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The map label for this gene is 76819393

Identifier: 76819393

GI number: 76819393

Start: 1277308

End: 1279119

Strand: Direct

Name: 76819393

Synonym: BURPS1710b_A1013

Alternate gene names: NA

Gene position: 1277308-1279119 (Clockwise)

Preceding gene: 76817616

Following gene: 76817925

Centisome position: 40.14

GC content: 69.48

Gene sequence:

>1812_bases
GTGCCGCGCGCACAGGCAGCCGGCGAGGACGCCCCATGCGCCGCTTCCTGTCTCGCGCGCGGCGAAAACCGGCCGCGCGC
CGCACCGCACAAACGCGCTGATGCAGGCGCCCTGAGGTCTGCCGCCTCACGCCGAACGCCCGCCGCCCCATGCCTGCGTC
GAACGCGCAGCCCGCCGCCCGCATGCGGACGGCCGTCCGTACCGGCGTCGATTTCGCCGCGCCGCAGCATCCCCATGCAT
CCTCTTCATGCAACCTCGCCGACGGCGGATTCGTGCGCCGCGGCGCGCCCGCACCCGCGCCTTCATCCGTTCATGCCCCT
TTTCGTCACGCCTGCCGGCGCTTCGCCGCGCGGATTGATCCACGTCAGCAAGGCGCGCGTCGCGTGTAGTGCAATGGGCG
CATCGAACACCACACGCATTCCGGGAGGTCTCATGAAACTGACGTTCCTCGGCGCGACGGAAACCGTCACCGGCTCGAAG
TATCTGCTCGAGGACGCCGGGACACGCGTCCTGATCGACTGCGGGCTGTTCCAGGGCACGAAGAAGCTGCGGCTGCGCAA
CTGGAGCCCGCTGCCCGTGCCCGCCGATTCGATCGACGCCGTCGTGCTCACGCATGCGCATCTCGATCACAGCGGCTATC
TGCCGGTGCTCGTGCGCGAGGGCTTCCGCGGGCCGATCTATTGCACGCACGGCACCGCGGCGCTCTGCGAGATCATGCTG
ATCGACAGCGCGCGGCTCCTCGAGGAAGAAGCCGATTTCGCGAACCGCCACGGCTACTCGAAACATCATCCGGCGTTGCC
GCTCTACACGACCGACGACGCGAAGCGCACGCTCGAGCGCCTCGCGCCGCGCGATTTCGACGCGCCGAGCGCGCTCGCGG
GCGATCTGCACTTCCGTCTGCTGCCCGCCGGGCACATTCTCGGCGCGGCGAGCGTCGTCGTCTGCTGGCGGCATACGCTG
CTCGCGTTCTCCGGCGATCTCGGCCGCGCGCACGATCCGATCATGCGCGCGCCCGTGCCGCCCGTTCATGCGGACTATCT
CGTCGTCGAATCGACGTACGGCGACCGGCTGCACGATGCGAGCGATCCGCAGACCGAGCTCGCCGACGTGTTCGCGAAGA
CGTTCGCGCGCGGCGGCGTGGTCGTGATGCCGTGCTTCACGGTCGGGCGCGCGCAGGAGATCCTTTACTACATCGCGCAA
TTGAAGCAGACCGGGCGGATGCCGCACGTCCCCGTCTTTCTCGACAGCCCGATGGCGACGAGCGTCACCGAGATCTACCG
GCGGCGGCTGTCCGACCACCGGCTCACGATGTCCGACGCGGATGCGATCGGTCATGCGGCGGTGATGGTGCGCACGGTCG
AGCAATCGAAGGCGATCGCCGATCACCATGGGCCGATGGTCATCATCGCCGGCAGCGGCATGGCGACGGGCGGCCGCGTG
CTGCATCATCTCGCGCGCTACGCGCCCGACAGCCGCAACACGGTCCTGCTCGTCGGCTACCAGGCGGCGGGCACGCGCGG
GGCGGCGCTCGCCGCGCACGAGCCGACGCTGAAGATTCACGGCGAATACGTGCGCGTGCGCGCGCAGGTCCAGATGATCT
CGTCGCTGTCCGCGCACGCGGATTACGGCGAGATCCTCGGATGGCTCGGCGCGCAATCGAGCGCGCCCGCGCGCACGTTC
GTCACGCACGGCGAGCCCGCAGCGGCCGACGCGCTGCGGCGGCGAATCGAGGAAACCCTGCATTGGCGTTGCGACGTGCC
GTCGTACCTCGAATCGGTCGAACTGGAGGACGCGCCCACACGCGCGGCATGA

Upstream 100 bases:

>100_bases
ACACATTCTTCGTTGCGGAATTTCCCTAACTCACGCCCGCGCGCCCCCGGCGGGCGGGGGTCGCGGCGGCGCCCGAGCGC
CTCCTTCAAACGGCTCGCCC

Downstream 100 bases:

>100_bases
TCCGGGCGAGCGCAGCGAGGCCGCCGGGCGAGCGGCGAGGCCCGCCGTTTTGCCGCATCGAATCGGTGAATCGGTGAATT
GGCGGAATGCGCGGAATGGG

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MPRAQAAGEDAPCAASCLARGENRPRAAPHKRADAGALRSAASRRTPAAPCLRRTRSPPPACGRPSVPASISPRRSIPMH
PLHATSPTADSCAAARPHPRLHPFMPLFVTPAGASPRGLIHVSKARVACSAMGASNTTRIPGGLMKLTFLGATETVTGSK
YLLEDAGTRVLIDCGLFQGTKKLRLRNWSPLPVPADSIDAVVLTHAHLDHSGYLPVLVREGFRGPIYCTHGTAALCEIML
IDSARLLEEEADFANRHGYSKHHPALPLYTTDDAKRTLERLAPRDFDAPSALAGDLHFRLLPAGHILGAASVVVCWRHTL
LAFSGDLGRAHDPIMRAPVPPVHADYLVVESTYGDRLHDASDPQTELADVFAKTFARGGVVVMPCFTVGRAQEILYYIAQ
LKQTGRMPHVPVFLDSPMATSVTEIYRRRLSDHRLTMSDADAIGHAAVMVRTVEQSKAIADHHGPMVIIAGSGMATGGRV
LHHLARYAPDSRNTVLLVGYQAAGTRGAALAAHEPTLKIHGEYVRVRAQVQMISSLSAHADYGEILGWLGAQSSAPARTF
VTHGEPAAADALRRRIEETLHWRCDVPSYLESVELEDAPTRAA

Sequences:

>Translated_603_residues
MPRAQAAGEDAPCAASCLARGENRPRAAPHKRADAGALRSAASRRTPAAPCLRRTRSPPPACGRPSVPASISPRRSIPMH
PLHATSPTADSCAAARPHPRLHPFMPLFVTPAGASPRGLIHVSKARVACSAMGASNTTRIPGGLMKLTFLGATETVTGSK
YLLEDAGTRVLIDCGLFQGTKKLRLRNWSPLPVPADSIDAVVLTHAHLDHSGYLPVLVREGFRGPIYCTHGTAALCEIML
IDSARLLEEEADFANRHGYSKHHPALPLYTTDDAKRTLERLAPRDFDAPSALAGDLHFRLLPAGHILGAASVVVCWRHTL
LAFSGDLGRAHDPIMRAPVPPVHADYLVVESTYGDRLHDASDPQTELADVFAKTFARGGVVVMPCFTVGRAQEILYYIAQ
LKQTGRMPHVPVFLDSPMATSVTEIYRRRLSDHRLTMSDADAIGHAAVMVRTVEQSKAIADHHGPMVIIAGSGMATGGRV
LHHLARYAPDSRNTVLLVGYQAAGTRGAALAAHEPTLKIHGEYVRVRAQVQMISSLSAHADYGEILGWLGAQSSAPARTF
VTHGEPAAADALRRRIEETLHWRCDVPSYLESVELEDAPTRAA
>Mature_602_residues
PRAQAAGEDAPCAASCLARGENRPRAAPHKRADAGALRSAASRRTPAAPCLRRTRSPPPACGRPSVPASISPRRSIPMHP
LHATSPTADSCAAARPHPRLHPFMPLFVTPAGASPRGLIHVSKARVACSAMGASNTTRIPGGLMKLTFLGATETVTGSKY
LLEDAGTRVLIDCGLFQGTKKLRLRNWSPLPVPADSIDAVVLTHAHLDHSGYLPVLVREGFRGPIYCTHGTAALCEIMLI
DSARLLEEEADFANRHGYSKHHPALPLYTTDDAKRTLERLAPRDFDAPSALAGDLHFRLLPAGHILGAASVVVCWRHTLL
AFSGDLGRAHDPIMRAPVPPVHADYLVVESTYGDRLHDASDPQTELADVFAKTFARGGVVVMPCFTVGRAQEILYYIAQL
KQTGRMPHVPVFLDSPMATSVTEIYRRRLSDHRLTMSDADAIGHAAVMVRTVEQSKAIADHHGPMVIIAGSGMATGGRVL
HHLARYAPDSRNTVLLVGYQAAGTRGAALAAHEPTLKIHGEYVRVRAQVQMISSLSAHADYGEILGWLGAQSSAPARTFV
THGEPAAADALRRRIEETLHWRCDVPSYLESVELEDAPTRAA

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=466, Percent_Identity=26.8240343347639, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI7706427, Length=423, Percent_Identity=27.8959810874704, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI32566029, Length=446, Percent_Identity=27.8026905829596, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI32564696, Length=464, Percent_Identity=25.8620689655172, Blast_Score=154, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323307, Length=454, Percent_Identity=28.4140969162996, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24648013, Length=451, Percent_Identity=28.3813747228381, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI21358523, Length=467, Percent_Identity=27.4089935760171, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 64888; Mature: 64757

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRAQAAGEDAPCAASCLARGENRPRAAPHKRADAGALRSAASRRTPAAPCLRRTRSPPP
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCCC
ACGRPSVPASISPRRSIPMHPLHATSPTADSCAAARPHPRLHPFMPLFVTPAGASPRGLI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEE
HVSKARVACSAMGASNTTRIPGGLMKLTFLGATETVTGSKYLLEDAGTRVLIDCGLFQGT
EEHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCEEEEECCCCCCC
KKLRLRNWSPLPVPADSIDAVVLTHAHLDHSGYLPVLVREGFRGPIYCTHGTAALCEIML
HHHEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHEECCCCCCEEEECCHHHHHHHHH
IDSARLLEEEADFANRHGYSKHHPALPLYTTDDAKRTLERLAPRDFDAPSALAGDLHFRL
HCCHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCHHHCCEEEEE
LPAGHILGAASVVVCWRHTLLAFSGDLGRAHDPIMRAPVPPVHADYLVVESTYGDRLHDA
ECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCEEEEECCCCCCCCCC
SDPQTELADVFAKTFARGGVVVMPCFTVGRAQEILYYIAQLKQTGRMPHVPVFLDSPMAT
CCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHH
SVTEIYRRRLSDHRLTMSDADAIGHAAVMVRTVEQSKAIADHHGPMVIIAGSGMATGGRV
HHHHHHHHHHHCCEEECCCHHHHHHHHHHEEHHHHHHHHHHCCCCEEEEECCCCCCHHHH
LHHLARYAPDSRNTVLLVGYQAAGTRGAALAAHEPTLKIHGEYVRVRAQVQMISSLSAHA
HHHHHHHCCCCCCEEEEEEEECCCCCCCEEEECCCCEEECCCEEEHHHHHHHHHHHHHCC
DYGEILGWLGAQSSAPARTFVTHGEPAAADALRRRIEETLHWRCDVPSYLESVELEDAPT
CHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCCCC
RAA
CCC
>Mature Secondary Structure 
PRAQAAGEDAPCAASCLARGENRPRAAPHKRADAGALRSAASRRTPAAPCLRRTRSPPP
CCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCCC
ACGRPSVPASISPRRSIPMHPLHATSPTADSCAAARPHPRLHPFMPLFVTPAGASPRGLI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEE
HVSKARVACSAMGASNTTRIPGGLMKLTFLGATETVTGSKYLLEDAGTRVLIDCGLFQGT
EEHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCEEEEECCCCCCC
KKLRLRNWSPLPVPADSIDAVVLTHAHLDHSGYLPVLVREGFRGPIYCTHGTAALCEIML
HHHEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHEECCCCCCEEEECCHHHHHHHHH
IDSARLLEEEADFANRHGYSKHHPALPLYTTDDAKRTLERLAPRDFDAPSALAGDLHFRL
HCCHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCHHHCCEEEEE
LPAGHILGAASVVVCWRHTLLAFSGDLGRAHDPIMRAPVPPVHADYLVVESTYGDRLHDA
ECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCEEEEECCCCCCCCCC
SDPQTELADVFAKTFARGGVVVMPCFTVGRAQEILYYIAQLKQTGRMPHVPVFLDSPMAT
CCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHH
SVTEIYRRRLSDHRLTMSDADAIGHAAVMVRTVEQSKAIADHHGPMVIIAGSGMATGGRV
HHHHHHHHHHHCCEEECCCHHHHHHHHHHEEHHHHHHHHHHCCCCEEEEECCCCCCHHHH
LHHLARYAPDSRNTVLLVGYQAAGTRGAALAAHEPTLKIHGEYVRVRAQVQMISSLSAHA
HHHHHHHCCCCCCEEEEEEEECCCCCCCEEEECCCCEEECCCEEEHHHHHHHHHHHHHCC
DYGEILGWLGAQSSAPARTFVTHGEPAAADALRRRIEETLHWRCDVPSYLESVELEDAPT
CHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCCCC
RAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA