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The map label for this gene is rfbC [H]

Identifier: 77456517

GI number: 77456517

Start: 335825

End: 336406

Strand: Reverse

Name: rfbC [H]

Synonym: Pfl01_0289

Alternate gene names: 77456517

Gene position: 336406-335825 (Counterclockwise)

Preceding gene: 77456521

Following gene: 77456516

Centisome position: 5.22

GC content: 58.08

Gene sequence:

>582_bases
ATGTCGGCCATTCACACCTGCCACTGGAAAATCTACATGAATGTAATCACCACCGACCTGCCTGGTGTCTTGATCATCGA
ACCCAAGGTATTTGGTGACGAACGCGGGTTCTTTTACGAAAGCTTCAATGCGAAAGCCTTTCAGGACGCGACCGGCCTGG
ACACGCAATTTGTCCAGGACAACCATTCGCGCTCGCAGAAAGGCGTTCTGCGCGGGCTGCATTACCAGTTGGAAAATACC
CAGGGCAAACTGGTCCGCGTTACCGCCGGCGAAGTCCTCGACGTCGCCGTGGATATCCGTCGCAGCTCGCCGCATTTCGG
CAAGTGGGTGGCCGTGCGTCTGTCCGCCGACAACCACCGTCAATTGTGGGTTCCGGAAGGTTTCGCCCACGGTTTCGTGG
TGCTGAGCGAGTTCGCCGAATTCCTCTACAAGACCACCGACTACTACAACCCGTCTTCCGAGCGCAGCATTCGTTGGGAC
GACCCGGATCTGGGCATCGACTGGCAGCTGGATGAAGCGCCGAAACTGTCGGCCAAGGACCAGGCGGCGGCACTGCTCAA
GGACGCCGACGTCTTTTCCTGA

Upstream 100 bases:

>100_bases
CTTCGGGCGATAAGCAACCCCCGACCATCCGTCCCCCGACTCGCTGCGAGACCGGCGGATTTGCAAGCGCCCCTCGCACC
TGTCGACGCTTTGCGCAAGA

Downstream 100 bases:

>100_bases
AGTCCTGTGTGAATCTTCAGCGCCGCTGCGGACCCGGCCACGGGTGCGCAGACTGCGCCGGCAAGCCTAGGCATAATGCG
CCTGTACCCACAGGCGCTCG

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSAIHTCHWKIYMNVITTDLPGVLIIEPKVFGDERGFFYESFNAKAFQDATGLDTQFVQDNHSRSQKGVLRGLHYQLENT
QGKLVRVTAGEVLDVAVDIRRSSPHFGKWVAVRLSADNHRQLWVPEGFAHGFVVLSEFAEFLYKTTDYYNPSSERSIRWD
DPDLGIDWQLDEAPKLSAKDQAAALLKDADVFS

Sequences:

>Translated_193_residues
MSAIHTCHWKIYMNVITTDLPGVLIIEPKVFGDERGFFYESFNAKAFQDATGLDTQFVQDNHSRSQKGVLRGLHYQLENT
QGKLVRVTAGEVLDVAVDIRRSSPHFGKWVAVRLSADNHRQLWVPEGFAHGFVVLSEFAEFLYKTTDYYNPSSERSIRWD
DPDLGIDWQLDEAPKLSAKDQAAALLKDADVFS
>Mature_192_residues
SAIHTCHWKIYMNVITTDLPGVLIIEPKVFGDERGFFYESFNAKAFQDATGLDTQFVQDNHSRSQKGVLRGLHYQLENTQ
GKLVRVTAGEVLDVAVDIRRSSPHFGKWVAVRLSADNHRQLWVPEGFAHGFVVLSEFAEFLYKTTDYYNPSSERSIRWDD
PDLGIDWQLDEAPKLSAKDQAAALLKDADVFS

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=170, Percent_Identity=61.7647058823529, Blast_Score=211, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17550412, Length=152, Percent_Identity=50, Blast_Score=148, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 21908; Mature: 21777

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIHTCHWKIYMNVITTDLPGVLIIEPKVFGDERGFFYESFNAKAFQDATGLDTQFVQD
CCCCEEEEEEEEEEEEECCCCCEEEECCEEECCCCCEEEECCCCCEECCCCCCCHHHHCC
NHSRSQKGVLRGLHYQLENTQGKLVRVTAGEVLDVAVDIRRSSPHFGKWVAVRLSADNHR
CCCCHHHHHHHHHHEEEECCCCCEEEEECCCEEEEEEEEECCCCCCCEEEEEEECCCCCE
QLWVPEGFAHGFVVLSEFAEFLYKTTDYYNPSSERSIRWDDPDLGIDWQLDEAPKLSAKD
EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCH
QAAALLKDADVFS
HHHHHHHCCCCCC
>Mature Secondary Structure 
SAIHTCHWKIYMNVITTDLPGVLIIEPKVFGDERGFFYESFNAKAFQDATGLDTQFVQD
CCCEEEEEEEEEEEEECCCCCEEEECCEEECCCCCEEEECCCCCEECCCCCCCHHHHCC
NHSRSQKGVLRGLHYQLENTQGKLVRVTAGEVLDVAVDIRRSSPHFGKWVAVRLSADNHR
CCCCHHHHHHHHHHEEEECCCCCEEEEECCCEEEEEEEEECCCCCCCEEEEEEECCCCCE
QLWVPEGFAHGFVVLSEFAEFLYKTTDYYNPSSERSIRWDDPDLGIDWQLDEAPKLSAKD
EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCH
QAAALLKDADVFS
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609; 10802738 [H]