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The map label for this gene is fac-dex [H]

Identifier: 75908853

GI number: 75908853

Start: 3268553

End: 3269137

Strand: Direct

Name: fac-dex [H]

Synonym: Ava_2640

Alternate gene names: 75908853

Gene position: 3268553-3269137 (Clockwise)

Preceding gene: 75908852

Following gene: 75908854

Centisome position: 51.35

GC content: 41.71

Gene sequence:

>585_bases
ATGTTCACCAACTTTGAACAAACCATAGTTGATACAACAGCAGCTCAAATCAATCTAGTCAAAGGAGGTCAAGGCGCGCC
ACTACTTTTATTACATGGCTATCCTCAAACCCATGTCATGTGGCATAAGATAGCACCTCTCTTAGCTGAAAACTTCACCG
TAGTCGCCACAGATTTAAGAGGATACGGTGACAGTTCCACACCCACCAGTACACCCAATCACATCAATTATTCCAAAAGG
GTGATGGCGCAAGATCAAGTCGAGGTCATGTCAAAGCTAGGATACGAAGAATTTTATGTCGTCGGCCATGACCGAGGAGC
GCGAGTTGCTCATCGTCTGGCGTTAGATTATCCTCATCGTGTCAAAAAACTAGCCTTACTAGATATTGCACCCACCCATA
AAATGTACAGGACAACCGATCAAGAATTTGCCACAGCTTATTATCATTGGTTCTTTTTGATTCAACCCGATAATTTACCA
GAAACCTTAATCGGAGCTAATCCCGAATATTATCTACGCAACTGTTTAGAAAAATGGGGTAAAGATTTTTCAGCTTTTCA
TCCTCAGAGGCTATTTATAAAGTAA

Upstream 100 bases:

>100_bases
CGACTGGATTACGCCACACCATCCAGTGGTATCTAACTCATCGCCATTGGTGGGAAGCACTTTTACCAAAGGAGTAGGTC
AAGATTATCAGGGAAAAATC

Downstream 100 bases:

>100_bases
ATCTAAAAGTGAGTATAAAAGTAAGCTTGGAGGTATAGGATACATGAAATATAGTGTATTTACATAGCTACTCATGGGAC
GAAAGTCTTACCCCACAGAC

Product: putative hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MFTNFEQTIVDTTAAQINLVKGGQGAPLLLLHGYPQTHVMWHKIAPLLAENFTVVATDLRGYGDSSTPTSTPNHINYSKR
VMAQDQVEVMSKLGYEEFYVVGHDRGARVAHRLALDYPHRVKKLALLDIAPTHKMYRTTDQEFATAYYHWFFLIQPDNLP
ETLIGANPEYYLRNCLEKWGKDFSAFHPQRLFIK

Sequences:

>Translated_194_residues
MFTNFEQTIVDTTAAQINLVKGGQGAPLLLLHGYPQTHVMWHKIAPLLAENFTVVATDLRGYGDSSTPTSTPNHINYSKR
VMAQDQVEVMSKLGYEEFYVVGHDRGARVAHRLALDYPHRVKKLALLDIAPTHKMYRTTDQEFATAYYHWFFLIQPDNLP
ETLIGANPEYYLRNCLEKWGKDFSAFHPQRLFIK
>Mature_194_residues
MFTNFEQTIVDTTAAQINLVKGGQGAPLLLLHGYPQTHVMWHKIAPLLAENFTVVATDLRGYGDSSTPTSTPNHINYSKR
VMAQDQVEVMSKLGYEEFYVVGHDRGARVAHRLALDYPHRVKKLALLDIAPTHKMYRTTDQEFATAYYHWFFLIQPDNLP
ETLIGANPEYYLRNCLEKWGKDFSAFHPQRLFIK

Specific function: Catalyzes the hydrolytic defluorination of fluoroacetate to produce glycolate. Has only very low activity towards chloroacetate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=151, Percent_Identity=31.7880794701987, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI27597073, Length=114, Percent_Identity=34.2105263157895, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI218777840, Length=187, Percent_Identity=28.3422459893048, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI13376164, Length=187, Percent_Identity=28.3422459893048, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17554012, Length=159, Percent_Identity=32.7044025157233, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324392, Length=105, Percent_Identity=34.2857142857143, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.3 [H]

Molecular weight: Translated: 22271; Mature: 22271

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTNFEQTIVDTTAAQINLVKGGQGAPLLLLHGYPQTHVMWHKIAPLLAENFTVVATDLR
CCCCHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECC
GYGDSSTPTSTPNHINYSKRVMAQDQVEVMSKLGYEEFYVVGHDRGARVAHRLALDYPHR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHH
VKKLALLDIAPTHKMYRTTDQEFATAYYHWFFLIQPDNLPETLIGANPEYYLRNCLEKWG
HHHHHEEECCCCCHHHHCCHHHHHEEEEEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHC
KDFSAFHPQRLFIK
CCCHHCCCEEEECC
>Mature Secondary Structure
MFTNFEQTIVDTTAAQINLVKGGQGAPLLLLHGYPQTHVMWHKIAPLLAENFTVVATDLR
CCCCHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECC
GYGDSSTPTSTPNHINYSKRVMAQDQVEVMSKLGYEEFYVVGHDRGARVAHRLALDYPHR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHH
VKKLALLDIAPTHKMYRTTDQEFATAYYHWFFLIQPDNLPETLIGANPEYYLRNCLEKWG
HHHHHEEECCCCCHHHHCCHHHHHEEEEEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHC
KDFSAFHPQRLFIK
CCCHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA