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The map label for this gene is lysS

Identifier: 75909357

GI number: 75909357

Start: 3912207

End: 3913892

Strand: Direct

Name: lysS

Synonym: Ava_3150

Alternate gene names: 75909357

Gene position: 3912207-3913892 (Clockwise)

Preceding gene: 75909354

Following gene: 75909358

Centisome position: 61.46

GC content: 43.83

Gene sequence:

>1686_bases
ATGTCGGAAGAAGATATCCGTGCCGCTAGGCTGGAGAAAGTAGAACAACTCAAGCAGCTAGGAACTAACCCCTACGCTTA
CCGTTGGGAGTCTACCCATCACGCCGCCCAATTGCAAGAAAAATTTGCTGATTTAACCAGTGGTGAAGAAGTCGATACAG
AAGTTGCCATTGCCGGACGCATTATGGCGCGTCGCGTTTTCGGTAAATTGGCTTTCTTCACCTTGGAAGATGAAACAGGC
ACTATTCAGCTTTATTTAGAGAAAAATCGTATCCAAGAAAGCATGGCAGAAACTGATGCCGATGCTTTTAATCATCTCAA
ACAACTCACAGATGTAGGAGATATTCTGGGAGCCAAGGGAACCATAAAACGGACTGAAAAGGGCGAGTTATCGATTTACG
TCAAAGAATATACCATCCTCACCAAATCCCTACTGCCGCTACCCGACAAGTGGCATGGGTTAACGGATGTTGCCAAGCGC
TACCGTCAACGCTACGTTGATTTAATTGTTAACCCCGAAGTCCGCCAAACTTTCCGCCGTCGCGCCCAAATTACGGCTGG
GATTCGCCGCTATTTGGAACAAAGGGATTTTCTAGAGATTGAAACCCCAGTTTTGCAAAGTGAAACTGGTGGTGCTGATG
CGCGTCCCTTCATCACTTACCACAACACCTTAGAAATGGAGTTGTATCTGCGGATTGCCACAGAACTCCACCTCAAACGG
TTGATTGTCGGTGGTTTTGAAAAAGTATTTGAGTTGGGGCGCGTTTTCCGCAATGAGGGAATTTCTACCAGACACAACCC
TGAATTTACCTCAATTGAAATTTACCAAGCCTACGCCGACTACAACGATATGATGGCGCTAACAGAAGGTATTATCACCA
CTGTTGCCCAAGATGTACTCGGTACGCTGCAAATTACCTACCAAGGCGAAACGGTAGATTTGACACCACCTTGGCGACGG
GTGACAATGCACGATTTAGTGAAAGAATATACGGGCTTGGATTTCCATTCTTTCCAAACACTAGAAGAAGCGAAATCAGC
AAGTAAAAATGCTGGAATTCCTGGTGTAGATGAAGCCCAAACTATAGGAAAAATCCTGAATTTAGCATTTGAAGAAAAGG
TAGAAGCTAACTTAATTCAGCCGACCTTTGTCATTGATTATCCTGTAGAAATTTCGCCATTAGCTAAACCTCACCGTTCT
CAACCTGGGTTAGTAGAAAGATTTGAATTATTCATAGTCGGGCGGGAGACTGCGAATAGTTTCTCAGAATTAACAGACCC
CATCGACCAAAGAGAACGTTTGGAAGCCCAAGCAGCCAAAAAAGCCGCCGGTGACTTAGAAGCCCAAGGTGTAGATGAAG
ATTTCTTAACTGCGTTGGAATATGGTATGCCACCCACAGGCGGTTTAGGTATTGGGATTGATCGGTTAGTCATGTTATTA
ACTGATTCTGCCAGCATTCGAGATGTAATTGCTTTCCCTCTACTCAAACCCGAAGGCAGCTTTATTAAGGAATATCGCTA
TGAGTCAACAACTCAAACACTGACTATGGAGTTTGATAGTGGAAGTGTTTACGAATATTTCAAAGTACCGCTTACTGTCA
AGGAAGAATTAGATAATGCACCGTCTAAGGGTCAATATTTCCATAAGTTTATTAAAGGGAAATTCAAGTATGAACAATTG
AGTTGA

Upstream 100 bases:

>100_bases
CTCCACAAATCATAAGAATTTTTCCCTAATTCCCAATCCCTACTCTCTAATCCCTAATCCCTATTTATAATTAATCTTGC
CCTCTGAATAGTTCGTTACC

Downstream 100 bases:

>100_bases
TGGAATAAGTAGAAAATAAAATTTCAAGGGTGATTTAGGTAAAATACTAAATCACCCTATTTTTATTAATTTGGTCAGGC
GATCGCTATCCTAGTTTTTT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MSEEDIRAARLEKVEQLKQLGTNPYAYRWESTHHAAQLQEKFADLTSGEEVDTEVAIAGRIMARRVFGKLAFFTLEDETG
TIQLYLEKNRIQESMAETDADAFNHLKQLTDVGDILGAKGTIKRTEKGELSIYVKEYTILTKSLLPLPDKWHGLTDVAKR
YRQRYVDLIVNPEVRQTFRRRAQITAGIRRYLEQRDFLEIETPVLQSETGGADARPFITYHNTLEMELYLRIATELHLKR
LIVGGFEKVFELGRVFRNEGISTRHNPEFTSIEIYQAYADYNDMMALTEGIITTVAQDVLGTLQITYQGETVDLTPPWRR
VTMHDLVKEYTGLDFHSFQTLEEAKSASKNAGIPGVDEAQTIGKILNLAFEEKVEANLIQPTFVIDYPVEISPLAKPHRS
QPGLVERFELFIVGRETANSFSELTDPIDQRERLEAQAAKKAAGDLEAQGVDEDFLTALEYGMPPTGGLGIGIDRLVMLL
TDSASIRDVIAFPLLKPEGSFIKEYRYESTTQTLTMEFDSGSVYEYFKVPLTVKEELDNAPSKGQYFHKFIKGKFKYEQL
S

Sequences:

>Translated_561_residues
MSEEDIRAARLEKVEQLKQLGTNPYAYRWESTHHAAQLQEKFADLTSGEEVDTEVAIAGRIMARRVFGKLAFFTLEDETG
TIQLYLEKNRIQESMAETDADAFNHLKQLTDVGDILGAKGTIKRTEKGELSIYVKEYTILTKSLLPLPDKWHGLTDVAKR
YRQRYVDLIVNPEVRQTFRRRAQITAGIRRYLEQRDFLEIETPVLQSETGGADARPFITYHNTLEMELYLRIATELHLKR
LIVGGFEKVFELGRVFRNEGISTRHNPEFTSIEIYQAYADYNDMMALTEGIITTVAQDVLGTLQITYQGETVDLTPPWRR
VTMHDLVKEYTGLDFHSFQTLEEAKSASKNAGIPGVDEAQTIGKILNLAFEEKVEANLIQPTFVIDYPVEISPLAKPHRS
QPGLVERFELFIVGRETANSFSELTDPIDQRERLEAQAAKKAAGDLEAQGVDEDFLTALEYGMPPTGGLGIGIDRLVMLL
TDSASIRDVIAFPLLKPEGSFIKEYRYESTTQTLTMEFDSGSVYEYFKVPLTVKEELDNAPSKGQYFHKFIKGKFKYEQL
S
>Mature_560_residues
SEEDIRAARLEKVEQLKQLGTNPYAYRWESTHHAAQLQEKFADLTSGEEVDTEVAIAGRIMARRVFGKLAFFTLEDETGT
IQLYLEKNRIQESMAETDADAFNHLKQLTDVGDILGAKGTIKRTEKGELSIYVKEYTILTKSLLPLPDKWHGLTDVAKRY
RQRYVDLIVNPEVRQTFRRRAQITAGIRRYLEQRDFLEIETPVLQSETGGADARPFITYHNTLEMELYLRIATELHLKRL
IVGGFEKVFELGRVFRNEGISTRHNPEFTSIEIYQAYADYNDMMALTEGIITTVAQDVLGTLQITYQGETVDLTPPWRRV
TMHDLVKEYTGLDFHSFQTLEEAKSASKNAGIPGVDEAQTIGKILNLAFEEKVEANLIQPTFVIDYPVEISPLAKPHRSQ
PGLVERFELFIVGRETANSFSELTDPIDQRERLEAQAAKKAAGDLEAQGVDEDFLTALEYGMPPTGGLGIGIDRLVMLLT
DSASIRDVIAFPLLKPEGSFIKEYRYESTTQTLTMEFDSGSVYEYFKVPLTVKEELDNAPSKGQYFHKFIKGKFKYEQLS

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=504, Percent_Identity=43.6507936507937, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI194272210, Length=504, Percent_Identity=43.6507936507937, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI45439306, Length=479, Percent_Identity=25.2609603340292, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI40789249, Length=262, Percent_Identity=26.7175572519084, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790571, Length=514, Percent_Identity=48.8326848249027, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI1789256, Length=493, Percent_Identity=50.3042596348884, Blast_Score=484, Evalue=1e-138,
Organism=Escherichia coli, GI87082379, Length=320, Percent_Identity=33.125, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788173, Length=301, Percent_Identity=26.9102990033223, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17535925, Length=516, Percent_Identity=43.0232558139535, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17535927, Length=516, Percent_Identity=43.0232558139535, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71994340, Length=516, Percent_Identity=43.0232558139535, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI32566633, Length=303, Percent_Identity=23.4323432343234, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17551876, Length=477, Percent_Identity=23.0607966457023, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320242, Length=514, Percent_Identity=41.2451361867704, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324256, Length=501, Percent_Identity=31.5369261477046, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6323011, Length=490, Percent_Identity=26.1224489795918, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6325153, Length=261, Percent_Identity=25.6704980842912, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24640849, Length=508, Percent_Identity=41.9291338582677, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24640851, Length=508, Percent_Identity=41.9291338582677, Blast_Score=394, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24584738, Length=335, Percent_Identity=23.8805970149254, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_ANAVT (Q3M8C8)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_323653.1
- ProteinModelPortal:   Q3M8C8
- SMR:   Q3M8C8
- STRING:   Q3M8C8
- GeneID:   3680784
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_3150
- NMPDR:   fig|240292.3.peg.3155
- eggNOG:   COG1190
- HOGENOM:   HBG631383
- OMA:   RNEGMDH
- PhylomeDB:   Q3M8C8
- ProtClustDB:   PRK00484
- BioCyc:   AVAR240292:AVA_3150-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 63748; Mature: 63617

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEDIRAARLEKVEQLKQLGTNPYAYRWESTHHAAQLQEKFADLTSGEEVDTEVAIAGR
CCCHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IMARRVFGKLAFFTLEDETGTIQLYLEKNRIQESMAETDADAFNHLKQLTDVGDILGAKG
HHHHHHHHHEEEEEEECCCCEEEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
TIKRTEKGELSIYVKEYTILTKSLLPLPDKWHGLTDVAKRYRQRYVDLIVNPEVRQTFRR
CCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHH
RAQITAGIRRYLEQRDFLEIETPVLQSETGGADARPFITYHNTLEMELYLRIATELHLKR
HHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEECCEEEEEHHHHHHHHHHHHH
LIVGGFEKVFELGRVFRNEGISTRHNPEFTSIEIYQAYADYNDMMALTEGIITTVAQDVL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEHHCHHHHHHHHHHHHHHHHHHHH
GTLQITYQGETVDLTPPWRRVTMHDLVKEYTGLDFHSFQTLEEAKSASKNAGIPGVDEAQ
HEEEEEEECCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHH
TIGKILNLAFEEKVEANLIQPTFVIDYPVEISPLAKPHRSQPGLVERFELFIVGRETANS
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHEEEEEEEEECHHHHH
FSELTDPIDQRERLEAQAAKKAAGDLEAQGVDEDFLTALEYGMPPTGGLGIGIDRLVMLL
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TDSASIRDVIAFPLLKPEGSFIKEYRYESTTQTLTMEFDSGSVYEYFKVPLTVKEELDNA
CCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEECCCCEEEEEECCEEEHHHHCCC
PSKGQYFHKFIKGKFKYEQLS
CCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SEEDIRAARLEKVEQLKQLGTNPYAYRWESTHHAAQLQEKFADLTSGEEVDTEVAIAGR
CCHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IMARRVFGKLAFFTLEDETGTIQLYLEKNRIQESMAETDADAFNHLKQLTDVGDILGAKG
HHHHHHHHHEEEEEEECCCCEEEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
TIKRTEKGELSIYVKEYTILTKSLLPLPDKWHGLTDVAKRYRQRYVDLIVNPEVRQTFRR
CCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHH
RAQITAGIRRYLEQRDFLEIETPVLQSETGGADARPFITYHNTLEMELYLRIATELHLKR
HHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEECCEEEEEHHHHHHHHHHHHH
LIVGGFEKVFELGRVFRNEGISTRHNPEFTSIEIYQAYADYNDMMALTEGIITTVAQDVL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEHHCHHHHHHHHHHHHHHHHHHHH
GTLQITYQGETVDLTPPWRRVTMHDLVKEYTGLDFHSFQTLEEAKSASKNAGIPGVDEAQ
HEEEEEEECCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHH
TIGKILNLAFEEKVEANLIQPTFVIDYPVEISPLAKPHRSQPGLVERFELFIVGRETANS
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHEEEEEEEEECHHHHH
FSELTDPIDQRERLEAQAAKKAAGDLEAQGVDEDFLTALEYGMPPTGGLGIGIDRLVMLL
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TDSASIRDVIAFPLLKPEGSFIKEYRYESTTQTLTMEFDSGSVYEYFKVPLTVKEELDNA
CCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEECCCCEEEEEECCEEEHHHHCCC
PSKGQYFHKFIKGKFKYEQLS
CCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA