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The map label for this gene is gltP [H]

Identifier: 77456270

GI number: 77456270

Start: 46001

End: 47332

Strand: Reverse

Name: gltP [H]

Synonym: Pfl01_0042

Alternate gene names: 77456270

Gene position: 47332-46001 (Counterclockwise)

Preceding gene: 77456271

Following gene: 77456269

Centisome position: 0.74

GC content: 59.16

Gene sequence:

>1332_bases
ATGAAGAAGGCAAAGCTTAGCCTCGCCTGGCAGATCCTCATCGGTCTGGTATTGGGAATTGCAATCGGTGCGTTGCTCAA
CCATTTCAGTGCCGAGAAGGCCTGGTGGATCAGCAATGTCCTGCAACCGGCAGGCGATATCTTTATCCGTCTGATCAAAA
TGATCGTGATCCCGATCGTTATCTCTTCCCTGATCGTCGGCATCGCCGGCGTGGGCGACGCCAAGAAGCTCGGGCGCATC
GGCCTGAAGACCATCATCTACTTCGAAATCGTCACCACCATCGCCATCGTTGTCGGCCTGCTGCTGGCCAACCTGTTCCA
CCCGGGTGCCGGCATCGACATGAGCACCCTGGGCACTGTGGATATCTCCAAGTACCAGGCGACCGCCGCCGAAGTGCAGC
ATGAACACGCGTTCATCGAGACCATCCTCAACCTGATCCCGTCGAACATCTTCGCGGCCATGGCCCGCGGCGAGATGCTG
CCGATCATCTTCTTCTCCGTACTGTTCGGTCTCGGTCTGTCGAGCCTGCAGTCGGACCTGCGCGAGCCGCTGGTAAAGAT
GTTCCAGGGCGTCTCGGAAAGCATGTTCAAAGTCACCCACATGATCATGAACTACGCCCCGATCGGCGTATTCGCCCTGA
TCGCGGTGACCGTGGCCAACTTCGGTTTCGCCTCACTGCTGCCGCTGGCCAAACTGGTAATCCTGGTTTACGTCGCCATC
GCCTTCTTCGCCTTCGTGATTCTCGGCCTGATCGCCAAGATGTTCGGTTTCTCGGTGATCAAGCTGATGCGCATCTTCAA
GGATGAGTTGGTGCTGGCTTACTCCACCGCTTCCTCGGAAACCGTGCTGCCACGGGTGATCGAGAAGATGGAAGCCTACG
GCGCACCGAAAGCCATCTGCAGTTTCGTAGTGCCGACCGGCTACTCGTTCAACCTCGACGGCTCGACCCTGTACCAGTCC
ATCGCGGCGATTTTCATTGCCCAGCTGTACGGCATCGACCTGTCGATCAGCCAGCAACTGCTGCTGGTCCTGACCCTGAT
GGTTACCTCCAAAGGCATCGCCGGCGTACCGGGCGTGTCCTTCGTGGTGCTGCTGGCCACCCTGGGCAGCGTGGGTATTC
CGCTGGAAGGCCTGGCCTTCATCGCCGGTGTCGACCGTGTGATGGACATGGCGCGGACCGCCCTGAACGTGATCGGCAAC
GCCCTCGCCGTACTGGTCATCGCCCGTTGGGAAGGCATGTACGACGACGCCAAGGGCCAGCGCTACTGGAACTCGCTGCC
GCATTGGCGCAGCAAGGAAAAACTGCCGGCCGGTGACGTTTCGAAAAACTGA

Upstream 100 bases:

>100_bases
TCGGGGCACCTTATACGGAGGCAGATGCACAGACTTTTCCGCTGATGAGCGTTCCAGTTCCTGCATGTGCCTGAGTCAAA
CGCAAGTAAGGGTAAAGATA

Downstream 100 bases:

>100_bases
TCCCGCCCGCAAGGCACCCTGACAAACCCCGGAGAAATCCGGGGTTTGTCGTTTCTGGCGACCCCGCTATCATTCGCCGC
ATCTTCCGGGGGGATTTGAC

Product: glutamate/aspartate:proton symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MKKAKLSLAWQILIGLVLGIAIGALLNHFSAEKAWWISNVLQPAGDIFIRLIKMIVIPIVISSLIVGIAGVGDAKKLGRI
GLKTIIYFEIVTTIAIVVGLLLANLFHPGAGIDMSTLGTVDISKYQATAAEVQHEHAFIETILNLIPSNIFAAMARGEML
PIIFFSVLFGLGLSSLQSDLREPLVKMFQGVSESMFKVTHMIMNYAPIGVFALIAVTVANFGFASLLPLAKLVILVYVAI
AFFAFVILGLIAKMFGFSVIKLMRIFKDELVLAYSTASSETVLPRVIEKMEAYGAPKAICSFVVPTGYSFNLDGSTLYQS
IAAIFIAQLYGIDLSISQQLLLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRVMDMARTALNVIGN
ALAVLVIARWEGMYDDAKGQRYWNSLPHWRSKEKLPAGDVSKN

Sequences:

>Translated_443_residues
MKKAKLSLAWQILIGLVLGIAIGALLNHFSAEKAWWISNVLQPAGDIFIRLIKMIVIPIVISSLIVGIAGVGDAKKLGRI
GLKTIIYFEIVTTIAIVVGLLLANLFHPGAGIDMSTLGTVDISKYQATAAEVQHEHAFIETILNLIPSNIFAAMARGEML
PIIFFSVLFGLGLSSLQSDLREPLVKMFQGVSESMFKVTHMIMNYAPIGVFALIAVTVANFGFASLLPLAKLVILVYVAI
AFFAFVILGLIAKMFGFSVIKLMRIFKDELVLAYSTASSETVLPRVIEKMEAYGAPKAICSFVVPTGYSFNLDGSTLYQS
IAAIFIAQLYGIDLSISQQLLLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRVMDMARTALNVIGN
ALAVLVIARWEGMYDDAKGQRYWNSLPHWRSKEKLPAGDVSKN
>Mature_443_residues
MKKAKLSLAWQILIGLVLGIAIGALLNHFSAEKAWWISNVLQPAGDIFIRLIKMIVIPIVISSLIVGIAGVGDAKKLGRI
GLKTIIYFEIVTTIAIVVGLLLANLFHPGAGIDMSTLGTVDISKYQATAAEVQHEHAFIETILNLIPSNIFAAMARGEML
PIIFFSVLFGLGLSSLQSDLREPLVKMFQGVSESMFKVTHMIMNYAPIGVFALIAVTVANFGFASLLPLAKLVILVYVAI
AFFAFVILGLIAKMFGFSVIKLMRIFKDELVLAYSTASSETVLPRVIEKMEAYGAPKAICSFVVPTGYSFNLDGSTLYQS
IAAIFIAQLYGIDLSISQQLLLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRVMDMARTALNVIGN
ALAVLVIARWEGMYDDAKGQRYWNSLPHWRSKEKLPAGDVSKN

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=490, Percent_Identity=26.9387755102041, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI21314632, Length=456, Percent_Identity=26.9736842105263, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI169790839, Length=420, Percent_Identity=27.1428571428571, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI66773030, Length=459, Percent_Identity=28.7581699346405, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI194239697, Length=467, Percent_Identity=27.1948608137045, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI5032093, Length=375, Percent_Identity=28, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4827012, Length=257, Percent_Identity=32.6848249027237, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI223468564, Length=249, Percent_Identity=30.1204819277108, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI223468566, Length=249, Percent_Identity=30.1204819277108, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI262359914, Length=368, Percent_Identity=25.5434782608696, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI301601644, Length=218, Percent_Identity=30.2752293577982, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1790514, Length=423, Percent_Identity=73.9952718676123, Blast_Score=628, Evalue=0.0,
Organism=Escherichia coli, GI1789947, Length=429, Percent_Identity=39.6270396270396, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1788024, Length=389, Percent_Identity=25.706940874036, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789473, Length=381, Percent_Identity=21.7847769028871, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71983099, Length=485, Percent_Identity=27.6288659793814, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI71983106, Length=485, Percent_Identity=27.6288659793814, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71996953, Length=481, Percent_Identity=27.2349272349272, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17537407, Length=424, Percent_Identity=27.3584905660377, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI193206505, Length=464, Percent_Identity=28.2327586206897, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI193206654, Length=488, Percent_Identity=26.844262295082, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17541374, Length=409, Percent_Identity=26.8948655256724, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24583025, Length=466, Percent_Identity=24.8927038626609, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17137668, Length=466, Percent_Identity=24.8927038626609, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24583023, Length=466, Percent_Identity=24.8927038626609, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI281360483, Length=483, Percent_Identity=26.9151138716356, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137666, Length=483, Percent_Identity=26.9151138716356, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281360481, Length=483, Percent_Identity=26.9151138716356, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47785; Mature: 47785

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]