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The map label for this gene is ubiB [H]

Identifier: 77456613

GI number: 77456613

Start: 438453

End: 440057

Strand: Reverse

Name: ubiB [H]

Synonym: Pfl01_0385

Alternate gene names: 77456613

Gene position: 440057-438453 (Counterclockwise)

Preceding gene: 77456614

Following gene: 77456612

Centisome position: 6.83

GC content: 62.93

Gene sequence:

>1605_bases
ATGAAGCTGCTCGCCGTCCGCCGTCTGTTGCGCATCCAGCGCGTCGTGATCCGCTACCGCCTCGATGACCTGCTGTTCGA
TCTGCCTTTGCCGTGGTTCCTGCTGGCGTTGCGCTACGTCCTGCCGTGGCGCTGGTTTCCGCGCAAGCCGCTGGAGCTCA
GTCGTGGGGCACGCCTGCGCCTGGCGCTGCAGGACCTGGGACCGATCTTCATCAAGTTCGGGCAGATCCTTTCGACCCGC
CGCGACCTGCTGCCGGAAGACATCGCCGATGAGCTGATGCGGTTGCAGGACCGCGTGCCGCCGTTCGATTCGCAGCTGTC
GGTCAAGCTGATCGAAGAGCAACTGGGCAAGAAGATCAGCGAAGTGTTCAGTCGCTTCGACGTCGAACCGCTGGCCTCGG
CCTCGGTGGCGCAGGTACACGCCGCGCAACTGAAGACCGGCGAAGAAGTGGTGGTCAAGGTGATCCGCCCGGGCCTGAAA
CCGATCATCGCGCAGGATCTGGCGTGGCTGTTCATCCTCGCCCGCGCTGCCGAAAAGGTCTCGGCCGACGCCCGCCTGCT
GCACCCGGTGGACGTGGTCAGCGACTACGAAAAAACCATCTACGACGAACTCGACCTGTTGCGCGAGGCAGCCAACGCCA
GCCAGTTGAAGCGCAACTTCGAAGGCTCGCCGCTGCTGTATGTGCCGCAAGTCTATTGGGACTGGTGCCGGCCGAAAGTG
CTGGTGATGGAGCGCATCTACGGGATTCAGGTGACGGATCTGGCGACCCTCGCCGACCAGCGCACCGACATGAAAATGCT
CGCCGAGCGCGGCGTGGAGATCTTCTTCACCCAGGTGTTCCGCGACAGTTTCTTCCACGCCGACATGCACCCGGGCAACA
TCTTCGTCAGCACCGTCAATCCGTGGAGCCCGCAGTACATCGCGATCGACTGCGGCATCGTCGGCAGCCTGACCCCGGAA
GACCAGGACTATCTGGCGCGCAACCTGTTCGCCTTCTTCAAGCGCGACTACCGCCGCGTGGCGCAATTGCACATCGATTC
GGGCTGGGTGCCGGCGGAAACCAAGCTCAACGAATTCGAAGCGGCGATCCGTACCGTGTGCGAGCCGATCTTCGAAAAAC
CATTAAAAGATATTTCATTTGGCCAGGTGCTGATGCGCCTGTTCCAGACCGCGCGCCGCTTCAACATGGAAGTGCAGCCG
CAACTCGTATTGCTGCAAAAGACCCTGCTGAATATCGAAGGCCTGGGCCGTCAGCTGTACCCGGACCTCGATCTGTGGAA
CACCGCGCAGCCGTTCCTCGAACGCTGGATGCGCGAGCGCGTCAGCCCGAAAGCCTTGCTCGGCAACGTCCAGAGCCAGT
TCGAACAACTGCCGCACCTGGCCAACATGGCTCGCGACCTGCTCGAACGCATGTCCCAGCCCCACGCCAACGACCCGCCA
CCGCCGTGGAAAAAACGCAAGGACGACTGGTTCCTGCGCCTGCTCGGCAGCGCCCATCTGGCGGGCGGTACGATCCTCGC
CGCCGGGGGCCCGTTGCACGAACTGGGGCATTGGCCCGCCGGGATCATGGTGGCAGTCGGCTTGTATCTGGTCGTTCGCC
GATAG

Upstream 100 bases:

>100_bases
AAGCCCGTTTCAGCGAACTGGACCGGATCAAACTCGATCTGGAACGTCTCGAGGCGCGCTTCGAGCGCCTTTCCCGATCC
CTCGACCCAAGCGATAACGC

Downstream 100 bases:

>100_bases
CCAGTTCCGTGATCGGCTGGCACACTGTTTCAACGCCTGAACCCGACTATTGAAGTGTGGGTTCGCTGTCGGAGTCGAAG
ATGAAAAACTGGCTGGACGA

Product: 2-octaprenylphenol hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MKLLAVRRLLRIQRVVIRYRLDDLLFDLPLPWFLLALRYVLPWRWFPRKPLELSRGARLRLALQDLGPIFIKFGQILSTR
RDLLPEDIADELMRLQDRVPPFDSQLSVKLIEEQLGKKISEVFSRFDVEPLASASVAQVHAAQLKTGEEVVVKVIRPGLK
PIIAQDLAWLFILARAAEKVSADARLLHPVDVVSDYEKTIYDELDLLREAANASQLKRNFEGSPLLYVPQVYWDWCRPKV
LVMERIYGIQVTDLATLADQRTDMKMLAERGVEIFFTQVFRDSFFHADMHPGNIFVSTVNPWSPQYIAIDCGIVGSLTPE
DQDYLARNLFAFFKRDYRRVAQLHIDSGWVPAETKLNEFEAAIRTVCEPIFEKPLKDISFGQVLMRLFQTARRFNMEVQP
QLVLLQKTLLNIEGLGRQLYPDLDLWNTAQPFLERWMRERVSPKALLGNVQSQFEQLPHLANMARDLLERMSQPHANDPP
PPWKKRKDDWFLRLLGSAHLAGGTILAAGGPLHELGHWPAGIMVAVGLYLVVRR

Sequences:

>Translated_534_residues
MKLLAVRRLLRIQRVVIRYRLDDLLFDLPLPWFLLALRYVLPWRWFPRKPLELSRGARLRLALQDLGPIFIKFGQILSTR
RDLLPEDIADELMRLQDRVPPFDSQLSVKLIEEQLGKKISEVFSRFDVEPLASASVAQVHAAQLKTGEEVVVKVIRPGLK
PIIAQDLAWLFILARAAEKVSADARLLHPVDVVSDYEKTIYDELDLLREAANASQLKRNFEGSPLLYVPQVYWDWCRPKV
LVMERIYGIQVTDLATLADQRTDMKMLAERGVEIFFTQVFRDSFFHADMHPGNIFVSTVNPWSPQYIAIDCGIVGSLTPE
DQDYLARNLFAFFKRDYRRVAQLHIDSGWVPAETKLNEFEAAIRTVCEPIFEKPLKDISFGQVLMRLFQTARRFNMEVQP
QLVLLQKTLLNIEGLGRQLYPDLDLWNTAQPFLERWMRERVSPKALLGNVQSQFEQLPHLANMARDLLERMSQPHANDPP
PPWKKRKDDWFLRLLGSAHLAGGTILAAGGPLHELGHWPAGIMVAVGLYLVVRR
>Mature_534_residues
MKLLAVRRLLRIQRVVIRYRLDDLLFDLPLPWFLLALRYVLPWRWFPRKPLELSRGARLRLALQDLGPIFIKFGQILSTR
RDLLPEDIADELMRLQDRVPPFDSQLSVKLIEEQLGKKISEVFSRFDVEPLASASVAQVHAAQLKTGEEVVVKVIRPGLK
PIIAQDLAWLFILARAAEKVSADARLLHPVDVVSDYEKTIYDELDLLREAANASQLKRNFEGSPLLYVPQVYWDWCRPKV
LVMERIYGIQVTDLATLADQRTDMKMLAERGVEIFFTQVFRDSFFHADMHPGNIFVSTVNPWSPQYIAIDCGIVGSLTPE
DQDYLARNLFAFFKRDYRRVAQLHIDSGWVPAETKLNEFEAAIRTVCEPIFEKPLKDISFGQVLMRLFQTARRFNMEVQP
QLVLLQKTLLNIEGLGRQLYPDLDLWNTAQPFLERWMRERVSPKALLGNVQSQFEQLPHLANMARDLLERMSQPHANDPP
PPWKKRKDDWFLRLLGSAHLAGGTILAAGGPLHELGHWPAGIMVAVGLYLVVRR

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=279, Percent_Identity=32.6164874551971, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI41393593, Length=274, Percent_Identity=29.9270072992701, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI217035081, Length=212, Percent_Identity=32.5471698113208, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI32261307, Length=332, Percent_Identity=23.4939759036145, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI34147522, Length=191, Percent_Identity=27.2251308900524, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI2367309, Length=471, Percent_Identity=58.5987261146497, Blast_Score=537, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17559152, Length=248, Percent_Identity=29.4354838709677, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6325148, Length=476, Percent_Identity=23.3193277310924, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323282, Length=249, Percent_Identity=29.718875502008, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321319, Length=205, Percent_Identity=29.7560975609756, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI22024280, Length=250, Percent_Identity=32.8, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24662575, Length=230, Percent_Identity=33.0434782608696, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 61508; Mature: 61508

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLAVRRLLRIQRVVIRYRLDDLLFDLPLPWFLLALRYVLPWRWFPRKPLELSRGARLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
LALQDLGPIFIKFGQILSTRRDLLPEDIADELMRLQDRVPPFDSQLSVKLIEEQLGKKIS
EEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
EVFSRFDVEPLASASVAQVHAAQLKTGEEVVVKVIRPGLKPIIAQDLAWLFILARAAEKV
HHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SADARLLHPVDVVSDYEKTIYDELDLLREAANASQLKRNFEGSPLLYVPQVYWDWCRPKV
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHCCHHH
LVMERIYGIQVTDLATLADQRTDMKMLAERGVEIFFTQVFRDSFFHADMHPGNIFVSTVN
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECC
PWSPQYIAIDCGIVGSLTPEDQDYLARNLFAFFKRDYRRVAQLHIDSGWVPAETKLNEFE
CCCCCEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
AAIRTVCEPIFEKPLKDISFGQVLMRLFQTARRFNMEVQPQLVLLQKTLLNIEGLGRQLY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PDLDLWNTAQPFLERWMRERVSPKALLGNVQSQFEQLPHLANMARDLLERMSQPHANDPP
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PPWKKRKDDWFLRLLGSAHLAGGTILAAGGPLHELGHWPAGIMVAVGLYLVVRR
CCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLLAVRRLLRIQRVVIRYRLDDLLFDLPLPWFLLALRYVLPWRWFPRKPLELSRGARLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
LALQDLGPIFIKFGQILSTRRDLLPEDIADELMRLQDRVPPFDSQLSVKLIEEQLGKKIS
EEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
EVFSRFDVEPLASASVAQVHAAQLKTGEEVVVKVIRPGLKPIIAQDLAWLFILARAAEKV
HHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SADARLLHPVDVVSDYEKTIYDELDLLREAANASQLKRNFEGSPLLYVPQVYWDWCRPKV
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHCCHHH
LVMERIYGIQVTDLATLADQRTDMKMLAERGVEIFFTQVFRDSFFHADMHPGNIFVSTVN
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECC
PWSPQYIAIDCGIVGSLTPEDQDYLARNLFAFFKRDYRRVAQLHIDSGWVPAETKLNEFE
CCCCCEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
AAIRTVCEPIFEKPLKDISFGQVLMRLFQTARRFNMEVQPQLVLLQKTLLNIEGLGRQLY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PDLDLWNTAQPFLERWMRERVSPKALLGNVQSQFEQLPHLANMARDLLERMSQPHANDPP
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PPWKKRKDDWFLRLLGSAHLAGGTILAAGGPLHELGHWPAGIMVAVGLYLVVRR
CCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA