BacMap

Definition	Anabaena variabilis ATCC 29413 chromosome, complete genome.
Accession	NC_007413
Length	6,365,727

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The map label for this gene is iolS [H]

Identifier: 75909308

GI number: 75909308

Start: 3853069

End: 3854028

Strand: Direct

Name: iolS [H]

Synonym: Ava_3100

Alternate gene names: 75909308

Gene position: 3853069-3854028 (Clockwise)

Preceding gene: 75909305

Following gene: 75909309

Centisome position: 60.53

GC content: 44.69

Gene sequence:

>960_bases
ATGGAAAAGCGCACACTAGGCACATCCGATGTCAAAATTTCACCCATTCTGATGGGGACTTGGCAAGCCGGGAAGAAAAT
GTGGGTGGGAATTGAAGATGCTGACTCGATTAAAACCATTCGTGCAGCTTTTGAGGCAGGAATTACCACAGTTGACACAG
CCGAAGTTTATGGTGAAGGACATTCCGAACAGATTGTGGCTGAAGCTTTGTCTGATGTGCGTAACCAAGTTGAGTATGCC
ACAAAAGTTTTCGCCAACCATCTCAAGTATGATCAAGTAATTCAAGCTTGCGATCGCTCCCTGAAAAATCTCCAGACTGA
TTACATAGACTTATACCAAATTCATTGGCCTGCTGGTGCTTTCAATAGTGAAATAGTACCAATTGAGGAAACTATGAACG
CCCTGAACCATCTGAAAGAACAGGGTAAAATCCGCGCCATCGGTGTTTCTAACTTTTCCCGCGCCCAATTAGCAGAGGCC
TCACAATATGGCAGAATTGACAGCTTACAGCCTCCCTATTCTCTATTTTGGCGACAAGTAGAAAAAGATGCAGCACCTTA
CTGTGTGGAAAATCATATTTCTATCTTGGCTTATTCACCCTTAGCTCAGGGATTACTGACAGGGAAATTTACTCGCGGAC
AGCAATTTGATCCAGCCGATAACCGAGCTAAAAATAAACTGTTTCAAGGCGAAAACTTTGAACGCGCCCAACAAGCTTTA
GATAAACTGCGTCCCATCGCCGAAAGCCATAACGCTACTTTGGCGCAGTTGGCACTAGCTTGGTTAATTGCTCAACCCCA
AACGAATGCGATCGCTGGTGCGCGTTATCCTGAACAAGCAAAAGATAATGCCCAAGCTGCCAATATTCAACTCTCTCCTG
AGGAAATTAGCGAAATTGATGCGATCGGTCGTATTGTTACCGAGCATCATGATGATAGTGCTGTGATGTGGAACTGGTAA

Upstream 100 bases:

>100_bases
CAATTCTGTTAGCATCGCCATCTACTGTAACTCTGATTTAATTTACAGCGAAGACCGTTAAAGTATAAAACTATCCAGGG
AAGTGAATTAGGGAACCTTT

Downstream 100 bases:

>100_bases
AAGATTTCTTGAATATCACCCCAATTATTCACGAAAGATAGTTGGGGATCAAAGCTTTAAGTATTTATTGCAAAAATCTA
CAAAATATCAACTTTAGTAA

Product: aldo/keto reductase

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MEKRTLGTSDVKISPILMGTWQAGKKMWVGIEDADSIKTIRAAFEAGITTVDTAEVYGEGHSEQIVAEALSDVRNQVEYA
TKVFANHLKYDQVIQACDRSLKNLQTDYIDLYQIHWPAGAFNSEIVPIEETMNALNHLKEQGKIRAIGVSNFSRAQLAEA
SQYGRIDSLQPPYSLFWRQVEKDAAPYCVENHISILAYSPLAQGLLTGKFTRGQQFDPADNRAKNKLFQGENFERAQQAL
DKLRPIAESHNATLAQLALAWLIAQPQTNAIAGARYPEQAKDNAQAANIQLSPEEISEIDAIGRIVTEHHDDSAVMWNW

Sequences:

>Translated_319_residues
MEKRTLGTSDVKISPILMGTWQAGKKMWVGIEDADSIKTIRAAFEAGITTVDTAEVYGEGHSEQIVAEALSDVRNQVEYA
TKVFANHLKYDQVIQACDRSLKNLQTDYIDLYQIHWPAGAFNSEIVPIEETMNALNHLKEQGKIRAIGVSNFSRAQLAEA
SQYGRIDSLQPPYSLFWRQVEKDAAPYCVENHISILAYSPLAQGLLTGKFTRGQQFDPADNRAKNKLFQGENFERAQQAL
DKLRPIAESHNATLAQLALAWLIAQPQTNAIAGARYPEQAKDNAQAANIQLSPEEISEIDAIGRIVTEHHDDSAVMWNW
>Mature_319_residues
MEKRTLGTSDVKISPILMGTWQAGKKMWVGIEDADSIKTIRAAFEAGITTVDTAEVYGEGHSEQIVAEALSDVRNQVEYA
TKVFANHLKYDQVIQACDRSLKNLQTDYIDLYQIHWPAGAFNSEIVPIEETMNALNHLKEQGKIRAIGVSNFSRAQLAEA
SQYGRIDSLQPPYSLFWRQVEKDAAPYCVENHISILAYSPLAQGLLTGKFTRGQQFDPADNRAKNKLFQGENFERAQQAL
DKLRPIAESHNATLAQLALAWLIAQPQTNAIAGARYPEQAKDNAQAANIQLSPEEISEIDAIGRIVTEHHDDSAVMWNW

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436964, Length=331, Percent_Identity=29.3051359516616, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI27436966, Length=331, Percent_Identity=29.3051359516616, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI27436962, Length=331, Percent_Identity=29.3051359516616, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI27436969, Length=329, Percent_Identity=29.483282674772, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI4504825, Length=326, Percent_Identity=29.4478527607362, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI27436971, Length=329, Percent_Identity=27.0516717325228, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI41152114, Length=206, Percent_Identity=32.5242718446602, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI223718702, Length=320, Percent_Identity=28.125, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI41327764, Length=209, Percent_Identity=33.0143540669856, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI5453543, Length=333, Percent_Identity=27.027027027027, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI45446745, Length=336, Percent_Identity=27.0833333333333, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4503285, Length=336, Percent_Identity=27.0833333333333, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI223468663, Length=327, Percent_Identity=25.3822629969419, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310109920, Length=333, Percent_Identity=26.4264264264264, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI223718708, Length=151, Percent_Identity=33.7748344370861, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI310109922, Length=319, Percent_Identity=26.3322884012539, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI24497577, Length=317, Percent_Identity=23.0283911671924, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI5174391, Length=317, Percent_Identity=23.0283911671924, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788070, Length=314, Percent_Identity=37.2611464968153, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI87081735, Length=321, Percent_Identity=35.202492211838, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1788081, Length=300, Percent_Identity=33.6666666666667, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1789199, Length=350, Percent_Identity=31.7142857142857, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789375, Length=325, Percent_Identity=29.5384615384615, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786400, Length=284, Percent_Identity=29.5774647887324, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI48994888, Length=317, Percent_Identity=25.5520504731861, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082198, Length=294, Percent_Identity=25.1700680272109, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537077, Length=319, Percent_Identity=27.8996865203762, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17537075, Length=320, Percent_Identity=27.8125, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17550248, Length=313, Percent_Identity=25.5591054313099, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17566692, Length=313, Percent_Identity=25.5591054313099, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI212645785, Length=305, Percent_Identity=27.5409836065574, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17564128, Length=310, Percent_Identity=26.4516129032258, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17552492, Length=212, Percent_Identity=28.7735849056604, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538386, Length=306, Percent_Identity=24.1830065359477, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71998625, Length=305, Percent_Identity=24.2622950819672, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17537079, Length=326, Percent_Identity=24.2331288343558, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6325169, Length=333, Percent_Identity=29.4294294294294, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323998, Length=331, Percent_Identity=26.5861027190332, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319958, Length=299, Percent_Identity=25.4180602006689, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6319951, Length=331, Percent_Identity=23.8670694864048, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322615, Length=260, Percent_Identity=25.3846153846154, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324694, Length=218, Percent_Identity=28.4403669724771, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320079, Length=275, Percent_Identity=23.6363636363636, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6325384, Length=239, Percent_Identity=25.9414225941423, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644950, Length=316, Percent_Identity=28.4810126582279, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24646155, Length=180, Percent_Identity=35.5555555555556, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646159, Length=174, Percent_Identity=31.6091954022989, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24657054, Length=290, Percent_Identity=23.448275862069, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45553081, Length=276, Percent_Identity=26.0869565217391, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24662789, Length=220, Percent_Identity=26.3636363636364, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281366140, Length=272, Percent_Identity=25.7352941176471, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356425, Length=290, Percent_Identity=23.1034482758621, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640980, Length=335, Percent_Identity=23.5820895522388, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129731, Length=306, Percent_Identity=24.5098039215686, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45549126, Length=335, Percent_Identity=23.5820895522388, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35582; Mature: 35582

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRTLGTSDVKISPILMGTWQAGKKMWVGIEDADSIKTIRAAFEAGITTVDTAEVYGEG
CCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEHHHHHCCC
HSEQIVAEALSDVRNQVEYATKVFANHLKYDQVIQACDRSLKNLQTDYIDLYQIHWPAGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
FNSEIVPIEETMNALNHLKEQGKIRAIGVSNFSRAQLAEASQYGRIDSLQPPYSLFWRQV
CCCCCEEHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
EKDAAPYCVENHISILAYSPLAQGLLTGKFTRGQQFDPADNRAKNKLFQGENFERAQQAL
HHCCCCEEHHCCCEEEEECHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHH
DKLRPIAESHNATLAQLALAWLIAQPQTNAIAGARYPEQAKDNAQAANIQLSPEEISEID
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCEEEECHHHHHHHH
AIGRIVTEHHDDSAVMWNW
HHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MEKRTLGTSDVKISPILMGTWQAGKKMWVGIEDADSIKTIRAAFEAGITTVDTAEVYGEG
CCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEHHHHHCCC
HSEQIVAEALSDVRNQVEYATKVFANHLKYDQVIQACDRSLKNLQTDYIDLYQIHWPAGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
FNSEIVPIEETMNALNHLKEQGKIRAIGVSNFSRAQLAEASQYGRIDSLQPPYSLFWRQV
CCCCCEEHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
EKDAAPYCVENHISILAYSPLAQGLLTGKFTRGQQFDPADNRAKNKLFQGENFERAQQAL
HHCCCCEEHHCCCEEEEECHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHH
DKLRPIAESHNATLAQLALAWLIAQPQTNAIAGARYPEQAKDNAQAANIQLSPEEISEID
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCEEEECHHHHHHHH
AIGRIVTEHHDDSAVMWNW
HHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]