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The map label for this gene is degS [H]

Identifier: 76819799

GI number: 76819799

Start: 1781778

End: 1783178

Strand: Direct

Name: degS [H]

Synonym: BURPS1710b_A1462

Alternate gene names: 76819799

Gene position: 1781778-1783178 (Clockwise)

Preceding gene: 76817645

Following gene: 76817735

Centisome position: 56.0

GC content: 69.09

Gene sequence:

>1401_bases
ATGAGACTGAAATTCAAGATCTTCCTGCTCGCGATCGTGCCTTTCCTCGTGACGATCGCGGCGATCGGCCTCGGCGTGCG
GCAGCAGGCCACGGTGCTCGCGCGCACGCAGCATGCGACGATCGAAGCCGCCTATCTGTCGAGCAAGGAAATCGAGCTCA
AGCATTATGTCGACCTCGCGACGAGCGCCGTCGCCCCGCTGTACGAAGCGGGCCGCGCGAACGCCCGCGACGACGCGCTG
CTGCGCCTGCAGGCGCTCGCGATGCTGCAGAGGATGGAGTTCGGCCCCGACGGCTACTTCTTCGTGTACGACCTGCACGG
CAATGCGCTGATGCATCCGCGCGAGCCCGAGCGGGTCGGACACAATTACTGGACGCTGCGCGACCCGCGGGGCTCGCCGA
CCATTCAGCAGTTGATTGCGGCCGCTTCGCGCGGCGGCGGCTACGTGCGCTACGTGTGGCAGCGCCCGTCGACGGGCAAG
CTCGCGCCGAAGCTCGGTTACGTCGTTTCACTGCCGCGCTGGGGCTGGATGATCGGCACCGGCATCTATCTCGACGATGT
CGATAACGCGCTCGCGCGGATCGACGCGCGCGCGTCGGCGAACATCGAGCGCACGATGACGTGGCTGAGCGCGATCGCAC
TCGCGGGCGCCGCGGTCATCGCGCTGTGCGCGCTCGTGCTGAACGTCAGCGAATCGCGCAGCGCGGACGCGAAACTCAAG
CGCCTCGCGCAGCAAGTCGTCGAATCGCAGGAGCAGGAACGCGCGCGTCTTGCGCGTGAGCTGCACGACGGGATCAGCCA
GATGATGGTATCGGCGAAGCTGATGTTCGAATCGGCACTCGAGCGCCTTGCGCACCTGCCCGCGCGCGAGAACGCGGCGC
AAGCCGCGCTGTCCAAAGGCATTGCGCGGCTCGGCGATACGCTGCGCGAAGTGCGCCGCATCTCGCACGCGCTGCGCCCG
ACGATGCTCGACGATCTCGGCCTTGCCGCCGCGCTCGATCAGCTCGTGCGCGAGCTCGGCGCGGAAACGGGCGTCGAGCT
CGGCTTCACGCAGGTCGATCACAGCGGCGCGCCGCCGCTGCCCGCGCCCGTGAAAACGGCGCTCTTTCGTATCGCGCAGG
AAGCGCTGACGAACATCCTGCGGCATGCGCACGCGACGCGCGCGGCCGTCACGCTCGAGCTGTCGCCGCGCGAAGTCGCG
CTGACGATCGCCGACAACGGCCGCGGCTTCGACGCCGGGCGCGCTCAGGCGGACGCGCGCGGCGGCATCGGCCTGCGCAA
CATGCGCGAGCGGCTCGACGCGCTCGGCGGCACGCTCGAGATCAGCTCGCAGATCGGCCATACCGTCGTCGCCGCGCGCG
TGCCGCTGCGCGGCACGGACTCACCAGGAACCCCGCGATGA

Upstream 100 bases:

>100_bases
GCGGCGCGCGGCCGACCCGACGGACAATCGACGAAGCGTCACCCCGCGCGGCCTGCCAAACGCGCGCCGCGCACGCCCCC
ATGGACGGATACCTGTCGCG

Downstream 100 bases:

>100_bases
CTCCTGCCTCTTCCACGCCCCGCACCGCGCGCCTCTTGCTCGTCGACGATCATCCGCTCGTGCGCGACGGCCTGAAGATG
CGCCTCGAAGCGGCGCCCGG

Product: sensor kinase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MRLKFKIFLLAIVPFLVTIAAIGLGVRQQATVLARTQHATIEAAYLSSKEIELKHYVDLATSAVAPLYEAGRANARDDAL
LRLQALAMLQRMEFGPDGYFFVYDLHGNALMHPREPERVGHNYWTLRDPRGSPTIQQLIAAASRGGGYVRYVWQRPSTGK
LAPKLGYVVSLPRWGWMIGTGIYLDDVDNALARIDARASANIERTMTWLSAIALAGAAVIALCALVLNVSESRSADAKLK
RLAQQVVESQEQERARLARELHDGISQMMVSAKLMFESALERLAHLPARENAAQAALSKGIARLGDTLREVRRISHALRP
TMLDDLGLAAALDQLVRELGAETGVELGFTQVDHSGAPPLPAPVKTALFRIAQEALTNILRHAHATRAAVTLELSPREVA
LTIADNGRGFDAGRAQADARGGIGLRNMRERLDALGGTLEISSQIGHTVVAARVPLRGTDSPGTPR

Sequences:

>Translated_466_residues
MRLKFKIFLLAIVPFLVTIAAIGLGVRQQATVLARTQHATIEAAYLSSKEIELKHYVDLATSAVAPLYEAGRANARDDAL
LRLQALAMLQRMEFGPDGYFFVYDLHGNALMHPREPERVGHNYWTLRDPRGSPTIQQLIAAASRGGGYVRYVWQRPSTGK
LAPKLGYVVSLPRWGWMIGTGIYLDDVDNALARIDARASANIERTMTWLSAIALAGAAVIALCALVLNVSESRSADAKLK
RLAQQVVESQEQERARLARELHDGISQMMVSAKLMFESALERLAHLPARENAAQAALSKGIARLGDTLREVRRISHALRP
TMLDDLGLAAALDQLVRELGAETGVELGFTQVDHSGAPPLPAPVKTALFRIAQEALTNILRHAHATRAAVTLELSPREVA
LTIADNGRGFDAGRAQADARGGIGLRNMRERLDALGGTLEISSQIGHTVVAARVPLRGTDSPGTPR
>Mature_466_residues
MRLKFKIFLLAIVPFLVTIAAIGLGVRQQATVLARTQHATIEAAYLSSKEIELKHYVDLATSAVAPLYEAGRANARDDAL
LRLQALAMLQRMEFGPDGYFFVYDLHGNALMHPREPERVGHNYWTLRDPRGSPTIQQLIAAASRGGGYVRYVWQRPSTGK
LAPKLGYVVSLPRWGWMIGTGIYLDDVDNALARIDARASANIERTMTWLSAIALAGAAVIALCALVLNVSESRSADAKLK
RLAQQVVESQEQERARLARELHDGISQMMVSAKLMFESALERLAHLPARENAAQAALSKGIARLGDTLREVRRISHALRP
TMLDDLGLAAALDQLVRELGAETGVELGFTQVDHSGAPPLPAPVKTALFRIAQEALTNILRHAHATRAAVTLELSPREVA
LTIADNGRGFDAGRAQADARGGIGLRNMRERLDALGGTLEISSQIGHTVVAARVPLRGTDSPGTPR

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=229, Percent_Identity=36.2445414847162, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788812, Length=196, Percent_Identity=31.1224489795918, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787474, Length=216, Percent_Identity=29.6296296296296, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50602; Mature: 50602

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKFKIFLLAIVPFLVTIAAIGLGVRQQATVLARTQHATIEAAYLSSKEIELKHYVDLA
CCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHH
TSAVAPLYEAGRANARDDALLRLQALAMLQRMEFGPDGYFFVYDLHGNALMHPREPERVG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEECCCCCHHHCC
HNYWTLRDPRGSPTIQQLIAAASRGGGYVRYVWQRPSTGKLAPKLGYVVSLPRWGWMIGT
CCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCHHHCC
GIYLDDVDNALARIDARASANIERTMTWLSAIALAGAAVIALCALVLNVSESRSADAKLK
CEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
RLAQQVVESQEQERARLARELHDGISQMMVSAKLMFESALERLAHLPARENAAQAALSKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IARLGDTLREVRRISHALRPTMLDDLGLAAALDQLVRELGAETGVELGFTQVDHSGAPPL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHCCCCCCCEECCCCCCCCC
PAPVKTALFRIAQEALTNILRHAHATRAAVTLELSPREVALTIADNGRGFDAGRAQADAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEEECCCCCCCCCCCCCCCC
GGIGLRNMRERLDALGGTLEISSQIGHTVVAARVPLRGTDSPGTPR
CCCCHHHHHHHHHHCCCCEEEHHHCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MRLKFKIFLLAIVPFLVTIAAIGLGVRQQATVLARTQHATIEAAYLSSKEIELKHYVDLA
CCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHH
TSAVAPLYEAGRANARDDALLRLQALAMLQRMEFGPDGYFFVYDLHGNALMHPREPERVG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEECCCCCHHHCC
HNYWTLRDPRGSPTIQQLIAAASRGGGYVRYVWQRPSTGKLAPKLGYVVSLPRWGWMIGT
CCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCHHHCC
GIYLDDVDNALARIDARASANIERTMTWLSAIALAGAAVIALCALVLNVSESRSADAKLK
CEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
RLAQQVVESQEQERARLARELHDGISQMMVSAKLMFESALERLAHLPARENAAQAALSKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IARLGDTLREVRRISHALRPTMLDDLGLAAALDQLVRELGAETGVELGFTQVDHSGAPPL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHCCCCCCCEECCCCCCCCC
PAPVKTALFRIAQEALTNILRHAHATRAAVTLELSPREVALTIADNGRGFDAGRAQADAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEEECCCCCCCCCCCCCCCC
GGIGLRNMRERLDALGGTLEISSQIGHTVVAARVPLRGTDSPGTPR
CCCCHHHHHHHHHHCCCCEEEHHHCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]