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The map label for this gene is rnr [H]

Identifier: 75675905

GI number: 75675905

Start: 1867458

End: 1869806

Strand: Direct

Name: rnr [H]

Synonym: Nwi_1713

Alternate gene names: 75675905

Gene position: 1867458-1869806 (Clockwise)

Preceding gene: 75675904

Following gene: 75675906

Centisome position: 54.89

GC content: 63.69

Gene sequence:

>2349_bases
GTGAGCAAACCGCGCGCCAGGAATTTTCCGGATCGCGAGGCCATCGTCGCTTTCATCCGCGCGCATCCCGGCCGGGCTGG
CACACGCGAGATCGCTCATGAGTTCGGCTTGAAGAACGCCGATCGCGCCGAACTCAAGCATATCCTTCGCGCGCTCGCGG
ATGACGGAACAATCGTGAAACGGAGCCGCAAGCTGCGGAAGCCGGAAACGCTGCCGCCAACGCTGGTAGCCGATATTACG
GGGCGAGATCGCGACGGCGAACTGATCGCCACGCCGACCGAATGGGACGATGAAGCAACGCCCGCGCCGAGGATTCTCAT
TCATGTGCCGCGTCGGGCGAAGCCCGGCACCGTGGCAGGCGTCGGCGATCGTGCGCTGCTGCGCATCGAGACAATCGAGT
CCGACGAAACCGCAAGCTATCGCGCTCGCGTCATCAGGGTCATCGATCGCACCCGCGCGCGTATGCTCGGCATCTATCGC
GCGTCGCCTCAGGGCGGCGGACGCCTTGTGCCGGTGGACAAGAAGCAGGCCGGGCGCGAGCTGAACATCGCGAAAGCCGA
CAGCGCGGGCGCGGAGGACGGCGATCTCGTGAGTGTCGAACTGGTGCGGACCCGCGGTTTCGGACTTGCTTCTGGCAAGG
TGAAGGAGCGGCTTGGCTCGCTCGCGACCGAAAAGGCCGTCAGCCTGATCGCGATCCACGCCCATGACATTCCGCAGGAG
TTTACGCCGGCCGCCTTGCGCGAAGCCGCCGCTGCGAAGCCTTCCGCCTTGCAAGGTCGCGAAGACTGGCGCGCGGTGCC
GCTCATCACCATCGATCCCCCCGATGCGAAGGATCACGACGACGCGGTTCACGCCGCGCCGGACGATGATCCCAACAACA
CGGGCGGCGCCATCGTCACCGTCGCCATCGCTGACGTCGCCTATTATGTGCGGCCTGAATCGGCGCTGGATCGTGAAGCT
CTGGAGCGCGGCAATTCGGTCTATTTCCCGGATCGCGTGGTCCCGATGCTGCCCGAGCGCATTTCAAACGATCTCTGCTC
ACTTGTTCCGGGCGAAGCACGCGGGGCTCTCGCCGTGCGCATGGTGATCGACGCCGACGGACGCAAGCGTTCGCACACCT
TTCATCGCATCCTGATGCGCTCGGCAGCGAAGCTTGCTTACTCGCAGGTGCAGGCCGCGATCGACGGCAACCCGGATGAC
GCGACCGCCCCCCTGCTCGAACCGATCCTGAAACCGCTCTACGCGGCCTTTGCTCTGGTGAAGCGCGCGCGCGACGAGCG
CGATCCGCTCGATCTTGAATTACCCGAACGCAAGATTCTGCTGAAGAAGGACGGAACGGTCGATCGTGTGATCGTTCCGG
ATCGGCTCGATGCGCATCGGCTGATCGAGGAATTCATGATCCTTGCAAACGTCGCCGCGGCCGAGATGCTGGAAAAGAAA
GGGCTGCCGCTGATCTATCGCGTGCACGACGAGCCGACGGTCGAGAAGGTTCACAACCTGCGCGAGTTCCTGAAAACTCT
CGATATGTCCTTCGCCAGAAGCGGCGCGCTGAGGCCGGAGTTGTTCAATCGCGTGCTGGATCAGGTCAGGGGCCATGATT
CCGAATCGCTGGTGAACGAGGTGGTTCTTCGTTCGCAGGCACAGGCTGAGTATTCGGCGGAGAACTATGGCCACTTTGGT
CTCAACCTGCGGCGCTACGCGCATTTCACATCGCCGATCAGGCGATATGCAGATCTCGTCGTGCACCGCGCCCTGCTCCG
TGCGCTCGGTCTTGGCGACGGCGCGCTGCCGGATTCCGACAACGCCGAAACGCTCGCCGAAATAGCCGCGCGCATTTCCG
TCACCGAGCGGCGCGCCATGAAGGCCGAACGCGAGACGGCCGATCGCCTGATCGCGCATTTTCTCGCCGACCGCATCGGC
AACATCTTCGAGGCGCGTATTTCCGGTGTCACCCGCGCAGGGCTTTTCGTGAAGCTGGCCGACACCGGCGCCGACGGGCT
GATCCCGATTCGCTCGCTGGGGACCGAATATTTCAAGTACGACGAGACCCGGCATGCCCTGGTGGGGTCCCGCAGCGGTT
CCATGCACAAGCTGGGTGACGTGGTGGAGGTTCGTCTGGTAGAAGCTGTACCCTTGGCTGGCGCTCTGCGGTTCGAACTC
TTATCCGGAGCCGAGGTGAGGCCGCGCTCCCCCCGCGCGCGGGGTGGAGGGAAAATAAAGACGCCGCGTGGTCGGAACGC
GGGTCATCCTGATGTTCATTCGAAAGCCCATCCGGGCCGTAAACCGCGCGGGACATCGCGCAAGCCGGGCAGGAGCAAGG
CCGGCAAACCGAAGAAGGGCAAATCATGA

Upstream 100 bases:

>100_bases
GGCGCGTGGCTCGATCGCCGCGGCCAAAGCGCCGCCCAATACAGTGAAAGCGCCTACAAAAAAGAGCGCGGGCAAGAACG
GCTGACGTGAGCCAATTGAT

Downstream 100 bases:

>100_bases
CCGCGCTTCCTCCCGATACCGCGAGCACAGCAGGCAAAACCTGGACCCCGGAAGGCGAAAAGCGCGACACCTGGGCCGCG
ATGAGGCGCGGGTTATTCTG

Product: 3'-5' exoribonuclease, VacB and RNase II/ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 782; Mature: 781

Protein sequence:

>782_residues
MSKPRARNFPDREAIVAFIRAHPGRAGTREIAHEFGLKNADRAELKHILRALADDGTIVKRSRKLRKPETLPPTLVADIT
GRDRDGELIATPTEWDDEATPAPRILIHVPRRAKPGTVAGVGDRALLRIETIESDETASYRARVIRVIDRTRARMLGIYR
ASPQGGGRLVPVDKKQAGRELNIAKADSAGAEDGDLVSVELVRTRGFGLASGKVKERLGSLATEKAVSLIAIHAHDIPQE
FTPAALREAAAAKPSALQGREDWRAVPLITIDPPDAKDHDDAVHAAPDDDPNNTGGAIVTVAIADVAYYVRPESALDREA
LERGNSVYFPDRVVPMLPERISNDLCSLVPGEARGALAVRMVIDADGRKRSHTFHRILMRSAAKLAYSQVQAAIDGNPDD
ATAPLLEPILKPLYAAFALVKRARDERDPLDLELPERKILLKKDGTVDRVIVPDRLDAHRLIEEFMILANVAAAEMLEKK
GLPLIYRVHDEPTVEKVHNLREFLKTLDMSFARSGALRPELFNRVLDQVRGHDSESLVNEVVLRSQAQAEYSAENYGHFG
LNLRRYAHFTSPIRRYADLVVHRALLRALGLGDGALPDSDNAETLAEIAARISVTERRAMKAERETADRLIAHFLADRIG
NIFEARISGVTRAGLFVKLADTGADGLIPIRSLGTEYFKYDETRHALVGSRSGSMHKLGDVVEVRLVEAVPLAGALRFEL
LSGAEVRPRSPRARGGGKIKTPRGRNAGHPDVHSKAHPGRKPRGTSRKPGRSKAGKPKKGKS

Sequences:

>Translated_782_residues
MSKPRARNFPDREAIVAFIRAHPGRAGTREIAHEFGLKNADRAELKHILRALADDGTIVKRSRKLRKPETLPPTLVADIT
GRDRDGELIATPTEWDDEATPAPRILIHVPRRAKPGTVAGVGDRALLRIETIESDETASYRARVIRVIDRTRARMLGIYR
ASPQGGGRLVPVDKKQAGRELNIAKADSAGAEDGDLVSVELVRTRGFGLASGKVKERLGSLATEKAVSLIAIHAHDIPQE
FTPAALREAAAAKPSALQGREDWRAVPLITIDPPDAKDHDDAVHAAPDDDPNNTGGAIVTVAIADVAYYVRPESALDREA
LERGNSVYFPDRVVPMLPERISNDLCSLVPGEARGALAVRMVIDADGRKRSHTFHRILMRSAAKLAYSQVQAAIDGNPDD
ATAPLLEPILKPLYAAFALVKRARDERDPLDLELPERKILLKKDGTVDRVIVPDRLDAHRLIEEFMILANVAAAEMLEKK
GLPLIYRVHDEPTVEKVHNLREFLKTLDMSFARSGALRPELFNRVLDQVRGHDSESLVNEVVLRSQAQAEYSAENYGHFG
LNLRRYAHFTSPIRRYADLVVHRALLRALGLGDGALPDSDNAETLAEIAARISVTERRAMKAERETADRLIAHFLADRIG
NIFEARISGVTRAGLFVKLADTGADGLIPIRSLGTEYFKYDETRHALVGSRSGSMHKLGDVVEVRLVEAVPLAGALRFEL
LSGAEVRPRSPRARGGGKIKTPRGRNAGHPDVHSKAHPGRKPRGTSRKPGRSKAGKPKKGKS
>Mature_781_residues
SKPRARNFPDREAIVAFIRAHPGRAGTREIAHEFGLKNADRAELKHILRALADDGTIVKRSRKLRKPETLPPTLVADITG
RDRDGELIATPTEWDDEATPAPRILIHVPRRAKPGTVAGVGDRALLRIETIESDETASYRARVIRVIDRTRARMLGIYRA
SPQGGGRLVPVDKKQAGRELNIAKADSAGAEDGDLVSVELVRTRGFGLASGKVKERLGSLATEKAVSLIAIHAHDIPQEF
TPAALREAAAAKPSALQGREDWRAVPLITIDPPDAKDHDDAVHAAPDDDPNNTGGAIVTVAIADVAYYVRPESALDREAL
ERGNSVYFPDRVVPMLPERISNDLCSLVPGEARGALAVRMVIDADGRKRSHTFHRILMRSAAKLAYSQVQAAIDGNPDDA
TAPLLEPILKPLYAAFALVKRARDERDPLDLELPERKILLKKDGTVDRVIVPDRLDAHRLIEEFMILANVAAAEMLEKKG
LPLIYRVHDEPTVEKVHNLREFLKTLDMSFARSGALRPELFNRVLDQVRGHDSESLVNEVVLRSQAQAEYSAENYGHFGL
NLRRYAHFTSPIRRYADLVVHRALLRALGLGDGALPDSDNAETLAEIAARISVTERRAMKAERETADRLIAHFLADRIGN
IFEARISGVTRAGLFVKLADTGADGLIPIRSLGTEYFKYDETRHALVGSRSGSMHKLGDVVEVRLVEAVPLAGALRFELL
SGAEVRPRSPRARGGGKIKTPRGRNAGHPDVHSKAHPGRKPRGTSRKPGRSKAGKPKKGKS

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=430, Percent_Identity=31.3953488372093, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI190014625, Length=476, Percent_Identity=27.3109243697479, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI190014623, Length=476, Percent_Identity=27.3109243697479, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI19115966, Length=486, Percent_Identity=28.8065843621399, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI219521928, Length=486, Percent_Identity=28.3950617283951, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI156105695, Length=576, Percent_Identity=25.5208333333333, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI156105693, Length=576, Percent_Identity=25.5208333333333, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI87082383, Length=754, Percent_Identity=35.4111405835544, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1787542, Length=472, Percent_Identity=32.8389830508475, Blast_Score=173, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17553506, Length=454, Percent_Identity=29.295154185022, Blast_Score=166, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI212645896, Length=476, Percent_Identity=30.4621848739496, Blast_Score=163, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324552, Length=490, Percent_Identity=30.2040816326531, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320499, Length=390, Percent_Identity=24.8717948717949, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24649634, Length=521, Percent_Identity=27.447216890595, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24654592, Length=439, Percent_Identity=26.6514806378132, Blast_Score=134, Evalue=3e-31,
Organism=Drosophila melanogaster, GI19922976, Length=439, Percent_Identity=26.6514806378132, Blast_Score=134, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24654597, Length=439, Percent_Identity=26.6514806378132, Blast_Score=134, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 85738; Mature: 85607

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPRARNFPDREAIVAFIRAHPGRAGTREIAHEFGLKNADRAELKHILRALADDGTIVK
CCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHH
RSRKLRKPETLPPTLVADITGRDRDGELIATPTEWDDEATPAPRILIHVPRRAKPGTVAG
HHHHCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEC
VGDRALLRIETIESDETASYRARVIRVIDRTRARMLGIYRASPQGGGRLVPVDKKQAGRE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCHHHCCCE
LNIAKADSAGAEDGDLVSVELVRTRGFGLASGKVKERLGSLATEKAVSLIAIHAHDIPQE
EEEEECCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCC
FTPAALREAAAAKPSALQGREDWRAVPLITIDPPDAKDHDDAVHAAPDDDPNNTGGAIVT
CCHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEE
VAIADVAYYVRPESALDREALERGNSVYFPDRVVPMLPERISNDLCSLVPGEARGALAVR
EEEHHHHHEECCHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEE
MVIDADGRKRSHTFHRILMRSAAKLAYSQVQAAIDGNPDDATAPLLEPILKPLYAAFALV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
KRARDERDPLDLELPERKILLKKDGTVDRVIVPDRLDAHRLIEEFMILANVAAAEMLEKK
HHHHCCCCCCCCCCCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GLPLIYRVHDEPTVEKVHNLREFLKTLDMSFARSGALRPELFNRVLDQVRGHDSESLVNE
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHH
VVLRSQAQAEYSAENYGHFGLNLRRYAHFTSPIRRYADLVVHRALLRALGLGDGALPDSD
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NAETLAEIAARISVTERRAMKAERETADRLIAHFLADRIGNIFEARISGVTRAGLFVKLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCEEEEEE
DTGADGLIPIRSLGTEYFKYDETRHALVGSRSGSMHKLGDVVEVRLVEAVPLAGALRFEL
CCCCCCCEEHHHHCCHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
LSGAEVRPRSPRARGGGKIKTPRGRNAGHPDVHSKAHPGRKPRGTSRKPGRSKAGKPKKG
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KS
CC
>Mature Secondary Structure 
SKPRARNFPDREAIVAFIRAHPGRAGTREIAHEFGLKNADRAELKHILRALADDGTIVK
CCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHH
RSRKLRKPETLPPTLVADITGRDRDGELIATPTEWDDEATPAPRILIHVPRRAKPGTVAG
HHHHCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEC
VGDRALLRIETIESDETASYRARVIRVIDRTRARMLGIYRASPQGGGRLVPVDKKQAGRE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCHHHCCCE
LNIAKADSAGAEDGDLVSVELVRTRGFGLASGKVKERLGSLATEKAVSLIAIHAHDIPQE
EEEEECCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCC
FTPAALREAAAAKPSALQGREDWRAVPLITIDPPDAKDHDDAVHAAPDDDPNNTGGAIVT
CCHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEE
VAIADVAYYVRPESALDREALERGNSVYFPDRVVPMLPERISNDLCSLVPGEARGALAVR
EEEHHHHHEECCHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEE
MVIDADGRKRSHTFHRILMRSAAKLAYSQVQAAIDGNPDDATAPLLEPILKPLYAAFALV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
KRARDERDPLDLELPERKILLKKDGTVDRVIVPDRLDAHRLIEEFMILANVAAAEMLEKK
HHHHCCCCCCCCCCCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GLPLIYRVHDEPTVEKVHNLREFLKTLDMSFARSGALRPELFNRVLDQVRGHDSESLVNE
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHH
VVLRSQAQAEYSAENYGHFGLNLRRYAHFTSPIRRYADLVVHRALLRALGLGDGALPDSD
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NAETLAEIAARISVTERRAMKAERETADRLIAHFLADRIGNIFEARISGVTRAGLFVKLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCEEEEEE
DTGADGLIPIRSLGTEYFKYDETRHALVGSRSGSMHKLGDVVEVRLVEAVPLAGALRFEL
CCCCCCCEEHHHHCCHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
LSGAEVRPRSPRARGGGKIKTPRGRNAGHPDVHSKAHPGRKPRGTSRKPGRSKAGKPKKG
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]