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The map label for this gene is mre11 [H]

Identifier: 75909537

GI number: 75909537

Start: 4149701

End: 4150939

Strand: Direct

Name: mre11 [H]

Synonym: Ava_3331

Alternate gene names: 75909537

Gene position: 4149701-4150939 (Clockwise)

Preceding gene: 75909536

Following gene: 75909538

Centisome position: 65.19

GC content: 44.79

Gene sequence:

>1239_bases
ATGATTAAAATCCTCCATCTCTCCGACATCCACATGGGAAGCGGTTTTTCTCACGGACGCATTAATAGCGCCACGGGATT
AAATACGCGATTGGAGGATTTTGTCAATACTTTATCTGTGTGTATTGATCGGGCATTGGGAGATGCTGTAGATTTGGTCA
TATTTGGTGGTGATGCGTTTCCTGATGCTACGCCGCCGCCCTATGTGCAAGAAGCTTTTGCTAGTCAATTTCGTCGTTTA
GTCGATGCTGAAATTCCGACGGTGTTGTTAGTGGGGAACCATGACCAACATTCCCAAGGACAAGGAGGCGCTAGTTTAAA
TATTTACCGCACTTTGGGAGTGCCGGGGTTTGTGGTTGGTGATAGGTTAATGACTCATCATATCCAAACTCGTAACGGCA
AAGTGCAGGTGATTACTTTACCTTGGCTAACTCGTTCGACACTGATGACGCGTCAAGAGACGGAAGGTTTGGGGTTGGCT
GAAGTCAATCAACTATTAACAGAACGTCTGCAAGTGGTGATGGAAGGGGAAATTCGCCGTCTTGACCCTGATGTACCAAC
TGTGCTTTTAGCTCATTTGATGGCTGATAATGCGACGTTGGGGGCTGAACGCTATTTAGCTGTGGGTAAAGGTTTTACTC
TACCTTTATCTTTGCTGACTCGTCCCTGTTTTGATTATGTGGCCTTGGGACACGTCCACCGTCATCAAAATTTGAATAAA
TCTAATAACCCGCCAGTGATTTATCCGGGGAGTATTGAACGGGTAGATTTTAGCGAGGAGAAAGAGGATAAGGGTTATGT
AATGATTGAACTGGAACGGGGTAATGTGGAGTGGGAGTTTTGTTCCTTACCCGTCCGGACTTTTCGTACCATAGAAGTGG
ATGTGTCAAAGGCAGATGATCCACAAGCTGCTATTGTGAAGGCGATCGCTAAACATGATATTCAAGATGCTGTCGTACGC
CTAATCTACAAACTCCGTTCCGAACAAATGGATGTAATTGATAGCGCCTCCCTACATAACGCCTTGAGTTCTGCTCATAC
TTACACCATTCAAGCAGAATTATTAAGTCAATTGGCTCGACCCCGCATCCCTGAATTGAGTGCGAGTAGCAGCATCGACC
CAATGGAAGCATTAAAAACTTACTTGCAGAATCGTGAAGACCTAAAAGACATATCAGCATCCATGTTAGAAGCAGCTGAA
AAGCTACTAACTGATGATTTGGTAATGGGTAATTGGTAA

Upstream 100 bases:

>100_bases
CCATAGTTCAACACAAAGATGTTAACTATTTAACAGTCAATGGTTCAACGCTGAAAACAACCATTAATATTGACTATTGA
CTATTGACTATTGACTAATC

Downstream 100 bases:

>100_bases
TTGCTCAAAAGTTCTCTTTTTGTATTAAAGGGGTTGAAAAATAGCAGACTGGGGATGAGCAGGTTTATCTTTATTTAAAG
AAAGGCTAAATCCTGTATTT

Product: exonuclease SbcD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MIKILHLSDIHMGSGFSHGRINSATGLNTRLEDFVNTLSVCIDRALGDAVDLVIFGGDAFPDATPPPYVQEAFASQFRRL
VDAEIPTVLLVGNHDQHSQGQGGASLNIYRTLGVPGFVVGDRLMTHHIQTRNGKVQVITLPWLTRSTLMTRQETEGLGLA
EVNQLLTERLQVVMEGEIRRLDPDVPTVLLAHLMADNATLGAERYLAVGKGFTLPLSLLTRPCFDYVALGHVHRHQNLNK
SNNPPVIYPGSIERVDFSEEKEDKGYVMIELERGNVEWEFCSLPVRTFRTIEVDVSKADDPQAAIVKAIAKHDIQDAVVR
LIYKLRSEQMDVIDSASLHNALSSAHTYTIQAELLSQLARPRIPELSASSSIDPMEALKTYLQNREDLKDISASMLEAAE
KLLTDDLVMGNW

Sequences:

>Translated_412_residues
MIKILHLSDIHMGSGFSHGRINSATGLNTRLEDFVNTLSVCIDRALGDAVDLVIFGGDAFPDATPPPYVQEAFASQFRRL
VDAEIPTVLLVGNHDQHSQGQGGASLNIYRTLGVPGFVVGDRLMTHHIQTRNGKVQVITLPWLTRSTLMTRQETEGLGLA
EVNQLLTERLQVVMEGEIRRLDPDVPTVLLAHLMADNATLGAERYLAVGKGFTLPLSLLTRPCFDYVALGHVHRHQNLNK
SNNPPVIYPGSIERVDFSEEKEDKGYVMIELERGNVEWEFCSLPVRTFRTIEVDVSKADDPQAAIVKAIAKHDIQDAVVR
LIYKLRSEQMDVIDSASLHNALSSAHTYTIQAELLSQLARPRIPELSASSSIDPMEALKTYLQNREDLKDISASMLEAAE
KLLTDDLVMGNW
>Mature_412_residues
MIKILHLSDIHMGSGFSHGRINSATGLNTRLEDFVNTLSVCIDRALGDAVDLVIFGGDAFPDATPPPYVQEAFASQFRRL
VDAEIPTVLLVGNHDQHSQGQGGASLNIYRTLGVPGFVVGDRLMTHHIQTRNGKVQVITLPWLTRSTLMTRQETEGLGLA
EVNQLLTERLQVVMEGEIRRLDPDVPTVLLAHLMADNATLGAERYLAVGKGFTLPLSLLTRPCFDYVALGHVHRHQNLNK
SNNPPVIYPGSIERVDFSEEKEDKGYVMIELERGNVEWEFCSLPVRTFRTIEVDVSKADDPQAAIVKAIAKHDIQDAVVR
LIYKLRSEQMDVIDSASLHNALSSAHTYTIQAELLSQLARPRIPELSASSSIDPMEALKTYLQNREDLKDISASMLEAAE
KLLTDDLVMGNW

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR004593 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 45665; Mature: 45665

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKILHLSDIHMGSGFSHGRINSATGLNTRLEDFVNTLSVCIDRALGDAVDLVIFGGDAF
CEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
PDATPPPYVQEAFASQFRRLVDAEIPTVLLVGNHDQHSQGQGGASLNIYRTLGVPGFVVG
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCHHH
DRLMTHHIQTRNGKVQVITLPWLTRSTLMTRQETEGLGLAEVNQLLTERLQVVMEGEIRR
HHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHC
LDPDVPTVLLAHLMADNATLGAERYLAVGKGFTLPLSLLTRPCFDYVALGHVHRHQNLNK
CCCCHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SNNPPVIYPGSIERVDFSEEKEDKGYVMIELERGNVEWEFCSLPVRTFRTIEVDVSKADD
CCCCCEEECCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCHHHEEEEEEEECCCCC
PQAAIVKAIAKHDIQDAVVRLIYKLRSEQMDVIDSASLHNALSSAHTYTIQAELLSQLAR
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHC
PRIPELSASSSIDPMEALKTYLQNREDLKDISASMLEAAEKLLTDDLVMGNW
CCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKILHLSDIHMGSGFSHGRINSATGLNTRLEDFVNTLSVCIDRALGDAVDLVIFGGDAF
CEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
PDATPPPYVQEAFASQFRRLVDAEIPTVLLVGNHDQHSQGQGGASLNIYRTLGVPGFVVG
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCHHH
DRLMTHHIQTRNGKVQVITLPWLTRSTLMTRQETEGLGLAEVNQLLTERLQVVMEGEIRR
HHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHC
LDPDVPTVLLAHLMADNATLGAERYLAVGKGFTLPLSLLTRPCFDYVALGHVHRHQNLNK
CCCCHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SNNPPVIYPGSIERVDFSEEKEDKGYVMIELERGNVEWEFCSLPVRTFRTIEVDVSKADD
CCCCCEEECCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCHHHEEEEEEEECCCCC
PQAAIVKAIAKHDIQDAVVRLIYKLRSEQMDVIDSASLHNALSSAHTYTIQAELLSQLAR
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHC
PRIPELSASSSIDPMEALKTYLQNREDLKDISASMLEAAEKLLTDDLVMGNW
CCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]