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The map label for this gene is prlC [H]

Identifier: 77456318

GI number: 77456318

Start: 96180

End: 98258

Strand: Reverse

Name: prlC [H]

Synonym: Pfl01_0090

Alternate gene names: 77456318

Gene position: 98258-96180 (Counterclockwise)

Preceding gene: 77456321

Following gene: 77456317

Centisome position: 1.53

GC content: 62.77

Gene sequence:

>2079_bases
ATGTTTCTTCCAGCCAAGGTGCCAACCGTGAGCGTGAACAACCCTCTTCTGCAGTCCTACGACCTGCCGCCGTTCTCCGC
GATCCGTGCCGAACACGTGCAGCCGGCCATCGAAACCATCCTGGCCGACAACCGCGCCGCCATCGCCGAAATCCTCAAGA
CCCAAGGCCAGAACCCGACCTGGGCCGGGCTGGTGCTGGCGATGGACGAACTCAATGATCGCCTGGGCGCTGCCTGGAGT
CCGGTCAGCCACCTCAATGCCGTGTGCAACAGCGCCGAACTGCGTGAAGCCTACGAGTCGTGCCTGCCGGCATTGAGCGC
CTACTCCACCGAAATGGGCCAGAACCGCGAACTGTTCCAGGCCTATGAAGCCCTGGCCAACAGCCCGGCAGCCGCCGGTT
TCGACGTGGCGCAAAAAACCATTCTGGAACACGCCCTGCGCGATTTCCGCCTGTCGGGTATCGACCTGCCGGAAGCCGAA
CAGAAACGCTACGCCGAAGTGCAGAGCAAGCTATCGGAGCTGGGCAGCCGCTTTTCCAACCAGTTGCTCGACGCCACTCA
GGCCTGGACCAAGCACCTGACCGATGAAGCCGCCCTCGCCGGCCTGACCGATTCGGCCAAGGCGCAAATGGCTGCTGCGG
CACAGGCCAAGGGCCTCGACGGCTGGCTGATCACCCTGGAATTCCCGAGCTACTACGCGGTGATGACCTACGCCCAGGAC
CGTGCGCTGCGTGAAGAAGTCTACGCCGCCTACTGCACCCGTGCGTCGGATCAAGGCCCGAACGCCGGCCAGAACGACAA
TGGCCCGGTGATGGACGAAATCCTCGACCTGCGTCAGGAACTGGCAAAACTGCTCGGTTTTTCCAGCTTCTCCGAACTGA
GCTTGGCCACCAAAATGGCCGAGTCCAGCGATCAGGTGCTGAGCTTCCTGCGTGATCTGGCCAAGCGCAGCAAACCGTTC
GCCGCCCAGGATCTGCAACAGCTCAAGGCTTACGCCGCCGAGCAGGGCTGCGCCGATCTGCAAAGCTGGGACAGCGGTTT
CTACGGTGAAAAACTCCGTGAACAGCGTTACAGCGTCGCTCAGGAAACCCTGCGCGCCTACTTCCCGATCGACAAAGTGC
TGGGTGGTCTGTTCGCCATCGTTCAGCGCCTGTACGGCATCGAAATCGCCGAACTGAAAGGCTTCGACACCTGGCACCCG
GACGTGCGCCTGTTCGAAATCAAGGAAAACGGTCAGCACGTCGGCCGTTTCTTCTTCGACCTCTACGCCCGCGCCAACAA
GCGCGGCGGTGCGTGGATGGATGGCGCCCGCGACCGTCGCCGCACCGTCGACGGCGTGCTGCAAAGCCCGGTGGCCAACC
TTGTGTGCAACTTCACCCCGGCCGACAGCGGCAAACCTGCGCTGCTGACCCACGATGAAGTGACCACCCTGTTCCACGAA
TTCGGCCACGGCCTGCATCACCTGCTGACCCGCGTCGAGCATGCCGGCGTTTCCGGTATCAACGGCGTGGCGTGGGACGC
CGTCGAGTTGCCGAGCCAGTTCATGGAAAACTGGTGCTGGGAGCCGGAAGGTCTGGCGCTGATTTCCGGCCACTACGAGA
CCGGCGAGCCGCTGCCGCAGGATCTGCTGGAAAAAATGCTCGCGGCGAAGAACTTCCAGTCCGGCCTGATGATGGTGCGC
CAACTGGAATTCTCGCTGTTCGACTTCGAACTGCACGCCACCCACGGTGACGGCCGCAGCGTCGCGCAAGTGCTGGAAGG
CGTACGCAACGAAGTCTCGGTAATGCGACCTCCGGCCTACAACCGCTTCCCGAACAGCTTCGCGCACATCTTCGCCGGCG
GTTACGCGGCGGGTTACTACAGCTACAAATGGGCGGAAGTGCTGTCGGCAGATGCCTTCTCCAAGTTCGAAGAAGACGGC
GTGCTGAATGCCGACACCGGTCGCGCCTTCCGCGAAGCAATCCTCGCCCGCGGCGGCTCGCAGGAGCCGATGGTGCTGTT
CGTCGACTTCCGTGGCCGTGAGCCATCGATTGACGCACTCTTGCGCCACAGCGGCCTGAGTGAGGACGCGGCAGCATGA

Upstream 100 bases:

>100_bases
AAGCGTGGGGTGTGATTCTGGTACTTGCGAAGGGACACGATTAGTTCTCTCTCTGTCGCCGATAGCTGCGGTGGGTGTCG
ATTGTAATTAAGATGGGCGC

Downstream 100 bases:

>100_bases
GTGAGGCACCCGTGAAGACCAAAAAACGCTTTATCGCCGGGGCGGTCTGCCCGGCGTGCAGCGAGCCGGACAAACTGATG
ATGTGGAGCGAGGACGATGT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 692; Mature: 692

Protein sequence:

>692_residues
MFLPAKVPTVSVNNPLLQSYDLPPFSAIRAEHVQPAIETILADNRAAIAEILKTQGQNPTWAGLVLAMDELNDRLGAAWS
PVSHLNAVCNSAELREAYESCLPALSAYSTEMGQNRELFQAYEALANSPAAAGFDVAQKTILEHALRDFRLSGIDLPEAE
QKRYAEVQSKLSELGSRFSNQLLDATQAWTKHLTDEAALAGLTDSAKAQMAAAAQAKGLDGWLITLEFPSYYAVMTYAQD
RALREEVYAAYCTRASDQGPNAGQNDNGPVMDEILDLRQELAKLLGFSSFSELSLATKMAESSDQVLSFLRDLAKRSKPF
AAQDLQQLKAYAAEQGCADLQSWDSGFYGEKLREQRYSVAQETLRAYFPIDKVLGGLFAIVQRLYGIEIAELKGFDTWHP
DVRLFEIKENGQHVGRFFFDLYARANKRGGAWMDGARDRRRTVDGVLQSPVANLVCNFTPADSGKPALLTHDEVTTLFHE
FGHGLHHLLTRVEHAGVSGINGVAWDAVELPSQFMENWCWEPEGLALISGHYETGEPLPQDLLEKMLAAKNFQSGLMMVR
QLEFSLFDFELHATHGDGRSVAQVLEGVRNEVSVMRPPAYNRFPNSFAHIFAGGYAAGYYSYKWAEVLSADAFSKFEEDG
VLNADTGRAFREAILARGGSQEPMVLFVDFRGREPSIDALLRHSGLSEDAAA

Sequences:

>Translated_692_residues
MFLPAKVPTVSVNNPLLQSYDLPPFSAIRAEHVQPAIETILADNRAAIAEILKTQGQNPTWAGLVLAMDELNDRLGAAWS
PVSHLNAVCNSAELREAYESCLPALSAYSTEMGQNRELFQAYEALANSPAAAGFDVAQKTILEHALRDFRLSGIDLPEAE
QKRYAEVQSKLSELGSRFSNQLLDATQAWTKHLTDEAALAGLTDSAKAQMAAAAQAKGLDGWLITLEFPSYYAVMTYAQD
RALREEVYAAYCTRASDQGPNAGQNDNGPVMDEILDLRQELAKLLGFSSFSELSLATKMAESSDQVLSFLRDLAKRSKPF
AAQDLQQLKAYAAEQGCADLQSWDSGFYGEKLREQRYSVAQETLRAYFPIDKVLGGLFAIVQRLYGIEIAELKGFDTWHP
DVRLFEIKENGQHVGRFFFDLYARANKRGGAWMDGARDRRRTVDGVLQSPVANLVCNFTPADSGKPALLTHDEVTTLFHE
FGHGLHHLLTRVEHAGVSGINGVAWDAVELPSQFMENWCWEPEGLALISGHYETGEPLPQDLLEKMLAAKNFQSGLMMVR
QLEFSLFDFELHATHGDGRSVAQVLEGVRNEVSVMRPPAYNRFPNSFAHIFAGGYAAGYYSYKWAEVLSADAFSKFEEDG
VLNADTGRAFREAILARGGSQEPMVLFVDFRGREPSIDALLRHSGLSEDAAA
>Mature_692_residues
MFLPAKVPTVSVNNPLLQSYDLPPFSAIRAEHVQPAIETILADNRAAIAEILKTQGQNPTWAGLVLAMDELNDRLGAAWS
PVSHLNAVCNSAELREAYESCLPALSAYSTEMGQNRELFQAYEALANSPAAAGFDVAQKTILEHALRDFRLSGIDLPEAE
QKRYAEVQSKLSELGSRFSNQLLDATQAWTKHLTDEAALAGLTDSAKAQMAAAAQAKGLDGWLITLEFPSYYAVMTYAQD
RALREEVYAAYCTRASDQGPNAGQNDNGPVMDEILDLRQELAKLLGFSSFSELSLATKMAESSDQVLSFLRDLAKRSKPF
AAQDLQQLKAYAAEQGCADLQSWDSGFYGEKLREQRYSVAQETLRAYFPIDKVLGGLFAIVQRLYGIEIAELKGFDTWHP
DVRLFEIKENGQHVGRFFFDLYARANKRGGAWMDGARDRRRTVDGVLQSPVANLVCNFTPADSGKPALLTHDEVTTLFHE
FGHGLHHLLTRVEHAGVSGINGVAWDAVELPSQFMENWCWEPEGLALISGHYETGEPLPQDLLEKMLAAKNFQSGLMMVR
QLEFSLFDFELHATHGDGRSVAQVLEGVRNEVSVMRPPAYNRFPNSFAHIFAGGYAAGYYSYKWAEVLSADAFSKFEEDG
VLNADTGRAFREAILARGGSQEPMVLFVDFRGREPSIDALLRHSGLSEDAAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=610, Percent_Identity=33.2786885245902, Blast_Score=312, Evalue=7e-85,
Organism=Homo sapiens, GI14149738, Length=610, Percent_Identity=31.6393442622951, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI156105687, Length=634, Percent_Identity=25.3943217665615, Blast_Score=198, Evalue=2e-50,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=58.0882352941177, Blast_Score=796, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=693, Percent_Identity=33.1890331890332, Blast_Score=319, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI71999758, Length=570, Percent_Identity=26.140350877193, Blast_Score=155, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI32565901, Length=674, Percent_Identity=22.4035608308605, Blast_Score=126, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319793, Length=655, Percent_Identity=29.7709923664122, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6322715, Length=714, Percent_Identity=22.5490196078431, Blast_Score=141, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21356111, Length=580, Percent_Identity=29.8275862068966, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI20129717, Length=705, Percent_Identity=23.8297872340426, Blast_Score=177, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76418; Mature: 76418

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLPAKVPTVSVNNPLLQSYDLPPFSAIRAEHVQPAIETILADNRAAIAEILKTQGQNPT
CCCCCCCCEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
WAGLVLAMDELNDRLGAAWSPVSHLNAVCNSAELREAYESCLPALSAYSTEMGQNRELFQ
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AYEALANSPAAAGFDVAQKTILEHALRDFRLSGIDLPEAEQKRYAEVQSKLSELGSRFSN
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLLDATQAWTKHLTDEAALAGLTDSAKAQMAAAAQAKGLDGWLITLEFPSYYAVMTYAQD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHH
RALREEVYAAYCTRASDQGPNAGQNDNGPVMDEILDLRQELAKLLGFSSFSELSLATKMA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ESSDQVLSFLRDLAKRSKPFAAQDLQQLKAYAAEQGCADLQSWDSGFYGEKLREQRYSVA
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHH
QETLRAYFPIDKVLGGLFAIVQRLYGIEIAELKGFDTWHPDVRLFEIKENGQHVGRFFFD
HHHHHHHCCHHHHHHHHHHHHHHHHCCEEHHCCCCCCCCCCCEEEEECCCCHHHHHHHHH
LYARANKRGGAWMDGARDRRRTVDGVLQSPVANLVCNFTPADSGKPALLTHDEVTTLFHE
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEHHHHHHHHHH
FGHGLHHLLTRVEHAGVSGINGVAWDAVELPSQFMENWCWEPEGLALISGHYETGEPLPQ
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHH
DLLEKMLAAKNFQSGLMMVRQLEFSLFDFELHATHGDGRSVAQVLEGVRNEVSVMRPPAY
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCC
NRFPNSFAHIFAGGYAAGYYSYKWAEVLSADAFSKFEEDGVLNADTGRAFREAILARGGS
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC
QEPMVLFVDFRGREPSIDALLRHSGLSEDAAA
CCCEEEEEEECCCCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFLPAKVPTVSVNNPLLQSYDLPPFSAIRAEHVQPAIETILADNRAAIAEILKTQGQNPT
CCCCCCCCEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
WAGLVLAMDELNDRLGAAWSPVSHLNAVCNSAELREAYESCLPALSAYSTEMGQNRELFQ
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AYEALANSPAAAGFDVAQKTILEHALRDFRLSGIDLPEAEQKRYAEVQSKLSELGSRFSN
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLLDATQAWTKHLTDEAALAGLTDSAKAQMAAAAQAKGLDGWLITLEFPSYYAVMTYAQD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHH
RALREEVYAAYCTRASDQGPNAGQNDNGPVMDEILDLRQELAKLLGFSSFSELSLATKMA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ESSDQVLSFLRDLAKRSKPFAAQDLQQLKAYAAEQGCADLQSWDSGFYGEKLREQRYSVA
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHH
QETLRAYFPIDKVLGGLFAIVQRLYGIEIAELKGFDTWHPDVRLFEIKENGQHVGRFFFD
HHHHHHHCCHHHHHHHHHHHHHHHHCCEEHHCCCCCCCCCCCEEEEECCCCHHHHHHHHH
LYARANKRGGAWMDGARDRRRTVDGVLQSPVANLVCNFTPADSGKPALLTHDEVTTLFHE
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEHHHHHHHHHH
FGHGLHHLLTRVEHAGVSGINGVAWDAVELPSQFMENWCWEPEGLALISGHYETGEPLPQ
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHH
DLLEKMLAAKNFQSGLMMVRQLEFSLFDFELHATHGDGRSVAQVLEGVRNEVSVMRPPAY
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCC
NRFPNSFAHIFAGGYAAGYYSYKWAEVLSADAFSKFEEDGVLNADTGRAFREAILARGGS
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC
QEPMVLFVDFRGREPSIDALLRHSGLSEDAAA
CCCEEEEEEECCCCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]