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The map label for this gene is cyoE1 [H]

Identifier: 77456299

GI number: 77456299

Start: 76268

End: 77158

Strand: Reverse

Name: cyoE1 [H]

Synonym: Pfl01_0071

Alternate gene names: 77456299

Gene position: 77158-76268 (Counterclockwise)

Preceding gene: 77456300

Following gene: 77456298

Centisome position: 1.2

GC content: 64.87

Gene sequence:

>891_bases
CTGATCGGCGAACGTCCGGCGCAGGCGCTGTGGCGTGATTACCTGGAGCTGACCAAACCGAAAGTCGTGGTGCTGATGCT
GATCACCTCGCTGGTGGGCATGTTCCTCGCGACCCGCGCCGGGGTGCCGTGGACGGTGCTGGTGTTCGGCAACCTGGGGA
TCGCGTTGTGTGCCGGTGGCGCGGCGGCGGTCAATCATGTGGTGGACCGGCGCATCGATGCGGTCATGGCCCGCACCCAC
AAACGGCCGCTGGCCGACGGCCGGGTTTCGCCCACAGGCGCACTGACCTTTGCGCTGGTGCTGGCACTGCTCGGCCAGGC
CCTGCTGCTGACCTTCACCAATCCGCTGACTGCGTGGCTGACCCTGGCCTCGCTGCTCGGCTACGCGGTGATCTACACCG
GTTTCCTCAAACGCGCGACGCCGCAGAACATCGTCATCGGTGGCCTTGCCGGCGCCGCGCCGCCGCTGCTCGGCTGGACC
GCCGCGACCGGCCACGTCAGCGCCGAACCGTTGCTGCTGGTGCTGATCATCTTCGCCTGGACCCCGCCGCACTTCTGGGC
GCTGGCCATCCACCGCAAGGAGGAATACGCCAAGGCCGACATTCCGATGCTGCCGGTCACCCATGGCGAGCACTACACCA
AGGTGCACATTCTGCTGTACACCTTCGCCCTGCTGGCGGTCAGCCTGTTGCCGTACGTGATCCACATGAGCGGCCTGCTG
TACCTGATCTGCGCGCTCGGTCTGGGAGCCAGGTTTCTGCAATGGGCCGTGGTGCTGTACCGTGGCACTCGGCCGCACGC
GGCGATCAACACCTTCAAGTACTCTATCTGGTACCTGTTTCTGCTGTTCATCGCCCTGCTCGTAGACCACTACTTACTGT
TGAACCTATGA

Upstream 100 bases:

>100_bases
TGGTTCGGGTCAGGCAGCCGATGATCGCGCGCTGGCGCCTCAGCCCGCGCAAACACTCGGCGGCGCCCATCACTATTAAA
GGAGAGACGCCATGGCGATT

Downstream 100 bases:

>100_bases
CTCGAACCCAGAAAACCGTCTTCATCCTCGTCGCTGTGATCGCGCTGATCCTCGGCCTGACCGTCAACAAAGTGCTGAGC
GGCAAGGGCCAGGGCGACCC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase 1; Heme O synthase 1 [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MIGERPAQALWRDYLELTKPKVVVLMLITSLVGMFLATRAGVPWTVLVFGNLGIALCAGGAAAVNHVVDRRIDAVMARTH
KRPLADGRVSPTGALTFALVLALLGQALLLTFTNPLTAWLTLASLLGYAVIYTGFLKRATPQNIVIGGLAGAAPPLLGWT
AATGHVSAEPLLLVLIIFAWTPPHFWALAIHRKEEYAKADIPMLPVTHGEHYTKVHILLYTFALLAVSLLPYVIHMSGLL
YLICALGLGARFLQWAVVLYRGTRPHAAINTFKYSIWYLFLLFIALLVDHYLLLNL

Sequences:

>Translated_296_residues
MIGERPAQALWRDYLELTKPKVVVLMLITSLVGMFLATRAGVPWTVLVFGNLGIALCAGGAAAVNHVVDRRIDAVMARTH
KRPLADGRVSPTGALTFALVLALLGQALLLTFTNPLTAWLTLASLLGYAVIYTGFLKRATPQNIVIGGLAGAAPPLLGWT
AATGHVSAEPLLLVLIIFAWTPPHFWALAIHRKEEYAKADIPMLPVTHGEHYTKVHILLYTFALLAVSLLPYVIHMSGLL
YLICALGLGARFLQWAVVLYRGTRPHAAINTFKYSIWYLFLLFIALLVDHYLLLNL
>Mature_296_residues
MIGERPAQALWRDYLELTKPKVVVLMLITSLVGMFLATRAGVPWTVLVFGNLGIALCAGGAAAVNHVVDRRIDAVMARTH
KRPLADGRVSPTGALTFALVLALLGQALLLTFTNPLTAWLTLASLLGYAVIYTGFLKRATPQNIVIGGLAGAAPPLLGWT
AATGHVSAEPLLLVLIIFAWTPPHFWALAIHRKEEYAKADIPMLPVTHGEHYTKVHILLYTFALLAVSLLPYVIHMSGLL
YLICALGLGARFLQWAVVLYRGTRPHAAINTFKYSIWYLFLLFIALLVDHYLLLNL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=193, Percent_Identity=36.7875647668394, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786631, Length=281, Percent_Identity=32.0284697508897, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71998235, Length=264, Percent_Identity=32.1969696969697, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6325085, Length=186, Percent_Identity=33.8709677419355, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI19921064, Length=278, Percent_Identity=29.8561151079137, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32406; Mature: 32406

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGERPAQALWRDYLELTKPKVVVLMLITSLVGMFLATRAGVPWTVLVFGNLGIALCAGG
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCC
AAAVNHVVDRRIDAVMARTHKRPLADGRVSPTGALTFALVLALLGQALLLTFTNPLTAWL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
TLASLLGYAVIYTGFLKRATPQNIVIGGLAGAAPPLLGWTAATGHVSAEPLLLVLIIFAW
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
TPPHFWALAIHRKEEYAKADIPMLPVTHGEHYTKVHILLYTFALLAVSLLPYVIHMSGLL
CCCHHEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLICALGLGARFLQWAVVLYRGTRPHAAINTFKYSIWYLFLLFIALLVDHYLLLNL
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIGERPAQALWRDYLELTKPKVVVLMLITSLVGMFLATRAGVPWTVLVFGNLGIALCAGG
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCC
AAAVNHVVDRRIDAVMARTHKRPLADGRVSPTGALTFALVLALLGQALLLTFTNPLTAWL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
TLASLLGYAVIYTGFLKRATPQNIVIGGLAGAAPPLLGWTAATGHVSAEPLLLVLIIFAW
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
TPPHFWALAIHRKEEYAKADIPMLPVTHGEHYTKVHILLYTFALLAVSLLPYVIHMSGLL
CCCHHEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLICALGLGARFLQWAVVLYRGTRPHAAINTFKYSIWYLFLLFIALLVDHYLLLNL
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA