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The map label for this gene is tmk

Identifier: 75908183

GI number: 75908183

Start: 2438375

End: 2439010

Strand: Direct

Name: tmk

Synonym: Ava_1962

Alternate gene names: 75908183

Gene position: 2438375-2439010 (Clockwise)

Preceding gene: 75908182

Following gene: 75908184

Centisome position: 38.3

GC content: 46.07

Gene sequence:

>636_bases
ATGGGTGGCAGATTCATTGTATTTGAAGGGGTTGAAGGTTGCGGCAAAACTAGCCAAATGCAGCTTTGTGCAGAGTGGTT
GCAAAATTTGGGAATTTCTGTGATTCTCACCCGTGAACCAGGAGGAACAGAATTAGGTGTAGATTTGCGGCGCTTGTTGT
TACAGAAGGCGGAAGATAAGCCAATCGCTGAGGTGACAGAGTTATTATTATATGCTGCCGATCGCGCACAACACGTTGCC
CAAGAACTCAAACCTAAGTTAGCTCAGGGTAAGTATATATTATGCGATCGCTATGTTGACTCTACTATTGCCTACCAAGG
TTACGGTCGCAATTTGGACATGAATCTCATCCATCAGTTAAATGACATCGCCACTGGTGGGTTAACCAGTGACATCACCA
TCTGGCTAGATGTGGATGTTGAAGTCGGACTAGCCCGAAAACGGGGGGAAAATGTAGGACTAGACCGGATTGAACAAGAA
ACCATCGCTTTCCACCGCCGTGTACAGCAAGGCTATGCAAACTTAGCTGCATCCTCTCCCTCGCGCATCATCAGGGTTGA
TGGTCAATTGAGTAAAGAAACTGTACATAAAACCATTCAGGAGATTCTCAGCCCACATCTAAAGGAATGGCTGTAG

Upstream 100 bases:

>100_bases
TCAGAGTACAAGTGTTCACAACCCTTACTCCCCTAAACCCTTGCACAGCTAAAAATCTTGTTGAGCCAGTCCTCAAAACA
TCGGCGAACATAAAAACAGC

Downstream 100 bases:

>100_bases
TCAGTCGTTTGATATGTTTCGATGACAAAATCATCAGAATATTTATATCCAGCCCCAGCAAAACTTTATTTACTGGGAGT
TTTTATTATCAACAACAGTT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MGGRFIVFEGVEGCGKTSQMQLCAEWLQNLGISVILTREPGGTELGVDLRRLLLQKAEDKPIAEVTELLLYAADRAQHVA
QELKPKLAQGKYILCDRYVDSTIAYQGYGRNLDMNLIHQLNDIATGGLTSDITIWLDVDVEVGLARKRGENVGLDRIEQE
TIAFHRRVQQGYANLAASSPSRIIRVDGQLSKETVHKTIQEILSPHLKEWL

Sequences:

>Translated_211_residues
MGGRFIVFEGVEGCGKTSQMQLCAEWLQNLGISVILTREPGGTELGVDLRRLLLQKAEDKPIAEVTELLLYAADRAQHVA
QELKPKLAQGKYILCDRYVDSTIAYQGYGRNLDMNLIHQLNDIATGGLTSDITIWLDVDVEVGLARKRGENVGLDRIEQE
TIAFHRRVQQGYANLAASSPSRIIRVDGQLSKETVHKTIQEILSPHLKEWL
>Mature_210_residues
GGRFIVFEGVEGCGKTSQMQLCAEWLQNLGISVILTREPGGTELGVDLRRLLLQKAEDKPIAEVTELLLYAADRAQHVAQ
ELKPKLAQGKYILCDRYVDSTIAYQGYGRNLDMNLIHQLNDIATGGLTSDITIWLDVDVEVGLARKRGENVGLDRIEQET
IAFHRRVQQGYANLAASSPSRIIRVDGQLSKETVHKTIQEILSPHLKEWL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=214, Percent_Identity=41.588785046729, Blast_Score=142, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_ANAVT (Q3MBQ2)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_322479.1
- HSSP:   P65248
- ProteinModelPortal:   Q3MBQ2
- SMR:   Q3MBQ2
- STRING:   Q3MBQ2
- GeneID:   3681622
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_1962
- NMPDR:   fig|240292.3.peg.3042
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   KGHIVIS
- PhylomeDB:   Q3MBQ2
- ProtClustDB:   CLSK896248
- BioCyc:   AVAR240292:AVA_1962-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23565; Mature: 23434

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGRFIVFEGVEGCGKTSQMQLCAEWLQNLGISVILTREPGGTELGVDLRRLLLQKAEDK
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHCCCC
PIAEVTELLLYAADRAQHVAQELKPKLAQGKYILCDRYVDSTIAYQGYGRNLDMNLIHQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHCHHHEECCCCCCCCHHHHHHH
NDIATGGLTSDITIWLDVDVEVGLARKRGENVGLDRIEQETIAFHRRVQQGYANLAASSP
HHHHCCCCCCCEEEEEEECEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SRIIRVDGQLSKETVHKTIQEILSPHLKEWL
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GGRFIVFEGVEGCGKTSQMQLCAEWLQNLGISVILTREPGGTELGVDLRRLLLQKAEDK
CCEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHCCCC
PIAEVTELLLYAADRAQHVAQELKPKLAQGKYILCDRYVDSTIAYQGYGRNLDMNLIHQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHCHHHEECCCCCCCCHHHHHHH
NDIATGGLTSDITIWLDVDVEVGLARKRGENVGLDRIEQETIAFHRRVQQGYANLAASSP
HHHHCCCCCCCEEEEEEECEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SRIIRVDGQLSKETVHKTIQEILSPHLKEWL
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA