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The map label for this gene is zosA [H]

Identifier: 75676140

GI number: 75676140

Start: 2140202

End: 2142199

Strand: Direct

Name: zosA [H]

Synonym: Nwi_1949

Alternate gene names: 75676140

Gene position: 2140202-2142199 (Clockwise)

Preceding gene: 75676138

Following gene: 75676149

Centisome position: 62.91

GC content: 64.81

Gene sequence:

>1998_bases
GTGAGCAAACTATTTAATCTTGATCGCGCGATGATACTGACGGCCCTCACGGTCGCCGGAATGCTTCTGGCCATCCTCGG
ATTATTGCCGCTGCAGGGCCCCGCCGCCGGATTCTTCTCCCGCACAGGTCTGTCGCTCGTTTACCTCGCGGGCGGACTGC
CAGCCGCATGGCGGGCAGCGGTCGCCTTGTGGGAGGAGCGGATCCTCGACATCGACCTGCTAATGGTCGTCGCCGCGGTC
GCGGCCGCAGCGGTCGGGGCGCCCTTCGAGGGCGCCGTCTTGCTGACGCTGTTCAGCATCTCGACCACGCTGGAGGAACG
GGCGCTCGGGCGGGCGCGCCGCGCCATCGAGGCATTGATGGAACTCCGCCCCGAGACGGCATTGCGCAAGGCGCCGGATG
GCTCGGTCTCCGAGGTCCCTGCCGCCGACCTCAAGGTCGACGATACCGTGGTGCTGCGGCCAGGCGCGCGCGTTCCGGCC
GACGGCGTGATCGTCGGCGGCCGGGGCTCGCTCGACGAGGCGAACATCACGGGCGAGTCGATGCCGGTCGCCAAGCAGCC
GGGCGCCCAGGTCTTCGAGGCGACGGTCAACCTCGACGGCGTGCTTGAGGTGGCGGTGACGAAAACCGTGGAGGAGAGCA
CGGTCGCCCGCATGATCGCGCTGGTGACGGAGGCGCAGGCCGCCAAGGCGCCCTCGGAGCGGTTCAGCGCATGGTTCGGA
CAGCGCTATACGGTTGCGGTGATGGCCGGCGCCGTCCTGGCCTTTGCTGTCTTCTACTGGCTGGGGCGGGACTGGGAGGA
AGCGCTTTATCGATCCGCGACACTGCTGGTGGCCGCGAGCCCGTGCGCGATCGTCATCTCGGTGCCGGCGGCGATCCTGT
CGGCGCTATCGGCAGCAGCGCGGGGCGGTGTGTTGTTCAAGGGCGGGGCGGCGCTTGAGACACTGGCAGCAGTCGACATT
TTTGCCTTCGACAAGACCGGAACACTGACGACTGGCAAAGCATCGGTAACCGGGGTTGTGGCGCTCGACGGCGATGAGCG
GCTCTTCCTGTCTTTGCTTGCGGGGCTCGAGGCACATTCCGAACACCACAGCGCGGCGGCCATTCGGCAGGAAGCCGCCA
GCCGAGGCATTGCCCCCATCAGAGTGATGAACGTGATAACGCGGCCGAGTGCCGGCATCGTGGGCGATGACGATAAAGGG
CAATTATGGGCCGGCAATCCGCGTCTTGCCGTCCAGATGGGCGCACCCATCGACCACCCGATGCTGAAAGCGCTGGCCGC
TGACACGCAGACAGTCGTCTACGTGGGGCGGGATTCGCGCGTGATGGGGGCCGTCACCATCGCAGATCAGGCTCGCCCGA
CCTCCGCGCCGGCTCTCGCCGCTTTACGGGAGAGTGGAGTAAGCCAGATCGTCATGATGACCGGCGACCGTCGTCCCGTC
GCGTTGCGAATAGGCGCGGAGCTAGGGCTGAAGCCTGAAGAAATCTACGCCGACATGCTGCCGGAGGACAAGGTTCGGAT
GGCGGGCGAGCTGGCAACTACAACTAGAGGTATGGTTGCGTTCGTCGGAGATGGCGTCAACGACGCAGCAGCGCTCGCTC
GTGCTGATGTAGGGATTGCTATGGGCGCAGCCGGATCGGACGTCGCGCTGCAAGCGGCCGACGTGGCACTGTTGTCGGAG
GATATGGGAAGGCTTGCGGATGCGCATCGACTTGCCCGCCGCGCAGCAACAATTATCCGGCAAAATCTCGTCTTTGCCAT
GGGCGTCATGGCGATCCTCGTAACCGGCGGGCTGTTCTTCGAACTGCCGCTTCCGCTTGCAGTAATTGGCCACGAAGGTG
GAACGGTTCTGGTCGTACTCAACGGCTTACGCTTACTGAGGGACCCCATTCGCCGCGGCGAAACGAAACCAGCGCCAAAG
AGATCTGTTCATGCGAGTTCGAGCCAGCCAATTCCGCGACAGGCCTATAGGAGAAAGGTGCCGAGGCGAGCAAATTGA

Upstream 100 bases:

>100_bases
TCACCGACGATTACCCGTTGTCGCTGGGCGCACGACACCCGCGGTAGCGTTGCTGTGACCTGCCGCGCAAATTCCAGTGT
GCGGCTGACCAGGAGACGAA

Downstream 100 bases:

>100_bases
TAGAACTTGGCATGGAGAAGGTTAGACGCCAGGCCCCTCCGCTCCGCCATCATCCTGTAGCGAACTCTGATCACCGCTCT
TTGAGCGCTGGATTTCTCCC

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MSKLFNLDRAMILTALTVAGMLLAILGLLPLQGPAAGFFSRTGLSLVYLAGGLPAAWRAAVALWEERILDIDLLMVVAAV
AAAAVGAPFEGAVLLTLFSISTTLEERALGRARRAIEALMELRPETALRKAPDGSVSEVPAADLKVDDTVVLRPGARVPA
DGVIVGGRGSLDEANITGESMPVAKQPGAQVFEATVNLDGVLEVAVTKTVEESTVARMIALVTEAQAAKAPSERFSAWFG
QRYTVAVMAGAVLAFAVFYWLGRDWEEALYRSATLLVAASPCAIVISVPAAILSALSAAARGGVLFKGGAALETLAAVDI
FAFDKTGTLTTGKASVTGVVALDGDERLFLSLLAGLEAHSEHHSAAAIRQEAASRGIAPIRVMNVITRPSAGIVGDDDKG
QLWAGNPRLAVQMGAPIDHPMLKALAADTQTVVYVGRDSRVMGAVTIADQARPTSAPALAALRESGVSQIVMMTGDRRPV
ALRIGAELGLKPEEIYADMLPEDKVRMAGELATTTRGMVAFVGDGVNDAAALARADVGIAMGAAGSDVALQAADVALLSE
DMGRLADAHRLARRAATIIRQNLVFAMGVMAILVTGGLFFELPLPLAVIGHEGGTVLVVLNGLRLLRDPIRRGETKPAPK
RSVHASSSQPIPRQAYRRKVPRRAN

Sequences:

>Translated_665_residues
MSKLFNLDRAMILTALTVAGMLLAILGLLPLQGPAAGFFSRTGLSLVYLAGGLPAAWRAAVALWEERILDIDLLMVVAAV
AAAAVGAPFEGAVLLTLFSISTTLEERALGRARRAIEALMELRPETALRKAPDGSVSEVPAADLKVDDTVVLRPGARVPA
DGVIVGGRGSLDEANITGESMPVAKQPGAQVFEATVNLDGVLEVAVTKTVEESTVARMIALVTEAQAAKAPSERFSAWFG
QRYTVAVMAGAVLAFAVFYWLGRDWEEALYRSATLLVAASPCAIVISVPAAILSALSAAARGGVLFKGGAALETLAAVDI
FAFDKTGTLTTGKASVTGVVALDGDERLFLSLLAGLEAHSEHHSAAAIRQEAASRGIAPIRVMNVITRPSAGIVGDDDKG
QLWAGNPRLAVQMGAPIDHPMLKALAADTQTVVYVGRDSRVMGAVTIADQARPTSAPALAALRESGVSQIVMMTGDRRPV
ALRIGAELGLKPEEIYADMLPEDKVRMAGELATTTRGMVAFVGDGVNDAAALARADVGIAMGAAGSDVALQAADVALLSE
DMGRLADAHRLARRAATIIRQNLVFAMGVMAILVTGGLFFELPLPLAVIGHEGGTVLVVLNGLRLLRDPIRRGETKPAPK
RSVHASSSQPIPRQAYRRKVPRRAN
>Mature_664_residues
SKLFNLDRAMILTALTVAGMLLAILGLLPLQGPAAGFFSRTGLSLVYLAGGLPAAWRAAVALWEERILDIDLLMVVAAVA
AAAVGAPFEGAVLLTLFSISTTLEERALGRARRAIEALMELRPETALRKAPDGSVSEVPAADLKVDDTVVLRPGARVPAD
GVIVGGRGSLDEANITGESMPVAKQPGAQVFEATVNLDGVLEVAVTKTVEESTVARMIALVTEAQAAKAPSERFSAWFGQ
RYTVAVMAGAVLAFAVFYWLGRDWEEALYRSATLLVAASPCAIVISVPAAILSALSAAARGGVLFKGGAALETLAAVDIF
AFDKTGTLTTGKASVTGVVALDGDERLFLSLLAGLEAHSEHHSAAAIRQEAASRGIAPIRVMNVITRPSAGIVGDDDKGQ
LWAGNPRLAVQMGAPIDHPMLKALAADTQTVVYVGRDSRVMGAVTIADQARPTSAPALAALRESGVSQIVMMTGDRRPVA
LRIGAELGLKPEEIYADMLPEDKVRMAGELATTTRGMVAFVGDGVNDAAALARADVGIAMGAAGSDVALQAADVALLSED
MGRLADAHRLARRAATIIRQNLVFAMGVMAILVTGGLFFELPLPLAVIGHEGGTVLVVLNGLRLLRDPIRRGETKPAPKR
SVHASSSQPIPRQAYRRKVPRRAN

Specific function: Couples the hydrolysis of ATP with the transport of zinc into the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=722, Percent_Identity=27.9778393351801, Blast_Score=213, Evalue=7e-55,
Organism=Homo sapiens, GI55743071, Length=616, Percent_Identity=30.3571428571429, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI55743073, Length=520, Percent_Identity=30.7692307692308, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI48762687, Length=301, Percent_Identity=26.2458471760797, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI48762691, Length=301, Percent_Identity=26.2458471760797, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI48762685, Length=301, Percent_Identity=26.2458471760797, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI48762689, Length=301, Percent_Identity=26.2458471760797, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI22748667, Length=260, Percent_Identity=27.6923076923077, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI118498343, Length=194, Percent_Identity=32.9896907216495, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4502271, Length=260, Percent_Identity=26.1538461538462, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI153946397, Length=237, Percent_Identity=25.3164556962025, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI51944966, Length=250, Percent_Identity=27.6, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI21361181, Length=281, Percent_Identity=25.2669039145907, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI237681109, Length=281, Percent_Identity=25.2669039145907, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI237681111, Length=281, Percent_Identity=25.2669039145907, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1789879, Length=599, Percent_Identity=39.0651085141903, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI1786691, Length=548, Percent_Identity=33.5766423357664, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1786914, Length=497, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI2367363, Length=196, Percent_Identity=30.6122448979592, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17556548, Length=589, Percent_Identity=28.3531409168082, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17557770, Length=215, Percent_Identity=28.8372093023256, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI32566766, Length=215, Percent_Identity=28.8372093023256, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17559224, Length=260, Percent_Identity=26.5384615384615, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17557486, Length=220, Percent_Identity=28.1818181818182, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71997275, Length=193, Percent_Identity=26.4248704663212, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71997262, Length=193, Percent_Identity=26.4248704663212, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531459, Length=233, Percent_Identity=25.3218884120172, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71997269, Length=152, Percent_Identity=30.2631578947368, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=529, Percent_Identity=28.3553875236295, Blast_Score=212, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319772, Length=594, Percent_Identity=27.6094276094276, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6321430, Length=521, Percent_Identity=24.5681381957774, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325221, Length=583, Percent_Identity=24.0137221269297, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321271, Length=201, Percent_Identity=31.3432835820896, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221329854, Length=361, Percent_Identity=31.3019390581717, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24668708, Length=151, Percent_Identity=31.7880794701987, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24668704, Length=151, Percent_Identity=31.7880794701987, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281366617, Length=151, Percent_Identity=31.7880794701987, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161085803, Length=151, Percent_Identity=31.7880794701987, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24668696, Length=151, Percent_Identity=31.7880794701987, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281366676, Length=244, Percent_Identity=26.2295081967213, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 69497; Mature: 69365

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLFNLDRAMILTALTVAGMLLAILGLLPLQGPAAGFFSRTGLSLVYLAGGLPAAWRAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEEECCCCHHHHHH
VALWEERILDIDLLMVVAAVAAAAVGAPFEGAVLLTLFSISTTLEERALGRARRAIEALM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRPETALRKAPDGSVSEVPAADLKVDDTVVLRPGARVPADGVIVGGRGSLDEANITGES
HCCCHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCCC
MPVAKQPGAQVFEATVNLDGVLEVAVTKTVEESTVARMIALVTEAQAAKAPSERFSAWFG
CCCCCCCCHHHEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
QRYTVAVMAGAVLAFAVFYWLGRDWEEALYRSATLLVAASPCAIVISVPAAILSALSAAA
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEECCCEEEEEHHHHHHHHHHHHH
RGGVLFKGGAALETLAAVDIFAFDKTGTLTTGKASVTGVVALDGDERLFLSLLAGLEAHS
CCCEEEECCHHHHHHHHHEEEEECCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHH
EHHSAAAIRQEAASRGIAPIRVMNVITRPSAGIVGDDDKGQLWAGNPRLAVQMGAPIDHP
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCHH
MLKALAADTQTVVYVGRDSRVMGAVTIADQARPTSAPALAALRESGVSQIVMMTGDRRPV
HHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCE
ALRIGAELGLKPEEIYADMLPEDKVRMAGELATTTRGMVAFVGDGVNDAAALARADVGIA
EEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCEE
MGAAGSDVALQAADVALLSEDMGRLADAHRLARRAATIIRQNLVFAMGVMAILVTGGLFF
ECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
ELPLPLAVIGHEGGTVLVVLNGLRLLRDPIRRGETKPAPKRSVHASSSQPIPRQAYRRKV
EECCCEEEEECCCCEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCC
PRRAN
CCCCC
>Mature Secondary Structure 
SKLFNLDRAMILTALTVAGMLLAILGLLPLQGPAAGFFSRTGLSLVYLAGGLPAAWRAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEEECCCCHHHHHH
VALWEERILDIDLLMVVAAVAAAAVGAPFEGAVLLTLFSISTTLEERALGRARRAIEALM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRPETALRKAPDGSVSEVPAADLKVDDTVVLRPGARVPADGVIVGGRGSLDEANITGES
HCCCHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCCC
MPVAKQPGAQVFEATVNLDGVLEVAVTKTVEESTVARMIALVTEAQAAKAPSERFSAWFG
CCCCCCCCHHHEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
QRYTVAVMAGAVLAFAVFYWLGRDWEEALYRSATLLVAASPCAIVISVPAAILSALSAAA
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEECCCEEEEEHHHHHHHHHHHHH
RGGVLFKGGAALETLAAVDIFAFDKTGTLTTGKASVTGVVALDGDERLFLSLLAGLEAHS
CCCEEEECCHHHHHHHHHEEEEECCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHH
EHHSAAAIRQEAASRGIAPIRVMNVITRPSAGIVGDDDKGQLWAGNPRLAVQMGAPIDHP
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCHH
MLKALAADTQTVVYVGRDSRVMGAVTIADQARPTSAPALAALRESGVSQIVMMTGDRRPV
HHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCE
ALRIGAELGLKPEEIYADMLPEDKVRMAGELATTTRGMVAFVGDGVNDAAALARADVGIA
EEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCEE
MGAAGSDVALQAADVALLSEDMGRLADAHRLARRAATIIRQNLVFAMGVMAILVTGGLFF
ECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
ELPLPLAVIGHEGGTVLVVLNGLRLLRDPIRRGETKPAPKRSVHASSSQPIPRQAYRRKV
EECCCEEEEECCCCEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCC
PRRAN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]