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The map label for this gene is aroQ

Identifier: 75675943

GI number: 75675943

Start: 1921173

End: 1921643

Strand: Direct

Name: aroQ

Synonym: Nwi_1751

Alternate gene names: 75675943

Gene position: 1921173-1921643 (Clockwise)

Preceding gene: 75675942

Following gene: 75675944

Centisome position: 56.47

GC content: 58.17

Gene sequence:

>471_bases
ATGGCCAAGACGATCTACGTGCTCAACGGCCCGAACCTTAACATGCTCGGGACCCGAGAGCCGGATACCTATGGCCACGC
CAACCTTGCCGACGTCGAACAGCTTTGCGCCGAAACGGCCAAAAATTTTGGACTGGCCGCGGATTGCCGCCAGTCAAACC
GCGAGGGCGAGCTGATCGATTTCATTCACGAAGCTCATGCGAAGAACGCAGCCGGTATCGTCATCAACGCCGGCGGCTAC
TCGCACACTTCCATCGCACTTCACGACGCGCTGGTCGCGGTCAAAATTCCGACCGTCGAAGTTCATATCAGCAACATTCA
TGCGCGCGAGGACTTCCGTCATCACTCCTTCACGGCCAAGGCCGCGTTCGCAAGCCTGTCAGGCTTCGGAATTGACGGCT
ACCGGCTCGCGATCAATGGCCTTGCCGCCAAGATCGGCGCGGTAGACCCGTCGAACAAAGTTAAATCCTGA

Upstream 100 bases:

>100_bases
AATCAGGGACTGTTCAGGCTTCCCCTTGACGTTCTTGTTACATATAACGGCCCGAACTCCGGCGTTCGGCGGCGGAAATG
GCTGATTTTCAGGATTTCAG

Downstream 100 bases:

>100_bases
CACATCAGCGTCATTCTCACAGAAAGTTTCGGATCGAGATCATGTCCCGCCAGCCCGGAGAACCCGCAAAAAACAAAACC
GGCAACGATCTGCGCGAGGA

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type II DHQase

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MAKTIYVLNGPNLNMLGTREPDTYGHANLADVEQLCAETAKNFGLAADCRQSNREGELIDFIHEAHAKNAAGIVINAGGY
SHTSIALHDALVAVKIPTVEVHISNIHAREDFRHHSFTAKAAFASLSGFGIDGYRLAINGLAAKIGAVDPSNKVKS

Sequences:

>Translated_156_residues
MAKTIYVLNGPNLNMLGTREPDTYGHANLADVEQLCAETAKNFGLAADCRQSNREGELIDFIHEAHAKNAAGIVINAGGY
SHTSIALHDALVAVKIPTVEVHISNIHAREDFRHHSFTAKAAFASLSGFGIDGYRLAINGLAAKIGAVDPSNKVKS
>Mature_155_residues
AKTIYVLNGPNLNMLGTREPDTYGHANLADVEQLCAETAKNFGLAADCRQSNREGELIDFIHEAHAKNAAGIVINAGGYS
HTSIALHDALVAVKIPTVEVHISNIHAREDFRHHSFTAKAAFASLSGFGIDGYRLAINGLAAKIGAVDPSNKVKS

Specific function: Catalyzes a trans-dehydration via an enolate intermediate

COG id: COG0757

COG function: function code E; 3-dehydroquinate dehydratase II

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-II 3-dehydroquinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROQ_NITWN (Q3SRS9)

Other databases:

- EMBL:   CP000115
- RefSeq:   YP_318364.1
- HSSP:   Q48255
- ProteinModelPortal:   Q3SRS9
- SMR:   Q3SRS9
- STRING:   Q3SRS9
- GeneID:   3676474
- GenomeReviews:   CP000115_GR
- KEGG:   nwi:Nwi_1751
- NMPDR:   fig|323098.3.peg.1543
- eggNOG:   COG0757
- HOGENOM:   HBG284657
- OMA:   IMVINGP
- ProtClustDB:   PRK05395
- BioCyc:   NWIN323098:NWI_1751-MONOMER
- HAMAP:   MF_00169
- InterPro:   IPR001874
- InterPro:   IPR018509
- Gene3D:   G3DSA:3.40.50.9100
- PANTHER:   PTHR21272
- PIRSF:   PIRSF001399
- ProDom:   PD004527
- TIGRFAMs:   TIGR01088

Pfam domain/function: PF01220 DHquinase_II; SSF52304 DHquinase_II

EC number: =4.2.1.10

Molecular weight: Translated: 16620; Mature: 16489

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS01029 DEHYDROQUINASE_II

Important sites: ACT_SITE 24-24 ACT_SITE 102-102 BINDING 76-76 BINDING 82-82 BINDING 89-89 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTIYVLNGPNLNMLGTREPDTYGHANLADVEQLCAETAKNFGLAADCRQSNREGELID
CCEEEEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEHHHCCCCCCHHHH
FIHEAHAKNAAGIVINAGGYSHTSIALHDALVAVKIPTVEVHISNIHAREDFRHHSFTAK
HHHHHHCCCCCEEEEECCCCCCCEEEEEEEEEEEECCEEEEEECCEECCHHHHHCCCHHH
AAFASLSGFGIDGYRLAINGLAAKIGAVDPSNKVKS
HHHHHHCCCCCCCEEEEEECHHHEECCCCCCCCCCC
>Mature Secondary Structure 
AKTIYVLNGPNLNMLGTREPDTYGHANLADVEQLCAETAKNFGLAADCRQSNREGELID
CEEEEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEHHHCCCCCCHHHH
FIHEAHAKNAAGIVINAGGYSHTSIALHDALVAVKIPTVEVHISNIHAREDFRHHSFTAK
HHHHHHCCCCCEEEEECCCCCCCEEEEEEEEEEEECCEEEEEECCEECCHHHHHCCCHHH
AAFASLSGFGIDGYRLAINGLAAKIGAVDPSNKVKS
HHHHHHCCCCCCCEEEEEECHHHEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA