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The map label for this gene is ndhD2

Identifier: 75908525

GI number: 75908525

Start: 2868142

End: 2869827

Strand: Direct

Name: ndhD2

Synonym: Ava_2308

Alternate gene names: 75908525

Gene position: 2868142-2869827 (Clockwise)

Preceding gene: 75908524

Following gene: 75908526

Centisome position: 45.06

GC content: 45.26

Gene sequence:

>1686_bases
ATGATGGCGGATGGATTTCCTTGGCTGACCGCGATTATATTACTACCACTCGTTGCTTCTGCATTTATTCCCCTGCTGCC
TGATAAAGAAGGTAAGCTCGTGCGATGGTATGCCTTGGGTGTAGGAATCGCGGATTTTGTTTTGATGTGCTATACCTTTT
GGCACCATTACGATGCAAGCAGTGCGACTTTTCAACTAGTGGAGAAATATGATTGGGTACCTCAGATAGGTTTTAGCTGG
GCGGTCTCAGTCGATGGAATATCCATGCCACTAGTGTTGCTGGCAGGATTTGTGACGACCCTTTCTATGTTGGCTGCATG
GCAAGTTAATCTCAAGCCTCGCCTGTTTTATTTCTTAATGTTGGTGTTGTATTCTGCCCAAATCGGGGTATTTGTCGCCC
AAGATTTGCTGTTATTCTTCATTATGTGGGAACTGGAATTGGTTCCTGTTTACTTGCTTGTCTCGATTTGGGGCGGACAG
AAACGCCGCTACGCTGCGACAAAGTTCTTGCTTTATACAGCAGCAGCTTCAATTTTCATCTTAATCGCTGGGCTGGCAAT
GGCTCTCCACGGCGATAATACTACTTTCGATATTGTCGAACTCGGTGCGAAAAACTATCCTCTGGCTTTAGAGTTATTAC
TTTATGCTGGATTACTAATTGCCTTTGGTGTGAAGCTGGCAATTTTTCCCTTACACACCTGGTTGCCTGATGCCCACGGT
GAAGCTTCAGCACCTGTATCGATGATTTTGGCAGGGGTGCTTCTAAAAATGGGTGGTTACGGACTAATTCGCCTGAATTT
GGAATTACTGCCAGACGCTCATATTTACTTTGCTCCAGTGTTAGCAACTTTGGGTGTAATCAATATTATCTATGGCGGTT
TGAACTCCTTTGCTCAAACTCATATGAAGCGCCGCCTTGCTTATTCTTCCGTTTCCCACATGGGGTTTGTGCTGCTGGGT
ATTGCCTCTTTCACCGATGTGGGTGTGAGTGGTGCTATGCTGCAAATGCTTTCACACGGTTTGATTGCGGCGGTGTTGTT
CTTCTTGGCTGGTGTAACATACGATCGCACCCATACAATGGCGATGGATAATTTGGGTGGTATCGGTCAAGCTATGCCCA
AAGTGTTCGCTTTGTTTACCGCCGGCACAATGGCATCTTTGGCACTTCCAGGAATGAGTGGCTTTGTCAGCGAACTTAAG
GTGTTTATTGGTGTTACCACTAGCGACATTTACAGTCCGACATTCTGCACCGTTATGGTATTCCTCGCCGCAGTAGGAGT
TATCTTAACGCCGATTTATCTACTGTCTATGTTGAGACAAGTATTTTACGGCACTGGTGCAGAACTCAGTTGCAATATTA
ACAATGGTGCTTACGAGAACCAGGAAGATGAAGGAACAGCTTGCTTTGGTACAGACTGTCTCTTACCAGGGGAAGCTGTA
TACAGAGATGCCAGTATCCGGGAAGTATTTATTGCTGCGTCCTTCTTGGTGTTGATTATTGGTGTAGGTGTCTATCCTAA
AATCGCTACGCAACTTTACGATGTGAAAACCGTAGCAGTTAATACTCAGGTACGCCAATCCTATACCCAAATTGCCCAAA
GCAATCCTCAGATATATGCTAAAGGTTTCTTTGCTCCCAAAATTGTAGAGCCTGAAGTCATGGCGGTTTCGGGAATGATC
AAATAA

Upstream 100 bases:

>100_bases
ACTTCTATCAATAGAAAACTGCGGTAAATATTTATAAGAAAAAGTTTACAAAGTTTAATAGAATAGATTCATTCACCAAT
AAGTATTTTTGCTTAATAAC

Downstream 100 bases:

>100_bases
TCCCATCATTTAGATAATAAGTTAGGCGATCGCTTCTTTGTGGGGCGATCGTTTTTTCTTTGGTTTTATTGATAATTCGG
CTCTTAAAATAAAGATAAAC

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 2; NDH-1, chain 4 2

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MMADGFPWLTAIILLPLVASAFIPLLPDKEGKLVRWYALGVGIADFVLMCYTFWHHYDASSATFQLVEKYDWVPQIGFSW
AVSVDGISMPLVLLAGFVTTLSMLAAWQVNLKPRLFYFLMLVLYSAQIGVFVAQDLLLFFIMWELELVPVYLLVSIWGGQ
KRRYAATKFLLYTAAASIFILIAGLAMALHGDNTTFDIVELGAKNYPLALELLLYAGLLIAFGVKLAIFPLHTWLPDAHG
EASAPVSMILAGVLLKMGGYGLIRLNLELLPDAHIYFAPVLATLGVINIIYGGLNSFAQTHMKRRLAYSSVSHMGFVLLG
IASFTDVGVSGAMLQMLSHGLIAAVLFFLAGVTYDRTHTMAMDNLGGIGQAMPKVFALFTAGTMASLALPGMSGFVSELK
VFIGVTTSDIYSPTFCTVMVFLAAVGVILTPIYLLSMLRQVFYGTGAELSCNINNGAYENQEDEGTACFGTDCLLPGEAV
YRDASIREVFIAASFLVLIIGVGVYPKIATQLYDVKTVAVNTQVRQSYTQIAQSNPQIYAKGFFAPKIVEPEVMAVSGMI
K

Sequences:

>Translated_561_residues
MMADGFPWLTAIILLPLVASAFIPLLPDKEGKLVRWYALGVGIADFVLMCYTFWHHYDASSATFQLVEKYDWVPQIGFSW
AVSVDGISMPLVLLAGFVTTLSMLAAWQVNLKPRLFYFLMLVLYSAQIGVFVAQDLLLFFIMWELELVPVYLLVSIWGGQ
KRRYAATKFLLYTAAASIFILIAGLAMALHGDNTTFDIVELGAKNYPLALELLLYAGLLIAFGVKLAIFPLHTWLPDAHG
EASAPVSMILAGVLLKMGGYGLIRLNLELLPDAHIYFAPVLATLGVINIIYGGLNSFAQTHMKRRLAYSSVSHMGFVLLG
IASFTDVGVSGAMLQMLSHGLIAAVLFFLAGVTYDRTHTMAMDNLGGIGQAMPKVFALFTAGTMASLALPGMSGFVSELK
VFIGVTTSDIYSPTFCTVMVFLAAVGVILTPIYLLSMLRQVFYGTGAELSCNINNGAYENQEDEGTACFGTDCLLPGEAV
YRDASIREVFIAASFLVLIIGVGVYPKIATQLYDVKTVAVNTQVRQSYTQIAQSNPQIYAKGFFAPKIVEPEVMAVSGMI
K
>Mature_561_residues
MMADGFPWLTAIILLPLVASAFIPLLPDKEGKLVRWYALGVGIADFVLMCYTFWHHYDASSATFQLVEKYDWVPQIGFSW
AVSVDGISMPLVLLAGFVTTLSMLAAWQVNLKPRLFYFLMLVLYSAQIGVFVAQDLLLFFIMWELELVPVYLLVSIWGGQ
KRRYAATKFLLYTAAASIFILIAGLAMALHGDNTTFDIVELGAKNYPLALELLLYAGLLIAFGVKLAIFPLHTWLPDAHG
EASAPVSMILAGVLLKMGGYGLIRLNLELLPDAHIYFAPVLATLGVINIIYGGLNSFAQTHMKRRLAYSSVSHMGFVLLG
IASFTDVGVSGAMLQMLSHGLIAAVLFFLAGVTYDRTHTMAMDNLGGIGQAMPKVFALFTAGTMASLALPGMSGFVSELK
VFIGVTTSDIYSPTFCTVMVFLAAVGVILTPIYLLSMLRQVFYGTGAELSCNINNGAYENQEDEGTACFGTDCLLPGEAV
YRDASIREVFIAASFLVLIIGVGVYPKIATQLYDVKTVAVNTQVRQSYTQIAQSNPQIYAKGFFAPKIVEPEVMAVSGMI
K

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family

Homologues:

Organism=Homo sapiens, GI251831116, Length=348, Percent_Identity=33.0459770114943, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI251831117, Length=349, Percent_Identity=26.3610315186246, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1788613, Length=517, Percent_Identity=36.5570599613153, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1788827, Length=294, Percent_Identity=27.891156462585, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788831, Length=190, Percent_Identity=34.7368421052632, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788614, Length=389, Percent_Identity=27.5064267352185, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI2367154, Length=292, Percent_Identity=27.3972602739726, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693160, Length=250, Percent_Identity=34.8, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788829, Length=304, Percent_Identity=25.9868421052632, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU4C2_ANAVT (Q3MAR0)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_322821.1
- STRING:   Q3MAR0
- GeneID:   3678916
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_2308
- NMPDR:   fig|240292.3.peg.188
- eggNOG:   COG1008
- HOGENOM:   HBG643593
- OMA:   WIERFHI
- PhylomeDB:   Q3MAR0
- ProtClustDB:   PRK12561
- BioCyc:   AVAR240292:AVA_2308-MONOMER
- HAMAP:   MF_00491
- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- PRINTS:   PR01437
- TIGRFAMs:   TIGR01972

Pfam domain/function: PF00361 Oxidored_q1

EC number: 1.6.5.3

Molecular weight: Translated: 61064; Mature: 61064

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10bb80e4)-; HASH(0xf83e4f0)-; HASH(0x109ce748)-; HASH(0x1004ab34)-; HASH(0x10c12e9c)-; HASH(0xc90f3bc)-; HASH(0x100d08b4)-; HASH(0x10f26e4c)-; HASH(0x10a40778)-; HASH(0x102387e0)-; HASH(0x10db5960)-; HASH(0x10f26e94)-; HASH(0xfa60070)-; HASH(0x10f26eb8)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMADGFPWLTAIILLPLVASAFIPLLPDKEGKLVRWYALGVGIADFVLMCYTFWHHYDAS
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCC
SATFQLVEKYDWVPQIGFSWAVSVDGISMPLVLLAGFVTTLSMLAAWQVNLKPRLFYFLM
HHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LVLYSAQIGVFVAQDLLLFFIMWELELVPVYLLVSIWGGQKRRYAATKFLLYTAAASIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LIAGLAMALHGDNTTFDIVELGAKNYPLALELLLYAGLLIAFGVKLAIFPLHTWLPDAHG
HHHHHHHHCCCCCCEEEHEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCC
EASAPVSMILAGVLLKMGGYGLIRLNLELLPDAHIYFAPVLATLGVINIIYGGLNSFAQT
CCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMKRRLAYSSVSHMGFVLLGIASFTDVGVSGAMLQMLSHGLIAAVLFFLAGVTYDRTHTM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
AMDNLGGIGQAMPKVFALFTAGTMASLALPGMSGFVSELKVFIGVTTSDIYSPTFCTVMV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHH
FLAAVGVILTPIYLLSMLRQVFYGTGAELSCNINNGAYENQEDEGTACFGTDCLLPGEAV
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHH
YRDASIREVFIAASFLVLIIGVGVYPKIATQLYDVKTVAVNTQVRQSYTQIAQSNPQIYA
HCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEECHHHHHHHHHHHHCCCCEEE
KGFFAPKIVEPEVMAVSGMIK
ECCCCCCCCCCHHHHHCCCCH
>Mature Secondary Structure
MMADGFPWLTAIILLPLVASAFIPLLPDKEGKLVRWYALGVGIADFVLMCYTFWHHYDAS
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCC
SATFQLVEKYDWVPQIGFSWAVSVDGISMPLVLLAGFVTTLSMLAAWQVNLKPRLFYFLM
HHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LVLYSAQIGVFVAQDLLLFFIMWELELVPVYLLVSIWGGQKRRYAATKFLLYTAAASIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LIAGLAMALHGDNTTFDIVELGAKNYPLALELLLYAGLLIAFGVKLAIFPLHTWLPDAHG
HHHHHHHHCCCCCCEEEHEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCC
EASAPVSMILAGVLLKMGGYGLIRLNLELLPDAHIYFAPVLATLGVINIIYGGLNSFAQT
CCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMKRRLAYSSVSHMGFVLLGIASFTDVGVSGAMLQMLSHGLIAAVLFFLAGVTYDRTHTM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
AMDNLGGIGQAMPKVFALFTAGTMASLALPGMSGFVSELKVFIGVTTSDIYSPTFCTVMV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHH
FLAAVGVILTPIYLLSMLRQVFYGTGAELSCNINNGAYENQEDEGTACFGTDCLLPGEAV
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHH
YRDASIREVFIAASFLVLIIGVGVYPKIATQLYDVKTVAVNTQVRQSYTQIAQSNPQIYA
HCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEECHHHHHHHHHHHHCCCCEEE
KGFFAPKIVEPEVMAVSGMIK
ECCCCCCCCCCHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA