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The map label for this gene is 76817590

Identifier: 76817590

GI number: 76817590

Start: 2302640

End: 2303602

Strand: Direct

Name: 76817590

Synonym: BURPS1710b_A1887

Alternate gene names: NA

Gene position: 2302640-2303602 (Clockwise)

Preceding gene: 76818327

Following gene: 76818287

Centisome position: 72.37

GC content: 72.59

Gene sequence:

>963_bases
ATGCGCATTTCCACCCTGGATCGACGCGACATGAAGCACATCCACATCATCGATTCGCACACGGGCGGCGAACCCACGCG
CGTCGTCGTGTCCGGCTTTCCGGCGCTCGGCGGCGGCACGATGGCCGAGCGTCTGGCCGTGCTCGCGCGCGAGCACGACC
GCTACCGCGCCGCCTGCATCCTCGAGCCGCGCGGCAGCGACGTGCTCGTCGGCGCGCTGCTGTGCGAGCCCGTCTCGGCC
GGCGCGGCGGCGGGCGTGATCTTCTTCAACAACGCGGGCTATCTCGGCATGTGCGGGCACGGCACGATCGGCCTCGTGCG
CACGCTGCACCACATGGGGCGCATCGGGCCGGGCGTGCATCGGATCGAGACGCCGGTGGGCGACGTCGAGGCGACGCTGC
ACGACGATCTGTCCGTGAGCGTGCGCAACGTGCTCGCGTACCGGCACGCGAAGGACGTCGTTGTCGACGTGCCGGGGCAC
GGCGCGGTGACGGGCGACGTCGCGTGGGGCGGCAACTGGTTCTTCCTCGTGAGCGATCACGGCCAGCGCGTCGCGGGCGA
GAACGTCGCGGCGCTCGCCGCGTACGCGTCGGCGGTGCGCGCGGCGCTCGAGCGCGCGGGCGTGACGGGCCGCGACGGCG
CGCCGATCGATCACATCGAGCTGTTCGCCGACGATCCCGAGTACGACAGCCGCAGCTTCGTGCTCTGCCCGGGCCACGCG
TACGACCGCTCGCCGTGCGGCACCGGCACGAGCGCGAAGCTCGCGTGCCTCGCCGCCGACGGCAAGCTCGCGGCGGGCGT
GACGTGGCGGCAGGCGAGCGTGATCGGCAGCGTGTTCTCGGCGAGCTACGCGGCGGCCGAAGGCGGCGTCGTGCCGACGA
TCCGCGGCAGCGCGCACCTGAGCGCGGAGGCGACGCTCGTGATCGAGGACGACGATCCGTTCGGCTGGGGCATCGCATCG
TGA

Upstream 100 bases:

>100_bases
AATCGGGGCGGGATCGCCGCCGCGCGCGCCGGGCTGTGCCGATTTCGTCGCGCGCGTCATCGAAAACCCACAAGCGGCGC
GATCCGCGACAAGGGAAGCT

Downstream 100 bases:

>100_bases
CCGATTCGCCGACCGACGTCATCGTGATCGGCGCGGGCATCGTCGGCGCCGCGTGCGCGCACGAGTTCGCGCTGCGCGGG
CTGCGCGTCGTCGTCGTCGA

Product: hydroxyproline-2-epimerase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; BpHyPRE [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRISTLDRRDMKHIHIIDSHTGGEPTRVVVSGFPALGGGTMAERLAVLAREHDRYRAACILEPRGSDVLVGALLCEPVSA
GAAAGVIFFNNAGYLGMCGHGTIGLVRTLHHMGRIGPGVHRIETPVGDVEATLHDDLSVSVRNVLAYRHAKDVVVDVPGH
GAVTGDVAWGGNWFFLVSDHGQRVAGENVAALAAYASAVRAALERAGVTGRDGAPIDHIELFADDPEYDSRSFVLCPGHA
YDRSPCGTGTSAKLACLAADGKLAAGVTWRQASVIGSVFSASYAAAEGGVVPTIRGSAHLSAEATLVIEDDDPFGWGIAS

Sequences:

>Translated_320_residues
MRISTLDRRDMKHIHIIDSHTGGEPTRVVVSGFPALGGGTMAERLAVLAREHDRYRAACILEPRGSDVLVGALLCEPVSA
GAAAGVIFFNNAGYLGMCGHGTIGLVRTLHHMGRIGPGVHRIETPVGDVEATLHDDLSVSVRNVLAYRHAKDVVVDVPGH
GAVTGDVAWGGNWFFLVSDHGQRVAGENVAALAAYASAVRAALERAGVTGRDGAPIDHIELFADDPEYDSRSFVLCPGHA
YDRSPCGTGTSAKLACLAADGKLAAGVTWRQASVIGSVFSASYAAAEGGVVPTIRGSAHLSAEATLVIEDDDPFGWGIAS
>Mature_320_residues
MRISTLDRRDMKHIHIIDSHTGGEPTRVVVSGFPALGGGTMAERLAVLAREHDRYRAACILEPRGSDVLVGALLCEPVSA
GAAAGVIFFNNAGYLGMCGHGTIGLVRTLHHMGRIGPGVHRIETPVGDVEATLHDDLSVSVRNVLAYRHAKDVVVDVPGH
GAVTGDVAWGGNWFFLVSDHGQRVAGENVAALAAYASAVRAALERAGVTGRDGAPIDHIELFADDPEYDSRSFVLCPGHA
YDRSPCGTGTSAKLACLAADGKLAAGVTWRQASVIGSVFSASYAAAEGGVVPTIRGSAHLSAEATLVIEDDDPFGWGIAS

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases [H]

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=335, Percent_Identity=31.044776119403, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 33363; Mature: 33363

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISTLDRRDMKHIHIIDSHTGGEPTRVVVSGFPALGGGTMAERLAVLAREHDRYRAACI
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEE
LEPRGSDVLVGALLCEPVSAGAAAGVIFFNNAGYLGMCGHGTIGLVRTLHHMGRIGPGVH
ECCCCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCE
RIETPVGDVEATLHDDLSVSVRNVLAYRHAKDVVVDVPGHGAVTGDVAWGGNWFFLVSDH
EECCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCEEEECEEECCEEEEEECCC
GQRVAGENVAALAAYASAVRAALERAGVTGRDGAPIDHIELFADDPEYDSRSFVLCPGHA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCC
YDRSPCGTGTSAKLACLAADGKLAAGVTWRQASVIGSVFSASYAAAEGGVVPTIRGSAHL
CCCCCCCCCCCCEEEEEEECCCEEECEEEHHHHHHHHHHHHHHHHCCCCCCEEECCCEEE
SAEATLVIEDDDPFGWGIAS
CCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRISTLDRRDMKHIHIIDSHTGGEPTRVVVSGFPALGGGTMAERLAVLAREHDRYRAACI
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEE
LEPRGSDVLVGALLCEPVSAGAAAGVIFFNNAGYLGMCGHGTIGLVRTLHHMGRIGPGVH
ECCCCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCE
RIETPVGDVEATLHDDLSVSVRNVLAYRHAKDVVVDVPGHGAVTGDVAWGGNWFFLVSDH
EECCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCEEEECEEECCEEEEEECCC
GQRVAGENVAALAAYASAVRAALERAGVTGRDGAPIDHIELFADDPEYDSRSFVLCPGHA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCC
YDRSPCGTGTSAKLACLAADGKLAAGVTWRQASVIGSVFSASYAAAEGGVVPTIRGSAHL
CCCCCCCCCCCCEEEEEEECCCEEECEEEHHHHHHHHHHHHHHHHCCCCCCEEECCCEEE
SAEATLVIEDDDPFGWGIAS
CCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA