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The map label for this gene is fadD [C]

Identifier: 76819630

GI number: 76819630

Start: 1439747

End: 1441543

Strand: Direct

Name: fadD [C]

Synonym: BURPS1710b_A1154

Alternate gene names: 76819630

Gene position: 1439747-1441543 (Clockwise)

Preceding gene: 76817578

Following gene: 76819514

Centisome position: 45.25

GC content: 69.39

Gene sequence:

>1797_bases
GTGCGCGAAGCCGTCCCGAACCGACGAAAACCGGCGCGCGTCGGCGCGGTTCGAACGCGCCGGTCACGCAAGGCAACGAC
ACATCGCACCGAGACCGCGGCCGCGCCGCGCGCCGCGACGCGCAAGGAGACGACATTGACCTCGATCGCCCCGGAAAACC
TGCCGCTCGAACGCCTTCAGCACTGGGAACGCGCGCGCGCCGACGACGTATGGCTCGTGCAGCCGGGCGCCGACGGCGGC
GTGCGCCGCTTCACGTGGCGCGACGCCGTCGAGGAGGCGCGCCGCGTCGCCGCGTATCTGCGCGCGCTCGATCTGCCGCG
CGGATCGAACATCGCGATCCTGTCGAAGAACTGCGCGCACTGGGTCCTCGCCGATTTCGCGATCTGGCTGAGCGGCCACG
TATCCGTGCCGCTCTATCCAACGCTCGGCGCGGAATCGATCCGGCAGGTGCTCACGCATTGCGAAGCCGCCGCGCTGTTC
GTCGGCAAGCTCGATGCGTGGGAGACGATGCGCGCGGGCGTGCCGCCGCACGTGCGCAGCATCGGTCTGCCTTATCTGCA
CGATGCGTCGTCCGTCGGCGCGACGTGGGACGACATCGTGCGCGACACCGCGCCGCTCGCGGAGCACGTGACGCGCGCGG
CCGACGCGCTCGCGACGATCGTCTACACGTCCGGCACGACAGGCGAGCCGAAAGGCGTGATGCTGACGTTCGGCGCGCTC
GGCTGGTGCGTCGAGCCGGTGTTCGATCTGGTCGCGATCGGCCCGGACGACCGGATGATCTCGTATCTGCCGCTGTCGCA
CGTGGCCGAGCGCGGTTACGTCGAAATGCTGTCGGTGCGCGCGGGATTCACCGTCTACTTCAGCGATTCGCCCGATACGT
TCATCGCCGATCTGCAGCGCGCGCGGCCGACGTTCTTCATCTCGGTGCCGCGCTTGTGGGCGAAGTTCCGGCACGCGGTG
GCGAGCCGCCTGCCGCCGGGGCCGGTTCCCGACGCGATGAAGCCGATGATCCTGCGGCAGCTCGGCCTCGATCAGGTCCG
CCTCGCCGCGAGCGCCGCCGCCGCGATCGAGCCCGCGCTGCTGCGCTGGTATCGCGATCTCGGGCTCGAACTGCTCGAAG
GCTATGGGATGAGCGAAGTGTGCGGCGTGTCGCATTCGTGCCGGCAGCACGACATGCGCCTGGGCTACGTCGGCACGCCG
GTGCGCGACGTCGAGAGCCGCCTCGCCGACACGGGCGAGATCGAGATCCGCTCGCCCGGCAACACGATCGGCTATTACAA
GCGCCCCGACCTGAGCGCGGCGCTCTTCACGCCCGACGGCTTCGTGCGCAGCGGCGACAAGGGCGAGCTCGACGAAGCGG
GCCGCCTGAAGATCACCGGGCGGGTGAAGGAAATCTTCAAGACGAGCAAGGGCAAGTATGTCGCGCCGTCGCCGATCGAG
AGCCGGCTCGCGACGCATCCGTTCGTCGACGCGTGCTGCGTGGTCGGCTCGGGGCTCGCGCAGCCGTGCGCGCTCGTTTC
GCTGTCGGACGAAGGCCGCCGATTCGATGGCGACGGCCGGCGCGCGGCGCTCGAAACCTCGCTCGGCGAACATCTCGCGC
ACGTGAACGCAAGCCTCGACGATCACGAGAAGCTGCGCTTCGTCGTGGTCGTCGATTCGGTCTGGAACGAGACGAGCGGC
TTCGTCACACCGACGTTCAAGGTGCGCCGCAATCGCGTGGAGGCGCGGTACGCACCGTTTCTCGACGCGTGGGACGCGCG
CGGGGCGACGATCGTTTGGGAGTCCGACACGGCCTGA

Upstream 100 bases:

>100_bases
CGAGCCGCATCGCGGGCGGGACGCGCGCGCATGGTGCGCGTCACGCGGGCGCGCGGCGCGCATGCGGTCCGCATGATCGA
AAGGTGAGCATTTTCGGGAG

Downstream 100 bases:

>100_bases
CGGGCAGTGTCTTGCGGCGCGGCCATCGGGCGCGAACGGCGCGGCGCGACACGGCGACGATCCGGCCTTCGGCACGCCGT
TCGGCGCGGCGCACGCGCCC

Product: putative AMP-binding acetyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MREAVPNRRKPARVGAVRTRRSRKATTHRTETAAAPRAATRKETTLTSIAPENLPLERLQHWERARADDVWLVQPGADGG
VRRFTWRDAVEEARRVAAYLRALDLPRGSNIAILSKNCAHWVLADFAIWLSGHVSVPLYPTLGAESIRQVLTHCEAAALF
VGKLDAWETMRAGVPPHVRSIGLPYLHDASSVGATWDDIVRDTAPLAEHVTRAADALATIVYTSGTTGEPKGVMLTFGAL
GWCVEPVFDLVAIGPDDRMISYLPLSHVAERGYVEMLSVRAGFTVYFSDSPDTFIADLQRARPTFFISVPRLWAKFRHAV
ASRLPPGPVPDAMKPMILRQLGLDQVRLAASAAAAIEPALLRWYRDLGLELLEGYGMSEVCGVSHSCRQHDMRLGYVGTP
VRDVESRLADTGEIEIRSPGNTIGYYKRPDLSAALFTPDGFVRSGDKGELDEAGRLKITGRVKEIFKTSKGKYVAPSPIE
SRLATHPFVDACCVVGSGLAQPCALVSLSDEGRRFDGDGRRAALETSLGEHLAHVNASLDDHEKLRFVVVVDSVWNETSG
FVTPTFKVRRNRVEARYAPFLDAWDARGATIVWESDTA

Sequences:

>Translated_598_residues
MREAVPNRRKPARVGAVRTRRSRKATTHRTETAAAPRAATRKETTLTSIAPENLPLERLQHWERARADDVWLVQPGADGG
VRRFTWRDAVEEARRVAAYLRALDLPRGSNIAILSKNCAHWVLADFAIWLSGHVSVPLYPTLGAESIRQVLTHCEAAALF
VGKLDAWETMRAGVPPHVRSIGLPYLHDASSVGATWDDIVRDTAPLAEHVTRAADALATIVYTSGTTGEPKGVMLTFGAL
GWCVEPVFDLVAIGPDDRMISYLPLSHVAERGYVEMLSVRAGFTVYFSDSPDTFIADLQRARPTFFISVPRLWAKFRHAV
ASRLPPGPVPDAMKPMILRQLGLDQVRLAASAAAAIEPALLRWYRDLGLELLEGYGMSEVCGVSHSCRQHDMRLGYVGTP
VRDVESRLADTGEIEIRSPGNTIGYYKRPDLSAALFTPDGFVRSGDKGELDEAGRLKITGRVKEIFKTSKGKYVAPSPIE
SRLATHPFVDACCVVGSGLAQPCALVSLSDEGRRFDGDGRRAALETSLGEHLAHVNASLDDHEKLRFVVVVDSVWNETSG
FVTPTFKVRRNRVEARYAPFLDAWDARGATIVWESDTA
>Mature_598_residues
MREAVPNRRKPARVGAVRTRRSRKATTHRTETAAAPRAATRKETTLTSIAPENLPLERLQHWERARADDVWLVQPGADGG
VRRFTWRDAVEEARRVAAYLRALDLPRGSNIAILSKNCAHWVLADFAIWLSGHVSVPLYPTLGAESIRQVLTHCEAAALF
VGKLDAWETMRAGVPPHVRSIGLPYLHDASSVGATWDDIVRDTAPLAEHVTRAADALATIVYTSGTTGEPKGVMLTFGAL
GWCVEPVFDLVAIGPDDRMISYLPLSHVAERGYVEMLSVRAGFTVYFSDSPDTFIADLQRARPTFFISVPRLWAKFRHAV
ASRLPPGPVPDAMKPMILRQLGLDQVRLAASAAAAIEPALLRWYRDLGLELLEGYGMSEVCGVSHSCRQHDMRLGYVGTP
VRDVESRLADTGEIEIRSPGNTIGYYKRPDLSAALFTPDGFVRSGDKGELDEAGRLKITGRVKEIFKTSKGKYVAPSPIE
SRLATHPFVDACCVVGSGLAQPCALVSLSDEGRRFDGDGRRAALETSLGEHLAHVNASLDDHEKLRFVVVVDSVWNETSG
FVTPTFKVRRNRVEARYAPFLDAWDARGATIVWESDTA

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI83745141, Length=582, Percent_Identity=23.8831615120275, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI40807491, Length=551, Percent_Identity=26.1343012704174, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI57165412, Length=534, Percent_Identity=26.0299625468165, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI42794756, Length=567, Percent_Identity=24.8677248677249, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI42794760, Length=569, Percent_Identity=24.780316344464, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI42794758, Length=569, Percent_Identity=24.780316344464, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI57165410, Length=534, Percent_Identity=25.8426966292135, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI27477105, Length=467, Percent_Identity=25.2676659528908, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI42794754, Length=586, Percent_Identity=23.8907849829352, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI42794752, Length=586, Percent_Identity=23.8907849829352, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI187761345, Length=462, Percent_Identity=27.0562770562771, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI187761343, Length=462, Percent_Identity=27.0562770562771, Blast_Score=112, Evalue=8e-25,
Organism=Escherichia coli, GI1788107, Length=457, Percent_Identity=24.2888402625821, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693145, Length=464, Percent_Identity=25.2155172413793, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786810, Length=484, Percent_Identity=23.9669421487603, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17556552, Length=583, Percent_Identity=26.9296740994854, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17541856, Length=584, Percent_Identity=26.8835616438356, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17510401, Length=576, Percent_Identity=27.2569444444444, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI193204819, Length=510, Percent_Identity=29.2156862745098, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI25147511, Length=584, Percent_Identity=24.3150684931507, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17564090, Length=575, Percent_Identity=24.1739130434783, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17553312, Length=585, Percent_Identity=23.9316239316239, Blast_Score=122, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17558820, Length=298, Percent_Identity=28.1879194630872, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32563687, Length=367, Percent_Identity=26.7029972752044, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=331, Percent_Identity=26.5861027190332, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=296, Percent_Identity=26.3513513513513, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=390, Percent_Identity=26.1538461538462, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17538037, Length=316, Percent_Identity=27.5316455696203, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320852, Length=594, Percent_Identity=24.0740740740741, Blast_Score=134, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324893, Length=425, Percent_Identity=25.6470588235294, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323903, Length=427, Percent_Identity=26.2295081967213, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6322182, Length=417, Percent_Identity=25.6594724220624, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319699, Length=476, Percent_Identity=22.4789915966387, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17933690, Length=649, Percent_Identity=24.8073959938367, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI281366413, Length=573, Percent_Identity=27.0506108202443, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24666501, Length=573, Percent_Identity=27.0506108202443, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24666497, Length=573, Percent_Identity=27.0506108202443, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI62471681, Length=584, Percent_Identity=24.3150684931507, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI62471687, Length=584, Percent_Identity=24.3150684931507, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24586634, Length=584, Percent_Identity=24.3150684931507, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI22026970, Length=584, Percent_Identity=24.3150684931507, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI62471679, Length=585, Percent_Identity=24.4444444444444, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI62471683, Length=585, Percent_Identity=24.4444444444444, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI62471685, Length=585, Percent_Identity=24.4444444444444, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24586636, Length=585, Percent_Identity=24.4444444444444, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI62471689, Length=584, Percent_Identity=24.3150684931507, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19921316, Length=631, Percent_Identity=24.405705229794, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI18859661, Length=628, Percent_Identity=21.8152866242038, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 65748; Mature: 65748

