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The map label for this gene is menE [H]

Identifier: 75908849

GI number: 75908849

Start: 3262881

End: 3264272

Strand: Direct

Name: menE [H]

Synonym: Ava_2636

Alternate gene names: 75908849

Gene position: 3262881-3264272 (Clockwise)

Preceding gene: 75908848

Following gene: 75908852

Centisome position: 51.26

GC content: 39.3

Gene sequence:

>1392_bases
ATGGAACAACCCCTAGCCTATCTGAATCGCCTCACTTCCCATGATTGGCTGATTGGTTATGACAGCCGAGAGTTTCACCA
AAAAGCCACAGAACTGTACTTACAACTGAGTCAATTATCAACGCCAGAAACATCACCAAAAATTATCCTAGCCGAACGTG
AACCAGTAAACTTTCTCGCTAGTTTTATCGCCGCCTGTGCTGCTAATTGCCAAGTTTTTCTCTGTAACCCAGATTGGGGT
GAACAAGAATGGCATCAAGTATTTAATTTAGTACAACCCGATATTATTTTAGGCTTAGAAACTAAGGACAAATCAACTCA
AACCTCAACAACTACTACCCACTATCCAATCCCCAATTCCCACTCCCCACTCATCATGATTCCCACCGGTGGTTCATCGG
GACAAATTAAATTTGCCATTCACACTTGGGAAACCCTCACGGCTTCAGTGCAGGGATTTAGAGAATATTTTCACATCAAA
CAAGTTAATTCATATTGTATTTTACCTCTATATCATGTCAGTGGTTTAATGCAGTTTATGCGTTCTTTTACCACAGACGG
AAAGTTAGTAATTCAACCATTTAAATCATTAGAAAGCAGTCAAATATCCCCAATCAAACCTACAGAATTTTTCATATCTT
TAGTCCCGACACAATTACAACGCCTACTACAAAACTTAGAATTAACTACATGGTTATCCCAATTCAACACCGTACTTTTA
GGTGGTGCGCCAGCTTGGGATGAACTATTAGAAAAAGCCAAATTCCATAACATTCGATTAGCACCAACCTATGGAATGAC
AGAAACCGCCTCCCAAATTGCCACCCTCAAACCAGATGATTTTTTGAATGGTAAAATTAACAGTGGTCAAATTCTTCCCC
ATGCCCAAGTGACAATTTGTAATCAACAAGGGGAAGTTCTACCAGCAAATCACATAGGAAATATTACAATTCAAGCTCAA
TCTTTATCCCTTGGTTATTATCCTCAACTTGTGGAGAACCAAAATTATTTCCAAGTAGATGATTTAGGTTTTTTAGATGG
ACAAGGTTATCTAAACATTGTCGGCAGAAACAGCGACAAAATCATCACAGGTGGAGAAAACATCTACCCGATAGAAATAG
AATCAGCCATCCGCGCCACACAAATGGTAGCTGATGTTTGCGTAATTGGTATACCAGATCAGCAATGGGGACAAGCATTA
ACAGCAATTTATATTCCTAAAGACACCAATACATCTGTCAGTGAAATTAAAACTGCCATCTCCCATCAACTCAGCCGATT
TAAAATCCCCAAACATTGGATATCATTAGATACCTTACCCCGCAACCCTCAAGGTAAAATCAGTCGCCAACAACTACAAC
AAATAGCCCTGTTAAAAACAGAAACCAAGTAA

Upstream 100 bases:

>100_bases
CACTCCAACTAGCAGCAGAATTATCTCGTGACAACAGGGCTGTTGGTTTTGGCGTTAACCACTTTTTTTACCAAGAAGCA
GAAAACTGGCTGCAAAGTTT

Downstream 100 bases:

>100_bases
AAAAACTCCGCGTATCTTTGCGCCTCCCTCCGCGCCCCTCCGCGTTTAAAAACAATTTTCACCAAACCTCTACCTAACCA
GAAAACTCAGCCCGCAACTG

Product: O-succinylbenzoic acid--CoA ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MEQPLAYLNRLTSHDWLIGYDSREFHQKATELYLQLSQLSTPETSPKIILAEREPVNFLASFIAACAANCQVFLCNPDWG
EQEWHQVFNLVQPDIILGLETKDKSTQTSTTTTHYPIPNSHSPLIMIPTGGSSGQIKFAIHTWETLTASVQGFREYFHIK
QVNSYCILPLYHVSGLMQFMRSFTTDGKLVIQPFKSLESSQISPIKPTEFFISLVPTQLQRLLQNLELTTWLSQFNTVLL
GGAPAWDELLEKAKFHNIRLAPTYGMTETASQIATLKPDDFLNGKINSGQILPHAQVTICNQQGEVLPANHIGNITIQAQ
SLSLGYYPQLVENQNYFQVDDLGFLDGQGYLNIVGRNSDKIITGGENIYPIEIESAIRATQMVADVCVIGIPDQQWGQAL
TAIYIPKDTNTSVSEIKTAISHQLSRFKIPKHWISLDTLPRNPQGKISRQQLQQIALLKTETK

Sequences:

>Translated_463_residues
MEQPLAYLNRLTSHDWLIGYDSREFHQKATELYLQLSQLSTPETSPKIILAEREPVNFLASFIAACAANCQVFLCNPDWG
EQEWHQVFNLVQPDIILGLETKDKSTQTSTTTTHYPIPNSHSPLIMIPTGGSSGQIKFAIHTWETLTASVQGFREYFHIK
QVNSYCILPLYHVSGLMQFMRSFTTDGKLVIQPFKSLESSQISPIKPTEFFISLVPTQLQRLLQNLELTTWLSQFNTVLL
GGAPAWDELLEKAKFHNIRLAPTYGMTETASQIATLKPDDFLNGKINSGQILPHAQVTICNQQGEVLPANHIGNITIQAQ
SLSLGYYPQLVENQNYFQVDDLGFLDGQGYLNIVGRNSDKIITGGENIYPIEIESAIRATQMVADVCVIGIPDQQWGQAL
TAIYIPKDTNTSVSEIKTAISHQLSRFKIPKHWISLDTLPRNPQGKISRQQLQQIALLKTETK
>Mature_463_residues
MEQPLAYLNRLTSHDWLIGYDSREFHQKATELYLQLSQLSTPETSPKIILAEREPVNFLASFIAACAANCQVFLCNPDWG
EQEWHQVFNLVQPDIILGLETKDKSTQTSTTTTHYPIPNSHSPLIMIPTGGSSGQIKFAIHTWETLTASVQGFREYFHIK
QVNSYCILPLYHVSGLMQFMRSFTTDGKLVIQPFKSLESSQISPIKPTEFFISLVPTQLQRLLQNLELTTWLSQFNTVLL
GGAPAWDELLEKAKFHNIRLAPTYGMTETASQIATLKPDDFLNGKINSGQILPHAQVTICNQQGEVLPANHIGNITIQAQ
SLSLGYYPQLVENQNYFQVDDLGFLDGQGYLNIVGRNSDKIITGGENIYPIEIESAIRATQMVADVCVIGIPDQQWGQAL
TAIYIPKDTNTSVSEIKTAISHQLSRFKIPKHWISLDTLPRNPQGKISRQQLQQIALLKTETK

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=362, Percent_Identity=29.5580110497238, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI122937307, Length=256, Percent_Identity=26.5625, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI42544132, Length=265, Percent_Identity=26.0377358490566, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI115511026, Length=214, Percent_Identity=28.5046728971963, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI187761345, Length=385, Percent_Identity=25.7142857142857, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI187761343, Length=385, Percent_Identity=25.7142857142857, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI38505220, Length=260, Percent_Identity=26.1538461538462, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI157311624, Length=251, Percent_Identity=24.7011952191235, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI157311622, Length=251, Percent_Identity=24.7011952191235, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI27477105, Length=142, Percent_Identity=30.2816901408451, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788595, Length=335, Percent_Identity=30.7462686567164, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1788107, Length=350, Percent_Identity=26.2857142857143, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI145693145, Length=376, Percent_Identity=22.6063829787234, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI221142682, Length=206, Percent_Identity=29.126213592233, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786810, Length=457, Percent_Identity=22.9759299781182, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560308, Length=355, Percent_Identity=26.7605633802817, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17558820, Length=374, Percent_Identity=29.9465240641711, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI32563687, Length=345, Percent_Identity=27.8260869565217, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17557194, Length=301, Percent_Identity=26.9102990033223, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994703, Length=352, Percent_Identity=24.1477272727273, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71994694, Length=352, Percent_Identity=24.1477272727273, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71994690, Length=352, Percent_Identity=24.1477272727273, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=305, Percent_Identity=25.5737704918033, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17531443, Length=309, Percent_Identity=24.9190938511327, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=386, Percent_Identity=24.8704663212435, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=365, Percent_Identity=23.5616438356164, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=305, Percent_Identity=27.5409836065574, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24581924, Length=312, Percent_Identity=25.6410256410256, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18859661, Length=385, Percent_Identity=24.6753246753247, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24653035, Length=217, Percent_Identity=28.110599078341, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI161076582, Length=219, Percent_Identity=28.310502283105, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922652, Length=433, Percent_Identity=21.2471131639723, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355181, Length=493, Percent_Identity=21.7038539553753, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21356441, Length=266, Percent_Identity=26.6917293233083, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656500, Length=317, Percent_Identity=24.6056782334385, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648260, Length=264, Percent_Identity=26.1363636363636, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648253, Length=235, Percent_Identity=26.8085106382979, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648255, Length=235, Percent_Identity=27.2340425531915, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI20130357, Length=331, Percent_Identity=24.773413897281, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21356947, Length=244, Percent_Identity=25.4098360655738, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281365686, Length=236, Percent_Identity=25.8474576271186, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 51984; Mature: 51984

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQPLAYLNRLTSHDWLIGYDSREFHQKATELYLQLSQLSTPETSPKIILAEREPVNFLA
CCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHH
SFIAACAANCQVFLCNPDWGEQEWHQVFNLVQPDIILGLETKDKSTQTSTTTTHYPIPNS
HHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCC
HSPLIMIPTGGSSGQIKFAIHTWETLTASVQGFREYFHIKQVNSYCILPLYHVSGLMQFM
CCCEEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHH
RSFTTDGKLVIQPFKSLESSQISPIKPTEFFISLVPTQLQRLLQNLELTTWLSQFNTVLL
HHHCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
GGAPAWDELLEKAKFHNIRLAPTYGMTETASQIATLKPDDFLNGKINSGQILPHAQVTIC
CCCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHEECCCCCCCCCCCCCCEECCCCEEEEE
NQQGEVLPANHIGNITIQAQSLSLGYYPQLVENQNYFQVDDLGFLDGQGYLNIVGRNSDK
CCCCCEEECCCCCEEEEEEEEECCCCCHHHHCCCCCEEECCCEEECCCCEEEEEECCCCE
IITGGENIYPIEIESAIRATQMVADVCVIGIPDQQWGQALTAIYIPKDTNTSVSEIKTAI
EEECCCEEEEEEHHHHHHHHHHHHHHHEEECCCHHHCCEEEEEEECCCCCCCHHHHHHHH
SHQLSRFKIPKHWISLDTLPRNPQGKISRQQLQQIALLKTETK
HHHHHHCCCCHHHEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEQPLAYLNRLTSHDWLIGYDSREFHQKATELYLQLSQLSTPETSPKIILAEREPVNFLA
CCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHH
SFIAACAANCQVFLCNPDWGEQEWHQVFNLVQPDIILGLETKDKSTQTSTTTTHYPIPNS
HHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCC
HSPLIMIPTGGSSGQIKFAIHTWETLTASVQGFREYFHIKQVNSYCILPLYHVSGLMQFM
CCCEEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHH
RSFTTDGKLVIQPFKSLESSQISPIKPTEFFISLVPTQLQRLLQNLELTTWLSQFNTVLL
HHHCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
GGAPAWDELLEKAKFHNIRLAPTYGMTETASQIATLKPDDFLNGKINSGQILPHAQVTIC
CCCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHEECCCCCCCCCCCCCCEECCCCEEEEE
NQQGEVLPANHIGNITIQAQSLSLGYYPQLVENQNYFQVDDLGFLDGQGYLNIVGRNSDK
CCCCCEEECCCCCEEEEEEEEECCCCCHHHHCCCCCEEECCCEEECCCCEEEEEECCCCE
IITGGENIYPIEIESAIRATQMVADVCVIGIPDQQWGQALTAIYIPKDTNTSVSEIKTAI
EEECCCEEEEEEHHHHHHHHHHHHHHHEEECCCHHHCCEEEEEEECCCCCCCHHHHHHHH
SHQLSRFKIPKHWISLDTLPRNPQGKISRQQLQQIALLKTETK
HHHHHHCCCCHHHEEECCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA