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The map label for this gene is bcr [H]

Identifier: 76819626

GI number: 76819626

Start: 1199047

End: 1200252

Strand: Direct

Name: bcr [H]

Synonym: BURPS1710b_A0940

Alternate gene names: 76819626

Gene position: 1199047-1200252 (Clockwise)

Preceding gene: 76818196

Following gene: 76817338

Centisome position: 37.68

GC content: 74.38

Gene sequence:

>1206_bases
ATGCATCCGCTCCGATCGATTCTCCCGTTGGCCCTGTTCACCGCCGTCGGGCTGCTCGCCACCGACCTCTATCTCCCCGC
CGTGCCGTCGTTGCCGCAGCAGCTCGGCGGCTCCATCGAAAGCGCGCAGGCGACGCTCGCCGCGTTCTCGGCCGCGCTCG
CCGTGTCGCAGCTCGTCTGGGGCGCGGCCGCCGACCGCTTCGGGCACCGCCGCACGCTCGCGTTCGCGGTGCTGCTGCAA
CTCGTCGCGGGCGCCGCGTGCGCGCTCGCGCCTTCGATGGGCGCGCTGATCGGCGCGCGCCTCGCGCAGGGCTTCGGCGT
CGGCGCGGCGATGGTCATCGTCCCCGCGCTCGTGCGACAGTCGTTCGGCGACGGCGGCGCGGTCCGCGCGCTCGCATGGC
TCGGCATCGTCGAAAGCGCGGTGCCCGGACTCGCGCCCCTCGTCGGCGCGGCGCTGCTCGTCGTGGCCGACTGGCGAACG
AGCTTCTGGATCATCGTCGCGTTGTCCGCCATCGCGGCGCCGCTCGTGTTCCGCGTGATTCCGACGGCTCGCGCGATGCG
CGCGTGTGCGCCGGCGAACGTCGGCGCACACGCGGGCGGCTATCGGCGGCTGCTGCGCTCGCCCGTCTATCTCGGCTACG
CGCTCGGCCACGCGCTCTGCTTCGCCGCGCTGCTCGCGTTCGTCGCGAGCGCGCCGCAAGTCGTCGAGATCTGGCTCGGC
GCGGGGCCGTCGACGTTCAGCCTGATGCAGGCGTGCGGGGTCGCCGCGTTCATGCTGAGCGCCGCGCGCAGCGGCAAATG
GTCCGACGCGCTCGGCCTCGACCGGATCATCGCACTCGGCGCGCTGCTGCAGTTCGCGGCGTCGGCCGCGTTCCTGCTGC
TCGCGTATGCCGATTGGCGCTCGACGCCGCTCGTCGTCGCATCGTGGATGCTGTTCTGCGGCTCGCTCGGCCTGCGCGGG
CCGGCGTCGATGGCGCGCGCGCTCGCGGCCGAGCCCGCCGTCGCGGGACGCGCGGCCGGGCTGCTGATGTTCTTCGGGCT
CGGCGGCGCGGCGCTCGCGACACAGGCCGTCGCGCCGTTCCTGCGGCTGGGGCTCGCGCCCGTCGCGTGGATGTGCGCGG
GCTTCACGCTCGCGAGCGGCGCGGTCGTGCTGTGGGGCATCGCGATACGCGGCCGACATCGCGCGGCGGCCACGGAAATC
GCGTGA

Upstream 100 bases:

>100_bases
CGCGTCGCCCGTCGCCGCAAACGCGCGCCGCCCGGGCCGCGCGCATCGACGTGATATCGTCGGGCGCTCGCAAACCGACA
AAACCCTTTCCGTTTCACGC

Downstream 100 bases:

>100_bases
GCCGACGGAATCGGGCGCGCGGTGAATGCATGCACGCGCACGGAAAGGCATGCGCCGCGCGAAGCCGATGCGCCGCCCGC
ACGCCGATGCGCGAAGCCCG

Product: major facilitator family transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MHPLRSILPLALFTAVGLLATDLYLPAVPSLPQQLGGSIESAQATLAAFSAALAVSQLVWGAAADRFGHRRTLAFAVLLQ
LVAGAACALAPSMGALIGARLAQGFGVGAAMVIVPALVRQSFGDGGAVRALAWLGIVESAVPGLAPLVGAALLVVADWRT
SFWIIVALSAIAAPLVFRVIPTARAMRACAPANVGAHAGGYRRLLRSPVYLGYALGHALCFAALLAFVASAPQVVEIWLG
AGPSTFSLMQACGVAAFMLSAARSGKWSDALGLDRIIALGALLQFAASAAFLLLAYADWRSTPLVVASWMLFCGSLGLRG
PASMARALAAEPAVAGRAAGLLMFFGLGGAALATQAVAPFLRLGLAPVAWMCAGFTLASGAVVLWGIAIRGRHRAAATEI
A

Sequences:

>Translated_401_residues
MHPLRSILPLALFTAVGLLATDLYLPAVPSLPQQLGGSIESAQATLAAFSAALAVSQLVWGAAADRFGHRRTLAFAVLLQ
LVAGAACALAPSMGALIGARLAQGFGVGAAMVIVPALVRQSFGDGGAVRALAWLGIVESAVPGLAPLVGAALLVVADWRT
SFWIIVALSAIAAPLVFRVIPTARAMRACAPANVGAHAGGYRRLLRSPVYLGYALGHALCFAALLAFVASAPQVVEIWLG
AGPSTFSLMQACGVAAFMLSAARSGKWSDALGLDRIIALGALLQFAASAAFLLLAYADWRSTPLVVASWMLFCGSLGLRG
PASMARALAAEPAVAGRAAGLLMFFGLGGAALATQAVAPFLRLGLAPVAWMCAGFTLASGAVVLWGIAIRGRHRAAATEI
A
>Mature_401_residues
MHPLRSILPLALFTAVGLLATDLYLPAVPSLPQQLGGSIESAQATLAAFSAALAVSQLVWGAAADRFGHRRTLAFAVLLQ
LVAGAACALAPSMGALIGARLAQGFGVGAAMVIVPALVRQSFGDGGAVRALAWLGIVESAVPGLAPLVGAALLVVADWRT
SFWIIVALSAIAAPLVFRVIPTARAMRACAPANVGAHAGGYRRLLRSPVYLGYALGHALCFAALLAFVASAPQVVEIWLG
AGPSTFSLMQACGVAAFMLSAARSGKWSDALGLDRIIALGALLQFAASAAFLLLAYADWRSTPLVVASWMLFCGSLGLRG
PASMARALAAEPAVAGRAAGLLMFFGLGGAALATQAVAPFLRLGLAPVAWMCAGFTLASGAVVLWGIAIRGRHRAAATEI
A

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=347, Percent_Identity=27.3775216138329, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI48994889, Length=363, Percent_Identity=28.099173553719, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790146, Length=211, Percent_Identity=24.1706161137441, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081983, Length=165, Percent_Identity=29.6969696969697, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40827; Mature: 40827

Theoretical pI: Translated: 11.07; Mature: 11.07

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPLRSILPLALFTAVGLLATDLYLPAVPSLPQQLGGSIESAQATLAAFSAALAVSQLVW
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GAAADRFGHRRTLAFAVLLQLVAGAACALAPSMGALIGARLAQGFGVGAAMVIVPALVRQ
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SFGDGGAVRALAWLGIVESAVPGLAPLVGAALLVVADWRTSFWIIVALSAIAAPLVFRVI
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
PTARAMRACAPANVGAHAGGYRRLLRSPVYLGYALGHALCFAALLAFVASAPQVVEIWLG
HHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
AGPSTFSLMQACGVAAFMLSAARSGKWSDALGLDRIIALGALLQFAASAAFLLLAYADWR
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
STPLVVASWMLFCGSLGLRGPASMARALAAEPAVAGRAAGLLMFFGLGGAALATQAVAPF
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
LRLGLAPVAWMCAGFTLASGAVVLWGIAIRGRHRAAATEIA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure
MHPLRSILPLALFTAVGLLATDLYLPAVPSLPQQLGGSIESAQATLAAFSAALAVSQLVW
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GAAADRFGHRRTLAFAVLLQLVAGAACALAPSMGALIGARLAQGFGVGAAMVIVPALVRQ
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SFGDGGAVRALAWLGIVESAVPGLAPLVGAALLVVADWRTSFWIIVALSAIAAPLVFRVI
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
PTARAMRACAPANVGAHAGGYRRLLRSPVYLGYALGHALCFAALLAFVASAPQVVEIWLG
HHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
AGPSTFSLMQACGVAAFMLSAARSGKWSDALGLDRIIALGALLQFAASAAFLLLAYADWR
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
STPLVVASWMLFCGSLGLRGPASMARALAAEPAVAGRAAGLLMFFGLGGAALATQAVAPF
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
LRLGLAPVAWMCAGFTLASGAVVLWGIAIRGRHRAAATEIA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]