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVPNRRKPARVGAVRTRRSRKATTHRTETAAAPRAATRKETTLTSIAPENLPLERLQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHCCCCCCCHHHHH
HWERARADDVWLVQPGADGGVRRFTWRDAVEEARRVAAYLRALDLPRGSNIAILSKNCAH
HHHHCCCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHH
WVLADFAIWLSGHVSVPLYPTLGAESIRQVLTHCEAAALFVGKLDAWETMRAGVPPHVRS
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHH
IGLPYLHDASSVGATWDDIVRDTAPLAEHVTRAADALATIVYTSGTTGEPKGVMLTFGAL
CCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCEEEEHHHH
GWCVEPVFDLVAIGPDDRMISYLPLSHVAERGYVEMLSVRAGFTVYFSDSPDTFIADLQR
HHHHHHHHHHEEECCCCCEEEECCHHHHHHCCHHHHEEECCCEEEEECCCCCHHHHHHHH
ARPTFFISVPRLWAKFRHAVASRLPPGPVPDAMKPMILRQLGLDQVRLAASAAAAIEPAL
CCCEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LRWYRDLGLELLEGYGMSEVCGVSHSCRQHDMRLGYVGTPVRDVESRLADTGEIEIRSPG
HHHHHHHHHHHHHCCCCHHHHCCCHHHHHHCCEEEECCCCHHHHHHHHCCCCCEEEECCC
NTIGYYKRPDLSAALFTPDGFVRSGDKGELDEAGRLKITGRVKEIFKTSKGKYVAPSPIE
CCCCCEECCCCCEEEECCCCCEECCCCCCCCCCCCEEEEHHHHHHHHCCCCCEECCCCHH
SRLATHPFVDACCVVGSGLAQPCALVSLSDEGRRFDGDGRRAALETSLGEHLAHVNASLD
HHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHCCCCC
DHEKLRFVVVVDSVWNETSGFVTPTFKVRRNRVEARYAPFLDAWDARGATIVWESDTA
CCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCEEEECCCCC
>Mature Secondary Structure
MREAVPNRRKPARVGAVRTRRSRKATTHRTETAAAPRAATRKETTLTSIAPENLPLERLQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHCCCCCCCHHHHH
HWERARADDVWLVQPGADGGVRRFTWRDAVEEARRVAAYLRALDLPRGSNIAILSKNCAH
HHHHCCCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHH
WVLADFAIWLSGHVSVPLYPTLGAESIRQVLTHCEAAALFVGKLDAWETMRAGVPPHVRS
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHH
IGLPYLHDASSVGATWDDIVRDTAPLAEHVTRAADALATIVYTSGTTGEPKGVMLTFGAL
CCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCEEEEHHHH
GWCVEPVFDLVAIGPDDRMISYLPLSHVAERGYVEMLSVRAGFTVYFSDSPDTFIADLQR
HHHHHHHHHHEEECCCCCEEEECCHHHHHHCCHHHHEEECCCEEEEECCCCCHHHHHHHH
ARPTFFISVPRLWAKFRHAVASRLPPGPVPDAMKPMILRQLGLDQVRLAASAAAAIEPAL
CCCEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LRWYRDLGLELLEGYGMSEVCGVSHSCRQHDMRLGYVGTPVRDVESRLADTGEIEIRSPG
HHHHHHHHHHHHHCCCCHHHHCCCHHHHHHCCEEEECCCCHHHHHHHHCCCCCEEEECCC
NTIGYYKRPDLSAALFTPDGFVRSGDKGELDEAGRLKITGRVKEIFKTSKGKYVAPSPIE
CCCCCEECCCCCEEEECCCCCEECCCCCCCCCCCCEEEEHHHHHHHHCCCCCEECCCCHH
SRLATHPFVDACCVVGSGLAQPCALVSLSDEGRRFDGDGRRAALETSLGEHLAHVNASLD
HHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHCCCCC
DHEKLRFVVVVDSVWNETSGFVTPTFKVRRNRVEARYAPFLDAWDARGATIVWESDTA
CCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]