Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 75909963

GI number: 75909963

Start: 4680591

End: 4682171

Strand: Direct

Name: serA [H]

Synonym: Ava_3759

Alternate gene names: 75909963

Gene position: 4680591-4682171 (Clockwise)

Preceding gene: 75909961

Following gene: 75909964

Centisome position: 73.53

GC content: 49.72

Gene sequence:

>1581_bases
ATGTCTAAGGTTCTCGTCTCCGATCCTATTGACCAGGCTGGCATTGACATTCTCTCGCAAGTCGCTACTGTTGATGTCAA
TACAGGTCTCAAACCAGCAGAATTAATAGAAATTATTGGTCAGTATGACGCGTTAATGATTCGTTCGGGTACGCGCGTCA
CGCAAGAAATTATTGAAGCAGGTACACAGCTGAAAATCATCGGTCGTGCCGGTGTGGGTGTGGATAATGTAGATGTTCCG
GCTGCTACTCGTCGAGGAATTGTTGTTGTCAATTCTCCTGAGGGGAACACCATCGCCGCCGCCGAACACGCCTTGGCAAT
GATGCTGTCATTATCTCGCCACATCCCCGATGCTAACGCTTCCGTGAAACGCGGTGAGTGGGATCGCAAAACTTTCGTGG
GTGCGGAAGTTTACAAAAAAACTTTAGGGGTTGTGGGTTTAGGCAAAATTGGTTCCCATGTGGCTACTGTTGCGAAAGCA
ATGGGAATGAAATTGTTAGCTTACGATCCCTTCATTTCGACTGAACGGGCTGAACAACTTGGTTGTCAGTTAGTAGATTT
AGATTTGCTGATGCAGCAATCTGACTATATCACCCTGCACATTCCCAAAACCCCAGAAACCACCCACATCATCAACGCCA
CCACTCTGGCGAAAATGAAGCCCACCGCCCGGATTATCAACTGCGCCCGTGGGGGAATCATCGATGAAGCAGCTTTAGCC
GCAGCCGTTAAAGAGGGGAAAATTGCTGGGGCGGCGCTGGATGTGTTCGAGTCAGAACCACTGGGTGAATCAGACTTAAG
GGCGATCGGTAAGGATATTATCCTTACTCCCCACTTGGGTGCATCCACCACAGAAGCCCAGGTGAATGTAGCTATTGACG
TAGCGGAACAAATCCGCGATGTGTTGTTGGGTTTACCCGCACGTTCCGCCGTCAACATCCCCGGACTCGGCCCCGATGTG
TTGGAAGAACTCAAACCCTATATGCAGCTAGCGGAAACTTTGGGTAAGTTGGTAGGACAGTTAGCCGGTGGGCGAGTAGA
ACTACTCACCGTCCGCTTACAAGGTGAACTCGCTACTAATAAGAGTCAGCCTTTAGTAATTGCTTCCCTGAAAGGATTAC
TACACCAAGCCCTACGGGAACGAGTAAACTACGTCAACGCCAACATAGAAGCCAAGGAACGGGGAATCCGAGTTATTGAA
ACCCGCGACGCTTCCGCCCGTGACTATGCTGGTTCCCTACGCTTGGAAGCAACAGGAACCTTAGGCACTCATTCTGTCAC
TGGTGCATTGCTAGGCGATAAGGAAATTCACCTCACCGACGTTGATGGCTTCCCGATTAACGTCCCACCAAGCAAATATA
TGTTGTTTACCTTGCACCGTGATATGCCAGGAATCATTGGCAAACTCGGTTCCTTACTGGGCAGCTTTAATGTCAATATT
GCCAGTATGCAGGTAGGGCGCAAAATCGTCCGTGGTGATGCCGTTATGGCTCTCAGCATTGATGATCCCTTACCAGATGG
CATTTTGGCGGAAATCACCAAAGTACCCGGCATCCGGGACGCGTACACAGTAACACTATAG

Upstream 100 bases:

>100_bases
AGTTGTTATTAAAACGCAGATTTTTTGCTGAGGTGTAACGAATAAAGTCTAAACTAAAAAGTCTTGTGCAGCAAAACTTG
TCACTATAAATGATGTAATC

Downstream 100 bases:

>100_bases
GAGTCAGTAATCAGAACTCAGAAGTCAGCAGAAATAGTTTCTCCTGACTCCTGAATTCTGGATTCTCAATTTTCAACAAT
GGCAAACACTTGGTGGGAAA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSKVLVSDPIDQAGIDILSQVATVDVNTGLKPAELIEIIGQYDALMIRSGTRVTQEIIEAGTQLKIIGRAGVGVDNVDVP
AATRRGIVVVNSPEGNTIAAAEHALAMMLSLSRHIPDANASVKRGEWDRKTFVGAEVYKKTLGVVGLGKIGSHVATVAKA
MGMKLLAYDPFISTERAEQLGCQLVDLDLLMQQSDYITLHIPKTPETTHIINATTLAKMKPTARIINCARGGIIDEAALA
AAVKEGKIAGAALDVFESEPLGESDLRAIGKDIILTPHLGASTTEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGLGPDV
LEELKPYMQLAETLGKLVGQLAGGRVELLTVRLQGELATNKSQPLVIASLKGLLHQALRERVNYVNANIEAKERGIRVIE
TRDASARDYAGSLRLEATGTLGTHSVTGALLGDKEIHLTDVDGFPINVPPSKYMLFTLHRDMPGIIGKLGSLLGSFNVNI
ASMQVGRKIVRGDAVMALSIDDPLPDGILAEITKVPGIRDAYTVTL

Sequences:

>Translated_526_residues
MSKVLVSDPIDQAGIDILSQVATVDVNTGLKPAELIEIIGQYDALMIRSGTRVTQEIIEAGTQLKIIGRAGVGVDNVDVP
AATRRGIVVVNSPEGNTIAAAEHALAMMLSLSRHIPDANASVKRGEWDRKTFVGAEVYKKTLGVVGLGKIGSHVATVAKA
MGMKLLAYDPFISTERAEQLGCQLVDLDLLMQQSDYITLHIPKTPETTHIINATTLAKMKPTARIINCARGGIIDEAALA
AAVKEGKIAGAALDVFESEPLGESDLRAIGKDIILTPHLGASTTEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGLGPDV
LEELKPYMQLAETLGKLVGQLAGGRVELLTVRLQGELATNKSQPLVIASLKGLLHQALRERVNYVNANIEAKERGIRVIE
TRDASARDYAGSLRLEATGTLGTHSVTGALLGDKEIHLTDVDGFPINVPPSKYMLFTLHRDMPGIIGKLGSLLGSFNVNI
ASMQVGRKIVRGDAVMALSIDDPLPDGILAEITKVPGIRDAYTVTL
>Mature_525_residues
SKVLVSDPIDQAGIDILSQVATVDVNTGLKPAELIEIIGQYDALMIRSGTRVTQEIIEAGTQLKIIGRAGVGVDNVDVPA
ATRRGIVVVNSPEGNTIAAAEHALAMMLSLSRHIPDANASVKRGEWDRKTFVGAEVYKKTLGVVGLGKIGSHVATVAKAM
GMKLLAYDPFISTERAEQLGCQLVDLDLLMQQSDYITLHIPKTPETTHIINATTLAKMKPTARIINCARGGIIDEAALAA
AVKEGKIAGAALDVFESEPLGESDLRAIGKDIILTPHLGASTTEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGLGPDVL
EELKPYMQLAETLGKLVGQLAGGRVELLTVRLQGELATNKSQPLVIASLKGLLHQALRERVNYVNANIEAKERGIRVIET
RDASARDYAGSLRLEATGTLGTHSVTGALLGDKEIHLTDVDGFPINVPPSKYMLFTLHRDMPGIIGKLGSLLGSFNVNIA
SMQVGRKIVRGDAVMALSIDDPLPDGILAEITKVPGIRDAYTVTL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=408, Percent_Identity=41.9117647058824, Blast_Score=301, Evalue=7e-82,
Organism=Homo sapiens, GI4557497, Length=300, Percent_Identity=37, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI61743967, Length=300, Percent_Identity=37, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI145580578, Length=310, Percent_Identity=34.5161290322581, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4557499, Length=310, Percent_Identity=34.5161290322581, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI145580575, Length=301, Percent_Identity=34.21926910299, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI6912396, Length=326, Percent_Identity=30.0613496932515, Blast_Score=127, Evalue=4e-29,
Organism=Escherichia coli, GI1789279, Length=321, Percent_Identity=33.9563862928349, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI87082289, Length=272, Percent_Identity=35.2941176470588, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1787645, Length=211, Percent_Identity=39.3364928909953, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788660, Length=298, Percent_Identity=29.8657718120805, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI87081824, Length=238, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=320, Percent_Identity=45.9375, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI25147481, Length=309, Percent_Identity=31.7152103559871, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=327, Percent_Identity=38.8379204892966, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6322116, Length=300, Percent_Identity=39.3333333333333, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6324055, Length=242, Percent_Identity=30.9917355371901, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=313, Percent_Identity=29.073482428115, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=178, Percent_Identity=28.6516853932584, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=152, Percent_Identity=31.5789473684211, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=44.3708609271523, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24646446, Length=314, Percent_Identity=33.7579617834395, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646448, Length=314, Percent_Identity=33.7579617834395, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646452, Length=314, Percent_Identity=33.7579617834395, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646450, Length=314, Percent_Identity=33.7579617834395, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI62472511, Length=303, Percent_Identity=33.6633663366337, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28574284, Length=320, Percent_Identity=30.3125, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI45551003, Length=320, Percent_Identity=30.3125, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24585514, Length=320, Percent_Identity=30.3125, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28574282, Length=320, Percent_Identity=30.3125, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI45552429, Length=320, Percent_Identity=30.3125, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=32.475884244373, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574286, Length=278, Percent_Identity=30.9352517985612, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=26.517571884984, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55873; Mature: 55741

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3 ; PS00287 CYSTATIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVLVSDPIDQAGIDILSQVATVDVNTGLKPAELIEIIGQYDALMIRSGTRVTQEIIEA
CCCEEECCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHC
GTQLKIIGRAGVGVDNVDVPAATRRGIVVVNSPEGNTIAAAEHALAMMLSLSRHIPDANA
CCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCC
SVKRGEWDRKTFVGAEVYKKTLGVVGLGKIGSHVATVAKAMGMKLLAYDPFISTERAEQL
CCCCCCCCHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GCQLVDLDLLMQQSDYITLHIPKTPETTHIINATTLAKMKPTARIINCARGGIIDEAALA
CCEEEEHHHHHCCCCEEEEEECCCCCCCEEEEHHHHHHCCCHHHHHHHHCCCCCHHHHHH
AAVKEGKIAGAALDVFESEPLGESDLRAIGKDIILTPHLGASTTEAQVNVAIDVAEQIRD
HHHHCCCCCHHHHHHHCCCCCCHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEHHHHHHH
VLLGLPARSAVNIPGLGPDVLEELKPYMQLAETLGKLVGQLAGGRVELLTVRLQGELATN
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCC
KSQPLVIASLKGLLHQALRERVNYVNANIEAKERGIRVIETRDASARDYAGSLRLEATGT
CCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEHHCCEEEEEECCCCCCCCCCEEEEEECCC
LGTHSVTGALLGDKEIHLTDVDGFPINVPPSKYMLFTLHRDMPGIIGKLGSLLGSFNVNI
CCCCCCEEEEECCCEEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEE
ASMQVGRKIVRGDAVMALSIDDPLPDGILAEITKVPGIRDAYTVTL
EHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
SKVLVSDPIDQAGIDILSQVATVDVNTGLKPAELIEIIGQYDALMIRSGTRVTQEIIEA
CCEEECCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHC
GTQLKIIGRAGVGVDNVDVPAATRRGIVVVNSPEGNTIAAAEHALAMMLSLSRHIPDANA
CCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCC
SVKRGEWDRKTFVGAEVYKKTLGVVGLGKIGSHVATVAKAMGMKLLAYDPFISTERAEQL
CCCCCCCCHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GCQLVDLDLLMQQSDYITLHIPKTPETTHIINATTLAKMKPTARIINCARGGIIDEAALA
CCEEEEHHHHHCCCCEEEEEECCCCCCCEEEEHHHHHHCCCHHHHHHHHCCCCCHHHHHH
AAVKEGKIAGAALDVFESEPLGESDLRAIGKDIILTPHLGASTTEAQVNVAIDVAEQIRD
HHHHCCCCCHHHHHHHCCCCCCHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEHHHHHHH
VLLGLPARSAVNIPGLGPDVLEELKPYMQLAETLGKLVGQLAGGRVELLTVRLQGELATN
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCC
KSQPLVIASLKGLLHQALRERVNYVNANIEAKERGIRVIETRDASARDYAGSLRLEATGT
CCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEHHCCEEEEEECCCCCCCCCCEEEEEECCC
LGTHSVTGALLGDKEIHLTDVDGFPINVPPSKYMLFTLHRDMPGIIGKLGSLLGSFNVNI
CCCCCCEEEEECCCEEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEE
ASMQVGRKIVRGDAVMALSIDDPLPDGILAEITKVPGIRDAYTVTL
EHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]