Click here to switch to the map view.

The map label for this gene is vraR [H]

Identifier: 75909373

GI number: 75909373

Start: 3932593

End: 3933003

Strand: Direct

Name: vraR [H]

Synonym: Ava_3166

Alternate gene names: 75909373

Gene position: 3932593-3933003 (Clockwise)

Preceding gene: 75909372

Following gene: 75909375

Centisome position: 61.78

GC content: 39.17

Gene sequence:

>411_bases
ATGTTCTCTTGTGAGTCCTCTACCTTAAAGGTTCTAGTGGTTGACGATCATGAACTGACTCGTTTAACCTTACAATTAGC
CTTTTCTAGTCAGGAAAATATCCAAGTAGTCGGTTTAGCCAGTAACGGTCAAGAAGCGATAGAAATGGTAAGAGACAGTC
ATCCTGATGTCATTGTTCTAGACTTACAAATGCCAGTCATGGATGGTTGGAGCGCCTCTTGTCATATTAAAGCCATTTCT
CCCAACACACAAATACTAGCTTATTCGTCAGTAGAAGATATACGTTTTCTTGACACAAAGACAACTTCTAACTTTGATGA
TGTTTGTAAAAAAGATGTGCCTACCAAGGAACTTATTGCTTTGGTAAGAGAATTGGGAAGACGTGGGGCGAATAGTTCAA
TTTCCCAATAA

Upstream 100 bases:

>100_bases
GGTTACGCACAAATTATTCAACCATAGGATAGAGTAATCATTGGTACTTGTTCCCATAAACTATGGAAAATATCGTATTT
AGTTATTCCTGGGAATGTTA

Downstream 100 bases:

>100_bases
ATACATTTGCTACGTCGCTTAACTAAATCGGTATAGTTGAAAATGGGGACCTGAAGAAATTTTATCATTCAGAAGCGTCG
GTAAAATCGTTATTTGACGG

Product: response regulator receiver domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MFSCESSTLKVLVVDDHELTRLTLQLAFSSQENIQVVGLASNGQEAIEMVRDSHPDVIVLDLQMPVMDGWSASCHIKAIS
PNTQILAYSSVEDIRFLDTKTTSNFDDVCKKDVPTKELIALVRELGRRGANSSISQ

Sequences:

>Translated_136_residues
MFSCESSTLKVLVVDDHELTRLTLQLAFSSQENIQVVGLASNGQEAIEMVRDSHPDVIVLDLQMPVMDGWSASCHIKAIS
PNTQILAYSSVEDIRFLDTKTTSNFDDVCKKDVPTKELIALVRELGRRGANSSISQ
>Mature_136_residues
MFSCESSTLKVLVVDDHELTRLTLQLAFSSQENIQVVGLASNGQEAIEMVRDSHPDVIVLDLQMPVMDGWSASCHIKAIS
PNTQILAYSSVEDIRFLDTKTTSNFDDVCKKDVPTKELIALVRELGRRGANSSISQ

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 15010; Mature: 15010

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSCESSTLKVLVVDDHELTRLTLQLAFSSQENIQVVGLASNGQEAIEMVRDSHPDVIVL
CCCCCCCCEEEEEECCCCEEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCEEEE
DLQMPVMDGWSASCHIKAISPNTQILAYSSVEDIRFLDTKTTSNFDDVCKKDVPTKELIA
EEECCCCCCCCCEEEEEEECCCCEEEEECCCCCEEEEECCCCCCHHHHHHCCCCHHHHHH
LVRELGRRGANSSISQ
HHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFSCESSTLKVLVVDDHELTRLTLQLAFSSQENIQVVGLASNGQEAIEMVRDSHPDVIVL
CCCCCCCCEEEEEECCCCEEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCEEEE
DLQMPVMDGWSASCHIKAISPNTQILAYSSVEDIRFLDTKTTSNFDDVCKKDVPTKELIA
EEECCCCCCCCCEEEEEEECCCCEEEEECCCCCEEEEECCCCCCHHHHHHCCCCHHHHHH
LVRELGRRGANSSISQ
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]