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The map label for this gene is aroE

Identifier: 75909313

GI number: 75909313

Start: 3862024

End: 3862893

Strand: Direct

Name: aroE

Synonym: Ava_3106

Alternate gene names: 75909313

Gene position: 3862024-3862893 (Clockwise)

Preceding gene: 75909312

Following gene: 75909315

Centisome position: 60.67

GC content: 44.25

Gene sequence:

>870_bases
ATGATTACAGGCAAAACTAAACTATTAGGGGTAATTGGACATCCGGTGGAACATTCACTGTCACCGGTGATGCACAATGC
AGCGATCGCCCAATTGGGATTAGATTATGTATATCTACCTTTTCCTATAGCACCAGATAATTTAGAAGCAGCGATCGCTC
TTTTGGCTACTATTGGTGTAGTGGGATTTAGTGTGACGATTCCTCACAAACAGGCAATCATCCCCCTGCTGGCTGAAATT
AGCCCCGTTGCTCAAGCTATAGGCGCAGTAAATACTGTCACCCGTCAAAATAATCAATGGGTGGGGACAAACACAGATAT
AGAAGGGTTTATTGCCCCTTTGCAGACAACATATAAACGAGATTGGAGTCAGCAAATCGCCGTAATCTTGGGTAATGGTG
GCGCAGCGAGAGCTGTTGTCGCAGGTTGTTATCAACTGGGTTTTGCGGAAATTCATGTAGTGGGGCGCAATGTGCAACGC
CTAGAGGAATTTCGCCACAGTTGGGACAATTCCCCCATCGCTGAGAATTTACAAGTACATACCTGGGATTATTTAGCAAA
GCTCGTCCCTCAAGCTAACCTACTGGTGAACACAACCCCGATAGGAATGTATCCGCAGGTTGATGAGTCGCCTTTGAGTA
CCGAAGAACTGGCGAATTTACAAACTGGTGCTATTGCTTATGATTTGATATATATTCCCAAACCAACGCAATTTCTCCAA
AAAGCACAACAACAAGGCGCAATTGCTATTGATGGTTTAGAAATGTTAGTTCAGCAAGGAGTCGCCGCCTTAAAAATTTG
GTTGCAGCAAGACGATATCCCTGTAGATGTGATGCGTCAAGCATTACAAAAGCATCTTGGTTTGGTTTAA

Upstream 100 bases:

>100_bases
CCCTGCTATGTCCCAAGATTTTTCCCACCAGAATCTCAGAGGTGGTTATTTCAAGAGTCAAGACTTGGCTGGGACAAGGT
GTTGACAACTGACAAAAACA

Downstream 100 bases:

>100_bases
TAGTTCAGTAGAAGTAATGAGTAATGAGTAATGAATCAATACTCCCTACTCTTCTGCTTTTTCACTTCTTCGGCCAGCGC
CAATTATAGCGATTCCATTC

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MITGKTKLLGVIGHPVEHSLSPVMHNAAIAQLGLDYVYLPFPIAPDNLEAAIALLATIGVVGFSVTIPHKQAIIPLLAEI
SPVAQAIGAVNTVTRQNNQWVGTNTDIEGFIAPLQTTYKRDWSQQIAVILGNGGAARAVVAGCYQLGFAEIHVVGRNVQR
LEEFRHSWDNSPIAENLQVHTWDYLAKLVPQANLLVNTTPIGMYPQVDESPLSTEELANLQTGAIAYDLIYIPKPTQFLQ
KAQQQGAIAIDGLEMLVQQGVAALKIWLQQDDIPVDVMRQALQKHLGLV

Sequences:

>Translated_289_residues
MITGKTKLLGVIGHPVEHSLSPVMHNAAIAQLGLDYVYLPFPIAPDNLEAAIALLATIGVVGFSVTIPHKQAIIPLLAEI
SPVAQAIGAVNTVTRQNNQWVGTNTDIEGFIAPLQTTYKRDWSQQIAVILGNGGAARAVVAGCYQLGFAEIHVVGRNVQR
LEEFRHSWDNSPIAENLQVHTWDYLAKLVPQANLLVNTTPIGMYPQVDESPLSTEELANLQTGAIAYDLIYIPKPTQFLQ
KAQQQGAIAIDGLEMLVQQGVAALKIWLQQDDIPVDVMRQALQKHLGLV
>Mature_289_residues
MITGKTKLLGVIGHPVEHSLSPVMHNAAIAQLGLDYVYLPFPIAPDNLEAAIALLATIGVVGFSVTIPHKQAIIPLLAEI
SPVAQAIGAVNTVTRQNNQWVGTNTDIEGFIAPLQTTYKRDWSQQIAVILGNGGAARAVVAGCYQLGFAEIHVVGRNVQR
LEEFRHSWDNSPIAENLQVHTWDYLAKLVPQANLLVNTTPIGMYPQVDESPLSTEELANLQTGAIAYDLIYIPKPTQFLQ
KAQQQGAIAIDGLEMLVQQGVAALKIWLQQDDIPVDVMRQALQKHLGLV

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=286, Percent_Identity=29.7202797202797, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789675, Length=264, Percent_Identity=28.030303030303, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320332, Length=275, Percent_Identity=28, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_ANAVT (Q3M8H2)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_323609.1
- HSSP:   Q9SQT8
- ProteinModelPortal:   Q3M8H2
- SMR:   Q3M8H2
- STRING:   Q3M8H2
- GeneID:   3680852
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_3106
- NMPDR:   fig|240292.3.peg.2535
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   CALRSIN
- PhylomeDB:   Q3M8H2
- ProtClustDB:   PRK00258
- BioCyc:   AVAR240292:AVA_3106-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31411; Mature: 31411

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITGKTKLLGVIGHPVEHSLSPVMHNAAIAQLGLDYVYLPFPIAPDNLEAAIALLATIGV
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH
VGFSVTIPHKQAIIPLLAEISPVAQAIGAVNTVTRQNNQWVGTNTDIEGFIAPLQTTYKR
HHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
DWSQQIAVILGNGGAARAVVAGCYQLGFAEIHVVGRNVQRLEEFRHSWDNSPIAENLQVH
CCCCEEEEEEECCCHHHHHHHHHHHHCHHHEEEECCCHHHHHHHHHHCCCCCCCCCCEEE
TWDYLAKLVPQANLLVNTTPIGMYPQVDESPLSTEELANLQTGAIAYDLIYIPKPTQFLQ
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCHHHHH
KAQQQGAIAIDGLEMLVQQGVAALKIWLQQDDIPVDVMRQALQKHLGLV
HHHHCCCEEEHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITGKTKLLGVIGHPVEHSLSPVMHNAAIAQLGLDYVYLPFPIAPDNLEAAIALLATIGV
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH
VGFSVTIPHKQAIIPLLAEISPVAQAIGAVNTVTRQNNQWVGTNTDIEGFIAPLQTTYKR
HHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
DWSQQIAVILGNGGAARAVVAGCYQLGFAEIHVVGRNVQRLEEFRHSWDNSPIAENLQVH
CCCCEEEEEEECCCHHHHHHHHHHHHCHHHEEEECCCHHHHHHHHHHCCCCCCCCCCEEE
TWDYLAKLVPQANLLVNTTPIGMYPQVDESPLSTEELANLQTGAIAYDLIYIPKPTQFLQ
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCHHHHH
KAQQQGAIAIDGLEMLVQQGVAALKIWLQQDDIPVDVMRQALQKHLGLV
HHHHCCCEEEHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA