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The map label for this gene is lpxC [H]

Identifier: 75675252

GI number: 75675252

Start: 1156343

End: 1157299

Strand: Direct

Name: lpxC [H]

Synonym: Nwi_1059

Alternate gene names: 75675252

Gene position: 1156343-1157299 (Clockwise)

Preceding gene: 75675251

Following gene: 75675253

Centisome position: 33.99

GC content: 62.17

Gene sequence:

>957_bases
ATGAGATTCAATCGCCAGACGACGCTGCGTTCGCGAGCCACCGTGACGGGTGTCGGCGTTCATTCCGGATTACCGGCCAA
CCTGACTCTAGGGCCTGCGTCGATCGATGCGGGTTTTGTTTTTATCCGCACCTCTCCCGATGGAACCGAACGCCGGGTAC
AGGCCGCCGCGAAATCCGTGACATCGACCAATTTTGCCACGGTCCTGGGCGATCAGCAAGGCTCTCTCGTCTCCACCGCC
GAACACGTTCTTGCTGCGTTGCGTGGCCTTGGCGTCGACAACGCCACCATCGAACTCGACGGACCTGAAGTGCCGATTAT
GGATGGCAGTTCGGCTGCCTTCGTCGCCGCGATCGACCAGGCCGGGATTGTCGAGCAGTCGGCGGCGCGCCGCTTCATCC
AGGTTTTGAAACCGGTCCGGGTCACGAAGGGCGAGGCGGTCGGCGAATTGCGACCGTACAAGCGCGGCTTTCGCGTCGAG
GTCGAGATTGATTTCGCCAATCCGGTGATCGGCCATCAGGACTATTCCATCGATCTTGATCCCGAGAGCTTTCGTCGTGA
AATCAGCCGGGCGAGAACCTTCGGTTGCATGAACGATGTGGCAAGGCTCCGAAGCGCGGGTTTCGCGCTGGGTGCGTCAT
TGGAAAACTCGATGGTGTTCGATGACGAGCGCCTGTTGAATGCCGGTGGCCTGCGCTACGCCGACGAGTGCGTACGACAC
AAGGTTCTCGATGCGATCGGCGATCTGGCGCTCGCCGGGTTGCCGCTGATCGGCGGCTATCGCTCGGCGCGCGGCGGGCA
CAAGCTCAACCACGCGGTGCTGACGGCTTTGATGGCCGACCGGACCGCATGGCGGGTAGTTGAGGATCAGCCGGTTTCGC
GTCCGCGCAGTCAGGGCGAACTGGTCGGCGGAATGGTGGGCGGCATGGCTGCAGCCTATGGTCCCAACGTGTCCTGA

Upstream 100 bases:

>100_bases
TGCCGGTATGTTTTAGGCGTGACTTTGGGGATCACGAATCGATTCGCAGCCTTTCAGGCGAGAATTCGGCGTTCGGGATA
AGTCACTTGGGCCAGGCTTT

Downstream 100 bases:

>100_bases
TCCTCACCGGGTCTCGCACTGTTCGAGTCTCGCACCTTTTAAGCCGTTCTGCTGCGTATGCGCGCCGATCCGTGTTTGTG
CCGTGGCGGCTTGCAGGGGC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MRFNRQTTLRSRATVTGVGVHSGLPANLTLGPASIDAGFVFIRTSPDGTERRVQAAAKSVTSTNFATVLGDQQGSLVSTA
EHVLAALRGLGVDNATIELDGPEVPIMDGSSAAFVAAIDQAGIVEQSAARRFIQVLKPVRVTKGEAVGELRPYKRGFRVE
VEIDFANPVIGHQDYSIDLDPESFRREISRARTFGCMNDVARLRSAGFALGASLENSMVFDDERLLNAGGLRYADECVRH
KVLDAIGDLALAGLPLIGGYRSARGGHKLNHAVLTALMADRTAWRVVEDQPVSRPRSQGELVGGMVGGMAAAYGPNVS

Sequences:

>Translated_318_residues
MRFNRQTTLRSRATVTGVGVHSGLPANLTLGPASIDAGFVFIRTSPDGTERRVQAAAKSVTSTNFATVLGDQQGSLVSTA
EHVLAALRGLGVDNATIELDGPEVPIMDGSSAAFVAAIDQAGIVEQSAARRFIQVLKPVRVTKGEAVGELRPYKRGFRVE
VEIDFANPVIGHQDYSIDLDPESFRREISRARTFGCMNDVARLRSAGFALGASLENSMVFDDERLLNAGGLRYADECVRH
KVLDAIGDLALAGLPLIGGYRSARGGHKLNHAVLTALMADRTAWRVVEDQPVSRPRSQGELVGGMVGGMAAAYGPNVS
>Mature_318_residues
MRFNRQTTLRSRATVTGVGVHSGLPANLTLGPASIDAGFVFIRTSPDGTERRVQAAAKSVTSTNFATVLGDQQGSLVSTA
EHVLAALRGLGVDNATIELDGPEVPIMDGSSAAFVAAIDQAGIVEQSAARRFIQVLKPVRVTKGEAVGELRPYKRGFRVE
VEIDFANPVIGHQDYSIDLDPESFRREISRARTFGCMNDVARLRSAGFALGASLENSMVFDDERLLNAGGLRYADECVRH
KVLDAIGDLALAGLPLIGGYRSARGGHKLNHAVLTALMADRTAWRVVEDQPVSRPRSQGELVGGMVGGMAAAYGPNVS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=288, Percent_Identity=43.75, Blast_Score=241, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 33841; Mature: 33841

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFNRQTTLRSRATVTGVGVHSGLPANLTLGPASIDAGFVFIRTSPDGTERRVQAAAKSV
CCCCCCHHHHHCCEEEEECCCCCCCCCEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHH
TSTNFATVLGDQQGSLVSTAEHVLAALRGLGVDNATIELDGPEVPIMDGSSAAFVAAIDQ
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEECCCCCEEEEEECC
AGIVEQSAARRFIQVLKPVRVTKGEAVGELRPYKRGFRVEVEIDFANPVIGHQDYSIDLD
CCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCEEEEEEEECCCCCCCCCCEEECC
PESFRREISRARTFGCMNDVARLRSAGFALGASLENSMVFDDERLLNAGGLRYADECVRH
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEECHHHHHCCCCCHHHHHHHHH
KVLDAIGDLALAGLPLIGGYRSARGGHKLNHAVLTALMADRTAWRVVEDQPVSRPRSQGE
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHEEEECCCCCCCCCCCCH
LVGGMVGGMAAAYGPNVS
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRFNRQTTLRSRATVTGVGVHSGLPANLTLGPASIDAGFVFIRTSPDGTERRVQAAAKSV
CCCCCCHHHHHCCEEEEECCCCCCCCCEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHH
TSTNFATVLGDQQGSLVSTAEHVLAALRGLGVDNATIELDGPEVPIMDGSSAAFVAAIDQ
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEECCCCCEEEEEECC
AGIVEQSAARRFIQVLKPVRVTKGEAVGELRPYKRGFRVEVEIDFANPVIGHQDYSIDLD
CCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCEEEEEEEECCCCCCCCCCEEECC
PESFRREISRARTFGCMNDVARLRSAGFALGASLENSMVFDDERLLNAGGLRYADECVRH
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEECHHHHHCCCCCHHHHHHHHH
KVLDAIGDLALAGLPLIGGYRSARGGHKLNHAVLTALMADRTAWRVVEDQPVSRPRSQGE
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHEEEECCCCCCCCCCCCH
LVGGMVGGMAAAYGPNVS
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA