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The map label for this gene is ggt [H]

Identifier: 75909299

GI number: 75909299

Start: 3841838

End: 3843619

Strand: Direct

Name: ggt [H]

Synonym: Ava_3091

Alternate gene names: 75909299

Gene position: 3841838-3843619 (Clockwise)

Preceding gene: 75909297

Following gene: 75909300

Centisome position: 60.35

GC content: 46.91

Gene sequence:

>1782_bases
ATGCCTATTCTTGCTAAGTCCAAGCTGGTTGTATTTACAGTCTTTTCTCTGGGGGTTCTTTGCTACAACCAAATAGCCTC
AGCCACTATTACCTTACCTCTACGCAGTAAAAAAGGTATGGTAGTATCTGCCCATCCTTTGGCAAGTGAGACTGGTGTGG
CAATGTTACGCAAAGGTGGTAATGCAGTCGATGCAGCAGTAGCCACAACCTTTGCCATTTCTGTTGTTGAGCCTTTTTCT
GCCGGAATTGGTGGCGGGGGATTTTTGCTGATGCGTTCCCAGAAAACAGGAGAAATCAAAGCGTTAGATTTTCGGGAACG
CGCACCCCTCAAAGCCACGAGAAAGATGTATTTGGATGATGCAGGGAAGGTACGCCCAAATGCAAGTATCAACGGTTATT
TGGCGGTAGCTACACCAGGAACGATCGCCGGGATGTATGAAGTGCATCGTCGTTATGGTAAATTACCCTGGTATGAGGTG
GTAAAACCTGCGATCGCTCTAGCTAAGGATGGTTTCGTTCTTGCTCAAAAACCAACTTGGCGATCAATCCAAGTTTATGG
AACCCGCAAACAAGCAATTCTCAGCAACCAAGCAGCACGGGAAATTTTTACTCGCAACGGCGAATTTTATCAGCCTGGAG
AAAGGTTGGTACAGCGCGATTTGGCACGTACTTTAGCAGAGATCGCCCAAAATCCTCAAAGCTTTTACACTGGTGATATT
GCCCGTGCGATCGCGGCTGATATGGCGAAAAATGGCGGTTTAGTTACCTTAGCAGACCTGAAGGCCTACAAACCCATCTG
GCGTAATCCTGTCTGTGGCAATTTCCGTCAAGCTAAAATCTGCTCAATGCCACCACCTTCATCGGGGGGTGTGTTGCTAT
TGCAGATGTTAAATATTATTGGTGACACAGATTTAAAATCTTGGGGTTGGCATCATCCCAAGGCTCTGCATTTATTCACA
GAAGCAATGAAAATTGCCTACAGCGATCGCTCACAATATTTAGGCGACCCCGATTTTGTCAAAATTCCTCTACAAGCGCT
GCTTAGTCCTGCCTACGGCAAAAAGCGCCGTGCAGAAATTGATTTACACAGAGCCATACCCTCAACCCAAGTCAAACCCA
TCGCCCCACAAATTTTACAACGGTTCGGAAAAGCCGAGATTCCCCAAAGAATATATGCAAATCGCTATGAATCTCCCGAA
ACCAGCCATATAAGTGTCGTCGATAAAGAACGTAATGCAGTCAGCCTCACTTTTACAGTTAATTATGGTTTTGGTTCTGG
AGTGGTGGCATCGGGGACTGGTATTTTGCTCAACGATGAAATGGACGATTTTGCTGCTGCGCCAGGAGTTCCCAATGTAT
TCGGGTTAGTAGGAAGCGAAGCCAATGCGATCGCACCCCGCAAAACTCCCTTATCGAGTATGACACCGACTATCATCACC
GAGAACGAACGCCTCCGCATGGTAGTAGGTGCGCCTGGTGGTAGCACCATCATCACTCAAGTTTTGCAAATTATTCTCAA
TGTTTTAGAATACGATATGGATGTTGGTGCAGCCGTATCTGTCCCACGCATACATCACCAGTGGCTACCCGATGAGTTAC
GAGTAGAAACTTGGGGATTAGATGCGCTTACCCTACAAGACTTACGCCGACGCGGACATAACATCAAAGAAACTAATCCT
TGGGGCAATATTAATGCGATCGTTGTCACCAAAGAAGGCGACTTAGAAGGCGCAGCCGACCCACGCGGTGAAGGTTCTCC
TATAGCAAATGACCGTTTGTAG

Upstream 100 bases:

>100_bases
TCGGTGTATTTAGCTACTAAAATCTCCAAAAAATTGAAAGCAACTGGCGAGCATAGTAAAACTTAAGTCGCACAAAATAA
TCTCCGTTAAAGGTATAAAA

Downstream 100 bases:

>100_bases
GGTTTGGCAACACGTCTCAGTTAGTGAATTGGCTATCGGATGGCTATTCACTAACGAATGGAAACAATGGGACGTAGCAA
ACGCGGGACAGTTGGAATAG

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MPILAKSKLVVFTVFSLGVLCYNQIASATITLPLRSKKGMVVSAHPLASETGVAMLRKGGNAVDAAVATTFAISVVEPFS
AGIGGGGFLLMRSQKTGEIKALDFRERAPLKATRKMYLDDAGKVRPNASINGYLAVATPGTIAGMYEVHRRYGKLPWYEV
VKPAIALAKDGFVLAQKPTWRSIQVYGTRKQAILSNQAAREIFTRNGEFYQPGERLVQRDLARTLAEIAQNPQSFYTGDI
ARAIAADMAKNGGLVTLADLKAYKPIWRNPVCGNFRQAKICSMPPPSSGGVLLLQMLNIIGDTDLKSWGWHHPKALHLFT
EAMKIAYSDRSQYLGDPDFVKIPLQALLSPAYGKKRRAEIDLHRAIPSTQVKPIAPQILQRFGKAEIPQRIYANRYESPE
TSHISVVDKERNAVSLTFTVNYGFGSGVVASGTGILLNDEMDDFAAAPGVPNVFGLVGSEANAIAPRKTPLSSMTPTIIT
ENERLRMVVGAPGGSTIITQVLQIILNVLEYDMDVGAAVSVPRIHHQWLPDELRVETWGLDALTLQDLRRRGHNIKETNP
WGNINAIVVTKEGDLEGAADPRGEGSPIANDRL

Sequences:

>Translated_593_residues
MPILAKSKLVVFTVFSLGVLCYNQIASATITLPLRSKKGMVVSAHPLASETGVAMLRKGGNAVDAAVATTFAISVVEPFS
AGIGGGGFLLMRSQKTGEIKALDFRERAPLKATRKMYLDDAGKVRPNASINGYLAVATPGTIAGMYEVHRRYGKLPWYEV
VKPAIALAKDGFVLAQKPTWRSIQVYGTRKQAILSNQAAREIFTRNGEFYQPGERLVQRDLARTLAEIAQNPQSFYTGDI
ARAIAADMAKNGGLVTLADLKAYKPIWRNPVCGNFRQAKICSMPPPSSGGVLLLQMLNIIGDTDLKSWGWHHPKALHLFT
EAMKIAYSDRSQYLGDPDFVKIPLQALLSPAYGKKRRAEIDLHRAIPSTQVKPIAPQILQRFGKAEIPQRIYANRYESPE
TSHISVVDKERNAVSLTFTVNYGFGSGVVASGTGILLNDEMDDFAAAPGVPNVFGLVGSEANAIAPRKTPLSSMTPTIIT
ENERLRMVVGAPGGSTIITQVLQIILNVLEYDMDVGAAVSVPRIHHQWLPDELRVETWGLDALTLQDLRRRGHNIKETNP
WGNINAIVVTKEGDLEGAADPRGEGSPIANDRL
>Mature_592_residues
PILAKSKLVVFTVFSLGVLCYNQIASATITLPLRSKKGMVVSAHPLASETGVAMLRKGGNAVDAAVATTFAISVVEPFSA
GIGGGGFLLMRSQKTGEIKALDFRERAPLKATRKMYLDDAGKVRPNASINGYLAVATPGTIAGMYEVHRRYGKLPWYEVV
KPAIALAKDGFVLAQKPTWRSIQVYGTRKQAILSNQAAREIFTRNGEFYQPGERLVQRDLARTLAEIAQNPQSFYTGDIA
RAIAADMAKNGGLVTLADLKAYKPIWRNPVCGNFRQAKICSMPPPSSGGVLLLQMLNIIGDTDLKSWGWHHPKALHLFTE
AMKIAYSDRSQYLGDPDFVKIPLQALLSPAYGKKRRAEIDLHRAIPSTQVKPIAPQILQRFGKAEIPQRIYANRYESPET
SHISVVDKERNAVSLTFTVNYGFGSGVVASGTGILLNDEMDDFAAAPGVPNVFGLVGSEANAIAPRKTPLSSMTPTIITE
NERLRMVVGAPGGSTIITQVLQIILNVLEYDMDVGAAVSVPRIHHQWLPDELRVETWGLDALTLQDLRRRGHNIKETNPW
GNINAIVVTKEGDLEGAADPRGEGSPIANDRL

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=553, Percent_Identity=33.0922242314647, Blast_Score=249, Evalue=7e-66,
Organism=Homo sapiens, GI73915090, Length=553, Percent_Identity=33.0922242314647, Blast_Score=249, Evalue=7e-66,
Organism=Homo sapiens, GI73915096, Length=553, Percent_Identity=33.0922242314647, Blast_Score=249, Evalue=7e-66,
Organism=Homo sapiens, GI73915094, Length=553, Percent_Identity=33.0922242314647, Blast_Score=249, Evalue=7e-66,
Organism=Homo sapiens, GI113429324, Length=551, Percent_Identity=31.7604355716878, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI113429326, Length=556, Percent_Identity=31.6546762589928, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI109148539, Length=531, Percent_Identity=29.1902071563089, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI153266901, Length=498, Percent_Identity=29.5180722891566, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI153266885, Length=497, Percent_Identity=29.3762575452716, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI153266907, Length=497, Percent_Identity=27.9678068410463, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI30581157, Length=205, Percent_Identity=40.4878048780488, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI30581155, Length=205, Percent_Identity=40.4878048780488, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI218505805, Length=187, Percent_Identity=37.9679144385027, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI310124095, Length=203, Percent_Identity=33.4975369458128, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1789856, Length=553, Percent_Identity=46.8354430379747, Blast_Score=516, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI212646519, Length=518, Percent_Identity=35.3281853281853, Blast_Score=274, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI72000294, Length=518, Percent_Identity=35.3281853281853, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI193208245, Length=572, Percent_Identity=34.0909090909091, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI193208247, Length=572, Percent_Identity=34.0909090909091, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17506189, Length=573, Percent_Identity=33.3333333333333, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17542894, Length=599, Percent_Identity=32.220367278798, Blast_Score=239, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI72001495, Length=239, Percent_Identity=30.1255230125523, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI72001497, Length=239, Percent_Identity=30.1255230125523, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17564448, Length=455, Percent_Identity=23.2967032967033, Blast_Score=95, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6323330, Length=535, Percent_Identity=30.2803738317757, Blast_Score=183, Evalue=8e-47,
Organism=Drosophila melanogaster, GI161077878, Length=533, Percent_Identity=31.5196998123827, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI161077880, Length=533, Percent_Identity=31.5196998123827, Blast_Score=239, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24642670, Length=533, Percent_Identity=31.5196998123827, Blast_Score=239, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24642666, Length=533, Percent_Identity=31.5196998123827, Blast_Score=239, Evalue=5e-63,
Organism=Drosophila melanogaster, GI45551474, Length=533, Percent_Identity=31.5196998123827, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI18859893, Length=560, Percent_Identity=33.9285714285714, Blast_Score=228, Evalue=1e-59,
Organism=Drosophila melanogaster, GI161077496, Length=568, Percent_Identity=31.8661971830986, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI18859741, Length=541, Percent_Identity=28.0961182994455, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 64570; Mature: 64439

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPILAKSKLVVFTVFSLGVLCYNQIASATITLPLRSKKGMVVSAHPLASETGVAMLRKGG
CCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHCCC
NAVDAAVATTFAISVVEPFSAGIGGGGFLLMRSQKTGEIKALDFRERAPLKATRKMYLDD
CHHHHHHHHHHHHEEHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHCC
AGKVRPNASINGYLAVATPGTIAGMYEVHRRYGKLPWYEVVKPAIALAKDGFVLAQKPTW
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCC
RSIQVYGTRKQAILSNQAAREIFTRNGEFYQPGERLVQRDLARTLAEIAQNPQSFYTGDI
CEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ARAIAADMAKNGGLVTLADLKAYKPIWRNPVCGNFRQAKICSMPPPSSGGVLLLQMLNII
HHHHHHHHHCCCCEEEEECCHHCCHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHH
GDTDLKSWGWHHPKALHLFTEAMKIAYSDRSQYLGDPDFVKIPLQALLSPAYGKKRRAEI
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCEEEECHHHHCCCCCCCCCCCCC
DLHRAIPSTQVKPIAPQILQRFGKAEIPQRIYANRYESPETSHISVVDKERNAVSLTFTV
HHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEE
NYGFGSGVVASGTGILLNDEMDDFAAAPGVPNVFGLVGSEANAIAPRKTPLSSMTPTIIT
EECCCCCEEECCCEEEECCCCHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
ENERLRMVVGAPGGSTIITQVLQIILNVLEYDMDVGAAVSVPRIHHQWLPDELRVETWGL
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCCHHHEEEEECC
DALTLQDLRRRGHNIKETNPWGNINAIVVTKEGDLEGAADPRGEGSPIANDRL
CHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PILAKSKLVVFTVFSLGVLCYNQIASATITLPLRSKKGMVVSAHPLASETGVAMLRKGG
CCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHCCC
NAVDAAVATTFAISVVEPFSAGIGGGGFLLMRSQKTGEIKALDFRERAPLKATRKMYLDD
CHHHHHHHHHHHHEEHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHCC
AGKVRPNASINGYLAVATPGTIAGMYEVHRRYGKLPWYEVVKPAIALAKDGFVLAQKPTW
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCC
RSIQVYGTRKQAILSNQAAREIFTRNGEFYQPGERLVQRDLARTLAEIAQNPQSFYTGDI
CEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ARAIAADMAKNGGLVTLADLKAYKPIWRNPVCGNFRQAKICSMPPPSSGGVLLLQMLNII
HHHHHHHHHCCCCEEEEECCHHCCHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHH
GDTDLKSWGWHHPKALHLFTEAMKIAYSDRSQYLGDPDFVKIPLQALLSPAYGKKRRAEI
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCEEEECHHHHCCCCCCCCCCCCC
DLHRAIPSTQVKPIAPQILQRFGKAEIPQRIYANRYESPETSHISVVDKERNAVSLTFTV
HHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEE
NYGFGSGVVASGTGILLNDEMDDFAAAPGVPNVFGLVGSEANAIAPRKTPLSSMTPTIIT
EECCCCCEEECCCEEEECCCCHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
ENERLRMVVGAPGGSTIITQVLQIILNVLEYDMDVGAAVSVPRIHHQWLPDELRVETWGL
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCCHHHEEEEECC
DALTLQDLRRRGHNIKETNPWGNINAIVVTKEGDLEGAADPRGEGSPIANDRL
CHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]