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The map label for this gene is zraS [C]

Identifier: 75908371

GI number: 75908371

Start: 2663607

End: 2664635

Strand: Direct

Name: zraS [C]

Synonym: Ava_2152

Alternate gene names: 75908371

Gene position: 2663607-2664635 (Clockwise)

Preceding gene: 75908370

Following gene: 75908377

Centisome position: 41.84

GC content: 35.08

Gene sequence:

>1029_bases
ATGAATTGTGAACAAGAAATCCAGAGGCTGGAAAAAGCTAATAGAATCCTTCAGAAAAAATTAATTCGTTCAGAGGTTGA
TAGAGTTAGGTTAGAGGAAACTAACAGCAAAAAGGAAACTTTGCTTAAGAATGTAATTAATGAATTAAAGCAATCACAAA
TTCAATTAGAAGACAGGAGGCATGAATTAGAGAAAACCCTGTTTAATCTTCAGACAATGCAGGATAAAATGTCTGCCTTA
GGTAGTATGGTTGCAGATGTAGCTCACGAAATTAATAATCCTGTGGGATTTATCATGGGGAATTTGAACCCAGCATTTGA
GTATATTCATGAGTTATTCCGTCTGCTTGACTTGTATCAGCAATATTACCCCGAACCATGCCCAGAAATCCAGGCAGAAA
TGACAGCAATGGATTATGAATATGTGCGTGAGGATTTGCCTAAACTTATTTCCTCAATGAAAGAAGGAACTGATCGCATT
AGCAAGCTTAGTAATAGTTTACGGACTTTTTCCCGAACAGATGCAGAATATAAATTGCTTTTTAATATTCATGAAGGGAT
TGACAGTACTCTTTATATTCTTCAGCATCGTTTAAAGGCTACTCAAGACCGTCCACAAATTCAAGTAGTTAAAAAGTATG
CGGATATTCCTTTAATTGAATGTTTTCCCGGTCAATTGAATCAGGTGTTTATGAATCTTTTAGCTAATGCTATAGATGCG
TTGGAAGAGTCTAATTTTGGGTTAAGTTTTGCGGAGATTGAGCAAAAAAACAATCAAATTACGATTATCACTAGTTTATT
CGCCAATTCTATTTTAATTCAGGTTCAAGATAATGGTTTTGGGATATCAAATGAATTAAAATCAAAGATATTTGAACATT
CATTTACTACTAAACCTGTTGGTAAAGGTACAGGATTAGGGTTAGCGATCGCTCAACAAATTATTGTTCAAAAACATGGT
GGAAGGCTGGAGGTTAATTCAGTTCCAGGAGAGGGTTCGGAATTTATTATTACCCTTCCTATCGAATGA

Upstream 100 bases:

>100_bases
TGGAGAAATTTCCCCTATAAAACCAACAGGTGAAACACATTTTCATAATGAAACTTTTGTCACTTTAATTTTAGGAACTC
ATTAATAATTTAAGGATTGT

Downstream 100 bases:

>100_bases
TTTAAAAAAAATATCCCCGACTTTTGGGAAAAATCGGGGATAAATGGATTGAGATAGAGCTTACAAACCCTCTGATTTCT
CAGCAGGAATAGCACTTACC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MNCEQEIQRLEKANRILQKKLIRSEVDRVRLEETNSKKETLLKNVINELKQSQIQLEDRRHELEKTLFNLQTMQDKMSAL
GSMVADVAHEINNPVGFIMGNLNPAFEYIHELFRLLDLYQQYYPEPCPEIQAEMTAMDYEYVREDLPKLISSMKEGTDRI
SKLSNSLRTFSRTDAEYKLLFNIHEGIDSTLYILQHRLKATQDRPQIQVVKKYADIPLIECFPGQLNQVFMNLLANAIDA
LEESNFGLSFAEIEQKNNQITIITSLFANSILIQVQDNGFGISNELKSKIFEHSFTTKPVGKGTGLGLAIAQQIIVQKHG
GRLEVNSVPGEGSEFIITLPIE

Sequences:

>Translated_342_residues
MNCEQEIQRLEKANRILQKKLIRSEVDRVRLEETNSKKETLLKNVINELKQSQIQLEDRRHELEKTLFNLQTMQDKMSAL
GSMVADVAHEINNPVGFIMGNLNPAFEYIHELFRLLDLYQQYYPEPCPEIQAEMTAMDYEYVREDLPKLISSMKEGTDRI
SKLSNSLRTFSRTDAEYKLLFNIHEGIDSTLYILQHRLKATQDRPQIQVVKKYADIPLIECFPGQLNQVFMNLLANAIDA
LEESNFGLSFAEIEQKNNQITIITSLFANSILIQVQDNGFGISNELKSKIFEHSFTTKPVGKGTGLGLAIAQQIIVQKHG
GRLEVNSVPGEGSEFIITLPIE
>Mature_342_residues
MNCEQEIQRLEKANRILQKKLIRSEVDRVRLEETNSKKETLLKNVINELKQSQIQLEDRRHELEKTLFNLQTMQDKMSAL
GSMVADVAHEINNPVGFIMGNLNPAFEYIHELFRLLDLYQQYYPEPCPEIQAEMTAMDYEYVREDLPKLISSMKEGTDRI
SKLSNSLRTFSRTDAEYKLLFNIHEGIDSTLYILQHRLKATQDRPQIQVVKKYADIPLIECFPGQLNQVFMNLLANAIDA
LEESNFGLSFAEIEQKNNQITIITSLFANSILIQVQDNGFGISNELKSKIFEHSFTTKPVGKGTGLGLAIAQQIIVQKHG
GRLEVNSVPGEGSEFIITLPIE

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=271, Percent_Identity=26.5682656826568, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788549, Length=268, Percent_Identity=29.1044776119403, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790300, Length=263, Percent_Identity=25.8555133079848, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39076; Mature: 39076

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCEQEIQRLEKANRILQKKLIRSEVDRVRLEETNSKKETLLKNVINELKQSQIQLEDRR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
HELEKTLFNLQTMQDKMSALGSMVADVAHEINNPVGFIMGNLNPAFEYIHELFRLLDLYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHH
QYYPEPCPEIQAEMTAMDYEYVREDLPKLISSMKEGTDRISKLSNSLRTFSRTDAEYKLL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
FNIHEGIDSTLYILQHRLKATQDRPQIQVVKKYADIPLIECFPGQLNQVFMNLLANAIDA
EEHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
LEESNFGLSFAEIEQKNNQITIITSLFANSILIQVQDNGFGISNELKSKIFEHSFTTKPV
HHHCCCCCCHHHHHHCCCEEEEEHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
GKGTGLGLAIAQQIIVQKHGGRLEVNSVPGEGSEFIITLPIE
CCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCC
>Mature Secondary Structure
MNCEQEIQRLEKANRILQKKLIRSEVDRVRLEETNSKKETLLKNVINELKQSQIQLEDRR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
HELEKTLFNLQTMQDKMSALGSMVADVAHEINNPVGFIMGNLNPAFEYIHELFRLLDLYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHH
QYYPEPCPEIQAEMTAMDYEYVREDLPKLISSMKEGTDRISKLSNSLRTFSRTDAEYKLL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
FNIHEGIDSTLYILQHRLKATQDRPQIQVVKKYADIPLIECFPGQLNQVFMNLLANAIDA
EEHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
LEESNFGLSFAEIEQKNNQITIITSLFANSILIQVQDNGFGISNELKSKIFEHSFTTKPV
HHHCCCCCCHHHHHHCCCEEEEEHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
GKGTGLGLAIAQQIIVQKHGGRLEVNSVPGEGSEFIITLPIE
CCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]