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The map label for this gene is 75909190

Identifier: 75909190

GI number: 75909190

Start: 3697566

End: 3698525

Strand: Direct

Name: 75909190

Synonym: Ava_2981

Alternate gene names: NA

Gene position: 3697566-3698525 (Clockwise)

Preceding gene: 75909188

Following gene: 75909191

Centisome position: 58.09

GC content: 40.42

Gene sequence:

>960_bases
ATGAGTGAACGCAAGTATGCGATCGTGGGGACTGGTGCATTAGGCGGCTATTATGGTGCTAAATTGCAAAAAGCTGGTTC
GGATGTTCATTTTTTACTCAAACGTGACTACGGAAAAGTCAGTCAAGATGGTTTATTGGTAGAGTCTAAAGACGGCAACT
TTACCCTACCCCAAGTTAATGCTTATAGCGATGTGGCAAAGATGCCAAAATGTGACGTGGTAATCGTCGCCCTGAAAACT
ACACAAAATCATTTGCTACCAAAGTTATTACCATCTATTGTTAAAAATGATGGGATAGTTTTGGCATTACAAAATGGGCT
TGGTGTAGAAGAAGAAATTGCCGAGATTCTCCCTAAGGTTCACATAATTGGTGGGTTATGCTTTCTATGTTCTAATAAAG
TGGGTGCAGGGCATATTCATCACTTAGATTATGGACAAATTATTTTGGGTGAATATGCTCATGGGTATTCAAGTATGGGT
ATTACGGATAGGATGCAGCAAATAGCCCATGATTTTCAAGCTGCTGGTATTTCTATTGAATTAGTCGAAGACTTATTACT
GGGACGGTGGAAAAAACTGGTGTGGAATATTCCCTACAACGGGTTGTCTGTAGTTCTCAATGCCAGAACTGACGAATTAA
TGGCAGATACCTACACTCGTACATTAGTTGAACAATTAATGTATGAAGTCAAAGCAGGGGCAATTAGTATGGGGCGAAAT
CTTCCTGATAGTTTTATTCAAACCATGCTTGATTACACAGTAAAAATGAAGCCTTACCGCACCAGTATGAAAATCGACTA
TGATGAGTGCCGTCCCTTAGAAGTAGAAGCCATTGTTGGCAACCCATTACGCAAGGCTCAAGAAGTCGGTGTAAACTTAC
CGCAAATCAACTGTCTCTACCATCAACTCAAGTTTTTGGATGGGAGAAATAGGATTGGTCAGTTGACAGTTGACAGTTGA

Upstream 100 bases:

>100_bases
CAAAGTTTGTTTAAAAACATGACATTCAGATAATCCATATCTCAGCCGACTTGTGGAAGCTGTTCTATGATAATTATCGA
AAAATTCTGGCAGACAATTT

Downstream 100 bases:

>100_bases
TAGTTGTTATTCTCTTCAATCCCCAAGCCTGTGGCAAAATTTATTAGAGTCCTTCCAAACTGAAATTTCCCAGAATGACC
GCAACTATAACCAATCTTCC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSERKYAIVGTGALGGYYGAKLQKAGSDVHFLLKRDYGKVSQDGLLVESKDGNFTLPQVNAYSDVAKMPKCDVVIVALKT
TQNHLLPKLLPSIVKNDGIVLALQNGLGVEEEIAEILPKVHIIGGLCFLCSNKVGAGHIHHLDYGQIILGEYAHGYSSMG
ITDRMQQIAHDFQAAGISIELVEDLLLGRWKKLVWNIPYNGLSVVLNARTDELMADTYTRTLVEQLMYEVKAGAISMGRN
LPDSFIQTMLDYTVKMKPYRTSMKIDYDECRPLEVEAIVGNPLRKAQEVGVNLPQINCLYHQLKFLDGRNRIGQLTVDS

Sequences:

>Translated_319_residues
MSERKYAIVGTGALGGYYGAKLQKAGSDVHFLLKRDYGKVSQDGLLVESKDGNFTLPQVNAYSDVAKMPKCDVVIVALKT
TQNHLLPKLLPSIVKNDGIVLALQNGLGVEEEIAEILPKVHIIGGLCFLCSNKVGAGHIHHLDYGQIILGEYAHGYSSMG
ITDRMQQIAHDFQAAGISIELVEDLLLGRWKKLVWNIPYNGLSVVLNARTDELMADTYTRTLVEQLMYEVKAGAISMGRN
LPDSFIQTMLDYTVKMKPYRTSMKIDYDECRPLEVEAIVGNPLRKAQEVGVNLPQINCLYHQLKFLDGRNRIGQLTVDS
>Mature_318_residues
SERKYAIVGTGALGGYYGAKLQKAGSDVHFLLKRDYGKVSQDGLLVESKDGNFTLPQVNAYSDVAKMPKCDVVIVALKTT
QNHLLPKLLPSIVKNDGIVLALQNGLGVEEEIAEILPKVHIIGGLCFLCSNKVGAGHIHHLDYGQIILGEYAHGYSSMGI
TDRMQQIAHDFQAAGISIELVEDLLLGRWKKLVWNIPYNGLSVVLNARTDELMADTYTRTLVEQLMYEVKAGAISMGRNL
PDSFIQTMLDYTVKMKPYRTSMKIDYDECRPLEVEAIVGNPLRKAQEVGVNLPQINCLYHQLKFLDGRNRIGQLTVDS

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320057, Length=346, Percent_Identity=22.8323699421965, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 35367; Mature: 35235

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERKYAIVGTGALGGYYGAKLQKAGSDVHFLLKRDYGKVSQDGLLVESKDGNFTLPQVN
CCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCEECCCCC
AYSDVAKMPKCDVVIVALKTTQNHLLPKLLPSIVKNDGIVLALQNGLGVEEEIAEILPKV
CHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHH
HIIGGLCFLCSNKVGAGHIHHLDYGQIILGEYAHGYSSMGITDRMQQIAHDFQAAGISIE
HHHHHHHHHHCCCCCCCEEEECCCCCEEECHHHCCCCCCCHHHHHHHHHHHHHHCCCHHH
LVEDLLLGRWKKLVWNIPYNGLSVVLNARTDELMADTYTRTLVEQLMYEVKAGAISMGRN
HHHHHHHHHHHHHEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCC
LPDSFIQTMLDYTVKMKPYRTSMKIDYDECRPLEVEAIVGNPLRKAQEVGVNLPQINCLY
CCHHHHHHHHHHHEEECCCCCCEEECHHHCCCEEEEEECCCHHHHHHHHCCCCCHHHHHH
HQLKFLDGRNRIGQLTVDS
HHHHHHCCCCCCCEEEECC
>Mature Secondary Structure 
SERKYAIVGTGALGGYYGAKLQKAGSDVHFLLKRDYGKVSQDGLLVESKDGNFTLPQVN
CCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCEECCCCC
AYSDVAKMPKCDVVIVALKTTQNHLLPKLLPSIVKNDGIVLALQNGLGVEEEIAEILPKV
CHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHH
HIIGGLCFLCSNKVGAGHIHHLDYGQIILGEYAHGYSSMGITDRMQQIAHDFQAAGISIE
HHHHHHHHHHCCCCCCCEEEECCCCCEEECHHHCCCCCCCHHHHHHHHHHHHHHCCCHHH
LVEDLLLGRWKKLVWNIPYNGLSVVLNARTDELMADTYTRTLVEQLMYEVKAGAISMGRN
HHHHHHHHHHHHHEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCC
LPDSFIQTMLDYTVKMKPYRTSMKIDYDECRPLEVEAIVGNPLRKAQEVGVNLPQINCLY
CCHHHHHHHHHHHEEECCCCCCEEECHHHCCCEEEEEECCCHHHHHHHHCCCCCHHHHHH
HQLKFLDGRNRIGQLTVDS
HHHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]