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The map label for this gene is ndk

Identifier: 75909630

GI number: 75909630

Start: 4256489

End: 4256938

Strand: Direct

Name: ndk

Synonym: Ava_3424

Alternate gene names: 75909630

Gene position: 4256489-4256938 (Clockwise)

Preceding gene: 75909628

Following gene: 75909633

Centisome position: 66.87

GC content: 46.22

Gene sequence:

>450_bases
ATGGAACGCACATTCTTAGCAATTAAGCCTGATGGCGTACAGCGTGGACTGGTTGGAGAAATTATCCGTCGCTTTGAAAC
AAAAGGTTTTACCCTTGTGGGTTTGAAGTTCCTCCAAGTCAGTAAAGAATTGGCTGAACAACATTATGGCGTACACCGCG
AAAGACCATTCTTTCCTAGCTTAGTGGAATTTATCACCTCTGGCCCGGTGGTAGCGATGGTTTGGGAAGGTGATGGCGTG
ATTGCTTCTGCGAGAAAAATTATTGGTGCGACCAATCCTCTGACAGCAGAACCCGGAACAATTCGGGGCGATTTTGGCAT
TAACATCGGTCGCAATCTCATCCACGGTTCTGATGCGCCAGAAACCGCACAAAAAGAAGTAAGCCTATGGTTTACAGATG
CAGAATTAGTCAATTGGCAACCCCATTTAACACCTTGGTTGCACGAGTAA

Upstream 100 bases:

>100_bases
GTCATTGGTCATTAGCAGAAACGCTTAAACTGTGGACTATGGACTTTTGACTATGGACTCTTGACCAAATAAAAATTTTA
TTAAGCTTTGGGAGATAGTA

Downstream 100 bases:

>100_bases
TTAGTTAGGGAGTGGGGAGTTAGGGAGTACTGAATGAAATATTCTAGTCACTAGTTTTCATTTCCCAGTCCCCAATCCCC
AATCACCAATCCCTTTACTT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MERTFLAIKPDGVQRGLVGEIIRRFETKGFTLVGLKFLQVSKELAEQHYGVHRERPFFPSLVEFITSGPVVAMVWEGDGV
IASARKIIGATNPLTAEPGTIRGDFGINIGRNLIHGSDAPETAQKEVSLWFTDAELVNWQPHLTPWLHE

Sequences:

>Translated_149_residues
MERTFLAIKPDGVQRGLVGEIIRRFETKGFTLVGLKFLQVSKELAEQHYGVHRERPFFPSLVEFITSGPVVAMVWEGDGV
IASARKIIGATNPLTAEPGTIRGDFGINIGRNLIHGSDAPETAQKEVSLWFTDAELVNWQPHLTPWLHE
>Mature_149_residues
MERTFLAIKPDGVQRGLVGEIIRRFETKGFTLVGLKFLQVSKELAEQHYGVHRERPFFPSLVEFITSGPVVAMVWEGDGV
IASARKIIGATNPLTAEPGTIRGDFGINIGRNLIHGSDAPETAQKEVSLWFTDAELVNWQPHLTPWLHE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392227, Length=149, Percent_Identity=59.7315436241611, Blast_Score=196, Evalue=7e-51,
Organism=Homo sapiens, GI66392205, Length=149, Percent_Identity=59.7315436241611, Blast_Score=196, Evalue=7e-51,
Organism=Homo sapiens, GI4505409, Length=149, Percent_Identity=59.7315436241611, Blast_Score=196, Evalue=7e-51,
Organism=Homo sapiens, GI66392192, Length=149, Percent_Identity=59.7315436241611, Blast_Score=196, Evalue=7e-51,
Organism=Homo sapiens, GI66392203, Length=149, Percent_Identity=59.7315436241611, Blast_Score=196, Evalue=7e-51,
Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=60.8108108108108, Blast_Score=195, Evalue=1e-50,
Organism=Homo sapiens, GI4557797, Length=149, Percent_Identity=59.7315436241611, Blast_Score=194, Evalue=2e-50,
Organism=Homo sapiens, GI38045913, Length=149, Percent_Identity=59.7315436241611, Blast_Score=194, Evalue=3e-50,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=55.7971014492754, Blast_Score=174, Evalue=2e-44,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=36.0902255639098, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=36.0902255639098, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI5031951, Length=151, Percent_Identity=32.4503311258278, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=32.1167883211679, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=43.0656934306569, Blast_Score=127, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17506807, Length=149, Percent_Identity=54.3624161073826, Blast_Score=179, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17507605, Length=91, Percent_Identity=38.4615384615385, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322783, Length=148, Percent_Identity=54.7297297297297, Blast_Score=191, Evalue=3e-50,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=61.4864864864865, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=32.8358208955224, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_ANAVT (Q3M7K5)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_323926.1
- ProteinModelPortal:   Q3M7K5
- SMR:   Q3M7K5
- STRING:   Q3M7K5
- GeneID:   3679950
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_3424
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q3M7K5
- ProtClustDB:   PRK00668
- BioCyc:   AVAR240292:AVA_3424-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16604; Mature: 16604

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFLAIKPDGVQRGLVGEIIRRFETKGFTLVGLKFLQVSKELAEQHYGVHRERPFFPS
CCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHH
LVEFITSGPVVAMVWEGDGVIASARKIIGATNPLTAEPGTIRGDFGINIGRNLIHGSDAP
HHHHHCCCCEEEEEECCCCEEEHHHHHHCCCCCCCCCCCCEECCCCCCCCCCEECCCCCC
ETAQKEVSLWFTDAELVNWQPHLTPWLHE
CCHHHEEEEEEECHHEECCCCCCCCCCCC
>Mature Secondary Structure
MERTFLAIKPDGVQRGLVGEIIRRFETKGFTLVGLKFLQVSKELAEQHYGVHRERPFFPS
CCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHH
LVEFITSGPVVAMVWEGDGVIASARKIIGATNPLTAEPGTIRGDFGINIGRNLIHGSDAP
HHHHHCCCCEEEEEECCCCEEEHHHHHHCCCCCCCCCCCCEECCCCCCCCCCEECCCCCC
ETAQKEVSLWFTDAELVNWQPHLTPWLHE
CCHHHEEEEEEECHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA