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The map label for this gene is ispA [H]

Identifier: 76818772

GI number: 76818772

Start: 330136

End: 331104

Strand: Direct

Name: ispA [H]

Synonym: BURPS1710b_A0218

Alternate gene names: 76818772

Gene position: 330136-331104 (Clockwise)

Preceding gene: 76819497

Following gene: 76817700

Centisome position: 10.38

GC content: 66.25

Gene sequence:

>969_bases
ATGAGTTCCGACATCGCCGAACGGGACGGCCACGGCCCCGCAGTCGAAACGTCCGGCCTCTCGCCGAGCGCGCGTTTCGA
AGAGGCCGACGGGTGGACGAAGACGGCGATCCGGCAGACCGAAGCCACGCTCGATCGCATCCTGCCGTGCGCCGATGGGC
GGCTGACCGCGCTGCATGCCGCGATGCGATATGCGGTGTTCGGCGGCGGAAAACGCCTGCGCCCCTTGCTTTGCCACGCG
GCGGGCGAACTGGTGGATGCTTCGCGCGAGGCTCTGGCTCAAGTCTCCGCCGTGATCGAAATGATCCATGTCTTTTCGTT
GATTCAGGACGACTTGCCGGCGATGGACAACGACGACCTGCGGCACGGCCGATTGACGCTGCACAAGCAGTACGATGTCG
CGACGGCGCTGCTCGCGAGCGACGGCCTCATTTCGCAGGCGTTTCTCGCACTGAGCGAAGCTCCATTGCCGCTGGACGTC
CGTGTCGCGCTGATGCGCGAGTTGGCGTCGTCAATCGGTCCGTCGGGTTTGACGGGTGGACAATACATCGATTTGACGAG
CATCGGCGCGCATCTCGATCGAACGGAACTCGAGCAAATGCATCGGATGAAGACCGGCGCGCTAATTCGCGCGGCCGTCA
GAATGGGCGTGCTGTGCGGCACCGTCCCCGGCGCGGAGTTGGGCGCGGCTTGGCGCGCCGTGAGCGAATACGGCGAGCGG
CTCGGGCTCGCTTATCAGGTGGTCGACGACATCCTCGATTCCACCGCCGCCACCTCGGTGCTCGGCAAGACCGCCGGGAA
GGACGCGCGAGCGAACAAGGCCACCTACGTCACCGTGCTGGGTCTCGACGCGTCCCGCGCCTGGGCGCGCCAACTCGCCG
ACGAAGCGTGGGCGGCGCTCGCGCCGTTCGGCGGCCAGGCTCGTTTCCTGAGAAAACTGGTCGAGCGCGTCTTGCACCGC
CTGTCCTGA

Upstream 100 bases:

>100_bases
CGAGGCGACGCCGCATGAAACGGCCTCGCGGCCGATGCCAAGCATGCCTCGTTGCGTCGGCGCATTCCCCACTTCATCAG
CCCCTTTCCAGGAGATCGCC

Downstream 100 bases:

>100_bases
GCGGGGCGCCGCCCGCGTGCGCCGGCAGCGCCCGCGCATGACGCTGCCGCGACGCCACCGATGCCCTTTTGAGAATACCC
CCGCAGATGCCACGCAAGAG

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSSDIAERDGHGPAVETSGLSPSARFEEADGWTKTAIRQTEATLDRILPCADGRLTALHAAMRYAVFGGGKRLRPLLCHA
AGELVDASREALAQVSAVIEMIHVFSLIQDDLPAMDNDDLRHGRLTLHKQYDVATALLASDGLISQAFLALSEAPLPLDV
RVALMRELASSIGPSGLTGGQYIDLTSIGAHLDRTELEQMHRMKTGALIRAAVRMGVLCGTVPGAELGAAWRAVSEYGER
LGLAYQVVDDILDSTAATSVLGKTAGKDARANKATYVTVLGLDASRAWARQLADEAWAALAPFGGQARFLRKLVERVLHR
LS

Sequences:

>Translated_322_residues
MSSDIAERDGHGPAVETSGLSPSARFEEADGWTKTAIRQTEATLDRILPCADGRLTALHAAMRYAVFGGGKRLRPLLCHA
AGELVDASREALAQVSAVIEMIHVFSLIQDDLPAMDNDDLRHGRLTLHKQYDVATALLASDGLISQAFLALSEAPLPLDV
RVALMRELASSIGPSGLTGGQYIDLTSIGAHLDRTELEQMHRMKTGALIRAAVRMGVLCGTVPGAELGAAWRAVSEYGER
LGLAYQVVDDILDSTAATSVLGKTAGKDARANKATYVTVLGLDASRAWARQLADEAWAALAPFGGQARFLRKLVERVLHR
LS
>Mature_321_residues
SSDIAERDGHGPAVETSGLSPSARFEEADGWTKTAIRQTEATLDRILPCADGRLTALHAAMRYAVFGGGKRLRPLLCHAA
GELVDASREALAQVSAVIEMIHVFSLIQDDLPAMDNDDLRHGRLTLHKQYDVATALLASDGLISQAFLALSEAPLPLDVR
VALMRELASSIGPSGLTGGQYIDLTSIGAHLDRTELEQMHRMKTGALIRAAVRMGVLCGTVPGAELGAAWRAVSEYGERL
GLAYQVVDDILDSTAATSVLGKTAGKDARANKATYVTVLGLDASRAWARQLADEAWAALAPFGGQARFLRKLVERVLHRL
S

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=224, Percent_Identity=28.125, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786623, Length=278, Percent_Identity=42.0863309352518, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1789578, Length=215, Percent_Identity=32.5581395348837, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 34432; Mature: 34301

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDIAERDGHGPAVETSGLSPSARFEEADGWTKTAIRQTEATLDRILPCADGRLTALHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AMRYAVFGGGKRLRPLLCHAAGELVDASREALAQVSAVIEMIHVFSLIQDDLPAMDNDDL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RHGRLTLHKQYDVATALLASDGLISQAFLALSEAPLPLDVRVALMRELASSIGPSGLTGG
CCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
QYIDLTSIGAHLDRTELEQMHRMKTGALIRAAVRMGVLCGTVPGAELGAAWRAVSEYGER
CEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LGLAYQVVDDILDSTAATSVLGKTAGKDARANKATYVTVLGLDASRAWARQLADEAWAAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHH
APFGGQARFLRKLVERVLHRLS
CCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSDIAERDGHGPAVETSGLSPSARFEEADGWTKTAIRQTEATLDRILPCADGRLTALHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AMRYAVFGGGKRLRPLLCHAAGELVDASREALAQVSAVIEMIHVFSLIQDDLPAMDNDDL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RHGRLTLHKQYDVATALLASDGLISQAFLALSEAPLPLDVRVALMRELASSIGPSGLTGG
CCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
QYIDLTSIGAHLDRTELEQMHRMKTGALIRAAVRMGVLCGTVPGAELGAAWRAVSEYGER
CEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LGLAYQVVDDILDSTAATSVLGKTAGKDARANKATYVTVLGLDASRAWARQLADEAWAAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHH
APFGGQARFLRKLVERVLHRLS
CCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]