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The map label for this gene is pepQ [H]

Identifier: 75676553

GI number: 75676553

Start: 2588626

End: 2590560

Strand: Direct

Name: pepQ [H]

Synonym: Nwi_2368

Alternate gene names: 75676553

Gene position: 2588626-2590560 (Clockwise)

Preceding gene: 75676552

Following gene: 75676554

Centisome position: 76.09

GC content: 67.86

Gene sequence:

>1935_bases
ATGGTGCAGCCTGCTGATGCAGAACAGAGGGTGACTCGCCGGCTTGTTGCATGGCTGCACGCGAACGGGGTCCACTTCGC
TCGAAAACGCTATATGATGCCGGCAATGTTCGAGGCCTATTTCCAGACATTCGAGGATCCCGAAGGTGGCGTCGCGCTGA
CCGCCCGCCTCGCCGCGTTTCGCGAGGAGCTGGCGCGGCGGCAACTGACCGGATTTGTGATCCCTCGTGCCGACCGGCAG
CAGAACGAGTACGTCCCGCCTTCCGAGGAGCGGCTGGCATGGCTCACCGGCTTCACCGGATCGGCCGGCCTTGCGATCGT
GCTCGCGACGAAAGCCGCGGTGTTCGTCGACGGCCGCTACACCTTGCAGGCGGCGCAACAGGTGGATGTCCGGGCCTGGA
GCATCGCCTCGCTGGTCGATCCGCCGCCGGAGAGCTGGCTGGCGGAGCATCTCGCGGCCGGCGACCGCCTCGGCTACGAT
CCCTGGCTCCACACCTCGGCGGCGGTAGAGCGTCTTGCAAAGGCCTGTGCGAAAGCCGGCGCCGAACTGGTGCCGGTCGA
CAGCAACCCGATCGACAGCGTCTGGACCGACCGCCCCGCGCCGCCGCTCGGCCCGGTCACGATCCACGACGCGGCATTCG
CCGGCGAAGCGGAGGCCGACAAGCTCGCGCGGATCCGCGCCGAGATGACAAAGCTCGGCGTCGATGCGCTGGTGCTGTCG
GATTCCCACGCGGTGGCGTGGACCTTCAACATCCGCGGCGCGGATGTCTCGCATACGCCGCTGCCTTTGTCCTACGCGCT
GGCGCCGAAGGACGGCCGCCCCACGATCTTCATCGACCGCCGCAAACTCTCCGACAGCGCGCGCTCTCATCTCGAACGCA
ACGCCGATGTGCGCGAGCCGGATGAACTGACCGACGCGCTGACGAGGACGGCCCAATCCGGCGCGGCGATCGCGCTCGAC
AAAGCCACCGCCGCCGACGCATTGAGCCGCCTGATCACGTCCGCCGGCGGCAAGCCGGTGGGCGGCAACGATCCAGTCGC
GCTGTTGAAGGCAGTAAAGAACCCGACCGAGATCGCGGGCGCGCGCGCCGCGCATCGGCGCGACGCCGTGGCGCTGGCGC
GGTTTCTCGCCTGGATCGACCGCGAGGCGCCGAAGGGCACGCTGACCGAAATCGACGCGGTCGAGGCGCTGGAGACTTTT
CGCCGCGAGACCGGCGCGCTGAAGGACGTCTCCTTTCCCACCATCTCGGGCACCGGGCCGAACGGCGCCATCGTTCACTA
CCGCGTCACCCGCAAGAGCAACCGCCGCATCGTACCCGGTGACCTGCTGCTGATCGACTCCGGCGCGCAATACGAGGACG
GCACCACCGACGTCACCCGCACCATCGCGATCGGCGATCCGACCGACGAAATGCGCGACCGCTTCACCCGCGTGCTGCGC
GGCCATATCGCCATCGCCCGCGCGGTGTTTCCCGACGGCGCCACCGGCGCGCAACTCGATACGCTGGCGCGGCAGTTTCT
CTGGCAGGCCGGCCTCGACTTCGAGCACGGCACCGGCCACGGCGTCGGCAGCTATCTGTCGGTGCATGAAGGCCCGGCGC
GGATTTCGAAGCTTGGCACCACGCCGCTCAGGCGCGGCATGATCCTGTCCAACGAGCCGGGCTATTACAAGCGCGACGCG
TTCGGCATCCGGATCGAAAACCTGGTGCTGGTGACGGAAGCCGGGATTGCCGGCGCTGAGAAGCCCATGAACAGCTTCGA
GACCCTGACGCTGGCCCCGATCGACCGCCGCCTGATCGATCACCGCATCAGCAAGAAAGAGGTGGCGTGGCTCAACGACT
ATCACGCCCGCGTCCGCCGCGAGGTGCGCCCGCATCTCGACGAGGCCACGAAACTCTGGCTCGACGCCGCGACCGAGCCG
TTTTCTCTGGAATAG

Upstream 100 bases:

>100_bases
TGGTGATCCTCTCCGGGCTGCTGCCGCAGCATACCCGCGGCGTCATCGCGGCCTACCGCGCGCAGGGGCTGGTGTTGATC
CGGCAGTTGCGGATCGACGG

Downstream 100 bases:

>100_bases
CGCGCGCAGATCGTTGCGAGCTTCCTTGCCTGGAGCAGGACAAACAGAGCTGTTGCACCGTCCACCGATCAAGCAAACCT
TGCTCGATGCTATCAAGAAT

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MVQPADAEQRVTRRLVAWLHANGVHFARKRYMMPAMFEAYFQTFEDPEGGVALTARLAAFREELARRQLTGFVIPRADRQ
QNEYVPPSEERLAWLTGFTGSAGLAIVLATKAAVFVDGRYTLQAAQQVDVRAWSIASLVDPPPESWLAEHLAAGDRLGYD
PWLHTSAAVERLAKACAKAGAELVPVDSNPIDSVWTDRPAPPLGPVTIHDAAFAGEAEADKLARIRAEMTKLGVDALVLS
DSHAVAWTFNIRGADVSHTPLPLSYALAPKDGRPTIFIDRRKLSDSARSHLERNADVREPDELTDALTRTAQSGAAIALD
KATAADALSRLITSAGGKPVGGNDPVALLKAVKNPTEIAGARAAHRRDAVALARFLAWIDREAPKGTLTEIDAVEALETF
RRETGALKDVSFPTISGTGPNGAIVHYRVTRKSNRRIVPGDLLLIDSGAQYEDGTTDVTRTIAIGDPTDEMRDRFTRVLR
GHIAIARAVFPDGATGAQLDTLARQFLWQAGLDFEHGTGHGVGSYLSVHEGPARISKLGTTPLRRGMILSNEPGYYKRDA
FGIRIENLVLVTEAGIAGAEKPMNSFETLTLAPIDRRLIDHRISKKEVAWLNDYHARVRREVRPHLDEATKLWLDAATEP
FSLE

Sequences:

>Translated_644_residues
MVQPADAEQRVTRRLVAWLHANGVHFARKRYMMPAMFEAYFQTFEDPEGGVALTARLAAFREELARRQLTGFVIPRADRQ
QNEYVPPSEERLAWLTGFTGSAGLAIVLATKAAVFVDGRYTLQAAQQVDVRAWSIASLVDPPPESWLAEHLAAGDRLGYD
PWLHTSAAVERLAKACAKAGAELVPVDSNPIDSVWTDRPAPPLGPVTIHDAAFAGEAEADKLARIRAEMTKLGVDALVLS
DSHAVAWTFNIRGADVSHTPLPLSYALAPKDGRPTIFIDRRKLSDSARSHLERNADVREPDELTDALTRTAQSGAAIALD
KATAADALSRLITSAGGKPVGGNDPVALLKAVKNPTEIAGARAAHRRDAVALARFLAWIDREAPKGTLTEIDAVEALETF
RRETGALKDVSFPTISGTGPNGAIVHYRVTRKSNRRIVPGDLLLIDSGAQYEDGTTDVTRTIAIGDPTDEMRDRFTRVLR
GHIAIARAVFPDGATGAQLDTLARQFLWQAGLDFEHGTGHGVGSYLSVHEGPARISKLGTTPLRRGMILSNEPGYYKRDA
FGIRIENLVLVTEAGIAGAEKPMNSFETLTLAPIDRRLIDHRISKKEVAWLNDYHARVRREVRPHLDEATKLWLDAATEP
FSLE
>Mature_644_residues
MVQPADAEQRVTRRLVAWLHANGVHFARKRYMMPAMFEAYFQTFEDPEGGVALTARLAAFREELARRQLTGFVIPRADRQ
QNEYVPPSEERLAWLTGFTGSAGLAIVLATKAAVFVDGRYTLQAAQQVDVRAWSIASLVDPPPESWLAEHLAAGDRLGYD
PWLHTSAAVERLAKACAKAGAELVPVDSNPIDSVWTDRPAPPLGPVTIHDAAFAGEAEADKLARIRAEMTKLGVDALVLS
DSHAVAWTFNIRGADVSHTPLPLSYALAPKDGRPTIFIDRRKLSDSARSHLERNADVREPDELTDALTRTAQSGAAIALD
KATAADALSRLITSAGGKPVGGNDPVALLKAVKNPTEIAGARAAHRRDAVALARFLAWIDREAPKGTLTEIDAVEALETF
RRETGALKDVSFPTISGTGPNGAIVHYRVTRKSNRRIVPGDLLLIDSGAQYEDGTTDVTRTIAIGDPTDEMRDRFTRVLR
GHIAIARAVFPDGATGAQLDTLARQFLWQAGLDFEHGTGHGVGSYLSVHEGPARISKLGTTPLRRGMILSNEPGYYKRDA
FGIRIENLVLVTEAGIAGAEKPMNSFETLTLAPIDRRLIDHRISKKEVAWLNDYHARVRREVRPHLDEATKLWLDAATEP
FSLE

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=613, Percent_Identity=40.4567699836868, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI264681565, Length=613, Percent_Identity=38.8254486133768, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI93141226, Length=612, Percent_Identity=35.6209150326797, Blast_Score=381, Evalue=1e-105,
Organism=Escherichia coli, GI1788728, Length=238, Percent_Identity=33.1932773109244, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17509539, Length=597, Percent_Identity=35.0083752093802, Blast_Score=357, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI25149105, Length=611, Percent_Identity=28.9689034369885, Blast_Score=260, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6322999, Length=655, Percent_Identity=32.6717557251908, Blast_Score=332, Evalue=8e-92,
Organism=Drosophila melanogaster, GI17137632, Length=615, Percent_Identity=34.9593495934959, Blast_Score=337, Evalue=2e-92,
Organism=Drosophila melanogaster, GI161078230, Length=596, Percent_Identity=31.3758389261745, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI21357287, Length=596, Percent_Identity=31.3758389261745, Blast_Score=287, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 70289; Mature: 70289

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQPADAEQRVTRRLVAWLHANGVHFARKRYMMPAMFEAYFQTFEDPEGGVALTARLAAF
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
REELARRQLTGFVIPRADRQQNEYVPPSEERLAWLTGFTGSAGLAIVLATKAAVFVDGRY
HHHHHHHHHHCEEECCCCCCCCCCCCCCHHHEEEEECCCCCCCEEEEEEECEEEEECCCH
TLQAAQQVDVRAWSIASLVDPPPESWLAEHLAAGDRLGYDPWLHTSAAVERLAKACAKAG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
AELVPVDSNPIDSVWTDRPAPPLGPVTIHDAAFAGEAEADKLARIRAEMTKLGVDALVLS
CEEEECCCCCCCCCCCCCCCCCCCCEEEECCHHCCCCHHHHHHHHHHHHHHHCCEEEEEE
DSHAVAWTFNIRGADVSHTPLPLSYALAPKDGRPTIFIDRRKLSDSARSHLERNADVREP
CCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCH
DELTDALTRTAQSGAAIALDKATAADALSRLITSAGGKPVGGNDPVALLKAVKNPTEIAG
HHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHH
ARAAHRRDAVALARFLAWIDREAPKGTLTEIDAVEALETFRRETGALKDVSFPTISGTGP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCC
NGAIVHYRVTRKSNRRIVPGDLLLIDSGAQYEDGTTDVTRTIAIGDPTDEMRDRFTRVLR
CCCEEEEEEECCCCCEECCCCEEEEECCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHH
GHIAIARAVFPDGATGAQLDTLARQFLWQAGLDFEHGTGHGVGSYLSVHEGPARISKLGT
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCHHHHHHCCC
TPLRRGMILSNEPGYYKRDAFGIRIENLVLVTEAGIAGAEKPMNSFETLTLAPIDRRLID
CHHHCCEEECCCCCCEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCEEEECHHHHHHHH
HRISKKEVAWLNDYHARVRREVRPHLDEATKLWLDAATEPFSLE
HHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVQPADAEQRVTRRLVAWLHANGVHFARKRYMMPAMFEAYFQTFEDPEGGVALTARLAAF
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
REELARRQLTGFVIPRADRQQNEYVPPSEERLAWLTGFTGSAGLAIVLATKAAVFVDGRY
HHHHHHHHHHCEEECCCCCCCCCCCCCCHHHEEEEECCCCCCCEEEEEEECEEEEECCCH
TLQAAQQVDVRAWSIASLVDPPPESWLAEHLAAGDRLGYDPWLHTSAAVERLAKACAKAG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
AELVPVDSNPIDSVWTDRPAPPLGPVTIHDAAFAGEAEADKLARIRAEMTKLGVDALVLS
CEEEECCCCCCCCCCCCCCCCCCCCEEEECCHHCCCCHHHHHHHHHHHHHHHCCEEEEEE
DSHAVAWTFNIRGADVSHTPLPLSYALAPKDGRPTIFIDRRKLSDSARSHLERNADVREP
CCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCH
DELTDALTRTAQSGAAIALDKATAADALSRLITSAGGKPVGGNDPVALLKAVKNPTEIAG
HHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHH
ARAAHRRDAVALARFLAWIDREAPKGTLTEIDAVEALETFRRETGALKDVSFPTISGTGP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCC
NGAIVHYRVTRKSNRRIVPGDLLLIDSGAQYEDGTTDVTRTIAIGDPTDEMRDRFTRVLR
CCCEEEEEEECCCCCEECCCCEEEEECCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHH
GHIAIARAVFPDGATGAQLDTLARQFLWQAGLDFEHGTGHGVGSYLSVHEGPARISKLGT
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCHHHHHHCCC
TPLRRGMILSNEPGYYKRDAFGIRIENLVLVTEAGIAGAEKPMNSFETLTLAPIDRRLID
CHHHCCEEECCCCCCEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCEEEECHHHHHHHH
HRISKKEVAWLNDYHARVRREVRPHLDEATKLWLDAATEPFSLE
HHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]