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The map label for this gene is hemE [H]

Identifier: 75908009

GI number: 75908009

Start: 2232090

End: 2233142

Strand: Direct

Name: hemE [H]

Synonym: Ava_1788

Alternate gene names: 75908009

Gene position: 2232090-2233142 (Clockwise)

Preceding gene: 75908005

Following gene: 75908010

Centisome position: 35.06

GC content: 47.39

Gene sequence:

>1053_bases
ATGGGTGTTACTTCAACGGCTCCTCACCTTTTGCGGGCTGCTCGTGGTGAAATTGTAGATCGTCCCCCTGTATGGATGAT
GCGCCAAGCAGGACGATACATGAAAGCATATCGGGATTTAAGGGAAAAGTATCCTTCATTTCGCGATCGCTCTGAAATTC
CAGAGGTAGCGATTGAAGTTTCCCTACAACCTTGGAAAGCTTTCCAGCCAGACGGAGTAATTTTATTTTCCGATATTGTC
ACCCCCTTGCCAGGCTTAGGGATTGAAATGGACATTGCGGAAGGTAAAGGCCCCATCATTCATGCGCCCATTCGCACTCA
AGCACAAATTGAACAACTGCGTCCCTTAGAACCAGAAGCAGCTTTACCGTTCATTAAAACCATATTGCAGGCTTTACGCC
AAGAAGTGGGTCATCAATCAACGGTATTAGGCTTTGTAGGTGCGCCTTGGACGCTAGCCGCCTATGCTGTGGAGGGTAAA
GGTTCCAAAACCTACTCCATCATCAAAAATCTGGCATTCTCAGAACCAGCGATTCTGCATCAACTGTTAACTAAATTAGC
AGATGCGATCGCCATTTATGCTCGTTACCAAATCGACTCCGGCGCACAAGTAGTACAAATGTTCGATTCTTGGGCAGGAC
AACTCAGCCCCCAAGATTATGACACCTTTGCCCTACCCTATCAGCAGCGAGTATTCCAGCAAATCAAGCAAACCCATCCT
GATACACCCTTGATTTTGCTAGTCAGTGGTAGCGCCGGCGTACTAGAACGCATGGGACAATCTGGTGCGGATATTGTCAC
CGTCGATTGGACAGTAGACATGGCTGATGCTAGAGCCAGATTAGGCAAACAGATGAAAGTACAGGGCAATCTTGACCCCG
GTGTACTTTATGCCTCTAAACAGTTTATCCGCGATCGCATCATCGATACCGTTCGCAAAGCTGGTAACTGGGGTCATATT
CTCAACCTTGGACACGGTGTACTACCAGACACACCAGAAGAAAACGTCGCCTTCTTCTTTGAAACAGCCAAGCAACTAAA
TGTTTTGGTGTAG

Upstream 100 bases:

>100_bases
GCTTCCTGCCTCCTGCCCCCTACCTCCCTTCGATAAAGCGTAATCCCAGAATGATAAGCTAAACAGTGACATAAAAAAGT
GACTTAGGATGAAGTGTTAA

Downstream 100 bases:

>100_bases
TCAGTTGTCAGCTGACAGTTGACAGTTGACGATGGTCAGTTGTTAACTGTCAGTTGACAAATTCTCTTAATTTCCTCTCT
GCGCCCACCGAAGTTTGCTC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MGVTSTAPHLLRAARGEIVDRPPVWMMRQAGRYMKAYRDLREKYPSFRDRSEIPEVAIEVSLQPWKAFQPDGVILFSDIV
TPLPGLGIEMDIAEGKGPIIHAPIRTQAQIEQLRPLEPEAALPFIKTILQALRQEVGHQSTVLGFVGAPWTLAAYAVEGK
GSKTYSIIKNLAFSEPAILHQLLTKLADAIAIYARYQIDSGAQVVQMFDSWAGQLSPQDYDTFALPYQQRVFQQIKQTHP
DTPLILLVSGSAGVLERMGQSGADIVTVDWTVDMADARARLGKQMKVQGNLDPGVLYASKQFIRDRIIDTVRKAGNWGHI
LNLGHGVLPDTPEENVAFFFETAKQLNVLV

Sequences:

>Translated_350_residues
MGVTSTAPHLLRAARGEIVDRPPVWMMRQAGRYMKAYRDLREKYPSFRDRSEIPEVAIEVSLQPWKAFQPDGVILFSDIV
TPLPGLGIEMDIAEGKGPIIHAPIRTQAQIEQLRPLEPEAALPFIKTILQALRQEVGHQSTVLGFVGAPWTLAAYAVEGK
GSKTYSIIKNLAFSEPAILHQLLTKLADAIAIYARYQIDSGAQVVQMFDSWAGQLSPQDYDTFALPYQQRVFQQIKQTHP
DTPLILLVSGSAGVLERMGQSGADIVTVDWTVDMADARARLGKQMKVQGNLDPGVLYASKQFIRDRIIDTVRKAGNWGHI
LNLGHGVLPDTPEENVAFFFETAKQLNVLV
>Mature_349_residues
GVTSTAPHLLRAARGEIVDRPPVWMMRQAGRYMKAYRDLREKYPSFRDRSEIPEVAIEVSLQPWKAFQPDGVILFSDIVT
PLPGLGIEMDIAEGKGPIIHAPIRTQAQIEQLRPLEPEAALPFIKTILQALRQEVGHQSTVLGFVGAPWTLAAYAVEGKG
SKTYSIIKNLAFSEPAILHQLLTKLADAIAIYARYQIDSGAQVVQMFDSWAGQLSPQDYDTFALPYQQRVFQQIKQTHPD
TPLILLVSGSAGVLERMGQSGADIVTVDWTVDMADARARLGKQMKVQGNLDPGVLYASKQFIRDRIIDTVRKAGNWGHIL
NLGHGVLPDTPEENVAFFFETAKQLNVLV

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=349, Percent_Identity=38.6819484240688, Blast_Score=236, Evalue=3e-62,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=37.6470588235294, Blast_Score=259, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6320252, Length=349, Percent_Identity=32.0916905444126, Blast_Score=212, Evalue=8e-56,
Organism=Drosophila melanogaster, GI221330099, Length=342, Percent_Identity=36.2573099415205, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI19921920, Length=342, Percent_Identity=36.2573099415205, Blast_Score=232, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38823; Mature: 38692

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVTSTAPHLLRAARGEIVDRPPVWMMRQAGRYMKAYRDLREKYPSFRDRSEIPEVAIEV
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEE
SLQPWKAFQPDGVILFSDIVTPLPGLGIEMDIAEGKGPIIHAPIRTQAQIEQLRPLEPEA
EECCCCCCCCCCEEEEHHHHCCCCCCCEEEEECCCCCCEEECCCCCHHHHHHCCCCCCHH
ALPFIKTILQALRQEVGHQSTVLGFVGAPWTLAAYAVEGKGSKTYSIIKNLAFSEPAILH
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHH
QLLTKLADAIAIYARYQIDSGAQVVQMFDSWAGQLSPQDYDTFALPYQQRVFQQIKQTHP
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCC
DTPLILLVSGSAGVLERMGQSGADIVTVDWTVDMADARARLGKQMKVQGNLDPGVLYASK
CCCEEEEECCCCHHHHHCCCCCCCEEEEEEEECHHHHHHHCCCCEEEECCCCCCHHHHHH
QFIRDRIIDTVRKAGNWGHILNLGHGVLPDTPEENVAFFFETAKQLNVLV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GVTSTAPHLLRAARGEIVDRPPVWMMRQAGRYMKAYRDLREKYPSFRDRSEIPEVAIEV
CCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEE
SLQPWKAFQPDGVILFSDIVTPLPGLGIEMDIAEGKGPIIHAPIRTQAQIEQLRPLEPEA
EECCCCCCCCCCEEEEHHHHCCCCCCCEEEEECCCCCCEEECCCCCHHHHHHCCCCCCHH
ALPFIKTILQALRQEVGHQSTVLGFVGAPWTLAAYAVEGKGSKTYSIIKNLAFSEPAILH
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHH
QLLTKLADAIAIYARYQIDSGAQVVQMFDSWAGQLSPQDYDTFALPYQQRVFQQIKQTHP
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCC
DTPLILLVSGSAGVLERMGQSGADIVTVDWTVDMADARARLGKQMKVQGNLDPGVLYASK
CCCEEEEECCCCHHHHHCCCCCCCEEEEEEEECHHHHHHHCCCCEEEECCCCCCHHHHHH
QFIRDRIIDTVRKAGNWGHILNLGHGVLPDTPEENVAFFFETAKQLNVLV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA