Click here to switch to the map view.

The map label for this gene is prpD1 [H]

Identifier: 76817279

GI number: 76817279

Start: 1588017

End: 1589492

Strand: Direct

Name: prpD1 [H]

Synonym: BURPS1710b_A1275

Alternate gene names: 76817279

Gene position: 1588017-1589492 (Clockwise)

Preceding gene: 76817457

Following gene: 76819826

Centisome position: 49.91

GC content: 71.61

Gene sequence:

>1476_bases
ATGAATCGACGCCATTTCCTCGCCGCCGCCGTCGCGGCGGGCCTGCCGCTCGCCGCGACGCTCGCGCCGCGCGGCGCGCG
CGCGCAGCCGAACGCAACGCAGGCCGCCGCGCCCACGCTCGCGCGCCAACTCGCCGAATACGCGGCGGGGCTGCGCTACG
AGGATCTCGACTCGGCGACGATCGACATCGTCAAATCGCATCTGATCGACGCGCTCGGTTGCGCGCTCGCCGCGCTCGAC
GAGCCGCCCGTGCGCATCGCGCGCGACGCGGCGCGCAGCGCCGGCGGCGGCGGACCGTCGACGATCATCGGAACGGCCGA
GCGAACGAGCCCCGATCTCGCGACGTTCGCCACGGGCACCGCGCTGCGCTACTTCGATTTCAACGACGCATACGCGGGCC
GCGAAATCGGCCATCCGAGCGACAACATCGCCGCGTGCGTCGCGGTGGCCGAGGCGCAGCATGCGAGCGGCCGCGAGCTG
ATCCTGTCGATCGCGCTCGCCTACGAGATCGCATGCCGGCTGATGGACGCGGCCGCGATCAGCCCGCGCGGCTGGGACCA
CACGTGCTACTCGCTGCCCGCCGCCGCGCTCGCGGCGGGCAAGCTGATGCGCATGCCGGTCGAAGCGCTCACGCAGGCCG
TGAACCTGTCGCTCAACAGCCATCTCGCGCTGAACCAGACGCGCGTGCAGCAGCTATCGAACTGGAAGGCGCTCGCCGAC
GCGGACGCCGCGCGCAACGCGGTGTTCTCGACGCAGCTCGCCCGTGCGGGGCTCACCGGGCCGTCGCCGATCTTCGAGGG
CGAGGCGGGCTTCTTCCGCCAGGTATCGGGGCCGTTCGAGCTCGAGACGAGCCGTTTCGGCGGGCGCGGCGAGCCGTTCA
GGATCGCGCGCTGCTTCGTCAAATACTACCCGGCGCAAGGCTTCACGCAGACCGCGATTCCGGCCGCGCTCGACGTCGCG
TCGCAAGCGGGCGACCTGAGCCGCATCCGCCGCATCGATGTGCACACGACGCGCGTCGGCTACGTGACGGCCGGCAGCGA
GCCGGAGAAATGGAAGCCGTCGACGCGCGAAACGGCCGACCACAGCCTGCCGTACGTCGTCGCGCGCGCGATGCTCGACG
GCGACATCCGGACCACGAGCTTCTCGGACGCCGCGCTGCGCGATCCGGCGCTGCACGCGCTGATCGCGAAGATTCGCGTC
GAAGAGGATCCGGCGCTGACGGCGGGCTACCCCGCGCGCGCAGCGAATCGCGTGACCGCGCATTGCCGCGACGGCGCGGT
GTATGCGAAGCAGGTCGACGATCTGCCCGGCTCGCCGACGCGGCCGATGCGCCGTGAGGATTTCGAAGCGAAATTCGTGA
AGAACGGCGGCGCGCGCCTGAGCGAGCAGCGCATGCGCGCGGCGCTCGACAGGTTGTGGCGGCTCGACGAGCTGCAGGAT
GTCGCCGCGCTGCCGCCGCTGCTCGTCGCGGGCTGA

Upstream 100 bases:

>100_bases
TCGCCGGCGCGCGCGCCGGCAGCGCGGGCGTCGCCGTCGGCGTGCGCAAGTTGTTCTGAGCCGCGCGCCCCGATCCTTTC
GTCACAGGAGCCTCATCACC

Downstream 100 bases:

>100_bases
GCAAGGCGGGCCCAGCGGACCAAGGGGAGTCGAACGCGCGCGGCGCGGGCCCGCAGCGCGCCGCGCTCGCCCGCCTCACG
TGGCGGCGGCGGCGGCGGAG

Product: MmgE/PrpD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNRRHFLAAAVAAGLPLAATLAPRGARAQPNATQAAAPTLARQLAEYAAGLRYEDLDSATIDIVKSHLIDALGCALAALD
EPPVRIARDAARSAGGGGPSTIIGTAERTSPDLATFATGTALRYFDFNDAYAGREIGHPSDNIAACVAVAEAQHASGREL
ILSIALAYEIACRLMDAAAISPRGWDHTCYSLPAAALAAGKLMRMPVEALTQAVNLSLNSHLALNQTRVQQLSNWKALAD
ADAARNAVFSTQLARAGLTGPSPIFEGEAGFFRQVSGPFELETSRFGGRGEPFRIARCFVKYYPAQGFTQTAIPAALDVA
SQAGDLSRIRRIDVHTTRVGYVTAGSEPEKWKPSTRETADHSLPYVVARAMLDGDIRTTSFSDAALRDPALHALIAKIRV
EEDPALTAGYPARAANRVTAHCRDGAVYAKQVDDLPGSPTRPMRREDFEAKFVKNGGARLSEQRMRAALDRLWRLDELQD
VAALPPLLVAG

Sequences:

>Translated_491_residues
MNRRHFLAAAVAAGLPLAATLAPRGARAQPNATQAAAPTLARQLAEYAAGLRYEDLDSATIDIVKSHLIDALGCALAALD
EPPVRIARDAARSAGGGGPSTIIGTAERTSPDLATFATGTALRYFDFNDAYAGREIGHPSDNIAACVAVAEAQHASGREL
ILSIALAYEIACRLMDAAAISPRGWDHTCYSLPAAALAAGKLMRMPVEALTQAVNLSLNSHLALNQTRVQQLSNWKALAD
ADAARNAVFSTQLARAGLTGPSPIFEGEAGFFRQVSGPFELETSRFGGRGEPFRIARCFVKYYPAQGFTQTAIPAALDVA
SQAGDLSRIRRIDVHTTRVGYVTAGSEPEKWKPSTRETADHSLPYVVARAMLDGDIRTTSFSDAALRDPALHALIAKIRV
EEDPALTAGYPARAANRVTAHCRDGAVYAKQVDDLPGSPTRPMRREDFEAKFVKNGGARLSEQRMRAALDRLWRLDELQD
VAALPPLLVAG
>Mature_491_residues
MNRRHFLAAAVAAGLPLAATLAPRGARAQPNATQAAAPTLARQLAEYAAGLRYEDLDSATIDIVKSHLIDALGCALAALD
EPPVRIARDAARSAGGGGPSTIIGTAERTSPDLATFATGTALRYFDFNDAYAGREIGHPSDNIAACVAVAEAQHASGREL
ILSIALAYEIACRLMDAAAISPRGWDHTCYSLPAAALAAGKLMRMPVEALTQAVNLSLNSHLALNQTRVQQLSNWKALAD
ADAARNAVFSTQLARAGLTGPSPIFEGEAGFFRQVSGPFELETSRFGGRGEPFRIARCFVKYYPAQGFTQTAIPAALDVA
SQAGDLSRIRRIDVHTTRVGYVTAGSEPEKWKPSTRETADHSLPYVVARAMLDGDIRTTSFSDAALRDPALHALIAKIRV
EEDPALTAGYPARAANRVTAHCRDGAVYAKQVDDLPGSPTRPMRREDFEAKFVKNGGARLSEQRMRAALDRLWRLDELQD
VAALPPLLVAG

Specific function: Catalyzes the dehydration of 2-methylcitrate to 2- methyl-cis-aconitate [H]

COG id: COG2079

COG function: function code R; Uncharacterized protein involved in propionate catabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prpD family [H]

Homologues:

Organism=Homo sapiens, GI310129732, Length=469, Percent_Identity=24.0938166311301, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI310110533, Length=469, Percent_Identity=24.0938166311301, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI310123058, Length=458, Percent_Identity=24.4541484716157, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1786528, Length=473, Percent_Identity=26.0042283298097, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6325258, Length=380, Percent_Identity=25.7894736842105, Blast_Score=100, Evalue=8e-22,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005656 [H]

Pfam domain/function: PF03972 MmgE_PrpD [H]

EC number: =4.2.1.79 [H]

Molecular weight: Translated: 52402; Mature: 52402

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRHFLAAAVAAGLPLAATLAPRGARAQPNATQAAAPTLARQLAEYAAGLRYEDLDSAT
CCCHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
IDIVKSHLIDALGCALAALDEPPVRIARDAARSAGGGGPSTIIGTAERTSPDLATFATGT
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHCCC
ALRYFDFNDAYAGREIGHPSDNIAACVAVAEAQHASGRELILSIALAYEIACRLMDAAAI
EEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
SPRGWDHTCYSLPAAALAAGKLMRMPVEALTQAVNLSLNSHLALNQTRVQQLSNWKALAD
CCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECHHHHHHHHCCHHHHH
ADAARNAVFSTQLARAGLTGPSPIFEGEAGFFRQVSGPFELETSRFGGRGEPFRIARCFV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCEEECCCCCCCCCHHHHHHHHH
KYYPAQGFTQTAIPAALDVASQAGDLSRIRRIDVHTTRVGYVTAGSEPEKWKPSTRETAD
HHCCCCCCCHHHHHHHHHHHHHCCCHHHHHEEEEEEEEEEEEECCCCCCCCCCCCCCCHH
HSLPYVVARAMLDGDIRTTSFSDAALRDPALHALIAKIRVEEDPALTAGYPARAANRVTA
CCCHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCEE
HCRDGAVYAKQVDDLPGSPTRPMRREDFEAKFVKNGGARLSEQRMRAALDRLWRLDELQD
ECCCCCEEHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VAALPPLLVAG
HHHCCCHHHCC
>Mature Secondary Structure
MNRRHFLAAAVAAGLPLAATLAPRGARAQPNATQAAAPTLARQLAEYAAGLRYEDLDSAT
CCCHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
IDIVKSHLIDALGCALAALDEPPVRIARDAARSAGGGGPSTIIGTAERTSPDLATFATGT
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHCCC
ALRYFDFNDAYAGREIGHPSDNIAACVAVAEAQHASGRELILSIALAYEIACRLMDAAAI
EEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
SPRGWDHTCYSLPAAALAAGKLMRMPVEALTQAVNLSLNSHLALNQTRVQQLSNWKALAD
CCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECHHHHHHHHCCHHHHH
ADAARNAVFSTQLARAGLTGPSPIFEGEAGFFRQVSGPFELETSRFGGRGEPFRIARCFV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCEEECCCCCCCCCHHHHHHHHH
KYYPAQGFTQTAIPAALDVASQAGDLSRIRRIDVHTTRVGYVTAGSEPEKWKPSTRETAD
HHCCCCCCCHHHHHHHHHHHHHCCCHHHHHEEEEEEEEEEEEECCCCCCCCCCCCCCCHH
HSLPYVVARAMLDGDIRTTSFSDAALRDPALHALIAKIRVEEDPALTAGYPARAANRVTA
CCCHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCEE
HCRDGAVYAKQVDDLPGSPTRPMRREDFEAKFVKNGGARLSEQRMRAALDRLWRLDELQD
ECCCCCEEHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VAALPPLLVAG
HHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11976302; 12948626 [H]