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The map label for this gene is adk

Identifier: 75675577

GI number: 75675577

Start: 1511455

End: 1512075

Strand: Direct

Name: adk

Synonym: Nwi_1385

Alternate gene names: 75675577

Gene position: 1511455-1512075 (Clockwise)

Preceding gene: 75675576

Following gene: 75675578

Centisome position: 44.43

GC content: 61.51

Gene sequence:

>621_bases
ATGAGACTGATTCTTCTGGGGCCGCCTGGGGCGGGAAAAGGAACGCAGGCGCAACGTCTGGTTCATCATTACGGAATCAT
TCAGCTTTCAACAGGCGACATGCTGCGCGCCGCCGTCGCCGCCGGCACGCCGGTCGGTCTCAAGGCCAAGGACATCATGG
CGAGCGGGGGGCTGGTCCCGGATGATGTCGTTATCGGCATCATTTCCGATCGGCTGGAACAGGCGGACGCGAAGGACGGT
TTCATTCTCGACGGCTTTCCGCGCACCGTTCCGCAGGCCGAGGCGCTGGATATTCTGCTCCAATCCAAGAATCTTGCACT
TGATGCCGTGATCGAGCTGCGCGTCGATGAAAGCGCATTGCTGCAACGTGTAGAAAACCGCGTCGCGGAGACGACCGCGC
GGGGCGAGCAGGTAAGGGCCGATGACAACCCGGAGGTGCTCTCGCAGCGGTTGGCCAGCTATCGCGCGCTGACCGAGCCG
CTGATTCGCTACTATTCGGAGCGCGGCAGGCTGCTGACAGTTGACGGCATGATGGCGATCGATGATGTGACACGGGATAT
CCGCCGGGTTCTGAGGCGATCGGGAGTTCCGATGTCGAAGTTCGGGGTCCGCAGGTGGTAA

Upstream 100 bases:

>100_bases
CCGTAAGTGTTGCCGGTAGGGCGCAGACCGTGTCTTGGCTGTGCCTATATCGAAGCGCGGGTGTGCGGCTGCTCGCTCAC
CCGGCGATGGGGCAATGTTC

Downstream 100 bases:

>100_bases
GCAGGCCGGAATCCCCGCAATAGGGCGAGAAATGACGGCCCAAAAGTCACGAAAAAGCGAGCGAAAGCGGAGGAGCGGTT
GACGGAATGCCGCCGAGTCC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MRLILLGPPGAGKGTQAQRLVHHYGIIQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDDVVIGIISDRLEQADAKDG
FILDGFPRTVPQAEALDILLQSKNLALDAVIELRVDESALLQRVENRVAETTARGEQVRADDNPEVLSQRLASYRALTEP
LIRYYSERGRLLTVDGMMAIDDVTRDIRRVLRRSGVPMSKFGVRRW

Sequences:

>Translated_206_residues
MRLILLGPPGAGKGTQAQRLVHHYGIIQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDDVVIGIISDRLEQADAKDG
FILDGFPRTVPQAEALDILLQSKNLALDAVIELRVDESALLQRVENRVAETTARGEQVRADDNPEVLSQRLASYRALTEP
LIRYYSERGRLLTVDGMMAIDDVTRDIRRVLRRSGVPMSKFGVRRW
>Mature_206_residues
MRLILLGPPGAGKGTQAQRLVHHYGIIQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDDVVIGIISDRLEQADAKDG
FILDGFPRTVPQAEALDILLQSKNLALDAVIELRVDESALLQRVENRVAETTARGEQVRADDNPEVLSQRLASYRALTEP
LIRYYSERGRLLTVDGMMAIDDVTRDIRRVLRRSGVPMSKFGVRRW

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=208, Percent_Identity=41.8269230769231, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI7524346, Length=208, Percent_Identity=41.8269230769231, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=36.4130434782609, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=35.0253807106599, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=34.010152284264, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=34.010152284264, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=34.010152284264, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=34.010152284264, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI28144897, Length=189, Percent_Identity=31.7460317460317, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI28144899, Length=189, Percent_Identity=31.7460317460317, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI7706497, Length=201, Percent_Identity=29.3532338308458, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI22749187, Length=118, Percent_Identity=33.0508474576271, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=41.4746543778802, Blast_Score=157, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=38.3177570093458, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17567503, Length=183, Percent_Identity=35.5191256830601, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17533833, Length=190, Percent_Identity=28.4210526315789, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=190, Percent_Identity=27.3684210526316, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17537943, Length=216, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25147457, Length=196, Percent_Identity=24.4897959183673, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=41.8604651162791, Blast_Score=161, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=36.4102564102564, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322828, Length=198, Percent_Identity=30.8080808080808, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=42.1800947867299, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=34.5177664974619, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=34.5177664974619, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24663208, Length=180, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17647141, Length=180, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221459597, Length=195, Percent_Identity=26.6666666666667, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356893, Length=195, Percent_Identity=26.6666666666667, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_NITWN (Q3SSU5)

Other databases:

- EMBL:   CP000115
- RefSeq:   YP_317998.1
- HSSP:   P16304
- ProteinModelPortal:   Q3SSU5
- SMR:   Q3SSU5
- STRING:   Q3SSU5
- GeneID:   3677164
- GenomeReviews:   CP000115_GR
- KEGG:   nwi:Nwi_1385
- NMPDR:   fig|323098.3.peg.1388
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- BioCyc:   NWIN323098:NWI_1385-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 22567; Mature: 22567

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGPPGAGKGTQAQRLVHHYGIIQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVP
CEEEEECCCCCCCCHHHHHHHHHHCEEEECCCHHHHHHHHCCCCCCCCHHHHHHCCCCCC
DDVVIGIISDRLEQADAKDGFILDGFPRTVPQAEALDILLQSKNLALDAVIELRVDESAL
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEEEECCHHHH
LQRVENRVAETTARGEQVRADDNPEVLSQRLASYRALTEPLIRYYSERGRLLTVDGMMAI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHH
DDVTRDIRRVLRRSGVPMSKFGVRRW
HHHHHHHHHHHHHCCCCHHHHCCCCC
>Mature Secondary Structure
MRLILLGPPGAGKGTQAQRLVHHYGIIQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVP
CEEEEECCCCCCCCHHHHHHHHHHCEEEECCCHHHHHHHHCCCCCCCCHHHHHHCCCCCC
DDVVIGIISDRLEQADAKDGFILDGFPRTVPQAEALDILLQSKNLALDAVIELRVDESAL
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEEEECCHHHH
LQRVENRVAETTARGEQVRADDNPEVLSQRLASYRALTEPLIRYYSERGRLLTVDGMMAI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHH
DDVTRDIRRVLRRSGVPMSKFGVRRW
HHHHHHHHHHHHHCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA