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The map label for this gene is betT [H]

Identifier: 77456475

GI number: 77456475

Start: 290417

End: 292417

Strand: Direct

Name: betT [H]

Synonym: Pfl01_0247

Alternate gene names: 77456475

Gene position: 290417-292417 (Clockwise)

Preceding gene: 77456474

Following gene: 77456478

Centisome position: 4.51

GC content: 62.37

Gene sequence:

>2001_bases
ATGAGTGCATCGTCCACCCCCGCCAGCGGTCTGGTGCGCATGAATCCGCCGGTGTTCTGGTTCGCCGCGACGGTGATCCT
GCTGTTCGGCCTGACGGTCATCGCCATGCCGGAACAGGCCGGCGCCTGGCTTCTCGAAGCGCAAAACTGGGCGGCCAATA
CGGTCGGCTGGTACTACATGCTCGCGATGACCCTGTATCTGGTCTTCGTGGTGGTCACCGCGTTATCGGGCTACGGCAAG
ATCAAACTCGGTGCCGACCACGACGAACCCGAATTCAGTTACCTGTCCTGGGCCGGCATGCTGTTCGCCGCCGGGATCAG
CATCACGCTGTTTTTCTTCTGCGTATCCGAGCCGCTGACCCACATGCTTCAGCCGCCGCAAGGCGAGGCCGGCACCCCGG
AGGCGGCGCGTCAGGCGATGCAGATTCTGTTTCTGCACTGGGGCCTGCACGGCTGGGGCGTGTTCGCCTTTGTCGGCATG
GCGCTGGCGTATTTCGCTTATCGGCACAATCTGCCACTGGCCCTGCGTTCGGCGCTGTACCCGCTGATCGGCAAACGCAT
CAACGGCCCCATCGGCTACGCGGTGGACGGCTTCGGCATCATCGCCACGGTGTTCGGCCTCGGTGCGGACATGGGCTTCG
GCGTGCTCCATCTCAACTCCGGTCTGGACTACCTGTTCGGCATCGCCCACACCCAGTGGATTCAGGTCGGCCTGATCACG
CTGATGATGGGCGCAGCGATCATCGTCGCCGTCTCCGGTGTGGATAAAGGCGTGCGGGTCATGTCCGACATCAACATGCT
GCTGGCCTGTGCGCTGCTGCTGTTCGTGTTGTTCGCCGGCCCCACCCAGCATTTGCTCAACACCCTGATCCAGAATCTGG
GCGACTACCTCGGCGCGTTGCCGATGAAGAGTTTCGACCTCTACGCCTACGACAAACCGAGCGACTGGCTCGGCGGCTGG
ACGGTGTTCTACTGGGCCTGGTGGATTGCATGGTCGCCGTTCGTAGGCCTGTTCATCGCACGGATTTCCCGTGGCCGGAC
AATCCGCGAATTCGTCTTCGGCGTGCTGCTGATTCCGCTCGGTTTCACCCTGGCGTGGATGTCGATCTTCGGCAACAGCG
CCATCGACCAAGTGCTCAACCACGGTATGTCGGCGCTGGGCATGTCGGCCCTCGACAACCCGTCGATGACCCTCTACCTG
CTGCTGGAAACCTATCCGTGGAGCAAGACCGTCATCGCGGTGACGGTGTTCATCAGCTTCGTGTTCTTCGTCACCTCCGC
CGACTCCGGCACCGTGGTGCTCTCGACCCTGTCGGCCAAGGGCGGCAACCCGGATGAAGACGGGCCGAAATGGCTGCGGG
TGTTCTGGGGCGCGATGACCGCGCTGGTGACCAGTGCGCTGCTGTTCTCCGGCAGCATCGATGCGCTGAAGTCGGCGGTG
GTGCTGACCTCGTTGCCGTTCTCGCTGATTCTGCTGCTGATGATGTGGGGCCTGCACAAGGCGTTCTATCTGGAGTCGCA
GAAGCAGATCGCGCAACTGCATTCCCTGGCGCCGGTGTCCGGCTCACGGCGTGGCAAGGGCGGCTGGCGTCAGCGTCTGA
GCCAGGCCGTGCACTTCCCGTCGCGCGACGAGGTGTACCGCTTCATGGACACCACGGTGAAACCGGCCATCGAAGAAGTG
ACGGCCGTGTTTGCCGAGAAAGGCCTGAACGTGGTCACCCAACCGGATCCGGCGCACGACAGCGTCAGTCTGGAAATCGG
ACACGGCGAGCAGCACCCGTTTATTTATCAGGTGCAGATGCGCGGCTACTTCACGCCGTCGTTCGCCCGCGGAGGCATGG
GCTCCAAGCAGCTCAACAATCGCCGCTACTACCGCGCCGAAGTGCATCTGAGCGAGGGCAGTCAGGACTACGATCTGGTC
GGTTACACCAAAGAGCAGATCATCAACGACATCCTCGACCAGTACGAACGGCACATGCAGTTCCTGCATCTGGTGCGTTG
A

Upstream 100 bases:

>100_bases
AAGTTAAACCGGCGGTTCGCTGCCCGCTCACAACAGGAGGCTTGCCTTTGCTGAGTCCGATCATTTCAGCCATTTTCCAA
CCCCTTGAGGTGCACCGTTC

Downstream 100 bases:

>100_bases
TCGGGGCAGGGCGCCGGGACGCTTTCAGGTCTCGGCGCTCAGCACCATGAACAACACCATCGCCGCCAGCGGCACGCCAT
ACACGGCGCTGCCGATCGCA

Product: BCCT transporter

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MSASSTPASGLVRMNPPVFWFAATVILLFGLTVIAMPEQAGAWLLEAQNWAANTVGWYYMLAMTLYLVFVVVTALSGYGK
IKLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTHMLQPPQGEAGTPEAARQAMQILFLHWGLHGWGVFAFVGM
ALAYFAYRHNLPLALRSALYPLIGKRINGPIGYAVDGFGIIATVFGLGADMGFGVLHLNSGLDYLFGIAHTQWIQVGLIT
LMMGAAIIVAVSGVDKGVRVMSDINMLLACALLLFVLFAGPTQHLLNTLIQNLGDYLGALPMKSFDLYAYDKPSDWLGGW
TVFYWAWWIAWSPFVGLFIARISRGRTIREFVFGVLLIPLGFTLAWMSIFGNSAIDQVLNHGMSALGMSALDNPSMTLYL
LLETYPWSKTVIAVTVFISFVFFVTSADSGTVVLSTLSAKGGNPDEDGPKWLRVFWGAMTALVTSALLFSGSIDALKSAV
VLTSLPFSLILLLMMWGLHKAFYLESQKQIAQLHSLAPVSGSRRGKGGWRQRLSQAVHFPSRDEVYRFMDTTVKPAIEEV
TAVFAEKGLNVVTQPDPAHDSVSLEIGHGEQHPFIYQVQMRGYFTPSFARGGMGSKQLNNRRYYRAEVHLSEGSQDYDLV
GYTKEQIINDILDQYERHMQFLHLVR

Sequences:

>Translated_666_residues
MSASSTPASGLVRMNPPVFWFAATVILLFGLTVIAMPEQAGAWLLEAQNWAANTVGWYYMLAMTLYLVFVVVTALSGYGK
IKLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTHMLQPPQGEAGTPEAARQAMQILFLHWGLHGWGVFAFVGM
ALAYFAYRHNLPLALRSALYPLIGKRINGPIGYAVDGFGIIATVFGLGADMGFGVLHLNSGLDYLFGIAHTQWIQVGLIT
LMMGAAIIVAVSGVDKGVRVMSDINMLLACALLLFVLFAGPTQHLLNTLIQNLGDYLGALPMKSFDLYAYDKPSDWLGGW
TVFYWAWWIAWSPFVGLFIARISRGRTIREFVFGVLLIPLGFTLAWMSIFGNSAIDQVLNHGMSALGMSALDNPSMTLYL
LLETYPWSKTVIAVTVFISFVFFVTSADSGTVVLSTLSAKGGNPDEDGPKWLRVFWGAMTALVTSALLFSGSIDALKSAV
VLTSLPFSLILLLMMWGLHKAFYLESQKQIAQLHSLAPVSGSRRGKGGWRQRLSQAVHFPSRDEVYRFMDTTVKPAIEEV
TAVFAEKGLNVVTQPDPAHDSVSLEIGHGEQHPFIYQVQMRGYFTPSFARGGMGSKQLNNRRYYRAEVHLSEGSQDYDLV
GYTKEQIINDILDQYERHMQFLHLVR
>Mature_665_residues
SASSTPASGLVRMNPPVFWFAATVILLFGLTVIAMPEQAGAWLLEAQNWAANTVGWYYMLAMTLYLVFVVVTALSGYGKI
KLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTHMLQPPQGEAGTPEAARQAMQILFLHWGLHGWGVFAFVGMA
LAYFAYRHNLPLALRSALYPLIGKRINGPIGYAVDGFGIIATVFGLGADMGFGVLHLNSGLDYLFGIAHTQWIQVGLITL
MMGAAIIVAVSGVDKGVRVMSDINMLLACALLLFVLFAGPTQHLLNTLIQNLGDYLGALPMKSFDLYAYDKPSDWLGGWT
VFYWAWWIAWSPFVGLFIARISRGRTIREFVFGVLLIPLGFTLAWMSIFGNSAIDQVLNHGMSALGMSALDNPSMTLYLL
LETYPWSKTVIAVTVFISFVFFVTSADSGTVVLSTLSAKGGNPDEDGPKWLRVFWGAMTALVTSALLFSGSIDALKSAVV
LTSLPFSLILLLMMWGLHKAFYLESQKQIAQLHSLAPVSGSRRGKGGWRQRLSQAVHFPSRDEVYRFMDTTVKPAIEEVT
AVFAEKGLNVVTQPDPAHDSVSLEIGHGEQHPFIYQVQMRGYFTPSFARGGMGSKQLNNRRYYRAEVHLSEGSQDYDLVG
YTKEQIINDILDQYERHMQFLHLVR

Specific function: High-affinity uptake of choline driven by a proton- motive force [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=659, Percent_Identity=45.2200303490137, Blast_Score=596, Evalue=1e-171,
Organism=Escherichia coli, GI1788102, Length=451, Percent_Identity=29.490022172949, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1786224, Length=453, Percent_Identity=28.0353200883002, Blast_Score=162, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 73557; Mature: 73426

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00639 THIOL_PROTEASE_HIS ; PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASSTPASGLVRMNPPVFWFAATVILLFGLTVIAMPEQAGAWLLEAQNWAANTVGWYYM
CCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHH
LAMTLYLVFVVVTALSGYGKIKLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLT
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMLQPPQGEAGTPEAARQAMQILFLHWGLHGWGVFAFVGMALAYFAYRHNLPLALRSALY
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
PLIGKRINGPIGYAVDGFGIIATVFGLGADMGFGVLHLNSGLDYLFGIAHTQWIQVGLIT
HHHHHHCCCCCCEEECHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
LMMGAAIIVAVSGVDKGVRVMSDINMLLACALLLFVLFAGPTQHLLNTLIQNLGDYLGAL
HHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
PMKSFDLYAYDKPSDWLGGWTVFYWAWWIAWSPFVGLFIARISRGRTIREFVFGVLLIPL
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GFTLAWMSIFGNSAIDQVLNHGMSALGMSALDNPSMTLYLLLETYPWSKTVIAVTVFISF
HHHHHHHHHHCCHHHHHHHHCCHHHHCHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
VFFVTSADSGTVVLSTLSAKGGNPDEDGPKWLRVFWGAMTALVTSALLFSGSIDALKSAV
HHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VLTSLPFSLILLLMMWGLHKAFYLESQKQIAQLHSLAPVSGSRRGKGGWRQRLSQAVHFP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
SRDEVYRFMDTTVKPAIEEVTAVFAEKGLNVVTQPDPAHDSVSLEIGHGEQHPFIYQVQM
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCCCCEEEEEEE
RGYFTPSFARGGMGSKQLNNRRYYRAEVHLSEGSQDYDLVGYTKEQIINDILDQYERHMQ
CCCCCCHHHCCCCCCHHHCCCCEEEEEEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHH
FLHLVR
HHHHCC
>Mature Secondary Structure 
SASSTPASGLVRMNPPVFWFAATVILLFGLTVIAMPEQAGAWLLEAQNWAANTVGWYYM
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHH
LAMTLYLVFVVVTALSGYGKIKLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLT
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMLQPPQGEAGTPEAARQAMQILFLHWGLHGWGVFAFVGMALAYFAYRHNLPLALRSALY
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
PLIGKRINGPIGYAVDGFGIIATVFGLGADMGFGVLHLNSGLDYLFGIAHTQWIQVGLIT
HHHHHHCCCCCCEEECHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
LMMGAAIIVAVSGVDKGVRVMSDINMLLACALLLFVLFAGPTQHLLNTLIQNLGDYLGAL
HHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
PMKSFDLYAYDKPSDWLGGWTVFYWAWWIAWSPFVGLFIARISRGRTIREFVFGVLLIPL
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GFTLAWMSIFGNSAIDQVLNHGMSALGMSALDNPSMTLYLLLETYPWSKTVIAVTVFISF
HHHHHHHHHHCCHHHHHHHHCCHHHHCHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
VFFVTSADSGTVVLSTLSAKGGNPDEDGPKWLRVFWGAMTALVTSALLFSGSIDALKSAV
HHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VLTSLPFSLILLLMMWGLHKAFYLESQKQIAQLHSLAPVSGSRRGKGGWRQRLSQAVHFP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
SRDEVYRFMDTTVKPAIEEVTAVFAEKGLNVVTQPDPAHDSVSLEIGHGEQHPFIYQVQM
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCCCCEEEEEEE
RGYFTPSFARGGMGSKQLNNRRYYRAEVHLSEGSQDYDLVGYTKEQIINDILDQYERHMQ
CCCCCCHHHCCCCCCHHHCCCCEEEEEEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHH
FLHLVR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]