTGCAGTTCGACGAACTGCTGCGTCAGCTTGTGCCGTGGATCGAGGTGGATC
AGCGGCGTGTTGGCCTGATG

Product: thioredoxin-like

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MTDPLLIPCPSCNGLNRIPAERLNDHPKCGRCKSEVLLNKPFELKQGDYASQIKGDLPLLVDVWADWCGPCKSFAPVFEQ
AAAQLAGKCRLAKLDSEANQQLSAQLGIRSIPSLILLRNGREVARQSGAFPLPQLMAWLRSQGI

Sequences:

>Translated_144_residues
MTDPLLIPCPSCNGLNRIPAERLNDHPKCGRCKSEVLLNKPFELKQGDYASQIKGDLPLLVDVWADWCGPCKSFAPVFEQ
AAAQLAGKCRLAKLDSEANQQLSAQLGIRSIPSLILLRNGREVARQSGAFPLPQLMAWLRSQGI
>Mature_143_residues
TDPLLIPCPSCNGLNRIPAERLNDHPKCGRCKSEVLLNKPFELKQGDYASQIKGDLPLLVDVWADWCGPCKSFAPVFEQA
AAQLAGKCRLAKLDSEANQQLSAQLGIRSIPSLILLRNGREVARQSGAFPLPQLMAWLRSQGI

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=131, Percent_Identity=40.4580152671756, Blast_Score=126, Evalue=5e-31,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=37.1428571428571, Blast_Score=81, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193209454, Length=102, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=102, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=102, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573567, Length=87, Percent_Identity=36.7816091954023, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15795; Mature: 15663

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPLLIPCPSCNGLNRIPAERLNDHPKCGRCKSEVLLNKPFELKQGDYASQIKGDLPLL
CCCCCEEECCCCCCCCCCCHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCHH
VDVWADWCGPCKSFAPVFEQAAAQLAGKCRLAKLDSEANQQLSAQLGIRSIPSLILLRNG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCC
REVARQSGAFPLPQLMAWLRSQGI
HHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TDPLLIPCPSCNGLNRIPAERLNDHPKCGRCKSEVLLNKPFELKQGDYASQIKGDLPLL
CCCCEEECCCCCCCCCCCHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCHH
VDVWADWCGPCKSFAPVFEQAAAQLAGKCRLAKLDSEANQQLSAQLGIRSIPSLILLRNG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCC
REVARQSGAFPLPQLMAWLRSQGI
HHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]