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The map label for this gene is fumC [H]

Identifier: 75676538

GI number: 75676538

Start: 2574337

End: 2575746

Strand: Direct

Name: fumC [H]

Synonym: Nwi_2353

Alternate gene names: 75676538

Gene position: 2574337-2575746 (Clockwise)

Preceding gene: 75676537

Following gene: 75676539

Centisome position: 75.67

GC content: 61.42

Gene sequence:

>1410_bases
ATGGCCACGTCATCACGCACGGCGAAAACCCGCACGGAGACCGACAGCTTCGGCGCCATCGAGGTTCAGGCCGACCGCTA
CTGGGGAGCCCAGACCGAGCGCAGCCGGCAAAACTTCCGCATCGGCGAGGACCGGATGCCGATGCCGCTGATCAGAGCGC
TCGGCATCGTCAAGCTGGCGGCGGCACAGACCAATCAGGAGCTTGGCCTGCTCGACCGCCGGCGCGCGAAAGCAATCATT
CGCGCGGCGCGCGAGGTGATCGAGGGCAAGCTGGATGATCACTTTCCGCTCGTGGTCTGGCAGACGGGATCCGGCACGCA
GACCAACATGAACCTCAACGAGGTCATCGCCAACCGCGCCAACGAGATGCTCGGCGGCAAGCTCGGCGACAAGAAGCCTG
TTCATCCGAACGACCACGTCAACATGAGCCAATCGTCGAACGATACATTTCCGACGGCGATGCATATCGCGGCGGCTCAC
GGCATCGTGTCGGATCTCGTCCCCGCGCTGGCCGCTCTGCTCAGGGCGCTGCGCAAAAAGGAAAAGGCGTTCGCGTCTAT
CGTCAAGATAGGACGGACCCATACCCAGGATGCAACCCCGCTAACGCTCGGCCAGGAATTTTCCGGCTATGCGGCGCAGG
TCGAGAGTGGCCTGACGCGGCTTCGCATGGCGCTGAACGACCTCTATCCGCTGGCGCAAGGTGGAACCGCGGTGGGGACC
GGGCTCAACACGAAGCCCAAATTTGCGAAACTGTTCGCGAGGAACGCCGCTCTGCTCGCAAAACTCCCTTTCAAGAGCGC
TCCCAACAAGTTTGAAGCCCTCGCCTCAAACGACGCCTATGTCTTCGCTCACGGCGCGATCAACGCCGTCGCAACGGGCC
TGTTCAAGATCGCGAACGATATCCGCTTTCTGGGATCCGGACCTCGTTCCGGTCTCGGCGAGTTGATCCTTCCCGAGAAC
GAACCCGGATCGTCCATTATGCCGGGGAAGGTCAACCCCACTCAGTGCGAAGCCATAACCATGGTCTGCTGTCGGGTGTT
TGGAAATCACACGACCATGACCGTGGCCGGCAGTCAGGGACATTTCGAGCTCAACGTCTACAAGCCGGTCCTGGCTTATT
GCATGATCGATTCCATACGATTGCTCGCCGACGCCACGCGCTCATTCACCGAACACTGCATCAAGGGCATCCGCGCCGAC
GAGCAGCGGATCAGCGAATTGATGCAACGCTCGCTCATGCTGGTCACCGCGCTCGCACCGAAAATCGGCTACGATAACGC
GGCGAAGGTCGCCAAGGCCGCCCATGATCGCGGAACGACATTGAAGGAGGAGGCTCAGCGGCTCGGCTTTATTACGGCTG
CGGAGTTCGACCGGCTGGTGCAACCCAGCAAAATGACGCGGCCGGGGTAG

Upstream 100 bases:

>100_bases
TCCGCAAGAAGTAACAAGGCCGCCTGTGCCTGATCCTCCTTTCAAGGAGGTGGGGATGGGGACCGCGTCCGGCCGCGACA
TGAACATAACGGACTGAGCC

Downstream 100 bases:

>100_bases
TGATCGGCCGACGCTTCGATGCTTCTGTCATTCTAGAGTTTCTATAAGCGGCGACGGTCGTCTGATGATCAGCTTTTCGT
GAACAGCTCTATACTAATAT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MATSSRTAKTRTETDSFGAIEVQADRYWGAQTERSRQNFRIGEDRMPMPLIRALGIVKLAAAQTNQELGLLDRRRAKAII
RAAREVIEGKLDDHFPLVVWQTGSGTQTNMNLNEVIANRANEMLGGKLGDKKPVHPNDHVNMSQSSNDTFPTAMHIAAAH
GIVSDLVPALAALLRALRKKEKAFASIVKIGRTHTQDATPLTLGQEFSGYAAQVESGLTRLRMALNDLYPLAQGGTAVGT
GLNTKPKFAKLFARNAALLAKLPFKSAPNKFEALASNDAYVFAHGAINAVATGLFKIANDIRFLGSGPRSGLGELILPEN
EPGSSIMPGKVNPTQCEAITMVCCRVFGNHTTMTVAGSQGHFELNVYKPVLAYCMIDSIRLLADATRSFTEHCIKGIRAD
EQRISELMQRSLMLVTALAPKIGYDNAAKVAKAAHDRGTTLKEEAQRLGFITAAEFDRLVQPSKMTRPG

Sequences:

>Translated_469_residues
MATSSRTAKTRTETDSFGAIEVQADRYWGAQTERSRQNFRIGEDRMPMPLIRALGIVKLAAAQTNQELGLLDRRRAKAII
RAAREVIEGKLDDHFPLVVWQTGSGTQTNMNLNEVIANRANEMLGGKLGDKKPVHPNDHVNMSQSSNDTFPTAMHIAAAH
GIVSDLVPALAALLRALRKKEKAFASIVKIGRTHTQDATPLTLGQEFSGYAAQVESGLTRLRMALNDLYPLAQGGTAVGT
GLNTKPKFAKLFARNAALLAKLPFKSAPNKFEALASNDAYVFAHGAINAVATGLFKIANDIRFLGSGPRSGLGELILPEN
EPGSSIMPGKVNPTQCEAITMVCCRVFGNHTTMTVAGSQGHFELNVYKPVLAYCMIDSIRLLADATRSFTEHCIKGIRAD
EQRISELMQRSLMLVTALAPKIGYDNAAKVAKAAHDRGTTLKEEAQRLGFITAAEFDRLVQPSKMTRPG
>Mature_468_residues
ATSSRTAKTRTETDSFGAIEVQADRYWGAQTERSRQNFRIGEDRMPMPLIRALGIVKLAAAQTNQELGLLDRRRAKAIIR
AAREVIEGKLDDHFPLVVWQTGSGTQTNMNLNEVIANRANEMLGGKLGDKKPVHPNDHVNMSQSSNDTFPTAMHIAAAHG
IVSDLVPALAALLRALRKKEKAFASIVKIGRTHTQDATPLTLGQEFSGYAAQVESGLTRLRMALNDLYPLAQGGTAVGTG
LNTKPKFAKLFARNAALLAKLPFKSAPNKFEALASNDAYVFAHGAINAVATGLFKIANDIRFLGSGPRSGLGELILPENE
PGSSIMPGKVNPTQCEAITMVCCRVFGNHTTMTVAGSQGHFELNVYKPVLAYCMIDSIRLLADATRSFTEHCIKGIRADE
QRISELMQRSLMLVTALAPKIGYDNAAKVAKAAHDRGTTLKEEAQRLGFITAAEFDRLVQPSKMTRPG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=65, Blast_Score=599, Evalue=1e-171,
Organism=Homo sapiens, GI266458395, Length=59, Percent_Identity=52.5423728813559, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=56.8927789934354, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=39.2624728850325, Blast_Score=325, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=468, Percent_Identity=62.3931623931624, Blast_Score=600, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=61.1620795107034, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=63.2608695652174, Blast_Score=586, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=60.9544468546638, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=60.9544468546638, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24662684, Length=470, Percent_Identity=59.3617021276596, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=58.8744588744589, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=53.1317494600432, Blast_Score=493, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50878; Mature: 50747

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSSRTAKTRTETDSFGAIEVQADRYWGAQTERSRQNFRIGEDRMPMPLIRALGIVKLA
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
AAQTNQELGLLDRRRAKAIIRAAREVIEGKLDDHFPLVVWQTGSGTQTNMNLNEVIANRA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
NEMLGGKLGDKKPVHPNDHVNMSQSSNDTFPTAMHIAAAHGIVSDLVPALAALLRALRKK
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKAFASIVKIGRTHTQDATPLTLGQEFSGYAAQVESGLTRLRMALNDLYPLAQGGTAVGT
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
GLNTKPKFAKLFARNAALLAKLPFKSAPNKFEALASNDAYVFAHGAINAVATGLFKIAND
CCCCCHHHHHHHHHCHHHEEECCCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHHHHH
IRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAITMVCCRVFGNHTTMTVAGSQG
HHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCC
HFELNVYKPVLAYCMIDSIRLLADATRSFTEHCIKGIRADEQRISELMQRSLMLVTALAP
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
KIGYDNAAKVAKAAHDRGTTLKEEAQRLGFITAAEFDRLVQPSKMTRPG
CCCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ATSSRTAKTRTETDSFGAIEVQADRYWGAQTERSRQNFRIGEDRMPMPLIRALGIVKLA
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
AAQTNQELGLLDRRRAKAIIRAAREVIEGKLDDHFPLVVWQTGSGTQTNMNLNEVIANRA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
NEMLGGKLGDKKPVHPNDHVNMSQSSNDTFPTAMHIAAAHGIVSDLVPALAALLRALRKK
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKAFASIVKIGRTHTQDATPLTLGQEFSGYAAQVESGLTRLRMALNDLYPLAQGGTAVGT
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
GLNTKPKFAKLFARNAALLAKLPFKSAPNKFEALASNDAYVFAHGAINAVATGLFKIAND
CCCCCHHHHHHHHHCHHHEEECCCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHHHHH
IRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAITMVCCRVFGNHTTMTVAGSQG
HHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCC
HFELNVYKPVLAYCMIDSIRLLADATRSFTEHCIKGIRADEQRISELMQRSLMLVTALAP
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
KIGYDNAAKVAKAAHDRGTTLKEEAQRLGFITAAEFDRLVQPSKMTRPG
CCCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856685; 12597275 [H]