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The map label for this gene is hisA [H]

Identifier: 77456554

GI number: 77456554

Start: 371097

End: 371834

Strand: Direct

Name: hisA [H]

Synonym: Pfl01_0326

Alternate gene names: 77456554

Gene position: 371097-371834 (Clockwise)

Preceding gene: 77456553

Following gene: 77456555

Centisome position: 5.76

GC content: 61.25

Gene sequence:

>738_bases
ATGCTGATTATTCCCGCTATCGATCTTAAAGACGGTGCCTGCGTACGTCTGCGCCAGGGCCGCATGGAAGATTCCACAGT
GTTCTCCGATGACCCGGTGAGCATGGCTGCCAAGTGGGTGGAAGGCGGTTGCCGTCGTCTGCATCTGGTCGACCTGAACG
GGGCTTTCGAAGGCCAGCCGGTCAACGGCGAAGTGGTGACCGCGATCGCCAAGCGCTACCCGACCCTGCCGATCCAGATC
GGCGGCGGCATTCGTTCGCTGGAAACCATCGAGCACTACGTCAAGGCTGGCGTGAGCTACGTGATCATCGGCACCAAAGC
GGTGAAGGATCCGGCGTTTGTCGCTGAAGCCTGCCGCGCGTTCCCGGGCAAGATCATCGTCGGTCTGGATGCCAAGGACG
GTTTTGTCGCCACCGATGGCTGGGCTGAAATCAGCACCGTGCAAGTTATCGACCTGGCCAAGCAGTTCGAAGCCGACGGC
GTGTCCTCGATCGTTTATACCGACATCGCCAAAGACGGCATGATGCAGGGCTGCAACGTTCCGTTCACCGCCGCGCTGGC
GGCTGCCACGAAGATCCCGGTGATCGCTTCCGGCGGCATTCACAACCTCGGTGACATCAAGTCGCTGCTCGACGCCAAGG
TGCCAGGCATCATCGGCGCCATCACCGGCCGGGCGATCTACGAAGGCACTCTCGACGTCGCCGAAGCGCAAGCTTTCTGC
GACTCGTACCAAGGCTGA

Upstream 100 bases:

>100_bases
CCTCAAGGAGCGGTTTGAAAGCATCGAAAGCGACCTGTGGGCGCTCGAGAAAAACTGATTTCCGAGCCAAGCTGAACATT
CAAATTTGAAGGTTTGCCAG

Downstream 100 bases:

>100_bases
GGACTGACCATGGCGCTGGCCAAACGCATCATCCCTTGCCTGGACGTGGACAACGGCCGGGTCGTCAAAGGTGTGAAGTT
CGAGAACATCCGTGACGCCG

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MLIIPAIDLKDGACVRLRQGRMEDSTVFSDDPVSMAAKWVEGGCRRLHLVDLNGAFEGQPVNGEVVTAIAKRYPTLPIQI
GGGIRSLETIEHYVKAGVSYVIIGTKAVKDPAFVAEACRAFPGKIIVGLDAKDGFVATDGWAEISTVQVIDLAKQFEADG
VSSIVYTDIAKDGMMQGCNVPFTAALAAATKIPVIASGGIHNLGDIKSLLDAKVPGIIGAITGRAIYEGTLDVAEAQAFC
DSYQG

Sequences:

>Translated_245_residues
MLIIPAIDLKDGACVRLRQGRMEDSTVFSDDPVSMAAKWVEGGCRRLHLVDLNGAFEGQPVNGEVVTAIAKRYPTLPIQI
GGGIRSLETIEHYVKAGVSYVIIGTKAVKDPAFVAEACRAFPGKIIVGLDAKDGFVATDGWAEISTVQVIDLAKQFEADG
VSSIVYTDIAKDGMMQGCNVPFTAALAAATKIPVIASGGIHNLGDIKSLLDAKVPGIIGAITGRAIYEGTLDVAEAQAFC
DSYQG
>Mature_245_residues
MLIIPAIDLKDGACVRLRQGRMEDSTVFSDDPVSMAAKWVEGGCRRLHLVDLNGAFEGQPVNGEVVTAIAKRYPTLPIQI
GGGIRSLETIEHYVKAGVSYVIIGTKAVKDPAFVAEACRAFPGKIIVGLDAKDGFVATDGWAEISTVQVIDLAKQFEADG
VSSIVYTDIAKDGMMQGCNVPFTAALAAATKIPVIASGGIHNLGDIKSLLDAKVPGIIGAITGRAIYEGTLDVAEAQAFC
DSYQG

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=32.7868852459016, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1788336, Length=249, Percent_Identity=22.8915662650602, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 25755; Mature: 25755

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIIPAIDLKDGACVRLRQGRMEDSTVFSDDPVSMAAKWVEGGCRRLHLVDLNGAFEGQP
CEEEEEEECCCCCEEEEECCCCCCCCEECCCCHHHHHHHHHCCCEEEEEEECCCCCCCCC
VNGEVVTAIAKRYPTLPIQIGGGIRSLETIEHYVKAGVSYVIIGTKAVKDPAFVAEACRA
CCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHC
FPGKIIVGLDAKDGFVATDGWAEISTVQVIDLAKQFEADGVSSIVYTDIAKDGMMQGCNV
CCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
PFTAALAAATKIPVIASGGIHNLGDIKSLLDAKVPGIIGAITGRAIYEGTLDVAEAQAFC
CHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCEEHHCCCEEECCCHHHHHHHHHH
DSYQG
HCCCC
>Mature Secondary Structure
MLIIPAIDLKDGACVRLRQGRMEDSTVFSDDPVSMAAKWVEGGCRRLHLVDLNGAFEGQP
CEEEEEEECCCCCEEEEECCCCCCCCEECCCCHHHHHHHHHCCCEEEEEEECCCCCCCCC
VNGEVVTAIAKRYPTLPIQIGGGIRSLETIEHYVKAGVSYVIIGTKAVKDPAFVAEACRA
CCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHC
FPGKIIVGLDAKDGFVATDGWAEISTVQVIDLAKQFEADGVSSIVYTDIAKDGMMQGCNV
CCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
PFTAALAAATKIPVIASGGIHNLGDIKSLLDAKVPGIIGAITGRAIYEGTLDVAEAQAFC
CHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCEEHHCCCEEECCCHHHHHHHHHH
DSYQG
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA