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The map label for this gene is hhoB [H]

Identifier: 75908627

GI number: 75908627

Start: 2999314

End: 3000519

Strand: Direct

Name: hhoB [H]

Synonym: Ava_2411

Alternate gene names: 75908627

Gene position: 2999314-3000519 (Clockwise)

Preceding gene: 75908625

Following gene: 75908631

Centisome position: 47.12

GC content: 45.02

Gene sequence:

>1206_bases
ATGAATTTATCCCTAAAGCAACTGGCCGTTTATCTGTCTCTACTAGTAGTTGGTGGTAGTGCAGGTTTGTTAGGCAGTCG
CTATCTCCTCCCACAAAATCGCTCGTTCCAACAACTCAAAAATGTCACAGTCGGTTTGCCTTCGGAATCTGTAGCGTCTA
ATCCTGTCATAGGTTCTGCGGCAAATAATGGGGGGGATAATGTCAATTTTATTGCTAGTGCTGTGCAGAAAGTTGGCCCG
GCTGTAGTGCGAATTAATGCCACCCGTAAAGTTGCCAATCCTATCTCTGATGTTTTAAAGAATCCTCTATTACGTCGATT
TTTCGGTGAAGATGAACAGCCAATTCCGCAAGAACGAATTGAGCGGGGTACAGGTTCGGGGTTTATTTTGAGTGAAGATG
GGCAACTACTAACTAATGCCCATGTCGTAGCTGATACAGACACCGTACAAGTAACTCTTAAGGATGGTCGGACTTTTGAG
GGGAAGGTACTGGGAGTTGACCAGATTACAGATGTAGCTGTTGTCAAAATCCCTGGAAGAAACTTGCCGACAGTGAACTT
GGGGAATTCGCAAAACCTCATTCCAGGACAATGGGCGATCGCTATTGGCAATCCTCTCGGTTTAGATAATACTGTCACTA
TCGGCATTATCAGCGCCACCGACCGCACCAGCGCCCAAGTTGGAGTTCCCGATAAGCGAGTCAGCTTTATTCAAACCGAT
GCAGCAATCAACCCCGGTAATTCTGGCGGGCCTTTATTAAACGCTCAAGGGGAAGTAATTGGCGTTAACACTGCTATTCG
TGCAGATGCTCAAGGTCTTGGCTTTGCCATTCCCATAGAAACAGCTGCCCGTGTCGCTAATGAGCTTTTTACTAAGGGGA
GTGTACAACATCCGTTTTTAGGGATTGAAATGACAGACTTGTCCCCTAGCAAAAAACAGCAAATTAATATTGAAAACAAG
TTAAATATTCGACAAGACACTGGGGTGGTAATTAAAGGTGTCTTGGATGATTCTCCAGCCAAAGAAGCAGGCTTGCTCCC
TGGTGATGTGATTCAAAAAATTAACGGTAAAACAGTGAAAACATCAGCCCAGGTACAAAAATCGGTGGAATCCAGCACAG
TTGGAGATATTCTAACCGTCGAAGTTAACCGCAGTGGTGAAATTCTCACCTTAAAGGTTCAGTCGGGAGTTTATCCCAAC
AGATAG

Upstream 100 bases:

>100_bases
CAAAAAAGCAACTCTATGTTAAATTTATCTGTCCAGTTAGGAGTTGCTTGACTACACTTAGAAATTAGCAACTGCATTGC
TGTCCTTGAGCGTAGTCATT

Downstream 100 bases:

>100_bases
CTAGTGGTCAGTGGTCAGATGTCAGTTGTGATTGCTTTTGCAACTGACTACTAGCTATTAACAAATGACACTTAGCCATT
AGACAAATGATCTAACTGCA

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MNLSLKQLAVYLSLLVVGGSAGLLGSRYLLPQNRSFQQLKNVTVGLPSESVASNPVIGSAANNGGDNVNFIASAVQKVGP
AVVRINATRKVANPISDVLKNPLLRRFFGEDEQPIPQERIERGTGSGFILSEDGQLLTNAHVVADTDTVQVTLKDGRTFE
GKVLGVDQITDVAVVKIPGRNLPTVNLGNSQNLIPGQWAIAIGNPLGLDNTVTIGIISATDRTSAQVGVPDKRVSFIQTD
AAINPGNSGGPLLNAQGEVIGVNTAIRADAQGLGFAIPIETAARVANELFTKGSVQHPFLGIEMTDLSPSKKQQINIENK
LNIRQDTGVVIKGVLDDSPAKEAGLLPGDVIQKINGKTVKTSAQVQKSVESSTVGDILTVEVNRSGEILTLKVQSGVYPN
R

Sequences:

>Translated_401_residues
MNLSLKQLAVYLSLLVVGGSAGLLGSRYLLPQNRSFQQLKNVTVGLPSESVASNPVIGSAANNGGDNVNFIASAVQKVGP
AVVRINATRKVANPISDVLKNPLLRRFFGEDEQPIPQERIERGTGSGFILSEDGQLLTNAHVVADTDTVQVTLKDGRTFE
GKVLGVDQITDVAVVKIPGRNLPTVNLGNSQNLIPGQWAIAIGNPLGLDNTVTIGIISATDRTSAQVGVPDKRVSFIQTD
AAINPGNSGGPLLNAQGEVIGVNTAIRADAQGLGFAIPIETAARVANELFTKGSVQHPFLGIEMTDLSPSKKQQINIENK
LNIRQDTGVVIKGVLDDSPAKEAGLLPGDVIQKINGKTVKTSAQVQKSVESSTVGDILTVEVNRSGEILTLKVQSGVYPN
R
>Mature_401_residues
MNLSLKQLAVYLSLLVVGGSAGLLGSRYLLPQNRSFQQLKNVTVGLPSESVASNPVIGSAANNGGDNVNFIASAVQKVGP
AVVRINATRKVANPISDVLKNPLLRRFFGEDEQPIPQERIERGTGSGFILSEDGQLLTNAHVVADTDTVQVTLKDGRTFE
GKVLGVDQITDVAVVKIPGRNLPTVNLGNSQNLIPGQWAIAIGNPLGLDNTVTIGIISATDRTSAQVGVPDKRVSFIQTD
AAINPGNSGGPLLNAQGEVIGVNTAIRADAQGLGFAIPIETAARVANELFTKGSVQHPFLGIEMTDLSPSKKQQINIENK
LNIRQDTGVVIKGVLDDSPAKEAGLLPGDVIQKINGKTVKTSAQVQKSVESSTVGDILTVEVNRSGEILTLKVQSGVYPN
R

Specific function: A putative protease, its function overlaps that of the related putative proteases HtrA and HhoA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=331, Percent_Identity=37.7643504531722, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI22129776, Length=334, Percent_Identity=35.9281437125749, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI7019477, Length=332, Percent_Identity=39.4578313253012, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI24308541, Length=333, Percent_Identity=34.5345345345345, Blast_Score=171, Evalue=8e-43,
Organism=Escherichia coli, GI1789629, Length=331, Percent_Identity=35.6495468277946, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1786356, Length=351, Percent_Identity=33.9031339031339, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1789630, Length=285, Percent_Identity=36.8421052631579, Blast_Score=161, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24646839, Length=332, Percent_Identity=38.5542168674699, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42207; Mature: 42207

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSLKQLAVYLSLLVVGGSAGLLGSRYLLPQNRSFQQLKNVTVGLPSESVASNPVIGSA
CCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHCCEEECCCCHHCCCCCEECC
ANNGGDNVNFIASAVQKVGPAVVRINATRKVANPISDVLKNPLLRRFFGEDEQPIPQERI
CCCCCCCHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
ERGTGSGFILSEDGQLLTNAHVVADTDTVQVTLKDGRTFEGKVLGVDQITDVAVVKIPGR
HCCCCCEEEECCCCCEEECEEEEECCCEEEEEEECCCEECCEEEECCCCCCEEEEEECCC
NLPTVNLGNSQNLIPGQWAIAIGNPLGLDNTVTIGIISATDRTSAQVGVPDKRVSFIQTD
CCCEEECCCCCCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCHHEEEEEEC
AAINPGNSGGPLLNAQGEVIGVNTAIRADAQGLGFAIPIETAARVANELFTKGSVQHPFL
CCCCCCCCCCCEEECCCCEEEECEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCEE
GIEMTDLSPSKKQQINIENKLNIRQDTGVVIKGVLDDSPAKEAGLLPGDVIQKINGKTVK
EEEEECCCCCCHHEECCCCCEEEECCCCEEEEEEECCCCCHHCCCCCHHHHHHCCCCEEE
TSAQVQKSVESSTVGDILTVEVNRSGEILTLKVQSGVYPNR
HHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MNLSLKQLAVYLSLLVVGGSAGLLGSRYLLPQNRSFQQLKNVTVGLPSESVASNPVIGSA
CCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHCCEEECCCCHHCCCCCEECC
ANNGGDNVNFIASAVQKVGPAVVRINATRKVANPISDVLKNPLLRRFFGEDEQPIPQERI
CCCCCCCHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
ERGTGSGFILSEDGQLLTNAHVVADTDTVQVTLKDGRTFEGKVLGVDQITDVAVVKIPGR
HCCCCCEEEECCCCCEEECEEEEECCCEEEEEEECCCEECCEEEECCCCCCEEEEEECCC
NLPTVNLGNSQNLIPGQWAIAIGNPLGLDNTVTIGIISATDRTSAQVGVPDKRVSFIQTD
CCCEEECCCCCCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCHHEEEEEEC
AAINPGNSGGPLLNAQGEVIGVNTAIRADAQGLGFAIPIETAARVANELFTKGSVQHPFL
CCCCCCCCCCCEEECCCCEEEECEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCEE
GIEMTDLSPSKKQQINIENKLNIRQDTGVVIKGVLDDSPAKEAGLLPGDVIQKINGKTVK
EEEEECCCCCCHHEECCCCCEEEECCCCEEEEEEECCCCCHHCCCCCHHHHHHCCCCEEE
TSAQVQKSVESSTVGDILTVEVNRSGEILTLKVQSGVYPNR
HHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]