Click here to switch to the map view.

The map label for this gene is ddc [H]

Identifier: 75675295

GI number: 75675295

Start: 1213415

End: 1214893

Strand: Direct

Name: ddc [H]

Synonym: Nwi_1102

Alternate gene names: 75675295

Gene position: 1213415-1214893 (Clockwise)

Preceding gene: 75675294

Following gene: 75675297

Centisome position: 35.67

GC content: 64.77

Gene sequence:

>1479_bases
ATGAAGCCTGCATCGCGCGGTACGCTGCCGGAAGCCGATGAAACGCTCGATCCCGAAGACTGGGACACGCTTCGCGCGGA
AGGGCACCGGATGCTCGACGATATGTTCGATCATATCGCCGGTGTTCGCGAGCGTCCGGTCTGGCGGCCGATACCAGCGG
AAACGCGCGCCCGTTTCCGCGAAGACCTGCCGCGGAACGGCGTCGATGTCGCCGAGATTTATCGGGAGTTTGCCGAACAC
ATCGCCCCCTACACCGCCGGGAATATCCACCCCGGCTTCATGGGATGGGTCAACGGCGGCGGTACGGCGGTCGGGATGCT
GGCCGAGATGCTGGCGGCGGGGTTGAACACCAATGTCGCCGGACGGAATCAGATGCCGGTCGAAGTCGAGCGCCAGATCG
TGCTGTGGGTACGGCGGATGTTCGGCTTTCCCGATACCGCGAGCGGCGTGTTCGTCACGGGAACGTCGATGGCGAACCTG
ATGGGAATTCTGGTGGCGCGTTCGGCGCGGATCGGCCCCTCCGTGCGCCAGCGCGGCTTGCTGGATCGCGGCGCGCGCCT
CATCGCCTATACATCGGTTGCGACGCACGGCTGCATAGCCCAGGCCATGGATTGCGCCGGCTTCGGCGCCGACGCCCTGC
GGCGGATTCCGGTTGATCGCTGTCATCGCATCGATACTGACGCGTTGCGCGCGCAGATCGCCGCCGATCGCGCCGCGGGG
TTTGAGCCCTTTCTCGTGATCGGATCGGCGGGCACAGTCGATATCGGAGCCATCGACGACCTCGCGGTGCTGCATGAGGT
GTGCCGGGACGAGAAATTATGGCTGCATATCGACGGCGCGTTCGGCGCGCTCGGGGTGTTGTCGCCGGAGATCGCGCCGC
GTCTCGCGGGAATCGAGAGCGCCGACTCCATCGCTTTCGATTTCCACAAATGGGGCCAGGTGCCCTACGACGCAGGGTTC
CTTCTCGTCCGCGACGGAGAGCAGCATCGCCGGACGTTCGCAGCGCCGGCAGCCTATCTGCGCCGGGAAACGCGCGGGCT
TGCGGCGGGCTCGCCGTGGCCATGCGACTACAGCCTGGATATGTCCCGCGGCTTTCGCGCATTGAAGACGTGGTTCACGC
TGAAAGCCTACGGCACCGAAAGGCTCGGTGCGATGATTGACCGGACCTGCGCGCTGGCGCGCTGCCTGGAAGCGAAGGTC
GCTGCCGAACCAAAGCTCGAGCTGCTTGCGCCGGTGCAACTCAACATCGTGTGCTTCCGCTATCGGGCCGACGATGCCGA
CAGTGTCAATGCGGAGATCGTCGCGTCGCTGCACGAGTCGGGCATAACCGCGCCGTCCACGACCATGCTGGACGGCCGGC
TCGCGATCCGCGCGGCGATCGTCAACCATCGCACTGGAATGCGCGACATCGAAGCGCTGATATCGGCTGTGTTGGAATTG
GGCGCGCGTAAATCGCGAGGCTCTATGATTTTTATTTGA

Upstream 100 bases:

>100_bases
GCAAGGAAGCTTATTTCATGCGCAGTCTTGAAATTGAATTGGCTGTTCGCCATGACGATGCGTGGCGCACCAACGTCGCG
TGCGACGGGGAGCGCGCGGC

Downstream 100 bases:

>100_bases
CGCGTTTTCTTCACGCGAACCGGTGTCCATCCTTAGGGCTCAAGCCCGAGGACATGCCTCGCTCGAAAACGCTATCGCAG
ATCCGGAAGCTGCGACGATC

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MKPASRGTLPEADETLDPEDWDTLRAEGHRMLDDMFDHIAGVRERPVWRPIPAETRARFREDLPRNGVDVAEIYREFAEH
IAPYTAGNIHPGFMGWVNGGGTAVGMLAEMLAAGLNTNVAGRNQMPVEVERQIVLWVRRMFGFPDTASGVFVTGTSMANL
MGILVARSARIGPSVRQRGLLDRGARLIAYTSVATHGCIAQAMDCAGFGADALRRIPVDRCHRIDTDALRAQIAADRAAG
FEPFLVIGSAGTVDIGAIDDLAVLHEVCRDEKLWLHIDGAFGALGVLSPEIAPRLAGIESADSIAFDFHKWGQVPYDAGF
LLVRDGEQHRRTFAAPAAYLRRETRGLAAGSPWPCDYSLDMSRGFRALKTWFTLKAYGTERLGAMIDRTCALARCLEAKV
AAEPKLELLAPVQLNIVCFRYRADDADSVNAEIVASLHESGITAPSTTMLDGRLAIRAAIVNHRTGMRDIEALISAVLEL
GARKSRGSMIFI

Sequences:

>Translated_492_residues
MKPASRGTLPEADETLDPEDWDTLRAEGHRMLDDMFDHIAGVRERPVWRPIPAETRARFREDLPRNGVDVAEIYREFAEH
IAPYTAGNIHPGFMGWVNGGGTAVGMLAEMLAAGLNTNVAGRNQMPVEVERQIVLWVRRMFGFPDTASGVFVTGTSMANL
MGILVARSARIGPSVRQRGLLDRGARLIAYTSVATHGCIAQAMDCAGFGADALRRIPVDRCHRIDTDALRAQIAADRAAG
FEPFLVIGSAGTVDIGAIDDLAVLHEVCRDEKLWLHIDGAFGALGVLSPEIAPRLAGIESADSIAFDFHKWGQVPYDAGF
LLVRDGEQHRRTFAAPAAYLRRETRGLAAGSPWPCDYSLDMSRGFRALKTWFTLKAYGTERLGAMIDRTCALARCLEAKV
AAEPKLELLAPVQLNIVCFRYRADDADSVNAEIVASLHESGITAPSTTMLDGRLAIRAAIVNHRTGMRDIEALISAVLEL
GARKSRGSMIFI
>Mature_492_residues
MKPASRGTLPEADETLDPEDWDTLRAEGHRMLDDMFDHIAGVRERPVWRPIPAETRARFREDLPRNGVDVAEIYREFAEH
IAPYTAGNIHPGFMGWVNGGGTAVGMLAEMLAAGLNTNVAGRNQMPVEVERQIVLWVRRMFGFPDTASGVFVTGTSMANL
MGILVARSARIGPSVRQRGLLDRGARLIAYTSVATHGCIAQAMDCAGFGADALRRIPVDRCHRIDTDALRAQIAADRAAG
FEPFLVIGSAGTVDIGAIDDLAVLHEVCRDEKLWLHIDGAFGALGVLSPEIAPRLAGIESADSIAFDFHKWGQVPYDAGF
LLVRDGEQHRRTFAAPAAYLRRETRGLAAGSPWPCDYSLDMSRGFRALKTWFTLKAYGTERLGAMIDRTCALARCLEAKV
AAEPKLELLAPVQLNIVCFRYRADDADSVNAEIVASLHESGITAPSTTMLDGRLAIRAAIVNHRTGMRDIEALISAVLEL
GARKSRGSMIFI

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI92110055, Length=473, Percent_Identity=26.8498942917548, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI4503281, Length=476, Percent_Identity=24.5798319327731, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI132814448, Length=476, Percent_Identity=24.5798319327731, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI197276620, Length=450, Percent_Identity=26.8888888888889, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4503875, Length=450, Percent_Identity=26.8888888888889, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI197383062, Length=377, Percent_Identity=27.0557029177719, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI194294551, Length=405, Percent_Identity=27.6543209876543, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI58331246, Length=417, Percent_Identity=27.3381294964029, Blast_Score=129, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17534817, Length=477, Percent_Identity=26.6247379454927, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17534819, Length=477, Percent_Identity=26.6247379454927, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71981211, Length=525, Percent_Identity=22.6666666666667, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71981217, Length=534, Percent_Identity=22.2846441947566, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17555682, Length=417, Percent_Identity=28.2973621103118, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71993062, Length=417, Percent_Identity=28.2973621103118, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI133931025, Length=469, Percent_Identity=23.8805970149254, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71993058, Length=330, Percent_Identity=29.0909090909091, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17551992, Length=514, Percent_Identity=22.3735408560311, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24652373, Length=466, Percent_Identity=30.9012875536481, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28573972, Length=466, Percent_Identity=27.8969957081545, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24586044, Length=469, Percent_Identity=26.4392324093817, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI17136594, Length=371, Percent_Identity=29.1105121293801, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24585135, Length=488, Percent_Identity=25.8196721311475, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI221476190, Length=458, Percent_Identity=25.1091703056769, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24585143, Length=458, Percent_Identity=25.1091703056769, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24585139, Length=458, Percent_Identity=25.1091703056769, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17136190, Length=495, Percent_Identity=25.4545454545455, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21356415, Length=358, Percent_Identity=27.6536312849162, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24657193, Length=353, Percent_Identity=24.6458923512748, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24657185, Length=353, Percent_Identity=24.6458923512748, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24657188, Length=353, Percent_Identity=24.6458923512748, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 53660; Mature: 53660

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPASRGTLPEADETLDPEDWDTLRAEGHRMLDDMFDHIAGVRERPVWRPIPAETRARFR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCHHHHHHHH
EDLPRNGVDVAEIYREFAEHIAPYTAGNIHPGFMGWVNGGGTAVGMLAEMLAAGLNTNVA
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCC
GRNQMPVEVERQIVLWVRRMFGFPDTASGVFVTGTSMANLMGILVARSARIGPSVRQRGL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHCCH
LDRGARLIAYTSVATHGCIAQAMDCAGFGADALRRIPVDRCHRIDTDALRAQIAADRAAG
HHHCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCHHHHHHHHHHHHHCC
FEPFLVIGSAGTVDIGAIDDLAVLHEVCRDEKLWLHIDGAFGALGVLSPEIAPRLAGIES
CCCEEEECCCCCEECCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHCCHHHHHHHCCCCC
ADSIAFDFHKWGQVPYDAGFLLVRDGEQHRRTFAAPAAYLRRETRGLAAGSPWPCDYSLD
CCHHEEEHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MSRGFRALKTWFTLKAYGTERLGAMIDRTCALARCLEAKVAAEPKLELLAPVQLNIVCFR
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEEEEEEEE
YRADDADSVNAEIVASLHESGITAPSTTMLDGRLAIRAAIVNHRTGMRDIEALISAVLEL
EECCCCCCCCHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GARKSRGSMIFI
CCCCCCCCEEEC
>Mature Secondary Structure
MKPASRGTLPEADETLDPEDWDTLRAEGHRMLDDMFDHIAGVRERPVWRPIPAETRARFR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCHHHHHHHH
EDLPRNGVDVAEIYREFAEHIAPYTAGNIHPGFMGWVNGGGTAVGMLAEMLAAGLNTNVA
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCC
GRNQMPVEVERQIVLWVRRMFGFPDTASGVFVTGTSMANLMGILVARSARIGPSVRQRGL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHCCH
LDRGARLIAYTSVATHGCIAQAMDCAGFGADALRRIPVDRCHRIDTDALRAQIAADRAAG
HHHCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCHHHHHHHHHHHHHCC
FEPFLVIGSAGTVDIGAIDDLAVLHEVCRDEKLWLHIDGAFGALGVLSPEIAPRLAGIES
CCCEEEECCCCCEECCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHCCHHHHHHHCCCCC
ADSIAFDFHKWGQVPYDAGFLLVRDGEQHRRTFAAPAAYLRRETRGLAAGSPWPCDYSLD
CCHHEEEHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MSRGFRALKTWFTLKAYGTERLGAMIDRTCALARCLEAKVAAEPKLELLAPVQLNIVCFR
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEEEEEEEE
YRADDADSVNAEIVASLHESGITAPSTTMLDGRLAIRAAIVNHRTGMRDIEALISAVLEL
EECCCCCCCCHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GARKSRGSMIFI
CCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]