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The map label for this gene is yjcE [H]

Identifier: 75908262

GI number: 75908262

Start: 2525520

End: 2527082

Strand: Direct

Name: yjcE [H]

Synonym: Ava_2041

Alternate gene names: 75908262

Gene position: 2525520-2527082 (Clockwise)

Preceding gene: 75908260

Following gene: 75908264

Centisome position: 39.67

GC content: 42.87

Gene sequence:

>1563_bases
ATGGTACTTGAATCAGCAATTAGTGAAGAAGCGATCGCCACGAATCTCAAGCAGTTCCTTTTAGTACTTTCGGTTTCTTT
AGGCGTAGCCACCTTACCCCAAGTATTTAGTTGGTTTCGCCAAATCCCTTATACCTTACTCCTGGTAATTGTCGGCTTGG
GGTTAGCCGTTGTTGATGTGCGCCTAGTTGTTTTGTCTCCTGCTTTAATTTTGTCCATCTTTTTACCACCCTTATTATTT
GAAGCCGCATGGAATTTGAAATGGTCAGATTTACAGCGAGATTTTGTGCCAATTTCTCTGTATGCGGTGTTTGGGGTGAT
AATCTCAATTGCCGGAGTAGCAATTGGACTTAATCAACTAGGTGGAATTTCTTTAACTACGGCGTTACTCATCGGTGCGA
GTCTTTCTGCTACTGATCCGGTTTCTGTGACCGCTTTGTTTCGAGAATTGGGTGTAGGAACTCGTCTTGTCACCCTCATG
GAAGGCGAAAGCTTATTCAATGATGGTATGGCAGTAGTCGCCTTTGGTTTTTTGGTGGCTTTGCCTTTGGGAAGTGCCGA
ATTGGGTGTTCAACCGATTTTGTTACAGTTTTTTCAAGTAGTTGGTATCGGTGTAGCGATAGGCTGTTTGATTGGCTTTG
CTATTTCCTACCTGACCCAACGCTTTGATTTGCCAATGGTGGAACAGTCCTTAACTTTGGTGTCCGCTTACGGTACTTAT
CTCGTTACCGAAGACTTGGGCGGTTCCGGCGTGATTGGCGTTGTCACTACAGGTTTGATATTAGGTAACTTTGGTTCACG
CATAGGCATGAATCCCCGGACGCGGATTATTGTTTCCGAATTCTGGGAATTTTTAGCCTTTTTTGTCAATTCGATTGTTT
TTTTATTAATTGGCGACCAAATCCGCTTTGCCAGTTTAGGAGAAAACCTGCAAATCATTGCTATCACAGTAGGTGCAATG
ATTTTCATGCGAGCAGTTACACTATTTATTCTCAGCAAATTGAGCGTTATGATGACTCAATCACAAGTCTCCTTACCTGA
ACAGACTATTCTTTGGTGGGGTGGGTTACGTGGTTCGGTGTCAATTGCCCTGGCATTGAGTGTACCGACTGTATTGCCAG
GGCGAGAAAAAATCATTGCTACTGTCTTTGGAGTAGTCTTATTTACCCTACTAGTCCAGGGATTAACAATTAAGCCCCTG
CTACAAAAGCTCAATTTGCTCGGCGATGCACCCTTACGCGAACAATATTTACAATTAGTCGCCCGTATTGTTGCTCTAGA
ACGAGTATTGCAATACCTGCAAACAGAAAAACGTCCCGGTATCGGCCCAGAGTTTCTTCGTTACCAAGAAAAACTTGTCA
CAGGCGAAATTGCAGAATTGCAAACCAAGATTGATAAATTACACCATGAATACCCCAATCTTCAAAACTTTACAACAGAA
CAATTCCGCGATGAACTATTAGCAATTGAGGCAGATACTTATGCGGAATTTGTCAAGTCTGGGCGATTAAATAAAGAATT
AGCGCCGATGTTGGAAGATGTATTAGGGCATCAAAGAGACTAA

Upstream 100 bases:

>100_bases
CAAATATTCGCGGCTTGATGATTAAAATCTTATATTCAGCCGATGTTATCTGGATATCATACTTGGAGAATAAGTACAGT
ATTCTACTAAATACTTACTC

Downstream 100 bases:

>100_bases
AGTTGAGATCCTAGCGCTCAGAAATTATCTCTTACCCAATCCCCATCTTTACTTCATAACAGCAGCAAAAGGACAACGGC
TAGTTTGTAAATTTGCTGAT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MVLESAISEEAIATNLKQFLLVLSVSLGVATLPQVFSWFRQIPYTLLLVIVGLGLAVVDVRLVVLSPALILSIFLPPLLF
EAAWNLKWSDLQRDFVPISLYAVFGVIISIAGVAIGLNQLGGISLTTALLIGASLSATDPVSVTALFRELGVGTRLVTLM
EGESLFNDGMAVVAFGFLVALPLGSAELGVQPILLQFFQVVGIGVAIGCLIGFAISYLTQRFDLPMVEQSLTLVSAYGTY
LVTEDLGGSGVIGVVTTGLILGNFGSRIGMNPRTRIIVSEFWEFLAFFVNSIVFLLIGDQIRFASLGENLQIIAITVGAM
IFMRAVTLFILSKLSVMMTQSQVSLPEQTILWWGGLRGSVSIALALSVPTVLPGREKIIATVFGVVLFTLLVQGLTIKPL
LQKLNLLGDAPLREQYLQLVARIVALERVLQYLQTEKRPGIGPEFLRYQEKLVTGEIAELQTKIDKLHHEYPNLQNFTTE
QFRDELLAIEADTYAEFVKSGRLNKELAPMLEDVLGHQRD

Sequences:

>Translated_520_residues
MVLESAISEEAIATNLKQFLLVLSVSLGVATLPQVFSWFRQIPYTLLLVIVGLGLAVVDVRLVVLSPALILSIFLPPLLF
EAAWNLKWSDLQRDFVPISLYAVFGVIISIAGVAIGLNQLGGISLTTALLIGASLSATDPVSVTALFRELGVGTRLVTLM
EGESLFNDGMAVVAFGFLVALPLGSAELGVQPILLQFFQVVGIGVAIGCLIGFAISYLTQRFDLPMVEQSLTLVSAYGTY
LVTEDLGGSGVIGVVTTGLILGNFGSRIGMNPRTRIIVSEFWEFLAFFVNSIVFLLIGDQIRFASLGENLQIIAITVGAM
IFMRAVTLFILSKLSVMMTQSQVSLPEQTILWWGGLRGSVSIALALSVPTVLPGREKIIATVFGVVLFTLLVQGLTIKPL
LQKLNLLGDAPLREQYLQLVARIVALERVLQYLQTEKRPGIGPEFLRYQEKLVTGEIAELQTKIDKLHHEYPNLQNFTTE
QFRDELLAIEADTYAEFVKSGRLNKELAPMLEDVLGHQRD
>Mature_520_residues
MVLESAISEEAIATNLKQFLLVLSVSLGVATLPQVFSWFRQIPYTLLLVIVGLGLAVVDVRLVVLSPALILSIFLPPLLF
EAAWNLKWSDLQRDFVPISLYAVFGVIISIAGVAIGLNQLGGISLTTALLIGASLSATDPVSVTALFRELGVGTRLVTLM
EGESLFNDGMAVVAFGFLVALPLGSAELGVQPILLQFFQVVGIGVAIGCLIGFAISYLTQRFDLPMVEQSLTLVSAYGTY
LVTEDLGGSGVIGVVTTGLILGNFGSRIGMNPRTRIIVSEFWEFLAFFVNSIVFLLIGDQIRFASLGENLQIIAITVGAM
IFMRAVTLFILSKLSVMMTQSQVSLPEQTILWWGGLRGSVSIALALSVPTVLPGREKIIATVFGVVLFTLLVQGLTIKPL
LQKLNLLGDAPLREQYLQLVARIVALERVLQYLQTEKRPGIGPEFLRYQEKLVTGEIAELQTKIDKLHHEYPNLQNFTTE
QFRDELLAIEADTYAEFVKSGRLNKELAPMLEDVLGHQRD

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=384, Percent_Identity=27.34375, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI41872703, Length=358, Percent_Identity=27.0949720670391, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI148727259, Length=386, Percent_Identity=25.3886010362694, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI14211919, Length=379, Percent_Identity=27.4406332453826, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI27734935, Length=368, Percent_Identity=26.0869565217391, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI294997330, Length=373, Percent_Identity=27.6139410187668, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI110227626, Length=373, Percent_Identity=27.6139410187668, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI5454070, Length=371, Percent_Identity=27.7628032345013, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI194239733, Length=404, Percent_Identity=28.2178217821782, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI27777632, Length=401, Percent_Identity=24.4389027431421, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI4759144, Length=359, Percent_Identity=28.4122562674095, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1790501, Length=542, Percent_Identity=26.5682656826568, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25150332, Length=474, Percent_Identity=25.5274261603376, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71999817, Length=546, Percent_Identity=26.1904761904762, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71999819, Length=546, Percent_Identity=26.1904761904762, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71999821, Length=519, Percent_Identity=26.2042389210019, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71980847, Length=374, Percent_Identity=26.2032085561497, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71993590, Length=359, Percent_Identity=28.9693593314763, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71993582, Length=359, Percent_Identity=28.9693593314763, Blast_Score=118, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71990932, Length=397, Percent_Identity=25.1889168765743, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71990924, Length=397, Percent_Identity=25.1889168765743, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71987535, Length=392, Percent_Identity=27.8061224489796, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71987537, Length=392, Percent_Identity=27.8061224489796, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI25147678, Length=392, Percent_Identity=26.0204081632653, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71992107, Length=321, Percent_Identity=25.8566978193146, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71992101, Length=321, Percent_Identity=25.8566978193146, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71987559, Length=421, Percent_Identity=23.7529691211401, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71987545, Length=421, Percent_Identity=23.7529691211401, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320663, Length=339, Percent_Identity=25.9587020648968, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360447, Length=535, Percent_Identity=25.0467289719626, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI221510734, Length=369, Percent_Identity=27.6422764227642, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221510738, Length=373, Percent_Identity=28.4182305630027, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221473212, Length=436, Percent_Identity=25.6880733944954, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI281364513, Length=369, Percent_Identity=27.10027100271, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI221473215, Length=428, Percent_Identity=26.1682242990654, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI221473222, Length=369, Percent_Identity=27.10027100271, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221510736, Length=373, Percent_Identity=28.4182305630027, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI221510732, Length=373, Percent_Identity=28.4182305630027, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24585580, Length=373, Percent_Identity=28.4182305630027, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24585578, Length=373, Percent_Identity=28.4182305630027, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI221510740, Length=373, Percent_Identity=28.4182305630027, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 56709; Mature: 56709

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure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HHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]