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The map label for this gene is hisE [H]

Identifier: 77456611

GI number: 77456611

Start: 437646

End: 437978

Strand: Reverse

Name: hisE [H]

Synonym: Pfl01_0383

Alternate gene names: 77456611

Gene position: 437978-437646 (Counterclockwise)

Preceding gene: 77456612

Following gene: 77456610

Centisome position: 6.8

GC content: 61.86

Gene sequence:

>333_bases
ATGAGTGACACCCTGACCCGCCTCGCTCAGGTGCTGGAAGAGCGCAAGGGCGCTGCTGCCGACAGTTCGTATGTGGCTAG
TCTGTATCACAAGGGCTTGAACAAGATTCTGGAAAAGGTCGGCGAAGAATCGGTCGAAACGATCATCGCCGCCAAGGACG
CCGCCGTCAGCGGCGACTGCAGCGACGTGATCTACGAGACCGCCGACCTGTGGTTCCACAGCATGGTCATGCTTGCCCAG
CTGGGGCAGCATCCGCAGGCGGTGCTGGATGAACTGGATCGCCGTTTCGGCCTGTCCGGACACGTCGAGAAAGCCTCGCG
CCCGTCCGCCTGA

Upstream 100 bases:

>100_bases
CGTCAAAGCTGCTTCTACCGCGTCTTCGAAAACGGCGACTGGAAAACGGTCGACCCGGTCCTGAAAGACCCGCACGCTAT
TTACTCCGCAGGACACAAAC

Downstream 100 bases:

>100_bases
ACAACTTCAAGAGAGGAACAGCAACATGGGCATTTTTGACTGGAAACACTGGATCGTCATCCTGGTGGTCGTGGTACTGG
TGTTCGGTACCAAGAAACTG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MSDTLTRLAQVLEERKGAAADSSYVASLYHKGLNKILEKVGEESVETIIAAKDAAVSGDCSDVIYETADLWFHSMVMLAQ
LGQHPQAVLDELDRRFGLSGHVEKASRPSA

Sequences:

>Translated_110_residues
MSDTLTRLAQVLEERKGAAADSSYVASLYHKGLNKILEKVGEESVETIIAAKDAAVSGDCSDVIYETADLWFHSMVMLAQ
LGQHPQAVLDELDRRFGLSGHVEKASRPSA
>Mature_109_residues
SDTLTRLAQVLEERKGAAADSSYVASLYHKGLNKILEKVGEESVETIIAAKDAAVSGDCSDVIYETADLWFHSMVMLAQL
GQHPQAVLDELDRRFGLSGHVEKASRPSA

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=39.5604395604396, Blast_Score=60, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008179
- InterPro:   IPR021130 [H]

Pfam domain/function: PF01503 PRA-PH [H]

EC number: =3.6.1.31 [H]

Molecular weight: Translated: 11947; Mature: 11815

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTLTRLAQVLEERKGAAADSSYVASLYHKGLNKILEKVGEESVETIIAAKDAAVSGDC
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SDVIYETADLWFHSMVMLAQLGQHPQAVLDELDRRFGLSGHVEKASRPSA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDTLTRLAQVLEERKGAAADSSYVASLYHKGLNKILEKVGEESVETIIAAKDAAVSGDC
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SDVIYETADLWFHSMVMLAQLGQHPQAVLDELDRRFGLSGHVEKASRPSA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA