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The map label for this gene is betT [C]

Identifier: 76818977

GI number: 76818977

Start: 473600

End: 475630

Strand: Direct

Name: betT [C]

Synonym: BURPS1710b_A0328

Alternate gene names: 76818977

Gene position: 473600-475630 (Clockwise)

Preceding gene: 76817494

Following gene: 76819739

Centisome position: 14.88

GC content: 70.01

Gene sequence:

>2031_bases
ATGCCCCCATCCCGCTCCACGCCGCGCACGACGCTCAAGCCGCCAGTCGTCGTGCCGTCGCTCGCCGTGATCGGCGCGCT
CCTCGCCGTCTGCGCGCTGCGGCCGAACGAGGCCGGCGCCCTCTTCGGCGCGGCCCAGCAATGGATCGTCGAGCGATTCG
ACTGGTTCTACGTGCTCGCGATCACGACCTTCCTGATCTTCCTCGTGCTGATCGCCGCGAGCCGCTTCGGCAACATCAAG
CTCGGCCCCGACGACGCGGAGCCGGAATTCAGCTTCGTGTCGTGGACCGCGATGCTGTTCGCGGCCGGCATGGGCATCGG
CCTCATGTACTTCGGCGTCGGCGAGCCGATCCAGCATTACCTGTCGCCGCCGACGGCCGCGGGCGGCACGCCCGCCGCCG
CGCGCGAGGCGATGCTGATGTCGTTCTTCCATTGGGGCCTGCACGCATGGGCGACCTACGGCGTGATGGGTCTCGTGCTC
GCGTACTTCGGCTTTCGCTACAACCTGCCGCTCACGCTGCGCTCGGGCCTCTATCCGGTGCTGCGCGAAGGCGTGAACGG
CTGGATCGGGCACACGGTCGACGCGTTCGCGCTCGTCGGCACGGTGGCCGGGATCGCGGTGACGCTCGGCTACGGCGTGC
TGCAACTGAGCGCGGGCCTGCACACGATCGCCGGCTGGCAAACCGATACCGATACGTTCCGCATCGGCCTCGTCACGGTG
GTCGTCGCGCTCGCCGGACTCTCCGCCGCGAGCGGGCTCGACAAGGGCGTGCGCCGGCTGTCCGAGCTCAATCTGATGCT
CGCGTTCGCGTTGCTCGCGTTCGTCGTCGTCGCGGGGCCGACGTCGTTCCTGCTGCGCGCGATCGGCGACAACATCGGCG
AATATCTGTCGAAGCTCGTGTCGCTATCGTTTCGCACGTACGCATACGAAGCGCCGAACGACAAAGGCTGGTTCGGCGGC
TGGACGCTGCTCTACTGGGCGTGGTGGGTGTCGTGGTCGCCGTTCGTCGGGATGTTCATCGCCCGGATCTCGCGCGGCCG
CACGATCCGCCAGTTCGTGATCGGCGTGCTGCTCGTGCCCACCGCGTTCAATCTCGTCTGGATGACCGCGTTCGGCAACA
GCGCGATCTGGCTCGACACGCACGCGGCCGCGGGCGCGCTCGCGCAAACGGCGACCAACGTCGACGCGCTGCTGTTTCGC
TTCTTCGATTACCTGCCGCTCACGCAACTGCTGTCGGTCGCGGCGATCGTGCTGATCGCGGTGTTCTTCGTCACGTCGGC
CGATTCGGGCGCGTTCGTGATCGACGCGATCGCCACGCGCGGCGCGCCGCAATCGCCCGTGTGGCAGCGGCTCTTCTGGG
CGGCCGTGCTCGGCGTGACGGCGTCGGTGCTGCTCGTCGCGGGCGGGCTGAAGGCGCTGCAGGCGCTCACGCTCGTCGCC
GCGCTGCCCGTCGCGCTCGTGATGCTCGCGCTCTGCTACGGGCTCTGGCGCGGCCTGAAAGCCGACCATGCGCACTACTC
GCAGGACATGGCGCCCGCCACCAGCTTCTGGACCGGCCAGCACTGGCGCCACCGCCTGTCGCAGATCCTGCGGCACACGA
GCGACGCCGACGCGCGGCAGTTCATCGCGCAGACGGTCGAGCCCGCGCTGCGCAAGGTCGCCGACGAGCTGAAGGCGGGC
GGCGTCGACGCGCACGTCGCGCGCGACGACGACGACGCGGTGCGCCTCACGGTGCCCGCGCCCGCGCAGCGCGATTTCGT
CTATGGCGCGCGGGTGTCGCGCAAGTCCGCGCCCGCGTTCCGCATCCGCGAGGCGGCCGAGCCCGAGCCGCAGCGCGAGC
ACGTGTGCGAGGTGCTGACGTTCTTCGCGGACGGGCGGCTCGGCTACGACATCGAGTACCTGCGCGGCGACGAGATCATC
GCCGACGTGCTGCGGCAGTACGAGCGCTACGTGTCGCTCGCGGCGGACACGCGCACGCACCTGCTGAACCGCGCGCCCGA
GCACGCGGGGCCGGACGGTCTGTCGCGGTAG

Upstream 100 bases:

>100_bases
GCGCTTCGCGCGCGCCGCCGCATCCGCACTGTCCGTTCCGCTTCCGCGCCCGCGTCGGCCGCGGCGCGCGCCCGACGCCT
CTTTTTCCGGAGATCCGCCT

Downstream 100 bases:

>100_bases
GCGGCAAGCGGCCGCAGGCGCGGGACGGGCCGGCGCGCGGCGTGCCGCGCGGCACGCGACGGCCCGTGCCCGCCGCATCC
GGTGGCGCGCGGCCTGCGTC

Product: choline/carnitine/betaine transporter

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MPPSRSTPRTTLKPPVVVPSLAVIGALLAVCALRPNEAGALFGAAQQWIVERFDWFYVLAITTFLIFLVLIAASRFGNIK
LGPDDAEPEFSFVSWTAMLFAAGMGIGLMYFGVGEPIQHYLSPPTAAGGTPAAAREAMLMSFFHWGLHAWATYGVMGLVL
AYFGFRYNLPLTLRSGLYPVLREGVNGWIGHTVDAFALVGTVAGIAVTLGYGVLQLSAGLHTIAGWQTDTDTFRIGLVTV
VVALAGLSAASGLDKGVRRLSELNLMLAFALLAFVVVAGPTSFLLRAIGDNIGEYLSKLVSLSFRTYAYEAPNDKGWFGG
WTLLYWAWWVSWSPFVGMFIARISRGRTIRQFVIGVLLVPTAFNLVWMTAFGNSAIWLDTHAAAGALAQTATNVDALLFR
FFDYLPLTQLLSVAAIVLIAVFFVTSADSGAFVIDAIATRGAPQSPVWQRLFWAAVLGVTASVLLVAGGLKALQALTLVA
ALPVALVMLALCYGLWRGLKADHAHYSQDMAPATSFWTGQHWRHRLSQILRHTSDADARQFIAQTVEPALRKVADELKAG
GVDAHVARDDDDAVRLTVPAPAQRDFVYGARVSRKSAPAFRIREAAEPEPQREHVCEVLTFFADGRLGYDIEYLRGDEII
ADVLRQYERYVSLAADTRTHLLNRAPEHAGPDGLSR

Sequences:

>Translated_676_residues
MPPSRSTPRTTLKPPVVVPSLAVIGALLAVCALRPNEAGALFGAAQQWIVERFDWFYVLAITTFLIFLVLIAASRFGNIK
LGPDDAEPEFSFVSWTAMLFAAGMGIGLMYFGVGEPIQHYLSPPTAAGGTPAAAREAMLMSFFHWGLHAWATYGVMGLVL
AYFGFRYNLPLTLRSGLYPVLREGVNGWIGHTVDAFALVGTVAGIAVTLGYGVLQLSAGLHTIAGWQTDTDTFRIGLVTV
VVALAGLSAASGLDKGVRRLSELNLMLAFALLAFVVVAGPTSFLLRAIGDNIGEYLSKLVSLSFRTYAYEAPNDKGWFGG
WTLLYWAWWVSWSPFVGMFIARISRGRTIRQFVIGVLLVPTAFNLVWMTAFGNSAIWLDTHAAAGALAQTATNVDALLFR
FFDYLPLTQLLSVAAIVLIAVFFVTSADSGAFVIDAIATRGAPQSPVWQRLFWAAVLGVTASVLLVAGGLKALQALTLVA
ALPVALVMLALCYGLWRGLKADHAHYSQDMAPATSFWTGQHWRHRLSQILRHTSDADARQFIAQTVEPALRKVADELKAG
GVDAHVARDDDDAVRLTVPAPAQRDFVYGARVSRKSAPAFRIREAAEPEPQREHVCEVLTFFADGRLGYDIEYLRGDEII
ADVLRQYERYVSLAADTRTHLLNRAPEHAGPDGLSR
>Mature_675_residues
PPSRSTPRTTLKPPVVVPSLAVIGALLAVCALRPNEAGALFGAAQQWIVERFDWFYVLAITTFLIFLVLIAASRFGNIKL
GPDDAEPEFSFVSWTAMLFAAGMGIGLMYFGVGEPIQHYLSPPTAAGGTPAAAREAMLMSFFHWGLHAWATYGVMGLVLA
YFGFRYNLPLTLRSGLYPVLREGVNGWIGHTVDAFALVGTVAGIAVTLGYGVLQLSAGLHTIAGWQTDTDTFRIGLVTVV
VALAGLSAASGLDKGVRRLSELNLMLAFALLAFVVVAGPTSFLLRAIGDNIGEYLSKLVSLSFRTYAYEAPNDKGWFGGW
TLLYWAWWVSWSPFVGMFIARISRGRTIRQFVIGVLLVPTAFNLVWMTAFGNSAIWLDTHAAAGALAQTATNVDALLFRF
FDYLPLTQLLSVAAIVLIAVFFVTSADSGAFVIDAIATRGAPQSPVWQRLFWAAVLGVTASVLLVAGGLKALQALTLVAA
LPVALVMLALCYGLWRGLKADHAHYSQDMAPATSFWTGQHWRHRLSQILRHTSDADARQFIAQTVEPALRKVADELKAGG
VDAHVARDDDDAVRLTVPAPAQRDFVYGARVSRKSAPAFRIREAAEPEPQREHVCEVLTFFADGRLGYDIEYLRGDEIIA
DVLRQYERYVSLAADTRTHLLNRAPEHAGPDGLSR

Specific function: High-Affinity Uptake Of Choline Driven By A Proton- Motive Force. [C]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=679, Percent_Identity=36.9661266568483, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1788102, Length=463, Percent_Identity=28.5097192224622, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1786224, Length=488, Percent_Identity=27.2540983606557, Blast_Score=162, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 73492; Mature: 73361

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPSRSTPRTTLKPPVVVPSLAVIGALLAVCALRPNEAGALFGAAQQWIVERFDWFYVLA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ITTFLIFLVLIAASRFGNIKLGPDDAEPEFSFVSWTAMLFAAGMGIGLMYFGVGEPIQHY
HHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LSPPTAAGGTPAAAREAMLMSFFHWGLHAWATYGVMGLVLAYFGFRYNLPLTLRSGLYPV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCHHHHCCHHH
LREGVNGWIGHTVDAFALVGTVAGIAVTLGYGVLQLSAGLHTIAGWQTDTDTFRIGLVTV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHH
VVALAGLSAASGLDKGVRRLSELNLMLAFALLAFVVVAGPTSFLLRAIGDNIGEYLSKLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SLSFRTYAYEAPNDKGWFGGWTLLYWAWWVSWSPFVGMFIARISRGRTIRQFVIGVLLVP
HHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TAFNLVWMTAFGNSAIWLDTHAAAGALAQTATNVDALLFRFFDYLPLTQLLSVAAIVLIA
HHHHHHEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VFFVTSADSGAFVIDAIATRGAPQSPVWQRLFWAAVLGVTASVLLVAGGLKALQALTLVA
HHHHHCCCCCCEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALPVALVMLALCYGLWRGLKADHAHYSQDMAPATSFWTGQHWRHRLSQILRHTSDADARQ
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHCCCHHHHHHHHHHHHCCCCHHHHH
FIAQTVEPALRKVADELKAGGVDAHVARDDDDAVRLTVPAPAQRDFVYGARVSRKSAPAF
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCCCHHCCHHCCCCCCCH
RIREAAEPEPQREHVCEVLTFFADGRLGYDIEYLRGDEIIADVLRQYERYVSLAADTRTH
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LLNRAPEHAGPDGLSR
HHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PPSRSTPRTTLKPPVVVPSLAVIGALLAVCALRPNEAGALFGAAQQWIVERFDWFYVLA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH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HHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]